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Strain Name:
C57BL/6J-MtgxR7806Btlr/Mmmh
Stock Number:
045861-MU
Citation ID:
RRID:MMRRC_045861-MU
Other Names:
R7806 (G1)
Major Collection:

Strain Information

Dntt
Name: deoxynucleotidyltransferase, terminal
Synonyms: Tdt
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 21673
VEGA: 19
HGNC: HGNC:2983
Homologene: 3014
Cd80
Name: CD80 antigen
Synonyms: B7-1, Ly-53, Ly53, Cd28l, B7.1
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 12519
VEGA: 16
HGNC: HGNC:1700
Homologene: 3804
Adk
Name: adenosine kinase
Synonyms: AK, 5033405D03Rik, 2310026J05Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 11534
VEGA: 14
HGNC: HGNC:257
Homologene: 4891
Serpinb6a
Name: serine (or cysteine) peptidase inhibitor, clade B, member 6a
Synonyms: Spi3, ovalbumin, D330015H01Rik, 4930482L21Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 20719
HGNC: HGNC:8950
Homologene: 20956
Fsaf1
Name: 40S small subunit processome assembly factor 1
Synonyms: Ayu21-55, Gt(Ayu21)55Imeg, GtAyu21-55, 2810004N23Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 66523
Homologene: 11982
Rfesd
Name: Rieske (Fe-S) domain containing
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 218341
VEGA: 13
Homologene: 18282
Zic1
Name: zinc finger protein of the cerebellum 1
Synonyms: odd-paired homolog
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 22771
Homologene: 2562
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 75,438,937 bp
  • T to C, chromosome 1 at 131,271,898 bp
  • T to C, chromosome 1 at 132,360,789 bp
  • T to C, chromosome 1 at 155,862,063 bp
  • T to C, chromosome 1 at 171,338,494 bp
  • T to A, chromosome 2 at 62,503,414 bp
  • T to C, chromosome 2 at 80,541,499 bp
  • C to T, chromosome 2 at 121,205,061 bp
  • T to A, chromosome 2 at 156,551,111 bp
  • T to A, chromosome 3 at 28,806,813 bp
  • A to G, chromosome 3 at 63,982,670 bp
  • A to C, chromosome 3 at 95,127,604 bp
  • A to G, chromosome 3 at 101,077,132 bp
  • T to C, chromosome 3 at 144,932,396 bp
  • T to C, chromosome 3 at 155,098,807 bp
  • A to C, chromosome 4 at 45,912,801 bp
  • G to A, chromosome 4 at 95,600,966 bp
  • A to T, chromosome 4 at 124,785,088 bp
  • A to G, chromosome 4 at 138,288,196 bp
  • A to T, chromosome 4 at 155,792,980 bp
  • A to T, chromosome 5 at 8,092,825 bp
  • A to T, chromosome 5 at 24,593,262 bp
  • A to C, chromosome 5 at 135,134,543 bp
  • A to C, chromosome 5 at 146,514,280 bp
  • A to G, chromosome 5 at 150,643,250 bp
  • T to A, chromosome 6 at 41,674,933 bp
  • T to A, chromosome 6 at 111,246,353 bp
  • C to T, chromosome 7 at 46,285,776 bp
  • A to T, chromosome 7 at 85,559,193 bp
  • CGGCGGCGG to CGGCGGCGGGGGCGGCGG, chromosome 7 at 97,579,920 bp
  • T to A, chromosome 7 at 101,906,013 bp
  • A to G, chromosome 7 at 120,332,836 bp
  • T to C, chromosome 7 at 140,610,772 bp
  • T to C, chromosome 7 at 141,637,474 bp
  • A to T, chromosome 8 at 95,298,804 bp
  • T to C, chromosome 8 at 104,140,816 bp
  • C to A, chromosome 8 at 124,842,404 bp
  • T to C, chromosome 9 at 37,804,576 bp
  • G to T, chromosome 9 at 38,698,271 bp
  • T to C, chromosome 9 at 65,299,931 bp
  • G to A, chromosome 9 at 91,364,971 bp
  • A to G, chromosome 9 at 122,834,930 bp
  • A to G, chromosome 10 at 26,244,527 bp
  • A to C, chromosome 10 at 41,433,084 bp
  • G to C, chromosome 10 at 52,353,429 bp
  • A to G, chromosome 10 at 89,413,370 bp
  • G to T, chromosome 10 at 127,856,871 bp
  • T to A, chromosome 10 at 130,479,810 bp
  • C to T, chromosome 11 at 4,738,889 bp
  • A to G, chromosome 11 at 49,823,315 bp
  • A to G, chromosome 11 at 53,990,650 bp
  • A to G, chromosome 11 at 97,056,128 bp
  • G to A, chromosome 11 at 119,411,545 bp
  • A to T, chromosome 11 at 120,809,995 bp
  • A to G, chromosome 12 at 79,280,355 bp
  • A to T, chromosome 12 at 87,172,430 bp
  • A to T, chromosome 13 at 19,307,220 bp
  • G to T, chromosome 13 at 31,808,756 bp
  • T to C, chromosome 13 at 33,935,565 bp
  • A to G, chromosome 13 at 40,918,241 bp
  • T to C, chromosome 13 at 76,008,189 bp
  • A to C, chromosome 13 at 93,094,262 bp
  • G to A, chromosome 13 at 95,682,257 bp
  • G to A, chromosome 14 at 4,895,172 bp
  • T to A, chromosome 14 at 5,943,883 bp
  • C to G, chromosome 14 at 7,087,893 bp
  • C to A, chromosome 14 at 7,087,894 bp
  • A to G, chromosome 14 at 21,326,611 bp
  • A to G, chromosome 14 at 34,343,649 bp
  • A to G, chromosome 14 at 50,836,809 bp
  • G to A, chromosome 14 at 55,755,168 bp
  • T to A, chromosome 15 at 33,497,297 bp
  • C to A, chromosome 15 at 73,570,775 bp
  • A to G, chromosome 15 at 89,305,420 bp
  • A to G, chromosome 16 at 21,459,751 bp
  • A to G, chromosome 16 at 38,473,953 bp
  • T to A, chromosome 17 at 25,931,726 bp
  • A to C, chromosome 17 at 37,564,221 bp
  • T to G, chromosome 17 at 56,119,967 bp
  • A to G, chromosome 17 at 71,245,171 bp
  • T to A, chromosome 18 at 7,000,607 bp
  • T to C, chromosome 18 at 31,947,540 bp
  • T to C, chromosome 18 at 44,844,286 bp
  • T to C, chromosome 18 at 44,850,424 bp
  • T to C, chromosome 18 at 65,349,416 bp
  • T to A, chromosome 18 at 67,213,074 bp
  • T to A, chromosome 18 at 84,670,820 bp
  • T to C, chromosome 19 at 4,143,488 bp
  • A to T, chromosome 19 at 41,029,632 bp
  • A to G, chromosome 19 at 60,756,534 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
Gene Specific Genotyping:

To request gene-specific and other genotyping services for a strain, please contact the distribution MMRRC Center for more information.

Background Genetic Quality:

The MMRRC has developed a Genetic Quality Control pipeline using the MiniMUGA array to provide additional information to identify and validate genetic backgrounds of MMRRC strains. For more information on whether genetic background data is available, please contact MMRRC_GeneticQC@med.unc.edu. Note: that MiniMUGA genetic background data is not available on all strains, but can be ordered if desired.

Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7806 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045861-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.