Strain Name:
C57BL/6J-MtgxR7811Btlr/Mmmh
Stock Number:
045866-MU
Citation ID:
RRID:MMRRC_045866-MU
Other Names:
R7811 (G1)
Major Collection:

Strain Information

Fgb
Name: fibrinogen beta chain
Synonyms: 2510049G14Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 110135
HGNC: HGNC:3662
Homologene: 3772
Myo10
Name: myosin X
Synonyms: D15Ertd600e, myosin-X
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 17909
HGNC: HGNC:7593
Homologene: 36328
Ide
Name: insulin degrading enzyme
Synonyms: 1300012G03Rik, 4833415K22Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 15925
HGNC: HGNC:5381
Homologene: 3645
Htr4
Name: 5 hydroxytryptamine (serotonin) receptor 4
Synonyms: 5-HT4, 5-HT4L
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 15562
VEGA: 18
HGNC: HGNC:5299
Homologene: 20243
Slc6a1
Name: solute carrier family 6 (neurotransmitter transporter, GABA), member 1
Synonyms: Gat1, GAT-1, XT-1, Gabt, Gabt1, Xtrp1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232333
Homologene: 2290
Myo1e
Name: myosin IE
Synonyms: 9130023P14Rik, 2310020N23Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 71602
VEGA: 9
HGNC: HGNC:7599
Homologene: 55864
Ubap2
Name: ubiquitin-associated protein 2
Synonyms: 1190005K07Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 68926
Homologene: 73649
Cdk11b
Name: cyclin dependent kinase 11B
Synonyms: Cdc2l1, Cdc2l2, CDK11-p110, PITSLRE proteins, CDK11-p46, CDK11-p58
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 12537
Homologene: 22416
Hnrnpa1
Name: heterogeneous nuclear ribonucleoprotein A1
Synonyms: hnrnp-A, Hdp, D15Ertd119e, Hnrpa1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 15382
VEGA: 15
Homologene: 134628
Odf2l
Name: outer dense fiber of sperm tails 2-like
Synonyms: 9630045K08Rik, 4733401D09Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 52184
Homologene: 12011
Slc29a1
Name: solute carrier family 29 (nucleoside transporters), member 1
Synonyms: 1200014D21Rik, NBMPR-sensitive equilibrative nucleoside transporter, ENT1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 63959
Homologene: 37985
Zfp568
Name: zinc finger protein 568
Synonyms: chato, LOC381866
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 243905
Homologene: 136307
Golga4
Name: golgin A4
Synonyms: golgin-245, Olp-1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 54214
HGNC: HGNC:4427
Homologene: 68224
Diaph3
Name: diaphanous related formin 3
Synonyms: Diap3, mDia2, Drf3, 4930417P13Rik, p134MDia2
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 56419
VEGA: 14
Homologene: 84829
Bms1
Name: BMS1, ribosome biogenesis factor
Synonyms: Bms1l
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 213895
Homologene: 7065
Tbc1d10a
Name: TBC1 domain family, member 10a
Synonyms: EPI64, Tbc1d10
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 103724
Homologene: 32762
Satb2
Name: special AT-rich sequence binding protein 2
Synonyms: BAP002
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 212712
Homologene: 32249
Eya3
Name: EYA transcriptional coactivator and phosphatase 3
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 14050
HGNC: HGNC:3521
Homologene: 1508
Ass1
Name: argininosuccinate synthetase 1
Synonyms: ASS, Ass-1, fold
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 11898
HGNC: HGNC:758
Homologene: 6899
Ppp4r3a
Name: protein phosphatase 4 regulatory subunit 3A
Synonyms: 1110034C04Rik, Smek1
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 68734
VEGA: 12
Homologene: 69510
Ern1
Name: endoplasmic reticulum to nucleus signalling 1
Synonyms: Ire1a, Ire1p, Ire1alpha, 9030414B18Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 78943
HGNC: HGNC:3449
Homologene: 55580
Lypd8
Name: LY6/PLAUR domain containing 8
Synonyms: 2210415F13Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 70163
Homologene: 52815
Lrrn2
Name: leucine rich repeat protein 2, neuronal
Synonyms: 5730406J09Rik, NLRR-2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 16980
Homologene: 21274
Anxa7
Name: annexin A7
Synonyms: Anx7, synexin
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 11750
VEGA: 14
HGNC: HGNC:545
Homologene: 36149
Cntrl
Name: centriolin
Synonyms: Cep110, 6720467O09Rik, IB3/5, Ma2a8, Cep1, b2b1468Clo
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 26920
HGNC: HGNC:1858
Homologene: 38260
Eml2
Name: echinoderm microtubule associated protein like 2
Synonyms: 1600029N02Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 72205
Homologene: 8125
Nadk
Name: NAD kinase
Synonyms: 4432404C02Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 192185
Homologene: 49724
Bpifb1
Name: BPI fold containing family B, member 1
Synonyms: LPlunc1, von Ebner minor salivary protein, U46068
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228801
Homologene: 50047
Srcap
Name: Snf2-related CREBBP activator protein
Synonyms: B930091H02Rik, D030022P06Rik, F630004O05Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 100043597
Homologene: 38213
Abca3
Name: ATP-binding cassette, sub-family A member 3
Synonyms: 1810036E22Rik, ABC-C, Abc3
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 27410
HGNC: HGNC:33
Homologene: 37437
Abca13
Name: ATP-binding cassette, sub-family A member 13
Synonyms: A930002G16Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 268379
Homologene: 27991
Syne2
Name: spectrin repeat containing, nuclear envelope 2
Synonyms: dice, Cpfl8, diminished cone electroretinogram, syne-2, 6820443O06Rik, nesprin-2, Nesp2g, D12Ertd777e
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 319565
Homologene: 56700
Vmn2r57
Name: vomeronasal 2, receptor 57
Synonyms: EG269902
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 269902
Homologene: 104832
Cdh5
Name: cadherin 5
Synonyms: 7B4/cadherin-5, VEC, VEcad, CD144, VECD, VE-Cad, VE-cadherin
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 12562
HGNC: HGNC:1764
Homologene: 1359
Fsip2
Name: fibrous sheath-interacting protein 2
Synonyms: OTTMUSG00000013335
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241516
Homologene: 110349
Unc13c
Name: unc-13 homolog C
Synonyms: Unc13h3, D9Ertd414e, 1500037O19Rik, Munc13-3
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 208898
Homologene: 45443
Nalcn
Name: sodium leak channel, non-selective
Synonyms: Vgcnl1, A530023G15Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 338370
VEGA: 14
Homologene: 21832
Or2r3
Name: olfactory receptor family 2 subfamily R member 3
Synonyms: Olfr457, GA_x6K02T2P3E9-5088893-5089834, MOR257-1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 258989
Homologene: 133701
Stxbp5
Name: syntaxin binding protein 5 (tomosyn)
Synonyms: 4930565N16Rik, 0710001E20Rik, tomosyn 1, LGL3
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 78808
Homologene: 16402
Vmn2r88
Name: vomeronasal 2, receptor 88
Synonyms: V2r13, V2r3
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 669149
Homologene: 129606
Arhgef10l
Name: Rho guanine nucleotide exchange factor 10-like
Synonyms: 2810441C07Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 72754
Homologene: 10017
Vmn2r73
Name: vomeronasal 2, receptor 73
Synonyms: EG620928
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 620928
Homologene: 115466
Ush1c
Name: USH1 protein network component harmonin
Synonyms: Usher syndrome 1C, 2010016F01Rik, harmonin
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 72088
Homologene: 77476
Pde6c
Name: phosphodiesterase 6C, cGMP specific, cone, alpha prime
Synonyms: cpfl1
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 110855
VEGA: 19
HGNC: HGNC:8787
Homologene: 4521
Trim12c
Name: tripartite motif-containing 12C
Synonyms: 9230105E10Rik, Trim12-2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 319236
Homologene: 75345
Serpina6
Name: serine (or cysteine) peptidase inhibitor, clade A, member 6
Synonyms: Cbg
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 12401
HGNC: HGNC:1540
Homologene: 20417
Ip6k3
Name: inositol hexaphosphate kinase 3
Synonyms: D830007E07Rik, Ihpk3
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 271424
Homologene: 65257
Fbxl6
Name: F-box and leucine-rich repeat protein 6
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 30840
VEGA: 15
Homologene: 8130
Ccdc188
Name: coiled-coil domain containing 188
Synonyms: Gm7873
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 102638083
VEGA: 16
Homologene: 90442
Zswim5
Name: zinc finger SWIM-type containing 5
Synonyms: 4933426E21Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 74464
Homologene: 18958
Or13g1
Name: olfactory receptor family 13 subfamily G member 1
Synonyms: MOR251-4P, GA_x6K02T2NHDJ-9801340-9802266, Olfr309
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258196
Homologene: 47595
Zmym5
Name: zinc finger, MYM-type 5
Synonyms: 9830124H08Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 219105
Homologene: 16997
Ffar1
Name: free fatty acid receptor 1
Synonyms: Gpr40
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233081
HGNC: HGNC:4498
Homologene: 3876
Pus7l
Name: pseudouridylate synthase 7-like
Synonyms: 3000003F02Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 78895
Homologene: 12842
Spg7
Name: SPG7, paraplegin matrix AAA peptidase subunit
Synonyms: paraplegin, spastic paraplegia 7 homolog (human), Cmar
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234847
Homologene: 31133
Cbx4
Name: chromobox 4
Synonyms: PC2, MPc2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 12418
HGNC: HGNC:1554
Homologene: 2712
Keap1
Name: kelch-like ECH-associated protein 1
Synonyms: INrf2, ring canal protein
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 50868
Homologene: 8184
Clec5a
Name: C-type lectin domain family 5, member a
Synonyms: myeloid DAP12-associating lectin-1, MDL-1, Ly100, Clecsf5
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 23845
HGNC: HGNC:2054
Homologene: 8302
Gbx1
Name: gastrulation brain homeobox 1
Synonyms: Gbx-1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231044
HGNC: HGNC:4185
Homologene: 41063
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to A, chromosome 1 at 56,845,721 bp
  • T to C, chromosome 1 at 132,939,201 bp
  • G to A, chromosome 2 at 31,514,741 bp
  • T to C, chromosome 2 at 35,162,861 bp
  • T to C, chromosome 2 at 82,998,453 bp
  • T to A, chromosome 2 at 154,206,564 bp
  • T to C, chromosome 3 at 83,049,697 bp
  • A to G, chromosome 3 at 145,153,387 bp
  • T to C, chromosome 4 at 41,211,710 bp
  • A to G, chromosome 4 at 116,877,476 bp
  • T to C, chromosome 4 at 132,711,961 bp
  • G to T, chromosome 4 at 140,515,024 bp
  • A to T, chromosome 4 at 155,576,875 bp
  • A to G, chromosome 4 at 155,639,902 bp
  • T to C, chromosome 5 at 24,505,037 bp
  • C to T, chromosome 6 at 40,581,933 bp
  • T to A, chromosome 6 at 42,471,701 bp
  • T to C, chromosome 6 at 114,302,554 bp
  • T to C, chromosome 6 at 118,403,138 bp
  • T to A, chromosome 7 at 19,186,122 bp
  • A to G, chromosome 7 at 29,997,870 bp
  • A to G, chromosome 7 at 30,861,377 bp
  • A to T, chromosome 7 at 41,425,015 bp
  • G to A, chromosome 7 at 46,205,286 bp
  • T to C, chromosome 7 at 85,875,748 bp
  • T to A, chromosome 7 at 86,306,346 bp
  • T to C, chromosome 7 at 104,341,262 bp
  • T to C, chromosome 7 at 127,542,049 bp
  • A to G, chromosome 8 at 104,125,603 bp
  • T to C, chromosome 8 at 123,097,425 bp
  • A to G, chromosome 9 at 21,237,660 bp
  • T to A, chromosome 9 at 70,327,262 bp
  • G to T, chromosome 9 at 73,693,271 bp
  • T to C, chromosome 9 at 118,532,575 bp
  • T to C, chromosome 10 at 9,808,504 bp
  • T to C, chromosome 11 at 4,186,948 bp
  • T to A, chromosome 11 at 9,577,141 bp
  • A to T, chromosome 11 at 58,390,238 bp
  • A to T, chromosome 11 at 106,434,868 bp
  • A to C, chromosome 11 at 119,081,572 bp
  • A to G, chromosome 12 at 75,983,727 bp
  • C to A, chromosome 12 at 101,053,562 bp
  • A to G, chromosome 12 at 103,654,136 bp
  • A to T, chromosome 14 at 20,460,186 bp
  • A to T, chromosome 14 at 51,418,703 bp
  • A to G, chromosome 14 at 56,798,977 bp
  • T to C, chromosome 14 at 86,981,624 bp
  • A to T, chromosome 14 at 123,298,945 bp
  • T to C, chromosome 15 at 25,804,524 bp
  • T to C, chromosome 15 at 76,537,285 bp
  • A to C, chromosome 15 at 94,540,826 bp
  • T to C, chromosome 15 at 103,241,473 bp
  • A to G, chromosome 16 at 18,218,450 bp
  • A to G, chromosome 17 at 24,397,388 bp
  • A to T, chromosome 17 at 27,157,583 bp
  • T to C, chromosome 17 at 45,586,263 bp
  • A to G, chromosome 18 at 62,412,198 bp
  • A to C, chromosome 19 at 37,330,511 bp
  • T to C, chromosome 19 at 38,140,059 bp
  • A to T, chromosome 19 at 61,119,915 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7811 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045866-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.