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Strain Name:
C57BL/6J-MtgxR7793Btlr/Mmmh
Stock Number:
045849-MU
Citation ID:
RRID:MMRRC_045849-MU
Other Names:
R7793 (G1)
Major Collection:

Strain Information

Arhgef7
Name: Rho guanine nucleotide exchange factor
Synonyms: Cool, PIX, Pak interacting exchange factor, p85SPR, betaPix-c, betaPix-b, cool-1, betaPix
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 54126
Homologene: 2895
Sez6
Name: seizure related gene 6
Synonyms: sez-6, D11Bhm177e
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 20370
Homologene: 10948
Mysm1
Name: myb-like, SWIRM and MPN domains 1
Synonyms: C530050H10Rik, C130067A03Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 320713
Homologene: 66204
Trpm7
Name: transient receptor potential cation channel, subfamily M, member 7
Synonyms: 5033407O22Rik, 4833414K03Rik, Ltpr7, CHAK1, CHAK, TRP-PLIK, 2310022G15Rik, LTRPC7
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 58800
Homologene: 9774
Schip1
Name: schwannomin interacting protein 1
Synonyms: SCHIP-1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 30953
Homologene: 130673
Tacc2
Name: transforming, acidic coiled-coil containing protein 2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 57752
Homologene: 5087
Exoc2
Name: exocyst complex component 2
Synonyms: Sec5, 2410030I24Rik, Sec5l1, Gm29675
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 66482
Homologene: 10122
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 40,471,764 bp
  • T to C, chromosome 1 at 66,778,014 bp
  • A to G, chromosome 1 at 146,746,568 bp
  • A to G, chromosome 1 at 153,447,825 bp
  • A to C, chromosome 1 at 156,338,743 bp
  • T to C, chromosome 2 at 24,429,597 bp
  • A to G, chromosome 2 at 37,084,921 bp
  • T to A, chromosome 2 at 76,732,045 bp
  • A to T, chromosome 2 at 126,824,075 bp
  • G to A, chromosome 2 at 130,012,410 bp
  • A to C, chromosome 2 at 177,315,867 bp
  • A to T, chromosome 3 at 68,494,578 bp
  • A to T, chromosome 3 at 96,155,211 bp
  • T to A, chromosome 4 at 43,172,737 bp
  • C to A, chromosome 4 at 45,106,651 bp
  • T to C, chromosome 4 at 53,042,367 bp
  • T to C, chromosome 4 at 58,853,150 bp
  • C to T, chromosome 4 at 73,942,935 bp
  • T to C, chromosome 4 at 94,965,132 bp
  • G to A, chromosome 4 at 124,914,453 bp
  • T to C, chromosome 5 at 51,462,509 bp
  • G to A, chromosome 5 at 104,440,334 bp
  • A to T, chromosome 5 at 128,789,695 bp
  • A to G, chromosome 5 at 139,356,140 bp
  • A to T, chromosome 6 at 41,524,952 bp
  • T to C, chromosome 6 at 80,022,858 bp
  • AAGTA to AAGTAGAGTA, chromosome 6 at 113,399,159 bp
  • T to C, chromosome 6 at 121,760,604 bp
  • T to C, chromosome 6 at 124,399,341 bp
  • C to T, chromosome 6 at 125,686,520 bp
  • A to T, chromosome 6 at 137,416,820 bp
  • T to C, chromosome 7 at 3,245,400 bp
  • C to T, chromosome 7 at 6,353,887 bp
  • T to A, chromosome 7 at 10,725,074 bp
  • T to C, chromosome 7 at 12,153,314 bp
  • T to A, chromosome 7 at 12,632,269 bp
  • T to A, chromosome 7 at 23,423,918 bp
  • T to G, chromosome 7 at 30,699,943 bp
  • G to A, chromosome 7 at 35,429,928 bp
  • T to A, chromosome 7 at 43,574,684 bp
  • A to C, chromosome 7 at 48,878,075 bp
  • T to A, chromosome 7 at 57,179,580 bp
  • T to G, chromosome 7 at 105,433,591 bp
  • T to A, chromosome 7 at 130,623,113 bp
  • T to A, chromosome 8 at 11,824,507 bp
  • A to G, chromosome 8 at 71,913,141 bp
  • T to A, chromosome 8 at 105,055,661 bp
  • T to A, chromosome 9 at 4,331,221 bp
  • T to C, chromosome 9 at 44,508,966 bp
  • C to A, chromosome 9 at 44,509,697 bp
  • T to C, chromosome 9 at 63,144,885 bp
  • T to A, chromosome 9 at 71,725,635 bp
  • T to C, chromosome 9 at 105,898,735 bp
  • T to C, chromosome 9 at 106,211,880 bp
  • C to T, chromosome 9 at 121,263,668 bp
  • T to A, chromosome 9 at 121,416,198 bp
  • T to A, chromosome 10 at 23,226,816 bp
  • A to T, chromosome 10 at 76,278,583 bp
  • A to G, chromosome 10 at 130,477,544 bp
  • T to C, chromosome 11 at 35,869,109 bp
  • T to A, chromosome 11 at 62,847,387 bp
  • T to A, chromosome 11 at 65,009,924 bp
  • T to C, chromosome 11 at 69,495,214 bp
  • T to A, chromosome 11 at 73,009,253 bp
  • T to A, chromosome 11 at 74,044,788 bp
  • T to C, chromosome 11 at 77,977,600 bp
  • C to T, chromosome 11 at 78,273,205 bp
  • C to T, chromosome 11 at 79,937,730 bp
  • T to C, chromosome 11 at 87,764,310 bp
  • T to A, chromosome 11 at 97,712,439 bp
  • A to C, chromosome 12 at 8,008,124 bp
  • T to G, chromosome 12 at 84,307,801 bp
  • A to G, chromosome 12 at 118,849,409 bp
  • A to T, chromosome 13 at 30,911,178 bp
  • A to T, chromosome 13 at 74,331,436 bp
  • C to A, chromosome 14 at 69,796,831 bp
  • T to C, chromosome 15 at 76,359,107 bp
  • A to T, chromosome 15 at 78,540,388 bp
  • G to A, chromosome 15 at 78,773,065 bp
  • G to A, chromosome 16 at 20,688,614 bp
  • A to G, chromosome 16 at 32,619,167 bp
  • T to A, chromosome 16 at 97,546,883 bp
  • T to C, chromosome 17 at 13,225,626 bp
  • A to G, chromosome 17 at 30,855,944 bp
  • G to A, chromosome 17 at 37,047,501 bp
  • A to G, chromosome 18 at 36,002,979 bp
  • A to C, chromosome 18 at 61,005,779 bp
  • G to A, chromosome 19 at 10,798,358 bp
  • G to T, chromosome 19 at 38,159,753 bp
  • A to T, chromosome 19 at 43,388,070 bp
  • A to T, chromosome 19 at 46,515,614 bp
  • G to A, chromosome 19 at 46,891,581 bp
  • G to A, chromosome 19 at 47,106,432 bp
  • T to C, chromosome 19 at 56,864,377 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7793 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045849-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.