Strain Name:
C57BL/6J-MtgxR7857Btlr/Mmmh
Stock Number:
045910-MU
Citation ID:
RRID:MMRRC_045910-MU
Other Names:
R7857 (G1)
Major Collection:

Strain Information

Cck
Name: cholecystokinin
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 12424
VEGA: 9
HGNC: HGNC:1569
Homologene: 583
Cdon
Name: cell adhesion molecule-related/down-regulated by oncogenes
Synonyms: CAM-related/down-regulated by oncogenes, CDO
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 57810
Homologene: 22996
Herc3
Name: hect domain and RLD 3
Synonyms: 5730409F18Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 73998
HGNC: HGNC:4876
Homologene: 57095
Snta1
Name: syntrophin, acidic 1
Synonyms: alpha1-syntrophin, Snt1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 20648
Homologene: 2331
Epb41l4a
Name: erythrocyte membrane protein band 4.1 like 4a
Synonyms: NBL4, Epb4.1l4a
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 13824
VEGA: 18
Homologene: 8398
Zfp934
Name: zinc finger protein 934
Synonyms: 6720457D02Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 77117
VEGA: 13
Slc4a7
Name: solute carrier family 4, sodium bicarbonate cotransporter, member 7
Synonyms: E430014N10Rik, NBC3, NBCn1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 218756
VEGA: 14
Homologene: 2680
Plcd3
Name: phospholipase C, delta 3
Synonyms: 2610205J15Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 72469
HGNC: HGNC:9061
Homologene: 14858
Poli
Name: polymerase (DNA directed), iota
Synonyms: Rad30b
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 26447
HGNC: HGNC:9182
Homologene: 5209
Tmem121
Name: transmembrane protein 121
Synonyms: Hole, 2410008J05Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 69195
Homologene: 11900
Elp3
Name: elongator acetyltransferase complex subunit 3
Synonyms: 2610507P14Rik, KAT9
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 74195
VEGA: 14
Homologene: 7105
Ncaph
Name: non-SMC condensin I complex, subunit H
Synonyms: HCAP-H, A730011O11Rik, Brrn1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 215387
HGNC: HGNC:1112
Homologene: 133986
Smc4
Name: structural maintenance of chromosomes 4
Synonyms: 2500002A22Rik, Smc4l1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 70099
Homologene: 4015
Fbxo21
Name: F-box protein 21
Synonyms: 2810425J22Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231670
Homologene: 14145
Gapvd1
Name: GTPase activating protein and VPS9 domains 1
Synonyms: 2010005B09Rik, 4432404J10Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 66691
Homologene: 32637
Cnot1
Name: CCR4-NOT transcription complex, subunit 1
Synonyms: 6030411K04Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234594
HGNC: HGNC:7877
Homologene: 9453
Trps1
Name: transcriptional repressor GATA binding 1
Synonyms: D15Ertd586e, trichorhinophalangeal syndrome I (human)
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 83925
Homologene: 8556
Ash1l
Name: ASH1 like histone lysine methyltransferase
Synonyms: chromatin remodeling factor, 8030453L17Rik, E430018P19Rik, KMT2H
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 192195
Homologene: 10225
Robo1
Name: roundabout guidance receptor 1
Synonyms: DUTT1
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 19876
Homologene: 2206
Mei1
Name: meiotic double-stranded break formation protein 1
Synonyms: mei1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 74369
Homologene: 46535
Med19
Name: mediator complex subunit 19
Synonyms: LCMR1, 2410018M14Rik, 3110040A13Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 381379
Homologene: 14684
Tmem68
Name: transmembrane protein 68
Synonyms: 2010300G19Rik, Diesl
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 72098
Homologene: 12440
Zfp236
Name: zinc finger protein 236
Synonyms: LOC240456
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 329002
Homologene: 7198
Rfx7
Name: regulatory factor X, 7
Synonyms: 2510005N23Rik, 9930116O05Rik, D130086K05Rik, Rfxdc2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 319758
Homologene: 11275
Pcdhb18
Name: protocadherin beta 18
Synonyms: Pcdhb9, PcdhbR
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93889
Homologene: 137649
Prss22
Name: serine protease 22
Synonyms: SP001LA, BSSP-4, 4733401N09Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 70835
VEGA: 17
Homologene: 23344
Gcdh
Name: glutaryl-Coenzyme A dehydrogenase
Synonyms: D17825
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 270076
HGNC: HGNC:4189
Homologene: 130
Ctnnd2
Name: catenin delta 2
Synonyms: Nprap, Catnd2, neurojugin, catenin (cadherin associated protein), delta 2
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 18163
VEGA: 15
HGNC: HGNC:2516
Homologene: 55574
Efhc1
Name: EF-hand domain (C-terminal) containing 1
Synonyms: 1700029F22Rik, mRib72-1, myoclonin1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 71877
Homologene: 10003
Zfp831
Name: zinc finger protein 831
Synonyms: ENSMUSG00000050600, OTTMUSG00000017459
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 100043757
Homologene: 19013
Dnah3
Name: dynein, axonemal, heavy chain 3
Synonyms: Dnahc3
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 381917
HGNC: HGNC:2949
Homologene: 19674
Cyp2b13
Name: cytochrome P450, family 2, subfamily b, polypeptide 13
Synonyms: phenobarbital inducible, type c
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 13089
HGNC: HGNC:2615
Homologene: 74933
Ephb6
Name: Eph receptor B6
Synonyms: Mep, Cekl
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 13848
HGNC: HGNC:3396
Homologene: 20940
Tmx4
Name: thioredoxin-related transmembrane protein 4
Synonyms: 4930500L08Rik, 2810417D04Rik, D2Bwg1356e, Txndc13
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 52837
Homologene: 10901
Ltf
Name: lactotransferrin
Synonyms: Lf, lactoferrin
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 17002
HGNC: HGNC:6720
Homologene: 1754
Ahnak
Name: AHNAK nucleoprotein
Synonyms: DY6, 2310047C17Rik, 1110004P15Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 66395
VEGA: 19
HGNC: HGNC:347
Homologene: 67425
Entpd6
Name: ectonucleoside triphosphate diphosphohydrolase 6
Synonyms: NTPDase-6, Cd39l2, 2700026H11Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 12497
HGNC: HGNC:3368
Homologene: 68170
Vmn2r84
Name: vomeronasal 2, receptor 84
Synonyms: EG625068
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 625068
Homologene: 129606
Dsg1b
Name: desmoglein 1 beta
Synonyms: Dsg5
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 225256
HGNC: HGNC:3048
Homologene: 1463
Il1rl2
Name: interleukin 1 receptor-like 2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 107527
HGNC: HGNC:5999
Homologene: 2860
Lipg
Name: lipase, endothelial
Synonyms: mEDL, 3110013K01Rik, EL, endothelial lipase
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 16891
VEGA: 18
HGNC: HGNC:6623
Homologene: 21218
Grk3
Name: G protein-coupled receptor kinase 3
Synonyms: beta ARK2, Bark-2, Adrbk-2, 4833444A01Rik, Adrbk2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 320129
HGNC: HGNC:290
Homologene: 21072
Wbp2nl
Name: WBP2 N-terminal like
Synonyms: 4930521I23Rik, PAWP
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 74716
VEGA: 15
Homologene: 17633
Arhgef40
Name: Rho guanine nucleotide exchange factor 40
Synonyms: E130112L23Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 268739
Homologene: 19560
Lrrc74a
Name: leucine rich repeat containing 74A
Synonyms: Gm6772, Lrrc74
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 627607
VEGA: 12
Homologene: 19331
Psg26
Name: pregnancy-specific beta-1-glycoprotein 26
Synonyms: cea14, EG574429
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 574429
Homologene: 110989
Adam6b
Name: a disintegrin and metallopeptidase domain 6B
Synonyms: 4930523C11Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 238405
Homologene: 128362
Irag1
Name: inositol 1,4,5-triphosphate receptor associated 1
Synonyms: Ris1, Mrvi1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 17540
HGNC: HGNC:7237
Homologene: 4425
Wdr35
Name: WD repeat domain 35
Synonyms: 4930459M12Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 74682
Homologene: 10814
Gm10638
Name: predicted gene 10638
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 666945
VEGA: 8
Gsc
Name: goosecoid homeobox
Synonyms: goosecoid
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 14836
HGNC: HGNC:4612
Homologene: 7744
Usp21
Name: ubiquitin specific peptidase 21
Synonyms: Usp16, ESTM28, Usp23, W53272
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 30941
Homologene: 56572
Kif1c
Name: kinesin family member 1C
Synonyms: N-3 kinsin, D11Bwg1349e, B430105J22Rik, Orch3
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 16562
HGNC: HGNC:6317
Homologene: 4821
Hacd4
Name: 3-hydroxyacyl-CoA dehydratase 4
Synonyms: 4933428I03Rik, Ptplad2
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 66775
Homologene: 12033
Or51b6
Name: olfactory receptor family 51 subfamily B member 6
Synonyms: 5'[b]3, MOR1-2, GA_x6K02T2PBJ9-6634906-6633983, Olfr65
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 18365
Homologene: 66459
Npffr1
Name: neuropeptide FF receptor 1
Synonyms: LOC237362, NPFF1, Gpr147, NPFF1R
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 237362
Homologene: 23348
Pmm2
Name: phosphomannomutase 2
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 54128
HGNC: HGNC:9115
Homologene: 257
Reep5
Name: receptor accessory protein 5
Synonyms: DP1/TB2, TB2/DP1, Dp1
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 13476
VEGA: 18
Homologene: 68479
Pcdha7
Name: protocadherin alpha 7
Synonyms: Cnr4, Crnr4
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 12939
HGNC: HGNC:8673
Homologene: 117962
Pcdha12
Name: protocadherin alpha 12
Synonyms: Cnr5, Crnr5, Pcdha13
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 192164
HGNC: HGNC:8667
Homologene: 135870
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 20,975,002 bp
  • T to C, chromosome 1 at 40,327,482 bp
  • A to G, chromosome 1 at 171,286,762 bp
  • T to A, chromosome 2 at 34,729,067 bp
  • T to A, chromosome 2 at 52,222,984 bp
  • T to A, chromosome 2 at 84,685,625 bp
  • A to C, chromosome 2 at 127,104,245 bp
  • T to G, chromosome 2 at 134,639,662 bp
  • T to C, chromosome 2 at 150,765,553 bp
  • A to T, chromosome 2 at 154,383,897 bp
  • T to C, chromosome 2 at 174,705,242 bp
  • T to C, chromosome 3 at 69,033,219 bp
  • T to A, chromosome 3 at 88,984,309 bp
  • A to G, chromosome 4 at 3,551,825 bp
  • C to T, chromosome 4 at 88,437,465 bp
  • T to C, chromosome 5 at 5,508,209 bp
  • T to C, chromosome 5 at 112,961,561 bp
  • T to C, chromosome 5 at 117,988,813 bp
  • T to C, chromosome 6 at 41,613,397 bp
  • G to A, chromosome 6 at 58,843,652 bp
  • A to G, chromosome 7 at 18,478,290 bp
  • T to A, chromosome 7 at 26,088,728 bp
  • A to T, chromosome 7 at 103,906,610 bp
  • T to A, chromosome 7 at 110,923,535 bp
  • A to T, chromosome 7 at 119,951,704 bp
  • A to G, chromosome 8 at 84,892,464 bp
  • G to T, chromosome 8 at 86,746,263 bp
  • ACG to A, chromosome 8 at 95,745,647 bp
  • A to G, chromosome 9 at 35,456,612 bp
  • A to G, chromosome 9 at 72,593,323 bp
  • A to T, chromosome 9 at 111,022,376 bp
  • A to G, chromosome 9 at 121,493,448 bp
  • G to T, chromosome 10 at 61,613,986 bp
  • T to A, chromosome 10 at 130,390,869 bp
  • A to G, chromosome 11 at 70,728,277 bp
  • A to T, chromosome 11 at 103,077,934 bp
  • T to C, chromosome 12 at 9,008,113 bp
  • A to G, chromosome 12 at 86,741,711 bp
  • T to G, chromosome 12 at 104,472,165 bp
  • C to T, chromosome 12 at 113,189,076 bp
  • A to T, chromosome 12 at 113,490,484 bp
  • G to A, chromosome 13 at 62,517,547 bp
  • T to C, chromosome 14 at 14,772,624 bp
  • T to A, chromosome 14 at 51,988,755 bp
  • G to A, chromosome 14 at 65,563,310 bp
  • A to T, chromosome 15 at 30,619,930 bp
  • T to A, chromosome 15 at 50,661,005 bp
  • A to T, chromosome 15 at 82,092,717 bp
  • A to G, chromosome 15 at 82,306,072 bp
  • C to G, chromosome 16 at 8,642,768 bp
  • A to G, chromosome 16 at 72,970,211 bp
  • G to A, chromosome 17 at 23,993,879 bp
  • A to T, chromosome 18 at 20,396,463 bp
  • G to T, chromosome 18 at 34,006,045 bp
  • A to T, chromosome 18 at 34,372,468 bp
  • A to T, chromosome 18 at 36,975,839 bp
  • A to T, chromosome 18 at 37,022,415 bp
  • A to T, chromosome 18 at 37,491,311 bp
  • T to G, chromosome 18 at 70,509,154 bp
  • C to T, chromosome 18 at 74,945,820 bp
  • G to A, chromosome 18 at 82,668,601 bp
  • G to A, chromosome 19 at 9,007,468 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7857 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045910-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.