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Strain Name:
C57BL/6J-MtgxR7788Btlr/Mmmh
Stock Number:
045844-MU
Citation ID:
RRID:MMRRC_045844-MU
Other Names:
R7788 (G1)
Major Collection:

Strain Information

Aldh1l1
Name: aldehyde dehydrogenase 1 family, member L1
Synonyms: 1810048F20Rik, Fthfd
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 107747
HGNC: HGNC:3978
Homologene: 122031
Rilpl1
Name: Rab interacting lysosomal protein-like 1
Synonyms: 6330559I19Rik, 2900002H16Rik, GOSPEL
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 75695
Homologene: 15619
Arid5b
Name: AT-rich interaction domain 5B
Synonyms: 5430435G07Rik, Desrt, Mrf2beta, Mrf2alpha, Mrf2
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 71371
VEGA: 10
Homologene: 45872
Prdx2
Name: peroxiredoxin 2
Synonyms: TPx, thioredoxin reductase, TR, Prx II-1, Trx dependent peroxide reductase 1, thiol specific antioxidant protein, TSA, thioredoxin dependent peroxide reductase 1, TDX1, thioredoxin peroxidase, protector protein, PRP, Tdpx1, PrxII
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 21672
HGNC: HGNC:9353
Homologene: 21182
Aopep
Name: aminopeptidase O
Synonyms: ApO, 2010111I01Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 72061
HGNC: HGNC:1361
Homologene: 66273
Dnajc21
Name: DnaJ heat shock protein family (Hsp40) member C21
Synonyms: 9930116P15Rik, 4930461P20Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 78244
Homologene: 6752
Cilk1
Name: ciliogenesis associated kinase 1
Synonyms: 2210420N10Rik, Ick
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 56542
Homologene: 69218
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 36,531,727 bp
  • A to G, chromosome 1 at 174,042,084 bp
  • T to C, chromosome 1 at 182,895,202 bp
  • C to T, chromosome 2 at 11,723,593 bp
  • T to C, chromosome 2 at 76,885,756 bp
  • C to T, chromosome 2 at 157,027,584 bp
  • T to C, chromosome 2 at 164,819,779 bp
  • A to G, chromosome 3 at 88,332,642 bp
  • A to G, chromosome 3 at 94,875,233 bp
  • A to G, chromosome 3 at 142,503,080 bp
  • A to T, chromosome 4 at 42,793,546 bp
  • G to A, chromosome 4 at 75,998,604 bp
  • T to C, chromosome 4 at 109,062,494 bp
  • T to G, chromosome 4 at 113,546,518 bp
  • C to T, chromosome 5 at 65,075,569 bp
  • T to C, chromosome 5 at 73,415,034 bp
  • A to T, chromosome 5 at 101,848,357 bp
  • A to G, chromosome 5 at 120,801,042 bp
  • A to T, chromosome 5 at 124,496,137 bp
  • A to T, chromosome 5 at 134,417,131 bp
  • G to A, chromosome 5 at 145,032,610 bp
  • G to A, chromosome 6 at 29,456,444 bp
  • A to T, chromosome 6 at 38,332,756 bp
  • T to C, chromosome 6 at 71,885,557 bp
  • A to C, chromosome 6 at 90,569,912 bp
  • T to A, chromosome 6 at 91,988,459 bp
  • A to T, chromosome 6 at 113,385,604 bp
  • C to A, chromosome 6 at 121,861,220 bp
  • T to C, chromosome 6 at 123,637,600 bp
  • T to C, chromosome 6 at 149,068,566 bp
  • T to A, chromosome 7 at 30,427,178 bp
  • T to C, chromosome 7 at 41,286,694 bp
  • T to C, chromosome 7 at 46,099,755 bp
  • T to A, chromosome 8 at 24,547,226 bp
  • T to A, chromosome 8 at 45,381,517 bp
  • A to G, chromosome 8 at 84,971,674 bp
  • C to A, chromosome 8 at 95,368,148 bp
  • A to G, chromosome 8 at 105,308,244 bp
  • A to G, chromosome 9 at 9,704,929 bp
  • A to T, chromosome 9 at 67,940,483 bp
  • A to T, chromosome 9 at 75,279,345 bp
  • G to C, chromosome 9 at 78,167,620 bp
  • C to T, chromosome 10 at 68,098,587 bp
  • C to A, chromosome 10 at 99,109,113 bp
  • A to G, chromosome 11 at 54,694,399 bp
  • A to T, chromosome 11 at 73,955,122 bp
  • T to C, chromosome 11 at 79,527,942 bp
  • G to T, chromosome 11 at 82,982,641 bp
  • A to G, chromosome 11 at 86,775,676 bp
  • A to G, chromosome 12 at 33,060,320 bp
  • T to C, chromosome 12 at 69,984,221 bp
  • A to T, chromosome 12 at 103,457,009 bp
  • A to T, chromosome 13 at 3,804,121 bp
  • A to G, chromosome 13 at 43,383,147 bp
  • A to T, chromosome 13 at 63,156,593 bp
  • A to T, chromosome 13 at 81,573,314 bp
  • T to C, chromosome 13 at 100,055,251 bp
  • T to C, chromosome 14 at 52,581,124 bp
  • A to T, chromosome 14 at 68,512,645 bp
  • A to C, chromosome 14 at 101,898,576 bp
  • A to T, chromosome 14 at 118,883,393 bp
  • A to T, chromosome 14 at 121,276,253 bp
  • A to G, chromosome 15 at 10,460,047 bp
  • A to G, chromosome 15 at 71,952,317 bp
  • A to T, chromosome 15 at 78,292,841 bp
  • C to A, chromosome 16 at 16,225,408 bp
  • T to A, chromosome 16 at 17,212,704 bp
  • T to A, chromosome 16 at 97,576,229 bp
  • G to A, chromosome 16 at 97,951,454 bp
  • T to A, chromosome 17 at 27,118,597 bp
  • A to T, chromosome 17 at 35,618,906 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7788 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045844-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.