Strain Name:
C57BL/6J-MtgxR7828Btlr/Mmmh
Stock Number:
045882-MU
Citation ID:
RRID:MMRRC_045882-MU
Other Names:
R7828 (G1)
Major Collection:

Strain Information

Slc12a1
Name: solute carrier family 12, member 1
Synonyms: Nkcc2, mBSC1, D630042G03Rik, urehr3
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 20495
Homologene: 286
Scn3a
Name: sodium channel, voltage-gated, type III, alpha
Synonyms: LOC381367, Nav1.3
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 20269
Homologene: 56005
Ubap2
Name: ubiquitin-associated protein 2
Synonyms: 1190005K07Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 68926
Homologene: 73649
Ash2l
Name: ASH2 like histone lysine methyltransferase complex subunit
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 23808
HGNC: HGNC:744
Homologene: 3436
Cdk18
Name: cyclin dependent kinase 18
Synonyms: Pctk3
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 18557
HGNC: HGNC:8751
Homologene: 1949
Usp28
Name: ubiquitin specific peptidase 28
Synonyms: 9830148O20Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235323
VEGA: 9
Homologene: 10840
Usp1
Name: ubiquitin specific peptidase 1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230484
Homologene: 2528
Birc6
Name: baculoviral IAP repeat-containing 6
Synonyms: apollon, Bruce, A430032G04Rik, D630005A10Rik, A430040A19Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 12211
Homologene: 7248
Iars1
Name: isoleucyl-tRNA synthetase 1
Synonyms: E430001P04Rik, 2510016L12Rik, Iars
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 105148
HGNC: HGNC:5330
Homologene: 5325
Itpr1
Name: inositol 1,4,5-trisphosphate receptor 1
Synonyms: P400, IP3R1, Pcp-1, Itpr-1, Ip3r, opt, InsP3R type I, Pcp1, wblo
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 16438
HGNC: HGNC:6180
Homologene: 1673
Arid1b
Name: AT-rich interaction domain 1B
Synonyms: B230217J03Rik, 9330189K18Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 239985
Homologene: 32344
Aqr
Name: aquarius
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 11834
Homologene: 7629
Polr1b
Name: polymerase (RNA) I polypeptide B
Synonyms: RPA2, RPA116, 128kDa, D630020H17Rik, Rpo1-2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 20017
Homologene: 7133
Prr14l
Name: proline rich 14-like
Synonyms: 6030436E02Rik, C330019G07Rik, Prl14l
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 215476
Homologene: 65866
Gm14496
Name: predicted gene 14496
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 672125
Homologene: 129606
Hhip
Name: Hedgehog-interacting protein
Synonyms: Hip, Hip1, Hhip1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 15245
Homologene: 32469
Ppp3ca
Name: protein phosphatase 3, catalytic subunit, alpha isoform
Synonyms: PP2B alpha 1, PP2BA alpha, CnA, Caln, Calna, 2900074D19Rik, CN
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 19055
HGNC: HGNC:9314
Homologene: 55497
Cdc7
Name: cell division cycle 7
Synonyms: Cdc7, muCdc7, Cdc7l1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 12545
HGNC: HGNC:1745
Homologene: 31166
Maea
Name: macrophage erythroblast attacher
Synonyms: 1110030D19Rik, Gid9
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 59003
Homologene: 4298
Cab39l
Name: calcium binding protein 39-like
Synonyms: 2810425O13Rik, 1500031K13Rik, MO2L, 4930520C08Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 69008
VEGA: 14
Homologene: 69422
Edem3
Name: ER degradation enhancer, mannosidase alpha-like 3
Synonyms: 2310050N11Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 66967
Homologene: 11866
Pbrm1
Name: polybromo 1
Synonyms: BAF180, 2610016F04Rik, 2310032M22Rik, Pb1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 66923
Homologene: 10044
AU041133
Name: expressed sequence AU041133
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 216177
Homologene: 87560
Pcdh17
Name: protocadherin 17
Synonyms: LOC219228, C030033F14Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 219228
VEGA: 14
Homologene: 8700
Spink5
Name: serine peptidase inhibitor, Kazal type 5
Synonyms: LEKT1, 2310065D10Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 72432
Homologene: 4987
Bhmt
Name: betaine-homocysteine methyltransferase
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 12116
HGNC: HGNC:1047
Homologene: 1295
Hmcn2
Name: hemicentin 2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 665700
Homologene: 90772
Ttn
Name: titin
Synonyms: connectin, shru, D330041I19Rik, 2310057K23Rik, mdm, D830007G01Rik, 2310074I15Rik, 1100001C23Rik, 2310036G12Rik, L56
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 22138
Homologene: 130650
Wdfy4
Name: WD repeat and FYVE domain containing 4
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 545030
Homologene: 83473
Abcc12
Name: ATP-binding cassette, sub-family C member 12
Synonyms: MRP9, 4930467B22Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 244562
Homologene: 57211
Hfm1
Name: HFM1, ATP-dependent DNA helicase homolog
Synonyms: LOC381663, A330009G12Rik, Sec63d1, Mer3
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 330149
Homologene: 87103
Cdsn
Name: corneodesmosin
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 386463
HGNC: HGNC:1802
Epas1
Name: endothelial PAS domain protein 1
Synonyms: MOP2, HIF-2alpha, Hif like protein, hypoxia inducible transcription factor 2alpha, HLF, HRF, HIF2A, bHLHe73
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 13819
VEGA: 17
HGNC: HGNC:3374
Homologene: 1095
Naglu
Name: alpha-N-acetylglucosaminidase (Sanfilippo disease IIIB)
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 27419
HGNC: HGNC:7632
Homologene: 222
Mprip
Name: myosin phosphatase Rho interacting protein
Synonyms: RIP3, p116Rip, p116 Rho interacting protein, Rhoip3, Gm34094
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 26936
Homologene: 9034
Cgn
Name: cingulin
Synonyms: 6330408J11Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 70737
Homologene: 41394
Ctse
Name: cathepsin E
Synonyms: CE, CatE, A430072O03Rik, C920004C08Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 13034
HGNC: HGNC:2530
Homologene: 37551
Slc2a8
Name: solute carrier family 2, (facilitated glucose transporter), member 8
Synonyms: GLUT8, GlutX1, D2Ertd44e
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 56017
Homologene: 69170
Jag2
Name: jagged 2
Synonyms: Serh, D12Ggc2e
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 16450
VEGA: 12
HGNC: HGNC:6189
Homologene: 1677
Zfp595
Name: zinc finger protein 595
Synonyms: A230042K10Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 218314
Homologene: 120258
Man2a2
Name: mannosidase 2, alpha 2
Synonyms: alpha mannosidase IIx, MX, 4931438M07Rik, 1700052O22Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 140481
HGNC: HGNC:6825
Homologene: 55954
Nrxn1
Name: neurexin I
Synonyms: alpha-latrotoxin receptor (calcium-dependent), neurexin I beta, neurexin I alpha, neurexin I beta, neurexin I beta, neurexin I alpha, neurexin I alpha, 1700062G21Rik, A230068P09Rik, 9330127H16Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 18189
HGNC: HGNC:8008
Homologene: 21005
Il27ra
Name: interleukin 27 receptor, alpha
Synonyms: WSX-1, IL-27R, Tccr
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 50931
Homologene: 3562
Pcdhb7
Name: protocadherin beta 7
Synonyms: Pcdhb4B, PcdhbG
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93878
HGNC: HGNC:8689
Homologene: 87123
Ces3b
Name: carboxylesterase 3B
Synonyms: ES31L, Gm4738
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 13909
HGNC: HGNC:1865
Homologene: 84407
Sult2a5
Name: sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 5
Synonyms: EG434264, Gm15438
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 434264
Homologene: 37741
Or10q3
Name: olfactory receptor family 10 subfamily Q member 3
Synonyms: GA_x6K02T2RE5P-2222521-2221490, MOR266-10, Olfr1419
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 257938
Homologene: 79473
Oosp1
Name: oocyte secreted protein 1
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 170834
Homologene: 87189
Rcn2
Name: reticulocalbin 2
Synonyms: taipoxin-associated calcium binding protein 49, TCBP-49
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 26611
HGNC: HGNC:9935
Homologene: 2176
Setd7
Name: SET domain containing (lysine methyltransferase) 7
Synonyms: 1600028F23Rik, Set7, KMT7, Set7/9
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 73251
Homologene: 12741
Thoc5
Name: THO complex 5
Synonyms: PK1.3, 1700060C24Rik, Fmip, A430085L24Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 107829
Homologene: 37836
Or5b113
Name: olfactory receptor family 5 subfamily B member 113
Synonyms: GA_x6K02T2RE5P-3695694-3696620, MOR202-15, Olfr1467
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 258686
Homologene: 133888
Or7g12
Name: olfactory receptor family 7 subfamily G member 12
Synonyms: GA_x6K02T2PVTD-12724921-12725859, MOR153-2, MOR153-4_p, Olfr834
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258074
HGNC: HGNC:8467
Homologene: 128143
Ears2
Name: glutamyl-tRNA synthetase 2, mitochondrial
Synonyms: 3230401I01Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 67417
Homologene: 6907
Sh2d5
Name: SH2 domain containing 5
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230863
Homologene: 20002
Slc36a3
Name: solute carrier family 36 (proton/amino acid symporter), member 3
Synonyms: tramdorin2, PAT3, TRAMD2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 215332
Homologene: 76175
Upk3b
Name: uroplakin 3B
Synonyms: UpIIIb, P35, PMS2L14
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 100647
Homologene: 18435
Fcamr
Name: Fc receptor, IgA, IgM, high affinity
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 64435
Homologene: 12929
Asb16
Name: ankyrin repeat and SOCS box-containing 16
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217217
Homologene: 76813
Sbspon
Name: somatomedin B and thrombospondin, type 1 domain containing
Synonyms: LOC226866, Gm106
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226866
Homologene: 45950
Or6c74
Name: olfactory receptor family 6 subfamily C member 74
Synonyms: GA_x6K02T2PULF-11704843-11705775, MOR109-1, Olfr821
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 258772
Homologene: 27260
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to G, chromosome 1 at 15,860,319 bp
  • G to T, chromosome 1 at 130,811,706 bp
  • T to C, chromosome 1 at 131,662,753 bp
  • T to C, chromosome 1 at 132,116,904 bp
  • A to G, chromosome 1 at 151,811,635 bp
  • C to A, chromosome 2 at 31,405,875 bp
  • G to A, chromosome 2 at 32,980,068 bp
  • A to T, chromosome 2 at 65,508,574 bp
  • A to G, chromosome 2 at 76,975,037 bp
  • T to A, chromosome 2 at 114,149,016 bp
  • T to A, chromosome 2 at 125,166,682 bp
  • T to G, chromosome 2 at 129,105,280 bp
  • G to A, chromosome 2 at 181,991,378 bp
  • T to A, chromosome 3 at 51,536,657 bp
  • A to G, chromosome 3 at 94,769,179 bp
  • A to G, chromosome 3 at 136,797,774 bp
  • A to T, chromosome 4 at 41,221,615 bp
  • T to A, chromosome 4 at 98,932,307 bp
  • C to A, chromosome 4 at 138,256,797 bp
  • G to A, chromosome 5 at 32,844,391 bp
  • T to A, chromosome 5 at 33,360,378 bp
  • A to T, chromosome 5 at 106,881,791 bp
  • A to T, chromosome 5 at 106,972,950 bp
  • G to A, chromosome 5 at 136,040,139 bp
  • A to G, chromosome 6 at 108,482,931 bp
  • T to A, chromosome 7 at 13,628,843 bp
  • A to G, chromosome 7 at 80,366,926 bp
  • G to T, chromosome 7 at 122,048,340 bp
  • T to C, chromosome 8 at 25,823,186 bp
  • T to C, chromosome 8 at 79,998,208 bp
  • A to G, chromosome 8 at 84,031,558 bp
  • T to C, chromosome 8 at 86,528,275 bp
  • T to A, chromosome 8 at 105,086,596 bp
  • T to C, chromosome 9 at 18,988,920 bp
  • A to T, chromosome 9 at 49,003,902 bp
  • A to T, chromosome 9 at 56,052,982 bp
  • C to T, chromosome 10 at 82,151,220 bp
  • A to G, chromosome 10 at 130,033,887 bp
  • T to C, chromosome 11 at 4,902,306 bp
  • C to T, chromosome 11 at 55,151,198 bp
  • G to T, chromosome 11 at 59,737,089 bp
  • G to A, chromosome 11 at 101,076,610 bp
  • C to A, chromosome 11 at 102,277,927 bp
  • G to T, chromosome 12 at 112,913,180 bp
  • T to A, chromosome 13 at 49,725,272 bp
  • C to T, chromosome 13 at 67,317,705 bp
  • T to A, chromosome 13 at 93,617,648 bp
  • T to C, chromosome 14 at 31,030,891 bp
  • C to T, chromosome 14 at 32,988,921 bp
  • T to C, chromosome 14 at 59,499,710 bp
  • C to G, chromosome 14 at 84,532,985 bp
  • C to A, chromosome 17 at 5,097,668 bp
  • T to C, chromosome 17 at 35,554,981 bp
  • T to C, chromosome 17 at 74,579,506 bp
  • T to C, chromosome 17 at 86,827,699 bp
  • T to A, chromosome 17 at 90,059,551 bp
  • T to G, chromosome 18 at 37,343,862 bp
  • A to G, chromosome 18 at 44,010,229 bp
  • C to A, chromosome 19 at 11,691,005 bp
  • A to T, chromosome 19 at 11,870,805 bp
  • G to A, chromosome 19 at 13,365,146 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7828 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045882-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.