Strain Name:
C57BL/6J-MtgxR7797Btlr/Mmmh
Stock Number:
045853-MU
Citation ID:
RRID:MMRRC_045853-MU
Other Names:
R7797 (G1)
Major Collection:

Strain Information

Met
Name: met proto-oncogene
Synonyms: c-Met, Par4, HGF receptor
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 17295
HGNC: HGNC:7029
Homologene: 206
Ulk2
Name: unc-51 like kinase 2
Synonyms: A830085I22Rik, Unc51.2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 29869
Homologene: 5891
Osbpl1a
Name: oxysterol binding protein-like 1A
Synonyms: G430090F17Rik, LOC328902
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 64291
Homologene: 84746
Tlk2
Name: tousled-like kinase 2 (Arabidopsis)
Synonyms: PKUalpha, protein kinase U-alpha, 4933403M19Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 24086
Homologene: 4993
Asah2
Name: N-acylsphingosine amidohydrolase 2
Synonyms: neutral/alkaline ceramidase
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 54447
VEGA: 19
Homologene: 10310
Naa15
Name: N(alpha)-acetyltransferase 15, NatA auxiliary subunit
Synonyms: ASTBDN, tubedown, Tbdn-1, mNAT1, 5730450D16Rik, Narg1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 74838
Homologene: 14211
Kif1b
Name: kinesin family member 1B
Synonyms: A530096N05Rik, KIF1Bp130, KIF1Bp204, N-3 kinesin, D4Mil1e, Kif1b alpha, Kif1b beta
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 16561
Homologene: 99835
Ptpn23
Name: protein tyrosine phosphatase, non-receptor type 23
Synonyms: PTP-TD14
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 104831
Homologene: 135706
Rsf1
Name: remodeling and spacing factor 1
Synonyms: 4832420A03Rik, p325, C030033M12Rik, Hbxap, XAP8
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233532
Homologene: 41142
Pold1
Name: polymerase (DNA directed), delta 1, catalytic subunit
Synonyms: 125kDa
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 18971
HGNC: HGNC:9175
Homologene: 2014
Ryr2
Name: ryanodine receptor 2, cardiac
Synonyms: 9330127I20Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 20191
VEGA: 13
Homologene: 37423
Kif2c
Name: kinesin family member 2C
Synonyms: 4930402F02Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 73804
HGNC: HGNC:6393
Homologene: 21355
Psen1
Name: presenilin 1
Synonyms: presenilin-1, PS-1, S182, Ad3h, PS1
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 19164
VEGA: 12
HGNC: HGNC:9508
Homologene: 7186
Cul7
Name: cullin 7
Synonyms: p185, 2510004L20Rik, p193, C230011P08Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 66515
Homologene: 56683
Grhl3
Name: grainyhead like transcription factor 3
Synonyms: ct, Get1, Som
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230824
Homologene: 18864
Arnt
Name: aryl hydrocarbon receptor nuclear translocator
Synonyms: ESTM42, bHLHe2, Hif1b, D3Ertd557e
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 11863
HGNC: HGNC:700
Homologene: 1261
Tpst2
Name: protein-tyrosine sulfotransferase 2
Synonyms: Tango13b, grm, D5Ucla3, grt
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 22022
Homologene: 2666
Magi3
Name: membrane associated guanylate kinase, WW and PDZ domain containing 3
Synonyms: 4732496O19Rik, 6530407C02Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 99470
Homologene: 26431
Rrm2b
Name: ribonucleotide reductase M2 B (TP53 inducible)
Synonyms: p53R2
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 382985
Homologene: 56723
Ehbp1
Name: EH domain binding protein 1
Synonyms: KIAA0903-like, Flj21950
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 216565
Homologene: 22880
Blnk
Name: B cell linker
Synonyms: BASH, Bca, Ly-57, SLP-65, BCA, Ly57, BLNK
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 17060
Homologene: 32038
Dock2
Name: dedicator of cyto-kinesis 2
Synonyms: MBC, CED-5, Hch
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 94176
HGNC: HGNC:2988
Homologene: 37984
Cdh23
Name: cadherin related 23 (otocadherin)
Synonyms: mdfw, ahl, nmf112, nmf252, 4930542A03Rik, nmf181, sals, USH1D, bob
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 22295
Homologene: 11142
Adamts4
Name: ADAM metallopeptidase with thrombospondin type 1 motif 4
Synonyms: aggrecanase-1, ADAM-TS4
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 240913
HGNC: HGNC:220
Homologene: 36169
Rbm22
Name: RNA binding motif protein 22
Synonyms: 8430430L24Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 66810
Homologene: 69245
Cntnap5c
Name: contactin associated protein-like 5C
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 620292
VEGA: 17
Homologene: 128806
Hivep2
Name: human immunodeficiency virus type I enhancer binding protein 2
Synonyms: Gm20114, Shn-2, MIBP1, Schnurri-2
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 15273
HGNC: HGNC:4921
Homologene: 4900
Krt35
Name: keratin 35
Synonyms: Krt1-24, Ha5
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 53617
HGNC: HGNC:6453
Homologene: 1715
Hoxa7
Name: homeobox A7
Synonyms: Hox-1.1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 15404
HGNC: HGNC:5108
Homologene: 56001
Mroh2b
Name: maestro heat-like repeat family member 2B
Synonyms: 4930455B06Rik, Heatr7b2
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 223825
VEGA: 15
Homologene: 128807
Rpgrip1
Name: retinitis pigmentosa GTPase regulator interacting protein 1
Synonyms: nmf247, A930002K18Rik, 4930505G06Rik, 4930401L23Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 77945
Homologene: 10679
Vmn1r67
Name: vomeronasal 1 receptor 67
Synonyms: V1re10
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 171263
Homologene: 128344
Umodl1
Name: uromodulin-like 1
Synonyms: D17Ertd488e
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 52020
VEGA: 17
Homologene: 45466
Trim30a
Name: tripartite motif-containing 30A
Synonyms: Rpt-1, Rpt1, Trim30
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 20128
Homologene: 114426
Naip1
Name: NLR family, apoptosis inhibitory protein 1
Synonyms: D13Lsd1, Naip, Birc1a
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 17940
VEGA: 13
HGNC: HGNC:7634
Homologene: 113589
Phf8l
Name: PHD finger protein 8 like
Synonyms: Phf8-ps, 4921501E09Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 74042
VEGA: 17
Homologene: 66275
Adam34l
Name: a disintegrin and metallopeptidase domain 34 like
Synonyms: Gm5346
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 384813
Homologene: 78104
Abca8b
Name: ATP-binding cassette, sub-family A member 8b
Synonyms: Abca8
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 27404
HGNC: HGNC:38
Homologene: 56029
Baiap2l1
Name: BAI1-associated protein 2-like 1
Synonyms: 1300006M19Rik, IRTKS
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 66898
Homologene: 23123
Megf8
Name: multiple EGF-like-domains 8
Synonyms: m687Ddg, b2b288Clo, b2b1702Clo, Egfl4
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 269878
HGNC: HGNC:3233
Homologene: 15988
Cd19
Name: CD19 antigen
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 12478
HGNC: HGNC:1633
Homologene: 1341
Ngrn
Name: neugrin, neurite outgrowth associated
Synonyms: neurite outgrowth associated protein
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 83485
Homologene: 32330
Hbb-y
Name: hemoglobin Y, beta-like embryonic chain
Synonyms: epsilon Y globin, Hby, Ey
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 15135
Homologene: 128032
Cfap300
Name: cilia and flagella associated protein 300
Synonyms: 9230110C19Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 234912
VEGA: 9
Homologene: 13163
Kmt2d
Name: lysine (K)-specific methyltransferase 2D
Synonyms: C430014K11Rik, Mll4, Mll2, bapa
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 381022
HGNC: HGNC:7133
Homologene: 86893
Pcnx2
Name: pecanex homolog 2
Synonyms: Pcnxl2, E330039K12Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 270109
HGNC: HGNC:8736
Homologene: 8987
Jade2
Name: jade family PHD finger 2
Synonyms: 1200017K05Rik, Phf15
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 76901
Homologene: 9082
Mdga1
Name: MAM domain containing glycosylphosphatidylinositol anchor 1
Synonyms: Mamdc3, 1200011I03Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 74762
Homologene: 17780
Asb15
Name: ankyrin repeat and SOCS box-containing 15
Synonyms: 4930400E23Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 78910
Homologene: 43797
Miip
Name: migration and invasion inhibitory protein
Synonyms: D4Wsu114e
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 28010
Homologene: 15879
Sec16b
Name: SEC16 homolog B, endoplasmic reticulum export factor
Synonyms: Rgpr-p117, Lztr2, Rgpr
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 89867
Homologene: 13227
Vmn2r120
Name: vomeronasal 2, receptor 120
Synonyms: EG224916
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 224916
Rbfox3
Name: RNA binding protein, fox-1 homolog (C. elegans) 3
Synonyms: NeuN, Neuna60, D11Bwg0517e, Hrnbp3
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 52897
Homologene: 134629
Mmp11
Name: matrix metallopeptidase 11
Synonyms: ST3, stromelysin 3, Stmy3
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 17385
HGNC: HGNC:7157
Homologene: 38116
Zc3h6
Name: zinc finger CCCH type containing 6
Synonyms: 4631426G04Rik, 4833425H18Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 78751
Homologene: 35328
Ttll3
Name: tubulin tyrosine ligase-like family, member 3
Synonyms: 4833441J24Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 101100
Homologene: 134361
Fam50b
Name: family with sequence similarity 50, member B
Synonyms: D0H6S2654E, XAP-5-like, X5L
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 108161
VEGA: 13
Homologene: 101669
Ldlrad1
Name: low density lipoprotein receptor class A domain containing 1
Synonyms: OTTMUSG00000008594
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 546840
Homologene: 54473
Tmem200a
Name: transmembrane protein 200A
Synonyms: C030003D03Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 77220
VEGA: 10
Homologene: 14175
Cd44
Name: CD44 antigen
Synonyms: Pgp-1, Ly-24, HERMES
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 12505
HGNC: HGNC:1681
Homologene: 508
Adam3
Name: ADAM metallopeptidase domain 3
Synonyms: Taz83, ADAM3, Taz83, tMDC, Cyrn1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 11497
HGNC: HGNC:209
Homologene: 69052
Septin1
Name: septin 1
Synonyms: PNUTL3, Diff6, Sept1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 54204
HGNC: HGNC:2879
Homologene: 23009
Bend7
Name: BEN domain containing 7
Synonyms: 1110017O21Rik, E130319B15Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 209645
Homologene: 17660
Mapk7
Name: mitogen-activated protein kinase 7
Synonyms: Erk5-T, big MAP kinase 1, BMK1, b2b2346Clo, ERK5
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 23939
HGNC: HGNC:6880
Homologene: 2060
Mcidas
Name: multiciliate differentiation and DNA synthesis associated cell cycle protein
Synonyms: Gm6320, multicilin, Mcin, Idas, Mci
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 622408
VEGA: 13
Homologene: 83681
Igkv1-110
Name: immunoglobulin kappa variable 1-110
Synonyms: Gm16634
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 381777
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 157,561,675 bp
  • A to G, chromosome 1 at 171,257,818 bp
  • T to G, chromosome 2 at 4,749,644 bp
  • T to A, chromosome 2 at 102,848,734 bp
  • T to C, chromosome 2 at 129,015,635 bp
  • G to A, chromosome 3 at 51,448,610 bp
  • G to A, chromosome 3 at 95,480,261 bp
  • A to G, chromosome 3 at 104,051,302 bp
  • G to A, chromosome 4 at 107,209,491 bp
  • A to T, chromosome 4 at 117,171,743 bp
  • C to G, chromosome 4 at 135,559,105 bp
  • C to T, chromosome 4 at 147,862,918 bp
  • T to A, chromosome 4 at 149,237,387 bp
  • T to A, chromosome 5 at 112,307,916 bp
  • A to C, chromosome 5 at 144,318,950 bp
  • T to A, chromosome 6 at 17,533,953 bp
  • T to C, chromosome 6 at 24,562,506 bp
  • T to A, chromosome 6 at 52,215,890 bp
  • T to G, chromosome 6 at 68,270,993 bp
  • T to C, chromosome 6 at 113,394,777 bp
  • A to G, chromosome 7 at 10,446,976 bp
  • G to A, chromosome 7 at 25,334,597 bp
  • G to A, chromosome 7 at 44,541,789 bp
  • A to G, chromosome 7 at 80,264,437 bp
  • A to T, chromosome 7 at 97,661,485 bp
  • T to A, chromosome 7 at 103,851,881 bp
  • A to T, chromosome 7 at 104,411,200 bp
  • A to G, chromosome 7 at 126,413,508 bp
  • A to T, chromosome 7 at 127,214,765 bp
  • T to G, chromosome 8 at 24,694,644 bp
  • T to A, chromosome 8 at 43,626,374 bp
  • G to C, chromosome 8 at 125,785,348 bp
  • G to T, chromosome 9 at 8,027,129 bp
  • C to T, chromosome 9 at 110,393,807 bp
  • T to C, chromosome 10 at 14,130,103 bp
  • A to G, chromosome 10 at 25,993,966 bp
  • T to C, chromosome 10 at 60,385,194 bp
  • G to T, chromosome 10 at 75,923,480 bp
  • T to C, chromosome 11 at 22,096,109 bp
  • C to T, chromosome 11 at 34,282,652 bp
  • A to G, chromosome 11 at 51,817,299 bp
  • T to C, chromosome 11 at 61,489,415 bp
  • A to G, chromosome 11 at 61,782,102 bp
  • T to A, chromosome 11 at 100,094,887 bp
  • A to G, chromosome 11 at 105,210,618 bp
  • A to G, chromosome 11 at 109,971,683 bp
  • A to T, chromosome 11 at 118,496,484 bp
  • A to G, chromosome 12 at 83,699,622 bp
  • C to T, chromosome 13 at 11,801,180 bp
  • G to A, chromosome 13 at 34,747,101 bp
  • T to A, chromosome 13 at 100,444,478 bp
  • G to A, chromosome 13 at 112,998,987 bp
  • G to A, chromosome 14 at 52,133,820 bp
  • A to C, chromosome 15 at 4,949,105 bp
  • A to T, chromosome 15 at 37,927,261 bp
  • G to T, chromosome 15 at 98,864,406 bp
  • C to T, chromosome 17 at 29,842,840 bp
  • A to G, chromosome 17 at 30,959,151 bp
  • T to C, chromosome 17 at 33,067,690 bp
  • T to C, chromosome 17 at 46,658,642 bp
  • C to T, chromosome 17 at 57,508,874 bp
  • T to C, chromosome 17 at 58,359,275 bp
  • C to A, chromosome 18 at 12,882,264 bp
  • A to G, chromosome 18 at 60,561,272 bp
  • A to G, chromosome 19 at 32,022,361 bp
  • T to C, chromosome 19 at 40,959,788 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7797 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045853-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.