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Strain Name:
C57BL/6J-MtgxR7857Btlr/Mmmh
Stock Number:
045910-MU
Citation ID:
RRID:MMRRC_045910-MU
Other Names:
R7857 (G1)
Major Collection:

Strain Information

Cck
Name: cholecystokinin
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 12424
VEGA: 9
HGNC: HGNC:1569
Homologene: 583
Cdon
Name: cell adhesion molecule-related/down-regulated by oncogenes
Synonyms: CAM-related/down-regulated by oncogenes, CDO
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 57810
Homologene: 22996
Herc3
Name: hect domain and RLD 3
Synonyms: 5730409F18Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 73998
HGNC: HGNC:4876
Homologene: 57095
Snta1
Name: syntrophin, acidic 1
Synonyms: alpha1-syntrophin, Snt1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 20648
Homologene: 2331
Epb41l4a
Name: erythrocyte membrane protein band 4.1 like 4a
Synonyms: NBL4, Epb4.1l4a
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 13824
VEGA: 18
Homologene: 8398
Slc4a7
Name: solute carrier family 4, sodium bicarbonate cotransporter, member 7
Synonyms: E430014N10Rik, NBC3, NBCn1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 218756
VEGA: 14
Homologene: 2680
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 20,975,002 bp
  • T to C, chromosome 1 at 40,327,482 bp
  • A to G, chromosome 1 at 171,286,762 bp
  • T to A, chromosome 2 at 34,729,067 bp
  • T to A, chromosome 2 at 52,222,984 bp
  • T to A, chromosome 2 at 84,685,625 bp
  • A to C, chromosome 2 at 127,104,245 bp
  • T to G, chromosome 2 at 134,639,662 bp
  • T to C, chromosome 2 at 150,765,553 bp
  • A to T, chromosome 2 at 154,383,897 bp
  • T to C, chromosome 2 at 174,705,242 bp
  • T to C, chromosome 3 at 69,033,219 bp
  • T to A, chromosome 3 at 88,984,309 bp
  • A to G, chromosome 4 at 3,551,825 bp
  • C to T, chromosome 4 at 88,437,465 bp
  • T to C, chromosome 5 at 5,508,209 bp
  • T to C, chromosome 5 at 112,961,561 bp
  • T to C, chromosome 5 at 117,988,813 bp
  • T to C, chromosome 6 at 41,613,397 bp
  • G to A, chromosome 6 at 58,843,652 bp
  • A to G, chromosome 7 at 18,478,290 bp
  • T to A, chromosome 7 at 26,088,728 bp
  • A to T, chromosome 7 at 103,906,610 bp
  • T to A, chromosome 7 at 110,923,535 bp
  • A to T, chromosome 7 at 119,951,704 bp
  • A to G, chromosome 8 at 84,892,464 bp
  • G to T, chromosome 8 at 86,746,263 bp
  • ACG to A, chromosome 8 at 95,745,647 bp
  • A to G, chromosome 9 at 35,456,612 bp
  • A to G, chromosome 9 at 72,593,323 bp
  • A to T, chromosome 9 at 111,022,376 bp
  • A to G, chromosome 9 at 121,493,448 bp
  • G to T, chromosome 10 at 61,613,986 bp
  • T to A, chromosome 10 at 130,390,869 bp
  • A to G, chromosome 11 at 70,728,277 bp
  • A to T, chromosome 11 at 103,077,934 bp
  • T to C, chromosome 12 at 9,008,113 bp
  • A to G, chromosome 12 at 86,741,711 bp
  • T to G, chromosome 12 at 104,472,165 bp
  • C to T, chromosome 12 at 113,189,076 bp
  • A to T, chromosome 12 at 113,490,484 bp
  • G to A, chromosome 13 at 62,517,547 bp
  • T to C, chromosome 14 at 14,772,624 bp
  • T to A, chromosome 14 at 51,988,755 bp
  • G to A, chromosome 14 at 65,563,310 bp
  • A to T, chromosome 15 at 30,619,930 bp
  • T to A, chromosome 15 at 50,661,005 bp
  • A to T, chromosome 15 at 82,092,717 bp
  • A to G, chromosome 15 at 82,306,072 bp
  • C to G, chromosome 16 at 8,642,768 bp
  • A to G, chromosome 16 at 72,970,211 bp
  • G to A, chromosome 17 at 23,993,879 bp
  • A to T, chromosome 18 at 20,396,463 bp
  • G to T, chromosome 18 at 34,006,045 bp
  • A to T, chromosome 18 at 34,372,468 bp
  • A to T, chromosome 18 at 36,975,839 bp
  • A to T, chromosome 18 at 37,022,415 bp
  • A to T, chromosome 18 at 37,491,311 bp
  • T to G, chromosome 18 at 70,509,154 bp
  • C to T, chromosome 18 at 74,945,820 bp
  • G to A, chromosome 18 at 82,668,601 bp
  • G to A, chromosome 19 at 9,007,468 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
Gene Specific Genotyping:

To request gene-specific and other genotyping services for a strain, please contact the distribution MMRRC Center for more information.

Background Genetic Quality:

The MMRRC has developed a Genetic Quality Control pipeline using the MiniMUGA array to provide additional information to identify and validate genetic backgrounds of MMRRC strains. For more information on whether genetic background data is available, please contact MMRRC_GeneticQC@med.unc.edu. Note: that MiniMUGA genetic background data is not available on all strains, but can be ordered if desired.

Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7857 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045910-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.