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Strain Detail Sheet

Strain Name:
C57BL/6J-MtgxR7867Btlr/Mmmh
Stock Number:
045919-MU
Citation ID:
RRID:MMRRC_045919-MU
Other Names:
R7867 (G1)
Major Collection:
Beutler Mutagenetix

Strain Information

Gene Details

Prkaca
Name: protein kinase, cAMP dependent, catalytic, alpha
Synonyms: Cs, C alpha, PKA, Pkaca
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 18747
HGNC: HGNC:9380
Homologene: 121574

Additional Resources
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Gene Ontology
BioGPS
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Mouse Mine
KOMP Phenotyping
Monarch
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ClinGen
Fam117b
Name: family with sequence similarity 117, member B
Synonyms: 6330416D14Rik, 2810425F24Rik, Als2cr13
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 72750
Homologene: 18307

Additional Resources
IMPC
Google
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PubMed
IMSR
Gene Ontology
BioGPS
Gene Cloud
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Mouse Phenome DB
Mouse Mine
KOMP Phenotyping
Monarch
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ClinGen
Eno2
Name: enolase 2, gamma neuronal
Synonyms: Eno-2, D6Ertd375e, NSE
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 13807
HGNC: HGNC:3353
Homologene: 74414

Additional Resources
IMPC
Google
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PubMed
IMSR
Gene Ontology
BioGPS
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Mouse Phenome DB
Mouse Mine
KOMP Phenotyping
Monarch
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ClinGen
Fam131a
Name: family with sequence similarity 131, member A
Synonyms: 2900046G09Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 78408
Homologene: 82234

Additional Resources
IMPC
Google
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IMSR
Gene Ontology
BioGPS
Gene Cloud
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Mouse Mine
KOMP Phenotyping
Monarch
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ClinGen
Akap10
Name: A kinase anchor protein 10
Synonyms: D-AKAP2, 1500031L16Rik, B130049N18Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 56697
HGNC: HGNC:368
Homologene: 32452

Additional Resources
IMPC
Google
Entrez
PubMed
IMSR
Gene Ontology
BioGPS
Gene Cloud
IGTC
Mouse Phenome DB
Mouse Mine
KOMP Phenotyping
Monarch
GeneCards
ClinGen
Mtss1
Name: MTSS I-BAR domain containing 1
Synonyms: MIM, D130001D01Rik, 2310003N14Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 211401
VEGA: 15
Homologene: 8841

Additional Resources
IMPC
Google
Entrez
PubMed
IMSR
Gene Ontology
BioGPS
Gene Cloud
IGTC
Mouse Phenome DB
Mouse Mine
KOMP Phenotyping
Monarch
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ClinGen
Plekhm1
Name: pleckstrin homology domain containing, family M (with RUN domain) member 1
Synonyms: D330036J23Rik, AP162, B2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 353047
Homologene: 8871

Additional Resources
IMPC
Google
Entrez
PubMed
IMSR
Gene Ontology
BioGPS
Gene Cloud
IGTC
Mouse Phenome DB
Mouse Mine
KOMP Phenotyping
Monarch
GeneCards
ClinGen
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 59,974,887 bp
  • T to C, chromosome 1 at 161,837,796 bp
  • A to T, chromosome 2 at 26,340,436 bp
  • T to A, chromosome 2 at 130,278,285 bp
  • G to A, chromosome 2 at 148,407,744 bp
  • T to C, chromosome 3 at 86,368,589 bp
  • T to A, chromosome 3 at 89,185,776 bp
  • T to C, chromosome 3 at 90,086,468 bp
  • G to C, chromosome 3 at 94,265,847 bp
  • A to G, chromosome 3 at 121,455,055 bp
  • T to A, chromosome 4 at 35,709,302 bp
  • C to T, chromosome 4 at 43,232,573 bp
  • G to A, chromosome 4 at 49,502,925 bp
  • A to G, chromosome 4 at 100,988,562 bp
  • C to A, chromosome 4 at 141,905,591 bp
  • G to C, chromosome 5 at 24,446,666 bp
  • T to C, chromosome 5 at 104,483,120 bp
  • G to T, chromosome 5 at 139,161,810 bp
  • T to A, chromosome 6 at 90,640,927 bp
  • C to T, chromosome 6 at 118,776,446 bp
  • T to A, chromosome 6 at 121,873,634 bp
  • T to C, chromosome 6 at 123,267,164 bp
  • C to T, chromosome 6 at 124,763,174 bp
  • C to T, chromosome 7 at 3,620,004 bp
  • T to G, chromosome 7 at 31,143,567 bp
  • T to A, chromosome 7 at 42,012,283 bp
  • C to A, chromosome 7 at 43,812,909 bp
  • T to A, chromosome 7 at 97,973,978 bp
  • T to A, chromosome 7 at 117,475,514 bp
  • C to A, chromosome 7 at 132,049,071 bp
  • C to T, chromosome 7 at 140,493,136 bp
  • G to T, chromosome 7 at 141,256,611 bp
  • A to T, chromosome 8 at 13,061,027 bp
  • A to G, chromosome 8 at 45,286,965 bp
  • A to T, chromosome 8 at 83,995,334 bp
  • A to C, chromosome 8 at 105,932,865 bp
  • T to C, chromosome 9 at 52,143,948 bp
  • A to T, chromosome 9 at 107,751,731 bp
  • T to A, chromosome 10 at 60,314,611 bp
  • G to T, chromosome 10 at 62,664,944 bp
  • T to A, chromosome 11 at 9,262,139 bp
  • T to A, chromosome 11 at 59,000,826 bp
  • A to G, chromosome 11 at 61,900,446 bp
  • A to T, chromosome 11 at 84,249,524 bp
  • C to T, chromosome 11 at 95,834,025 bp
  • T to C, chromosome 11 at 100,121,182 bp
  • T to A, chromosome 11 at 103,380,327 bp
  • T to A, chromosome 11 at 120,448,127 bp
  • T to A, chromosome 12 at 65,116,466 bp
  • A to G, chromosome 12 at 65,118,399 bp
  • A to G, chromosome 12 at 75,983,727 bp
  • G to A, chromosome 12 at 98,705,176 bp
  • A to G, chromosome 12 at 110,874,123 bp
  • T to C, chromosome 13 at 77,902,718 bp
  • C to G, chromosome 13 at 94,483,263 bp
  • A to T, chromosome 14 at 4,166,115 bp
  • A to T, chromosome 15 at 58,971,009 bp
  • A to G, chromosome 15 at 82,617,224 bp
  • T to A, chromosome 15 at 102,151,163 bp
  • A to G, chromosome 16 at 14,128,606 bp
  • A to G, chromosome 16 at 20,695,834 bp
  • A to C, chromosome 16 at 32,681,235 bp
  • G to A, chromosome 16 at 33,989,791 bp
  • T to G, chromosome 17 at 3,177,719 bp
  • C to A, chromosome 17 at 35,961,998 bp
  • A to C, chromosome 18 at 37,413,566 bp
  • T to C, chromosome 19 at 4,058,808 bp
  • A to T, chromosome 19 at 10,878,102 bp
  • T to C, chromosome 19 at 32,815,494 bp
  • C to A, chromosome 19 at 50,230,260 bp

Strain Description

Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
Gene Specific Genotyping:

To request gene-specific and other genotyping services for a strain, please contact the distribution MMRRC Center for more information.

Background Genetic Quality:

The MMRRC has developed a Genetic Quality Control pipeline using the MiniMUGA array to provide additional information to identify and validate genetic backgrounds of MMRRC strains. For more information on whether genetic background data is available, please contact MMRRC_GeneticQC@med.unc.edu. Note: that MiniMUGA genetic background data is not available on all strains, but can be ordered if desired.

Suggested Control Mice
Littermates of all relevant genotypes.

Strain Origin

Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7867 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Health Status Report

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.

Appearance

Coat Color
Black

Breeding

MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain

Reproductive Statistics

Average litter size
Undetermined
Recommended wean age
3 weeks

Order Information

Availability Level

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Conditions of Distribution

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Fees

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*		 Units Notes
045919-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.