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Strain Name:
C57BL/6J-MtgxR7813Btlr/Mmmh
Stock Number:
045868-MU
Citation ID:
RRID:MMRRC_045868-MU
Other Names:
R7813 (G1)
Major Collection:

Strain Information

Sptbn1
Name: spectrin beta, non-erythrocytic 1
Synonyms: beta fodrin, Spnb-2, spectrin G, brain spectrin, elf3, elf1, 9930031C03Rik, non-erythrocytic, Spnb2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 20742
Homologene: 2354
Card11
Name: caspase recruitment domain family, member 11
Synonyms: CARMA1, BIMP3, 2410011D02Rik, 0610008L17Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 108723
Homologene: 13024
Ccnd1
Name: cyclin D1
Synonyms: Cyl-1, bcl-1, PRAD1, cD1, CycD1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 12443
HGNC: HGNC:1582
Homologene: 1334
Arpp21
Name: cyclic AMP-regulated phosphoprotein, 21
Synonyms: ARPP-21, Tarpp, D9Bwg1012e, 0710001E13Rik, R3hdm3
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 74100
Homologene: 32306
Zfp710
Name: zinc finger protein 710
Synonyms: 5430400N05Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 209225
Homologene: 19625
Acot7
Name: acyl-CoA thioesterase 7
Synonyms: 2410041A17Rik, Bach, AU014716
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 70025
Homologene: 15780
Itga5
Name: integrin alpha 5 (fibronectin receptor alpha)
Synonyms: Fnra, Cd49e
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 16402
VEGA: 15
HGNC: HGNC:6141
Homologene: 20508
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 53,618,086 bp
  • A to T, chromosome 1 at 60,291,889 bp
  • A to G, chromosome 1 at 126,025,426 bp
  • C to A, chromosome 1 at 173,344,389 bp
  • T to C, chromosome 2 at 11,481,908 bp
  • A to G, chromosome 2 at 16,660,867 bp
  • T to A, chromosome 2 at 26,945,876 bp
  • T to C, chromosome 2 at 30,110,373 bp
  • T to C, chromosome 2 at 66,676,345 bp
  • C to T, chromosome 2 at 73,381,985 bp
  • T to A, chromosome 2 at 76,767,497 bp
  • T to A, chromosome 2 at 111,138,975 bp
  • T to A, chromosome 2 at 127,481,783 bp
  • A to G, chromosome 2 at 158,538,700 bp
  • C to T, chromosome 2 at 161,530,493 bp
  • T to C, chromosome 3 at 72,925,468 bp
  • A to G, chromosome 3 at 87,443,623 bp
  • T to C, chromosome 3 at 133,473,643 bp
  • C to A, chromosome 3 at 145,084,965 bp
  • A to T, chromosome 4 at 108,579,080 bp
  • A to T, chromosome 4 at 145,178,063 bp
  • T to C, chromosome 4 at 152,223,118 bp
  • A to T, chromosome 5 at 36,024,614 bp
  • T to C, chromosome 5 at 140,899,664 bp
  • A to T, chromosome 6 at 29,923,913 bp
  • A to C, chromosome 6 at 42,673,429 bp
  • G to A, chromosome 6 at 67,356,651 bp
  • A to T, chromosome 6 at 89,892,210 bp
  • A to T, chromosome 6 at 124,580,529 bp
  • A to G, chromosome 7 at 19,514,199 bp
  • T to C, chromosome 7 at 43,616,767 bp
  • A to T, chromosome 7 at 55,800,696 bp
  • A to G, chromosome 7 at 80,081,111 bp
  • G to A, chromosome 7 at 141,696,300 bp
  • A to G, chromosome 7 at 144,937,885 bp
  • A to G, chromosome 9 at 108,509,471 bp
  • T to A, chromosome 9 at 112,179,065 bp
  • G to A, chromosome 10 at 29,224,900 bp
  • C to T, chromosome 11 at 6,599,071 bp
  • C to T, chromosome 11 at 30,138,455 bp
  • A to G, chromosome 11 at 53,272,036 bp
  • A to G, chromosome 11 at 67,327,230 bp
  • A to T, chromosome 11 at 68,597,708 bp
  • A to G, chromosome 11 at 68,785,909 bp
  • A to G, chromosome 11 at 99,418,483 bp
  • T to C, chromosome 13 at 97,945,681 bp
  • A to T, chromosome 14 at 53,616,766 bp
  • T to A, chromosome 15 at 103,357,314 bp
  • A to G, chromosome 16 at 20,735,405 bp
  • T to A, chromosome 17 at 3,197,274 bp
  • A to T, chromosome 17 at 3,437,247 bp
  • A to G, chromosome 17 at 74,024,546 bp
  • T to A, chromosome 17 at 88,000,817 bp
  • T to C, chromosome 18 at 53,738,506 bp
  • A to T, chromosome 18 at 56,783,091 bp
  • T to C, chromosome 18 at 60,916,654 bp
  • T to C, chromosome 19 at 16,651,456 bp
  • T to G, chromosome 19 at 32,491,403 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
Gene Specific Genotyping:

To request gene-specific and other genotyping services for a strain, please contact the distribution MMRRC Center for more information.

Background Genetic Quality:

The MMRRC has developed a Genetic Quality Control pipeline using the MiniMUGA array to provide additional information to identify and validate genetic backgrounds of MMRRC strains. For more information on whether genetic background data is available, please contact MMRRC_GeneticQC@med.unc.edu. Note: that MiniMUGA genetic background data is not available on all strains, but can be ordered if desired.

Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7813 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045868-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.