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Strain Detail Sheet

Strain Name:
C57BL/6J-MtgxR7763Btlr/Mmmh
Stock Number:
045819-MU
Citation ID:
RRID:MMRRC_045819-MU
Other Names:
R7763 (G1)
Major Collection:
Beutler Mutagenetix

Strain Information

Gene Details

Epha4
Name: Eph receptor A4
Synonyms: Sek, Sek1, Tyro1, Hek8, Cek8, 2900005C20Rik, rb
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 13838
HGNC: HGNC:3388
Homologene: 20933

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Cdon
Name: cell adhesion molecule-related/down-regulated by oncogenes
Synonyms: CAM-related/down-regulated by oncogenes, CDO
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 57810
Homologene: 22996

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Capzb
Name: capping actin protein of muscle Z-line subunit beta
Synonyms: CPbeta2, CPB2, CPbeta1, CPB1, 1700120C01Rik, Cappb1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 12345
HGNC: HGNC:1491
Homologene: 3620

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Rbpms
Name: RNA binding protein gene with multiple splicing
Synonyms: hermes, 2700019M19Rik, 2010300K22Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 19663
Homologene: 38238

Additional Resources
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Akap10
Name: A kinase anchor protein 10
Synonyms: D-AKAP2, 1500031L16Rik, B130049N18Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 56697
HGNC: HGNC:368
Homologene: 32452

Additional Resources
IMPC
Google
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PubMed
IMSR
Gene Ontology
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KOMP Phenotyping
Monarch
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ClinGen
Dop1b
Name: DOP1 leucine zipper like protein B
Synonyms: 0610038M01Rik, 2610510B01Rik, Dopey2
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 70028
VEGA: 16
HGNC: HGNC:1291
Homologene: 21068

Additional Resources
IMPC
Google
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PubMed
IMSR
Gene Ontology
BioGPS
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Mouse Phenome DB
Mouse Mine
KOMP Phenotyping
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ClinGen
Xrn1
Name: 5'-3' exoribonuclease 1
Synonyms: mXrn1, Dhm2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 24127
Homologene: 5894

Additional Resources
IMPC
Google
Entrez
PubMed
IMSR
Gene Ontology
BioGPS
Gene Cloud
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Mouse Phenome DB
Mouse Mine
KOMP Phenotyping
Monarch
GeneCards
ClinGen
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 52,708,640 bp
  • A to G, chromosome 1 at 77,390,031 bp
  • A to G, chromosome 1 at 87,926,949 bp
  • A to G, chromosome 1 at 136,516,383 bp
  • T to A, chromosome 1 at 173,642,879 bp
  • G to T, chromosome 2 at 33,242,382 bp
  • T to A, chromosome 2 at 58,823,636 bp
  • A to T, chromosome 2 at 69,503,388 bp
  • G to A, chromosome 2 at 119,027,347 bp
  • A to T, chromosome 2 at 164,771,291 bp
  • G to C, chromosome 2 at 166,713,709 bp
  • C to T, chromosome 3 at 95,904,372 bp
  • C to A, chromosome 4 at 45,869,570 bp
  • T to C, chromosome 4 at 101,837,141 bp
  • A to T, chromosome 4 at 114,227,708 bp
  • T to A, chromosome 4 at 116,612,033 bp
  • T to A, chromosome 4 at 128,787,031 bp
  • C to T, chromosome 4 at 139,280,553 bp
  • G to T, chromosome 5 at 34,852,190 bp
  • A to G, chromosome 5 at 72,948,610 bp
  • A to G, chromosome 5 at 106,881,861 bp
  • A to T, chromosome 5 at 115,987,001 bp
  • T to A, chromosome 6 at 30,583,645 bp
  • C to T, chromosome 6 at 32,223,980 bp
  • T to C, chromosome 6 at 42,955,789 bp
  • A to G, chromosome 6 at 68,910,579 bp
  • T to A, chromosome 6 at 83,527,368 bp
  • T to A, chromosome 6 at 88,618,197 bp
  • T to C, chromosome 6 at 122,964,340 bp
  • T to C, chromosome 6 at 124,854,432 bp
  • T to A, chromosome 6 at 141,676,224 bp
  • A to G, chromosome 6 at 149,068,658 bp
  • A to G, chromosome 7 at 5,410,913 bp
  • A to T, chromosome 7 at 13,044,091 bp
  • T to A, chromosome 7 at 19,080,340 bp
  • T to A, chromosome 7 at 24,275,218 bp
  • T to A, chromosome 7 at 24,333,263 bp
  • T to A, chromosome 7 at 73,943,321 bp
  • T to C, chromosome 7 at 85,005,701 bp
  • T to A, chromosome 7 at 96,895,692 bp
  • C to T, chromosome 7 at 100,645,663 bp
  • T to A, chromosome 7 at 108,925,826 bp
  • T to A, chromosome 7 at 110,052,799 bp
  • T to A, chromosome 7 at 120,514,602 bp
  • A to G, chromosome 8 at 33,789,453 bp
  • T to C, chromosome 8 at 84,251,028 bp
  • C to T, chromosome 8 at 91,409,443 bp
  • T to A, chromosome 8 at 99,279,674 bp
  • T to C, chromosome 8 at 110,505,843 bp
  • T to C, chromosome 8 at 122,574,935 bp
  • A to T, chromosome 9 at 20,347,323 bp
  • T to A, chromosome 9 at 35,454,415 bp
  • A to C, chromosome 9 at 38,741,162 bp
  • T to A, chromosome 9 at 42,043,909 bp
  • G to A, chromosome 9 at 95,998,348 bp
  • A to G, chromosome 9 at 109,326,633 bp
  • A to T, chromosome 10 at 51,491,046 bp
  • G to T, chromosome 10 at 60,312,577 bp
  • G to T, chromosome 10 at 129,541,455 bp
  • A to G, chromosome 11 at 6,338,558 bp
  • T to C, chromosome 11 at 16,891,266 bp
  • T to C, chromosome 11 at 43,444,765 bp
  • G to T, chromosome 11 at 49,327,671 bp
  • G to C, chromosome 11 at 61,915,505 bp
  • G to T, chromosome 11 at 73,123,269 bp
  • A to T, chromosome 11 at 83,214,788 bp
  • A to T, chromosome 11 at 110,272,497 bp
  • T to G, chromosome 12 at 46,720,698 bp
  • T to A, chromosome 12 at 55,757,955 bp
  • A to G, chromosome 12 at 101,844,855 bp
  • C to T, chromosome 12 at 104,997,495 bp
  • T to A, chromosome 12 at 114,153,207 bp
  • T to C, chromosome 12 at 116,122,718 bp
  • A to T, chromosome 13 at 22,620,669 bp
  • G to A, chromosome 13 at 31,808,028 bp
  • T to A, chromosome 13 at 42,159,461 bp
  • A to T, chromosome 13 at 54,717,692 bp
  • A to T, chromosome 13 at 62,172,664 bp
  • A to T, chromosome 14 at 7,926,478 bp
  • T to A, chromosome 14 at 23,300,006 bp
  • T to G, chromosome 14 at 27,876,204 bp
  • A to G, chromosome 14 at 44,859,078 bp
  • A to T, chromosome 14 at 50,281,488 bp
  • C to T, chromosome 14 at 59,573,834 bp
  • T to C, chromosome 14 at 67,821,327 bp
  • A to G, chromosome 14 at 70,492,084 bp
  • A to T, chromosome 15 at 28,313,855 bp
  • C to T, chromosome 15 at 74,624,705 bp
  • A to T, chromosome 15 at 76,658,547 bp
  • A to T, chromosome 15 at 81,586,583 bp
  • A to G, chromosome 16 at 19,085,489 bp
  • A to G, chromosome 16 at 20,618,529 bp
  • T to A, chromosome 16 at 32,753,311 bp
  • C to G, chromosome 16 at 89,041,299 bp
  • T to C, chromosome 16 at 91,399,293 bp
  • T to A, chromosome 16 at 93,755,514 bp
  • G to A, chromosome 17 at 15,733,041 bp
  • T to C, chromosome 17 at 19,080,535 bp
  • A to G, chromosome 17 at 22,603,118 bp
  • G to A, chromosome 17 at 24,225,012 bp
  • A to T, chromosome 17 at 26,638,827 bp
  • T to A, chromosome 17 at 30,986,456 bp
  • G to A, chromosome 17 at 34,582,418 bp
  • G to T, chromosome 17 at 49,490,022 bp
  • T to C, chromosome 17 at 50,698,715 bp
  • G to A, chromosome 17 at 73,934,834 bp
  • T to A, chromosome 17 at 80,413,713 bp
  • A to T, chromosome 18 at 34,433,287 bp
  • A to G, chromosome 18 at 37,411,882 bp
  • T to A, chromosome 19 at 16,746,000 bp
  • T to A, chromosome 19 at 39,807,168 bp
  • T to A, chromosome 19 at 44,523,835 bp

Strain Description

Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
Gene Specific Genotyping:

To request gene-specific and other genotyping services for a strain, please contact the distribution MMRRC Center for more information.

Background Genetic Quality:

The MMRRC has developed a Genetic Quality Control pipeline using the MiniMUGA array to provide additional information to identify and validate genetic backgrounds of MMRRC strains. For more information on whether genetic background data is available, please contact MMRRC_GeneticQC@med.unc.edu. Note: that MiniMUGA genetic background data is not available on all strains, but can be ordered if desired.

Suggested Control Mice
Littermates of all relevant genotypes.

Strain Origin

Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7763 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Health Status Report

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.

Appearance

Coat Color
Black

Breeding

MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain

Reproductive Statistics

Average litter size
Undetermined
Recommended wean age
3 weeks

Order Information

Availability Level

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Conditions of Distribution

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Fees

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*		 Units Notes
045819-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.