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Strain Name:
C57BL/6J-MtgxR7797Btlr/Mmmh
Stock Number:
045853-MU
Citation ID:
RRID:MMRRC_045853-MU
Other Names:
R7797 (G1)
Major Collection:

Strain Information

Met
Name: met proto-oncogene
Synonyms: HGF receptor, c-Met, Par4
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 17295
HGNC: HGNC:7029
Homologene: 206
Ulk2
Name: unc-51 like kinase 2
Synonyms: Unc51.2, A830085I22Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 29869
Homologene: 5891
Osbpl1a
Name: oxysterol binding protein-like 1A
Synonyms: LOC328902, G430090F17Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 64291
Homologene: 84746
Tlk2
Name: tousled-like kinase 2 (Arabidopsis)
Synonyms: protein kinase U-alpha, PKUalpha, 4933403M19Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 24086
Homologene: 4993
Asah2
Name: N-acylsphingosine amidohydrolase 2
Synonyms: neutral/alkaline ceramidase
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 54447
VEGA: 19
Homologene: 10310
Naa15
Name: N(alpha)-acetyltransferase 15, NatA auxiliary subunit
Synonyms: tubedown, Tbdn-1, mNAT1, 5730450D16Rik, Narg1, ASTBDN
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 74838
Homologene: 14211
Kif1b
Name: kinesin family member 1B
Synonyms: D4Mil1e, Kif1b alpha, Kif1b beta, KIF1Bp130, KIF1Bp204, N-3 kinesin, A530096N05Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 16561
Homologene: 99835
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 157,561,675 bp
  • A to G, chromosome 1 at 171,257,818 bp
  • T to G, chromosome 2 at 4,749,644 bp
  • T to A, chromosome 2 at 102,848,734 bp
  • T to C, chromosome 2 at 129,015,635 bp
  • G to A, chromosome 3 at 51,448,610 bp
  • G to A, chromosome 3 at 95,480,261 bp
  • A to G, chromosome 3 at 104,051,302 bp
  • G to A, chromosome 4 at 107,209,491 bp
  • A to T, chromosome 4 at 117,171,743 bp
  • C to G, chromosome 4 at 135,559,105 bp
  • C to T, chromosome 4 at 147,862,918 bp
  • T to A, chromosome 4 at 149,237,387 bp
  • T to A, chromosome 5 at 112,307,916 bp
  • A to C, chromosome 5 at 144,318,950 bp
  • T to A, chromosome 6 at 17,533,953 bp
  • T to C, chromosome 6 at 24,562,506 bp
  • T to A, chromosome 6 at 52,215,890 bp
  • T to G, chromosome 6 at 68,270,993 bp
  • T to C, chromosome 6 at 113,394,777 bp
  • A to G, chromosome 7 at 10,446,976 bp
  • G to A, chromosome 7 at 25,334,597 bp
  • G to A, chromosome 7 at 44,541,789 bp
  • A to G, chromosome 7 at 80,264,437 bp
  • A to T, chromosome 7 at 97,661,485 bp
  • T to A, chromosome 7 at 103,851,881 bp
  • A to T, chromosome 7 at 104,411,200 bp
  • A to G, chromosome 7 at 126,413,508 bp
  • A to T, chromosome 7 at 127,214,765 bp
  • T to G, chromosome 8 at 24,694,644 bp
  • T to A, chromosome 8 at 43,626,374 bp
  • G to C, chromosome 8 at 125,785,348 bp
  • G to T, chromosome 9 at 8,027,129 bp
  • C to T, chromosome 9 at 110,393,807 bp
  • T to C, chromosome 10 at 14,130,103 bp
  • A to G, chromosome 10 at 25,993,966 bp
  • T to C, chromosome 10 at 60,385,194 bp
  • G to T, chromosome 10 at 75,923,480 bp
  • T to C, chromosome 11 at 22,096,109 bp
  • C to T, chromosome 11 at 34,282,652 bp
  • A to G, chromosome 11 at 51,817,299 bp
  • T to C, chromosome 11 at 61,489,415 bp
  • A to G, chromosome 11 at 61,782,102 bp
  • T to A, chromosome 11 at 100,094,887 bp
  • A to G, chromosome 11 at 105,210,618 bp
  • A to G, chromosome 11 at 109,971,683 bp
  • A to T, chromosome 11 at 118,496,484 bp
  • A to G, chromosome 12 at 83,699,622 bp
  • C to T, chromosome 13 at 11,801,180 bp
  • G to A, chromosome 13 at 34,747,101 bp
  • T to A, chromosome 13 at 100,444,478 bp
  • G to A, chromosome 13 at 112,998,987 bp
  • G to A, chromosome 14 at 52,133,820 bp
  • A to C, chromosome 15 at 4,949,105 bp
  • A to T, chromosome 15 at 37,927,261 bp
  • G to T, chromosome 15 at 98,864,406 bp
  • C to T, chromosome 17 at 29,842,840 bp
  • A to G, chromosome 17 at 30,959,151 bp
  • T to C, chromosome 17 at 33,067,690 bp
  • T to C, chromosome 17 at 46,658,642 bp
  • C to T, chromosome 17 at 57,508,874 bp
  • T to C, chromosome 17 at 58,359,275 bp
  • C to A, chromosome 18 at 12,882,264 bp
  • A to G, chromosome 18 at 60,561,272 bp
  • A to G, chromosome 19 at 32,022,361 bp
  • T to C, chromosome 19 at 40,959,788 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7797 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045853-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.