Strain Name:
C57BL/6J-MtgxR7791Btlr/Mmmh
Stock Number:
045847-MU
Citation ID:
RRID:MMRRC_045847-MU
Other Names:
R7791 (G1)
Major Collection:

Strain Information

Htr3a
Name: 5-hydroxytryptamine (serotonin) receptor 3A
Synonyms: 5-HT3 receptor
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 15561
VEGA: 9
HGNC: HGNC:5297
Homologene: 671
Bahcc1
Name: BAH domain and coiled-coil containing 1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 268515
Homologene: 129585
Dst
Name: dystonin
Synonyms: Bpag, Macf2, A830042E19Rik, nmf339, 2310001O04Rik, BPAG1, BPAG1-n, bullous pemphigoid antigen 1, bullous pemphigoid antigen 1, athetoid, nmf203, Bpag1, ah
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 13518
HGNC: HGNC:1090
Homologene: 136716
Ctcf
Name: CCCTC-binding factor
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 13018
Homologene: 4786
Ndufv1
Name: NADH:ubiquinone oxidoreductase core subunit V1
Synonyms: 24 kDa (FP)
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 17995
HGNC: HGNC:7716
Homologene: 5151
Mtor
Name: mechanistic target of rapamycin kinase
Synonyms: Frap1, RAPT1, RAFT1, flat, 2610315D21Rik, FKBP-rapamycin-associated protein FRAP, mechanistic target of rapamycin (serine/threonine kinase)
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 56717
HGNC: HGNC:3942
Homologene: 3637
Eml4
Name: echinoderm microtubule associated protein like 4
Synonyms: 4930443C24Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 78798
VEGA: 17
HGNC: HGNC:1316
Homologene: 56841
Fbrsl1
Name: fibrosin-like 1
Synonyms: 2410025L10Rik, LOC381668, Gm29766
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 381668
Homologene: 45966
Ralgapa1
Name: Ral GTPase activating protein, alpha subunit 1
Synonyms: 2310003F20Rik, Garnl1, Tulip1, 4930400K19Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 56784
VEGA: 12
Homologene: 84805
Gpbp1l1
Name: GC-rich promoter binding protein 1-like 1
Synonyms: 5330440M15Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 77110
Homologene: 84840
Tfrc
Name: transferrin receptor
Synonyms: E430033M20Rik, Trfr, p90, Mtvr1, 2610028K12Rik, CD71, Mtvr-1, TfR1
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 22042
Homologene: 2429
Cux2
Name: cut-like homeobox 2
Synonyms: Cux2, Cux-2, 1700051K22Rik, ENSMUSG00000072641, Cutl2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 13048
Homologene: 22426
Gnb4
Name: guanine nucleotide binding protein (G protein), beta 4
Synonyms: 6720453A21Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 14696
Homologene: 69140
Pdia4
Name: protein disulfide isomerase associated 4
Synonyms: ERp72, Cai, U48620, Erp72
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 12304
Homologene: 21020
Bcl7b
Name: B cell CLL/lymphoma 7B
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 12054
HGNC: HGNC:1005
Homologene: 1290
Tsc1
Name: TSC complex subunit 1
Synonyms: tuberous sclerosis 1, hamartin
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 64930
Homologene: 314
N4bp1
Name: NEDD4 binding protein 1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 80750
Homologene: 23703
Mtus1
Name: mitochondrial tumor suppressor 1
Synonyms: MD44, B430305I03Rik, Atip1, MTSG1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 102103
Homologene: 100292
Agap3
Name: ArfGAP with GTPase domain, ankyrin repeat and PH domain 3
Synonyms: MRIP-1, Crag, Centg3
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 213990
Homologene: 23742
Pnpla7
Name: patatin-like phospholipase domain containing 7
Synonyms: E430013P11Rik, NRE
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241274
Homologene: 62431
Gemin5
Name: gem nuclear organelle associated protein 5
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 216766
Homologene: 9155
AAdacl4fm3
Name: AADACL4 family member 3
Synonyms: Gm13178
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 546849
Homologene: 82586
Loxhd1
Name: lipoxygenase homology domains 1
Synonyms: sba, 1700096C21Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 240411
Pkdrej
Name: polycystin (PKD) family receptor for egg jelly
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 18766
VEGA: 15
HGNC: HGNC:9015
Homologene: 4427
Gucy1b1
Name: guanylate cyclase 1, soluble, beta 1
Synonyms: beta 1 sGC, Gucy1b3
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 54195
HGNC: HGNC:4687
Homologene: 664
Zfp654
Name: zinc finger protein 654
Synonyms: 1600021C16Rik, Gm5488, 1810008K20Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 72020
Homologene: 10114
Scn5a
Name: sodium channel, voltage-gated, type V, alpha
Synonyms: Nav1.5, SkM2, Nav1.5c, mH1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 20271
Homologene: 22738
Ttc39a
Name: tetratricopeptide repeat domain 39A
Synonyms: 4922503N01Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230603
Homologene: 17739
Ulk4
Name: unc-51-like kinase 4
Synonyms: 4932415A06Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 209012
Homologene: 41205
Myoc
Name: myocilin
Synonyms: GLC1A, TIGR
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 17926
HGNC: HGNC:7610
Homologene: 220
Adamts9
Name: ADAM metallopeptidase with thrombospondin type 1 motif 9
Synonyms: 1810011L16Rik, E030027K14Rik, 8430403M15Rik, UND3, UND4, Mhdaund3, Mhdaund4, Gsfund3
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 101401
Homologene: 18821
Slc13a2
Name: solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2
Synonyms: sodium/dicarboxylate co-transporter, Nadc1, mNaDC-1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 20500
Homologene: 2965
Mmp1a
Name: matrix metallopeptidase 1a (interstitial collagenase)
Synonyms: Mcol-A
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 83995
VEGA: 9
HGNC: HGNC:7155
Homologene: 20544
Gnptab
Name: N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits
Synonyms: EG432486
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 432486
Homologene: 32576
Vil1
Name: villin 1
Synonyms: Villin
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 22349
Homologene: 5169
Mansc4
Name: MANSC domain containing 4
Synonyms: Gm5887
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 545893
Homologene: 86837
Padi2
Name: peptidyl arginine deiminase, type II
Synonyms: Pdi, Pdi2, PAD type II
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 18600
Homologene: 7214
Capn13
Name: calpain 13
Synonyms: LOC381122
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 381122
VEGA: 17
Homologene: 27026
Atp1a2
Name: ATPase, Na+/K+ transporting, alpha 2 polypeptide
Synonyms: Atpa-3
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 98660
HGNC: HGNC:800
Homologene: 47947
Vgf
Name: VGF nerve growth factor inducible
Synonyms: LOC381677
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 381677
Homologene: 2536
Or8g20
Name: olfactory receptor family 8 subfamily G member 20
Synonyms: MOR171-5, Olfr44, GA_x6K02T2PVTD-33181773-33180838, IB3
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 18343
VEGA: 9
HGNC: HGNC:8484
Homologene: 133633
Tbxa2r
Name: thromboxane A2 receptor
Synonyms: TP, Tp receptor
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 21390
VEGA: 10
Homologene: 825
C9
Name: complement component 9
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 12279
HGNC: HGNC:1358
Homologene: 74406
Or10h1
Name: olfactory receptor family 10 subfamily H member 1
Synonyms: MOR267-10, Olfr239, GA_x6K02T2KN0P-2543-1596
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 100038860
Homologene: 110515
Spdl1
Name: spindle apparatus coiled-coil protein 1
Synonyms: 2600001J17Rik, 2810049B11Rik, 1700018I02Rik, Ccdc99
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 70385
Homologene: 9837
4921517D22Rik
Name: RIKEN cDNA 4921517D22 gene
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 70900
VEGA: 13
Homologene: 87278
Exoc3l4
Name: exocyst complex component 3-like 4
Synonyms: 1600013K19Rik, 1200009I06Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 74190
VEGA: 12
Homologene: 41760
Eya4
Name: EYA transcriptional coactivator and phosphatase 4
Synonyms: B130023L16Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 14051
VEGA: 10
HGNC: HGNC:3522
Homologene: 3025
Nectin1
Name: nectin cell adhesion molecule 1
Synonyms: PRR1, Pvrl1, Cd111, nectin-1, PRR, HveC, HIgR
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 58235
VEGA: 9
HGNC: HGNC:9706
Homologene: 2138
Arhgap27
Name: Rho GTPase activating protein 27
Synonyms: Sh3d20, 2310069I04Rik, 5730442P18Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 544817
Homologene: 45715
Tmem52b
Name: transmembrane protein 52B
Synonyms: D630042F21Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 330428
Homologene: 27407
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 34,154,592 bp
  • T to C, chromosome 1 at 74,428,136 bp
  • T to C, chromosome 1 at 162,649,121 bp
  • T to A, chromosome 1 at 172,276,215 bp
  • C to A, chromosome 2 at 25,052,066 bp
  • T to C, chromosome 2 at 28,681,948 bp
  • A to G, chromosome 3 at 32,590,043 bp
  • A to T, chromosome 3 at 82,035,397 bp
  • A to G, chromosome 4 at 109,426,347 bp
  • T to A, chromosome 4 at 116,574,420 bp
  • C to T, chromosome 4 at 140,917,596 bp
  • A to G, chromosome 4 at 144,703,445 bp
  • G to T, chromosome 4 at 148,462,940 bp
  • C to T, chromosome 5 at 24,476,413 bp
  • T to C, chromosome 5 at 110,448,019 bp
  • T to C, chromosome 5 at 121,867,099 bp
  • T to A, chromosome 5 at 135,171,114 bp
  • T to C, chromosome 5 at 137,032,031 bp
  • A to T, chromosome 6 at 47,807,122 bp
  • A to T, chromosome 6 at 92,872,385 bp
  • A to G, chromosome 6 at 129,513,003 bp
  • G to A, chromosome 6 at 147,081,544 bp
  • A to T, chromosome 8 at 41,083,380 bp
  • A to G, chromosome 8 at 86,853,203 bp
  • A to G, chromosome 8 at 105,664,939 bp
  • TG to TGG, chromosome 9 at 7,465,083 bp
  • T to C, chromosome 9 at 39,484,881 bp
  • T to C, chromosome 9 at 43,792,039 bp
  • T to A, chromosome 9 at 48,901,575 bp
  • A to G, chromosome 9 at 119,543,336 bp
  • C to T, chromosome 9 at 121,263,668 bp
  • A to T, chromosome 10 at 23,113,926 bp
  • G to T, chromosome 10 at 81,334,706 bp
  • A to G, chromosome 10 at 88,440,222 bp
  • A to G, chromosome 11 at 34,813,477 bp
  • G to A, chromosome 11 at 58,124,993 bp
  • A to G, chromosome 11 at 78,422,064 bp
  • A to G, chromosome 11 at 103,339,194 bp
  • T to G, chromosome 11 at 120,268,377 bp
  • A to T, chromosome 12 at 55,741,519 bp
  • A to C, chromosome 12 at 111,423,540 bp
  • A to G, chromosome 12 at 113,736,545 bp
  • A to T, chromosome 13 at 59,690,694 bp
  • C to T, chromosome 15 at 6,489,878 bp
  • T to A, chromosome 15 at 85,815,931 bp
  • A to G, chromosome 16 at 32,619,167 bp
  • A to G, chromosome 16 at 64,783,271 bp
  • T to A, chromosome 17 at 33,199,352 bp
  • T to C, chromosome 17 at 73,382,888 bp
  • G to T, chromosome 17 at 83,473,706 bp
  • A to G, chromosome 18 at 77,383,729 bp
  • A to T, chromosome 19 at 4,011,533 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7791 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045847-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.