Strain Name:
C57BL/6J-MtgxR7848Btlr/Mmmh
Stock Number:
045902-MU
Citation ID:
RRID:MMRRC_045902-MU
Other Names:
R7848 (G1)
Major Collection:

Strain Information

Ippk
Name: inositol 1,3,4,5,6-pentakisphosphate 2-kinase
Synonyms: 1810043M15Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 75678
VEGA: 13
Homologene: 41495
Fn1
Name: fibronectin 1
Synonyms: Fn-1, Fn
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 14268
HGNC: HGNC:3778
Homologene: 1533
Itga8
Name: integrin alpha 8
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241226
HGNC: HGNC:6144
Homologene: 37396
Espl1
Name: extra spindle pole bodies 1, separase
Synonyms: separase, SSE, ESP1, PRCE, PRCE, Cerp
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 105988
VEGA: 15
Homologene: 32151
Ncam2
Name: neural cell adhesion molecule 2
Synonyms: RNCAM, R4B12 antigen, Ncam-2, Ocam
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 17968
HGNC: HGNC:7657
Homologene: 3336
Nup210l
Name: nucleoporin 210-like
Synonyms: 4930548O11Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 77595
Homologene: 28122
Ncoa7
Name: nuclear receptor coactivator 7
Synonyms: 9030406N13Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 211329
VEGA: 10
Homologene: 65245
Tm9sf4
Name: transmembrane 9 superfamily member 4
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 99237
Homologene: 21620
Mthfd1l
Name: methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like
Synonyms: 2410004L15Rik, Fthfsdc1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 270685
Homologene: 56706
Mapkapk5
Name: MAP kinase-activated protein kinase 5
Synonyms: PRAK, MK5
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 17165
HGNC: HGNC:6889
Homologene: 69077
Dnajc15
Name: DnaJ heat shock protein family (Hsp40) member C15
Synonyms: 1110003P16Rik, Dnajd1, MCJ
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 66148
VEGA: 14
Homologene: 22740
Lrch4
Name: leucine-rich repeats and calponin homology (CH) domain containing 4
Synonyms: 2900069C24Rik, LRRN4, LRN, 2810008P14Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231798
HGNC: HGNC:6691
Homologene: 20532
Gabpb2
Name: GA repeat binding protein, beta 2
Synonyms: 9430006E19Rik, Gabpb2-1, A430024B14Rik, 1810015F01Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 213054
Homologene: 34921
Dmxl1
Name: Dmx-like 1
Synonyms: C630007L23Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 240283
HGNC: HGNC:2937
Homologene: 21136
Gnpat
Name: glyceronephosphate O-acyltransferase
Synonyms: D1Ertd819e
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 14712
HGNC: HGNC:4416
Homologene: 40716
Nr2c1
Name: nuclear receptor subfamily 2, group C, member 1
Synonyms: TR2, Tr2-11, 4831444H07Rik, Eenr
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 22025
HGNC: HGNC:7971
Homologene: 55731
Aff4
Name: AF4/FMR2 family, member 4
Synonyms: Alf4, Laf4l
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 93736
Homologene: 8683
Cyth1
Name: cytohesin 1
Synonyms: CLM1, CTH-1, Pscd1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 19157
HGNC: HGNC:9501
Homologene: 31262
Nufip1
Name: nuclear FMR1 interacting protein 1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 27275
VEGA: 14
HGNC: HGNC:8057
Homologene: 8216
Cbln1
Name: cerebellin 1 precursor protein
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 12404
HGNC: HGNC:1543
Homologene: 74520
2900026A02Rik
Name: RIKEN cDNA 2900026A02 gene
Synonyms: LOC231620, Gm449
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 243219
Homologene: 129566
Smcr8
Name: Smith-Magenis syndrome chromosome region, candidate 8 homolog (human)
Synonyms: D030073L15Rik, 2310076G09Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 237782
Homologene: 16989
Tmem98
Name: transmembrane protein 98
Synonyms: 6530411B15Rik, Rwhs
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 103743
Homologene: 9185
Abca3
Name: ATP-binding cassette, sub-family A member 3
Synonyms: ABC-C, Abc3, 1810036E22Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 27410
HGNC: HGNC:33
Homologene: 37437
Cenatac
Name: centrosomal AT-AC splicing factor
Synonyms: D630044F24Rik, Ccdc84
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 382073
VEGA: 9
Homologene: 13886
Muc6
Name: mucin 6, gastric
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 353328
HGNC: HGNC:7517
Homologene: 18768
F5
Name: coagulation factor V
Synonyms: Cf-5, Cf5
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 14067
HGNC: HGNC:3542
Homologene: 104
Slc35e1
Name: solute carrier family 35, member E1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 270066
Homologene: 49075
Fhad1
Name: forkhead-associated phosphopeptide binding domain 1
Synonyms: 2900090M10Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 329977
Homologene: 77947
Fat4
Name: FAT atypical cadherin 4
Synonyms: 6030410K14Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 329628
Homologene: 14377
Trgv5
Name: T cell receptor gamma, variable 5
Synonyms: Tcrg-V5
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 21639
Mroh2b
Name: maestro heat-like repeat family member 2B
Synonyms: 4930455B06Rik, Heatr7b2
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 223825
VEGA: 15
Homologene: 128807
Scube3
Name: signal peptide, CUB domain, EGF-like 3
Synonyms: D030038I21Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 268935
Homologene: 65059
Klhl42
Name: kelch-like 42
Synonyms: C230080I20Rik, Klhdc5
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232539
Homologene: 45842
Frmd4a
Name: FERM domain containing 4A
Synonyms: C230040M21Rik, 2700017I06Rik, Gm13190
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 209630
Homologene: 9971
Pcdh18
Name: protocadherin 18
Synonyms: PCDH68L
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 73173
Homologene: 10389
Col6a5
Name: collagen, type VI, alpha 5
Synonyms: Col6a5, Gm7455
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 665033
Homologene: 122792
Ogfr
Name: opioid growth factor receptor
Synonyms: 2010013E17Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 72075
Homologene: 7199
Map3k13
Name: mitogen-activated protein kinase kinase kinase 13
Synonyms: C130026N12Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 71751
VEGA: 16
HGNC: HGNC:6852
Homologene: 37958
Pklr
Name: pyruvate kinase liver and red blood cell
Synonyms: Pk1, Pk-1, R-PK
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 18770
HGNC: HGNC:9020
Homologene: 37286
St18
Name: suppression of tumorigenicity 18
Synonyms: Nzf3, Myt3
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 240690
Homologene: 8792
Gstm7
Name: glutathione S-transferase, mu 7
Synonyms: Cd203c, 0610005A07Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 68312
HGNC: HGNC:4634
Homologene: 41816
Man2a2
Name: mannosidase 2, alpha 2
Synonyms: alpha mannosidase IIx, MX, 4931438M07Rik, 1700052O22Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 140481
HGNC: HGNC:6825
Homologene: 55954
Tmcc2
Name: transmembrane and coiled-coil domains 2
Synonyms: 1110063G11Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 68875
Homologene: 8905
Kcnb1
Name: potassium voltage gated channel, Shab-related subfamily, member 1
Synonyms: Kv2.1, Kcr1-1, Shab
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 16500
HGNC: HGNC:6231
Homologene: 37988
Fam120b
Name: family with sequence similarity 120, member B
Synonyms: CCPG, 4932442K08Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 67544
VEGA: 17
Homologene: 13033
Nrg3
Name: neuregulin 3
Synonyms: ska
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 18183
HGNC: HGNC:7999
Homologene: 32051
Gys2
Name: glycogen synthase 2
Synonyms: LGS, glycogen synthase, liver
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232493
HGNC: HGNC:4707
Homologene: 56580
Aldh1l2
Name: aldehyde dehydrogenase 1 family, member L2
Synonyms: D330038I09Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 216188
Homologene: 51942
Lims2
Name: LIM and senescent cell antigen like domains 2
Synonyms: PINCH2
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 225341
VEGA: 18
Homologene: 41214
Kiz
Name: kizuna centrosomal protein
Synonyms: LOC228730, Ncrna00153, Gm114, Plk1s1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228730
Homologene: 10219
Rbm12
Name: RNA binding motif protein 12
Synonyms: 5730420G12Rik, SWAN, 9430070C08Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 75710
HGNC: HGNC:9898
Homologene: 34993
Ccdc85a
Name: coiled-coil domain containing 85A
Synonyms: E030025D05Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 216613
Homologene: 65605
Pcare
Name: photoreceptor cilium actin regulator
Synonyms: BC027072
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 225004
VEGA: 17
Homologene: 19792
Col26a1
Name: collagen, type XXVI, alpha 1
Synonyms: Emu2, 9430032K24Rik, Collagen XXVI, Emid2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 140709
Homologene: 136636
Or51a43
Name: olfactory receptor family 51 subfamily A member 43
Synonyms: GA_x6K02T2PBJ9-6803062-6802118, MOR13-1, Olfr644
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 259125
Homologene: 17491
Or10am5
Name: olfactory receptor family 10 subfamily AM member 5
Synonyms: GA_x6K02T2QGBW-3245761-3244808, MOR232-8, Olfr1349
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 269862
Homologene: 133589
Ttll1
Name: tubulin tyrosine ligase-like 1
Synonyms: 6330444E16Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 319953
HGNC: HGNC:1312
Homologene: 8174
Rnase10
Name: ribonuclease, RNase A family, 10 (non-active)
Synonyms: 4930474F22Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 75019
VEGA: 14
Homologene: 19166
Oaf
Name: out at first homolog
Synonyms: D130038B21Rik, D9Ucla1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 102644
VEGA: 9
Homologene: 14334
Ccdc87
Name: coiled-coil domain containing 87
Synonyms: 4931419P11Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 399599
VEGA: 19
Homologene: 49531
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 6,857,445 bp
  • T to A, chromosome 1 at 71,650,601 bp
  • T to C, chromosome 1 at 132,360,621 bp
  • T to C, chromosome 1 at 164,161,877 bp
  • A to G, chromosome 2 at 4,591,917 bp
  • T to A, chromosome 2 at 12,191,737 bp
  • T to A, chromosome 2 at 146,889,180 bp
  • T to C, chromosome 2 at 150,411,226 bp
  • T to A, chromosome 2 at 153,202,355 bp
  • A to T, chromosome 2 at 156,096,216 bp
  • A to G, chromosome 2 at 167,106,268 bp
  • T to C, chromosome 2 at 180,592,433 bp
  • A to G, chromosome 3 at 38,887,851 bp
  • A to T, chromosome 3 at 49,755,997 bp
  • T to G, chromosome 3 at 89,142,978 bp
  • A to G, chromosome 3 at 90,203,905 bp
  • A to T, chromosome 3 at 95,190,648 bp
  • A to T, chromosome 3 at 107,928,586 bp
  • A to T, chromosome 4 at 141,905,602 bp
  • C to T, chromosome 5 at 113,192,141 bp
  • A to G, chromosome 5 at 121,545,169 bp
  • T to C, chromosome 5 at 136,747,053 bp
  • A to G, chromosome 5 at 137,633,854 bp
  • G to T, chromosome 6 at 142,446,015 bp
  • A to G, chromosome 6 at 147,108,100 bp
  • T to C, chromosome 7 at 6,514,862 bp
  • G to C, chromosome 7 at 80,368,865 bp
  • T to A, chromosome 7 at 104,068,095 bp
  • T to C, chromosome 7 at 141,645,921 bp
  • T to C, chromosome 8 at 72,492,436 bp
  • T to C, chromosome 8 at 87,471,700 bp
  • C to A, chromosome 8 at 124,886,891 bp
  • G to A, chromosome 9 at 43,222,780 bp
  • A to G, chromosome 9 at 44,413,642 bp
  • T to C, chromosome 9 at 105,928,186 bp
  • A to G, chromosome 10 at 4,083,739 bp
  • A to T, chromosome 10 at 30,648,418 bp
  • C to T, chromosome 10 at 83,499,843 bp
  • C to T, chromosome 10 at 94,190,646 bp
  • A to G, chromosome 11 at 28,396,123 bp
  • C to A, chromosome 11 at 53,404,512 bp
  • A to G, chromosome 11 at 60,779,924 bp
  • T to G, chromosome 11 at 80,819,932 bp
  • TGGGCAA to T, chromosome 11 at 118,183,923 bp
  • G to A, chromosome 13 at 19,192,679 bp
  • T to A, chromosome 13 at 49,443,496 bp
  • T to C, chromosome 14 at 38,668,283 bp
  • T to C, chromosome 14 at 51,009,513 bp
  • G to A, chromosome 14 at 76,114,221 bp
  • T to C, chromosome 14 at 77,840,203 bp
  • C to T, chromosome 15 at 4,938,379 bp
  • T to C, chromosome 15 at 83,497,372 bp
  • T to C, chromosome 15 at 102,316,526 bp
  • T to C, chromosome 16 at 21,905,871 bp
  • C to T, chromosome 16 at 81,490,379 bp
  • T to C, chromosome 17 at 15,405,774 bp
  • G to T, chromosome 17 at 24,384,532 bp
  • T to C, chromosome 17 at 28,165,595 bp
  • T to C, chromosome 17 at 71,749,193 bp
  • A to G, chromosome 18 at 31,958,248 bp
  • A to G, chromosome 18 at 49,840,490 bp
  • A to G, chromosome 19 at 4,841,508 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7848 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045902-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.