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Strain Name:
C57BL/6J-MtgxR7791Btlr/Mmmh
Stock Number:
045847-MU
Citation ID:
RRID:MMRRC_045847-MU
Other Names:
R7791 (G1)
Major Collection:

Strain Information

Htr3a
Name: 5-hydroxytryptamine (serotonin) receptor 3A
Synonyms: 5-HT3 receptor
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 15561
VEGA: 9
HGNC: HGNC:5297
Homologene: 671
Bahcc1
Name: BAH domain and coiled-coil containing 1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 268515
Homologene: 129585
Dst
Name: dystonin
Synonyms: bullous pemphigoid antigen 1, BPAG1-n, BPAG1, Bpag1, Bpag, ah, bullous pemphigoid antigen 1, athetoid, Macf2, 2310001O04Rik, nmf203, A830042E19Rik, nmf339
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 13518
HGNC: HGNC:1090
Homologene: 136716
Ctcf
Name: CCCTC-binding factor
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 13018
Homologene: 4786
Ndufv1
Name: NADH:ubiquinone oxidoreductase core subunit V1
Synonyms: 24 kDa (FP)
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 17995
HGNC: HGNC:7716
Homologene: 5151
Mtor
Name: mechanistic target of rapamycin kinase
Synonyms: FKBP-rapamycin-associated protein FRAP, 2610315D21Rik, RAPT1, RAFT1, flat, Frap1, mechanistic target of rapamycin (serine/threonine kinase)
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 56717
HGNC: HGNC:3942
Homologene: 3637
Eml4
Name: echinoderm microtubule associated protein like 4
Synonyms: 4930443C24Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 78798
VEGA: 17
HGNC: HGNC:1316
Homologene: 56841
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 34,154,592 bp
  • T to C, chromosome 1 at 74,428,136 bp
  • T to C, chromosome 1 at 162,649,121 bp
  • T to A, chromosome 1 at 172,276,215 bp
  • C to A, chromosome 2 at 25,052,066 bp
  • T to C, chromosome 2 at 28,681,948 bp
  • A to G, chromosome 3 at 32,590,043 bp
  • A to T, chromosome 3 at 82,035,397 bp
  • A to G, chromosome 4 at 109,426,347 bp
  • T to A, chromosome 4 at 116,574,420 bp
  • C to T, chromosome 4 at 140,917,596 bp
  • A to G, chromosome 4 at 144,703,445 bp
  • G to T, chromosome 4 at 148,462,940 bp
  • C to T, chromosome 5 at 24,476,413 bp
  • T to C, chromosome 5 at 110,448,019 bp
  • T to C, chromosome 5 at 121,867,099 bp
  • T to A, chromosome 5 at 135,171,114 bp
  • T to C, chromosome 5 at 137,032,031 bp
  • A to T, chromosome 6 at 47,807,122 bp
  • A to T, chromosome 6 at 92,872,385 bp
  • A to G, chromosome 6 at 129,513,003 bp
  • G to A, chromosome 6 at 147,081,544 bp
  • A to T, chromosome 8 at 41,083,380 bp
  • A to G, chromosome 8 at 86,853,203 bp
  • A to G, chromosome 8 at 105,664,939 bp
  • TG to TGG, chromosome 9 at 7,465,083 bp
  • T to C, chromosome 9 at 39,484,881 bp
  • T to C, chromosome 9 at 43,792,039 bp
  • T to A, chromosome 9 at 48,901,575 bp
  • A to G, chromosome 9 at 119,543,336 bp
  • C to T, chromosome 9 at 121,263,668 bp
  • A to T, chromosome 10 at 23,113,926 bp
  • G to T, chromosome 10 at 81,334,706 bp
  • A to G, chromosome 10 at 88,440,222 bp
  • A to G, chromosome 11 at 34,813,477 bp
  • G to A, chromosome 11 at 58,124,993 bp
  • A to G, chromosome 11 at 78,422,064 bp
  • A to G, chromosome 11 at 103,339,194 bp
  • T to G, chromosome 11 at 120,268,377 bp
  • A to T, chromosome 12 at 55,741,519 bp
  • A to C, chromosome 12 at 111,423,540 bp
  • A to G, chromosome 12 at 113,736,545 bp
  • A to T, chromosome 13 at 59,690,694 bp
  • C to T, chromosome 15 at 6,489,878 bp
  • T to A, chromosome 15 at 85,815,931 bp
  • A to G, chromosome 16 at 32,619,167 bp
  • A to G, chromosome 16 at 64,783,271 bp
  • T to A, chromosome 17 at 33,199,352 bp
  • T to C, chromosome 17 at 73,382,888 bp
  • G to T, chromosome 17 at 83,473,706 bp
  • A to G, chromosome 18 at 77,383,729 bp
  • A to T, chromosome 19 at 4,011,533 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
Gene Specific Genotyping:

To request gene-specific and other genotyping services for a strain, please contact the distribution MMRRC Center for more information.

Background Genetic Quality:

The MMRRC has developed a Genetic Quality Control pipeline using the MiniMUGA array to provide additional information to identify and validate genetic backgrounds of MMRRC strains. For more information on whether genetic background data is available, please contact MMRRC_GeneticQC@med.unc.edu. Note: that MiniMUGA genetic background data is not available on all strains, but can be ordered if desired.

Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7791 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045847-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.