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Strain Name:
C57BL/6J-MtgxR7833Btlr/Mmmh
Stock Number:
045887-MU
Citation ID:
RRID:MMRRC_045887-MU
Other Names:
R7833 (G1)
Major Collection:

Strain Information

Sulf2
Name: sulfatase 2
Synonyms: 2010004N24Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 72043
Homologene: 10313
Smarca4
Name: SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
Synonyms: SNF2beta, Brg1, SW1/SNF, b2b692Clo, b2b508.1Clo
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 20586
Homologene: 135927
Cd40
Name: CD40 antigen
Synonyms: Cd40, Bp50, p50, Tnfrsf5
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 21939
Homologene: 954
Htr6
Name: 5-hydroxytryptamine (serotonin) receptor 6
Synonyms: 5-HT6
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 15565
HGNC: HGNC:5301
Homologene: 673
Rubcn
Name: RUN domain and cysteine-rich domain containing, Beclin 1-interacting protein
Synonyms: 1700021K19Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 100502698
Homologene: 15687
Atf2
Name: activating transcription factor 2
Synonyms: mXBP, CRE-BP, Creb2, D130078H02Rik, ATF-2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 11909
HGNC: HGNC:784
Homologene: 31061
Utp20
Name: UTP20 small subunit processome component
Synonyms: mDRIM, DRIM, 3830408P06Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 70683
VEGA: 10
Homologene: 38373
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 39,326,147 bp
  • T to A, chromosome 1 at 74,091,331 bp
  • T to G, chromosome 1 at 175,763,945 bp
  • A to G, chromosome 2 at 26,459,533 bp
  • A to G, chromosome 2 at 26,916,268 bp
  • T to C, chromosome 2 at 66,676,150 bp
  • T to C, chromosome 2 at 73,853,885 bp
  • G to A, chromosome 2 at 79,341,380 bp
  • T to A, chromosome 2 at 85,799,949 bp
  • A to G, chromosome 2 at 90,815,433 bp
  • A to G, chromosome 2 at 122,324,388 bp
  • A to T, chromosome 2 at 163,470,099 bp
  • A to T, chromosome 2 at 165,066,511 bp
  • G to T, chromosome 2 at 166,079,536 bp
  • A to T, chromosome 2 at 168,674,857 bp
  • T to C, chromosome 3 at 36,189,602 bp
  • A to T, chromosome 3 at 36,640,672 bp
  • A to G, chromosome 3 at 56,002,797 bp
  • G to A, chromosome 4 at 100,974,815 bp
  • G to T, chromosome 4 at 118,366,219 bp
  • G to T, chromosome 4 at 139,061,831 bp
  • T to C, chromosome 5 at 124,645,031 bp
  • G to A, chromosome 6 at 48,025,138 bp
  • A to T, chromosome 6 at 97,161,411 bp
  • G to T, chromosome 6 at 113,409,337 bp
  • C to T, chromosome 6 at 119,824,486 bp
  • T to G, chromosome 6 at 131,367,863 bp
  • T to A, chromosome 6 at 137,416,863 bp
  • C to A, chromosome 7 at 4,468,867 bp
  • C to A, chromosome 7 at 17,159,853 bp
  • T to C, chromosome 7 at 45,817,893 bp
  • C to T, chromosome 7 at 86,228,684 bp
  • A to T, chromosome 8 at 57,857,537 bp
  • G to A, chromosome 8 at 110,589,460 bp
  • T to C, chromosome 9 at 21,081,314 bp
  • T to A, chromosome 9 at 21,647,359 bp
  • T to A, chromosome 9 at 30,922,105 bp
  • T to A, chromosome 9 at 35,777,110 bp
  • C to A, chromosome 9 at 58,234,685 bp
  • A to G, chromosome 9 at 73,481,109 bp
  • A to T, chromosome 9 at 123,130,919 bp
  • C to T, chromosome 10 at 81,498,492 bp
  • G to A, chromosome 10 at 88,801,136 bp
  • A to G, chromosome 10 at 116,315,251 bp
  • A to G, chromosome 11 at 72,442,901 bp
  • G to A, chromosome 11 at 74,121,837 bp
  • A to C, chromosome 11 at 84,818,643 bp
  • G to A, chromosome 11 at 84,909,267 bp
  • T to C, chromosome 11 at 116,455,765 bp
  • A to G, chromosome 11 at 117,813,156 bp
  • T to C, chromosome 12 at 11,456,655 bp
  • T to A, chromosome 12 at 69,283,168 bp
  • A to G, chromosome 12 at 84,075,827 bp
  • G to A, chromosome 12 at 87,795,552 bp
  • A to G, chromosome 12 at 103,598,148 bp
  • T to C, chromosome 13 at 64,312,278 bp
  • C to A, chromosome 13 at 73,973,747 bp
  • A to G, chromosome 13 at 95,700,918 bp
  • G to A, chromosome 13 at 100,781,351 bp
  • A to T, chromosome 14 at 13,896,968 bp
  • A to T, chromosome 14 at 54,664,602 bp
  • T to A, chromosome 14 at 70,395,441 bp
  • G to T, chromosome 15 at 27,774,086 bp
  • T to A, chromosome 15 at 74,821,368 bp
  • G to T, chromosome 16 at 30,260,345 bp
  • C to A, chromosome 16 at 32,868,274 bp
  • T to A, chromosome 17 at 8,961,920 bp
  • T to C, chromosome 17 at 29,367,395 bp
  • T to G, chromosome 17 at 37,056,969 bp
  • A to G, chromosome 17 at 64,666,751 bp
  • T to A, chromosome 17 at 85,985,454 bp
  • G to A, chromosome 18 at 34,747,243 bp
  • C to A, chromosome 18 at 37,716,024 bp
  • A to G, chromosome 19 at 41,584,585 bp
  • C to T, chromosome X at 140,933,126 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
Gene Specific Genotyping:

To request gene-specific and other genotyping services for a strain, please contact the distribution MMRRC Center for more information.

Background Genetic Quality:

The MMRRC has developed a Genetic Quality Control pipeline using the MiniMUGA array to provide additional information to identify and validate genetic backgrounds of MMRRC strains. For more information on whether genetic background data is available, please contact MMRRC_GeneticQC@med.unc.edu. Note: that MiniMUGA genetic background data is not available on all strains, but can be ordered if desired.

Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7833 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045887-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.