Strain Name:
C57BL/6J-MtgxR7875Btlr/Mmmh
Stock Number:
045927-MU
Citation ID:
RRID:MMRRC_045927-MU
Other Names:
R7875 (G1)
Major Collection:

Strain Information

Scn3a
Name: sodium channel, voltage-gated, type III, alpha
Synonyms: Nav1.3, LOC381367
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 20269
Homologene: 56005
Arid5b
Name: AT-rich interaction domain 5B
Synonyms: Mrf2alpha, 5430435G07Rik, Desrt, Mrf2, Mrf2beta
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 71371
VEGA: 10
Homologene: 45872
Ahdc1
Name: AT hook, DNA binding motif, containing 1
Synonyms: D030015G18Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230793
Homologene: 17144
Tagln
Name: transgelin
Synonyms: Sm22a, SM22alpha, SM-22 alpha, SM22
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 21345
VEGA: 9
Homologene: 2398
Acap2
Name: ArfGAP with coiled-coil, ankyrin repeat and PH domains 2
Synonyms: Centb2, 9530039J15Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 78618
VEGA: 16
Homologene: 8182
Dock9
Name: dedicator of cytokinesis 9
Synonyms: Zizimin1, D14Wsu89e, B230309H04Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 105445
Homologene: 41026
Sik3
Name: SIK family kinase 3
Synonyms: 5730525O22Rik, 9030204A07Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 70661
Homologene: 57023
Anp32b
Name: acidic nuclear phosphoprotein 32 family member B
Synonyms: 2410015B15Rik, PHAPI2a, PAL31
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 67628
Homologene: 137872
Kdm5a
Name: lysine demethylase 5A
Synonyms: RBP2, Rbbp2, Jarid1a
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 214899
HGNC: HGNC:9886
Homologene: 3419
Xrcc5
Name: X-ray repair complementing defective repair in Chinese hamster cells 5
Synonyms: Ku80, Ku86
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 22596
VEGA: 1
Homologene: 40681
Aspm
Name: abnormal spindle microtubule assembly
Synonyms: Sha1, MCPH5, D330028K02Rik, Aspm, Calmbp1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12316
Homologene: 7650
Ranbp2
Name: RAN binding protein 2
Synonyms: A430087B05Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 19386
VEGA: 10
Homologene: 87808
Gab1
Name: growth factor receptor bound protein 2-associated protein 1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 14388
HGNC: HGNC:4066
Homologene: 1542
Nfrkb
Name: nuclear factor related to kappa B binding protein
Synonyms: A530090G11Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235134
HGNC: HGNC:7802
Homologene: 4492
Ascc2
Name: activating signal cointegrator 1 complex subunit 2
Synonyms: 1700011I11Rik, 2610034L15Rik, ASC1p100
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 75452
Homologene: 41774
Zkscan5
Name: zinc finger with KRAB and SCAN domains 5
Synonyms: Zfp95, hKraba1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 22757
Homologene: 8734
Uhrf1
Name: ubiquitin-like, containing PHD and RING finger domains, 1
Synonyms: Np95, ICBP90
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 18140
Homologene: 7866
Gpc1
Name: glypican 1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 14733
HGNC: HGNC:4449
Homologene: 20477
Scn10a
Name: sodium channel, voltage-gated, type X, alpha
Synonyms: Nav1.8
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 20264
VEGA: 9
Homologene: 21300
Thra
Name: thyroid hormone receptor alpha
Synonyms: Rvr, 6430529J03Rik, Nr1a1, Thra2, Thra1, T3R[a], T3Ralpha, Erba, TR alpha 2, c-erbAalpha, TR alpha 1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 21833
Homologene: 37747
Lrrtm4
Name: leucine rich repeat transmembrane neuronal 4
Synonyms: 7530419J18Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 243499
Homologene: 11807
Slc12a7
Name: solute carrier family 12, member 7
Synonyms: Kcc4
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 20499
VEGA: 13
Homologene: 21312
Ints2
Name: integrator complex subunit 2
Synonyms: 2810417D08Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 70422
Homologene: 10801
Tars3
Name: threonyl-tRNA synthetase 3
Synonyms: A530046H20Rik, Tarsl2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 272396
Homologene: 65036
Wscd1
Name: WSC domain containing 1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 216881
Homologene: 18590
Plcxd2
Name: phosphatidylinositol-specific phospholipase C, X domain containing 2
Synonyms: EG433022
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 433022
Homologene: 44374
Col1a2
Name: collagen, type I, alpha 2
Synonyms: Col1a-2, Cola2, Cola-2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 12843
HGNC: HGNC:2198
Homologene: 69
Gdf11
Name: growth differentiation factor 11
Synonyms: Bmp11
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 14561
HGNC: HGNC:4216
Homologene: 21183
Col7a1
Name: collagen, type VII, alpha 1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 12836
HGNC: HGNC:2214
Homologene: 73
Cplane1
Name: ciliogenesis and planar polarity effector 1
Synonyms: 2410089E03Rik, Jbts17, b2b012Clo, Hug
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 73692
Homologene: 11315
Ccser1
Name: coiled-coil serine rich 1
Synonyms: C130092O11Rik, 6230405M12Rik, Fam190a
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232035
Homologene: 28086
Or4f6
Name: olfactory receptor family 4 subfamily F member 6
Synonyms: MOR245-3, GA_x6K02T2Q125-73056609-73055671, Olfr1310
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258441
Homologene: 74053
Vmn1r58
Name: vomeronasal 1 receptor 58
Synonyms: V3R4, V1rd4
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 81014
Homologene: 41799
Poteg
Name: POTE ankyrin domain family, member G
Synonyms: 4921537P18Rik, 4930456F22Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 70952
Homologene: 134158
Arhgef11
Name: Rho guanine nucleotide exchange factor 11
Synonyms: PDZ-RhoGEF, Prg
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 213498
Homologene: 11409
Syde2
Name: synapse defective 1, Rho GTPase, homolog 2 (C. elegans)
Synonyms: C430017H16Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 214804
Homologene: 19035
Adgre4
Name: adhesion G protein-coupled receptor E4
Synonyms: Gpr127, FIRE, Emr4, EGF-TM7, D17Ertd479e
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 52614
VEGA: 17
Homologene: 64640
Rab11fip2
Name: RAB11 family interacting protein 2 (class I)
Synonyms: nRip11, A830046J09Rik, Rab11-FIP2, 4930470G04Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 74998
Homologene: 8937
Topaz1
Name: testis and ovary specific PAZ domain containing 1
Synonyms: Gm9524
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 671232
VEGA: 9
Homologene: 19835
Spata31h1
Name: SPATA31 subfamily H member 1
Synonyms: 4932415D10Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 102635990
VEGA: 10
Homologene: 82476
Rin3
Name: Ras and Rab interactor 3
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 217835
Homologene: 11748
Aldh1a7
Name: aldehyde dehydrogenase family 1, subfamily A7
Synonyms: Aldh-pb, Ahd2-like
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 26358
HGNC: HGNC:402
Homologene: 137245
Ccng2
Name: cyclin G2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 12452
HGNC: HGNC:1593
Homologene: 3208
Mamdc4
Name: MAM domain containing 4
Synonyms: LOC381352
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 381352
Homologene: 17102
Or2ad1
Name: olfactory receptor family 2 subfamily AD member 1
Synonyms: GA_x6K02T2QHY8-12104556-12105500, MOR256-15, Olfr1368
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 258527
Homologene: 105156
Tas2r137
Name: taste receptor, type 2, member 137
Synonyms: mt2r41
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 574417
Homologene: 23231
Acp7
Name: acid phosphatase 7, tartrate resistant
Synonyms: Papl, C330005M16Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 101744
Homologene: 23924
Prdm9
Name: PR domain containing 9
Synonyms: repro7, Dsbc1, Rcr1, G1-419-29, Meisetz
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 213389
Homologene: 104139
Kcnt2
Name: potassium channel, subfamily T, member 2
Synonyms: E330038N15Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 240776
Homologene: 16121
Hnf4a
Name: hepatic nuclear factor 4, alpha
Synonyms: HNF-4, Tcf4, Nuclear receptor 2A1, Tcf14, HNF4 alpha, Hnf4, Nr2a1, MODY1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 15378
HGNC: HGNC:5024
Homologene: 395
Vnn3
Name: vanin 3
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 26464
Homologene: 48295
Or8k16
Name: olfactory receptor family 8 subfamily K member 16
Synonyms: Olfr1008, MOR187-3, GA_x6K02T2Q125-47170431-47171372
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258866
Upk3b
Name: uroplakin 3B
Synonyms: UpIIIb, P35, PMS2L14
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 100647
Homologene: 18435
Vmn1r219
Name: vomeronasal 1 receptor 219
Synonyms: V1rh13
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 171272
Homologene: 110880
Fam241b
Name: family with sequence similarity 241, member B
Synonyms: 2010107G23Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 69894
Homologene: 12338
Kbtbd7
Name: kelch repeat and BTB (POZ) domain containing 7
Synonyms: LOC211255, 1110008P08Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 211255
VEGA: 14
Homologene: 41849
Mzb1
Name: marginal zone B and B1 cell-specific protein 1
Synonyms: pERp1, 2010001M09Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 69816
VEGA: 18
Homologene: 12333
Or52r1b
Name: olfactory receptor family 52 subfamily R member 1B
Synonyms: MOR30-3, GA_x6K02T2PBJ9-5752857-5753801, Olfr582
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 259055
Homologene: 73943
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to T, chromosome 1 at 72,329,931 bp
  • T to C, chromosome 1 at 92,855,248 bp
  • A to T, chromosome 1 at 139,455,134 bp
  • A to G, chromosome 1 at 140,573,647 bp
  • C to T, chromosome 2 at 25,568,665 bp
  • A to G, chromosome 2 at 65,497,482 bp
  • G to A, chromosome 2 at 85,689,494 bp
  • A to G, chromosome 2 at 112,008,847 bp
  • G to T, chromosome 2 at 163,559,060 bp
  • A to T, chromosome 3 at 87,684,501 bp
  • A to G, chromosome 3 at 146,020,265 bp
  • T to G, chromosome 4 at 46,451,301 bp
  • A to G, chromosome 4 at 133,063,850 bp
  • C to G, chromosome 5 at 93,273,343 bp
  • A to T, chromosome 5 at 136,040,203 bp
  • A to C, chromosome 5 at 145,220,866 bp
  • T to A, chromosome 6 at 4,518,500 bp
  • A to G, chromosome 6 at 40,492,163 bp
  • A to T, chromosome 6 at 61,311,948 bp
  • A to T, chromosome 6 at 80,022,360 bp
  • C to A, chromosome 6 at 120,399,018 bp
  • T to C, chromosome 7 at 5,410,754 bp
  • A to T, chromosome 7 at 28,614,727 bp
  • T to A, chromosome 7 at 65,678,151 bp
  • A to G, chromosome 7 at 103,041,853 bp
  • C to T, chromosome 8 at 27,449,914 bp
  • C to T, chromosome 8 at 80,788,766 bp
  • A to G, chromosome 9 at 31,410,154 bp
  • T to C, chromosome 9 at 45,930,382 bp
  • T to A, chromosome 9 at 46,123,230 bp
  • T to C, chromosome 9 at 108,958,695 bp
  • C to T, chromosome 9 at 119,635,442 bp
  • A to G, chromosome 9 at 122,749,587 bp
  • C to A, chromosome 10 at 23,867,248 bp
  • G to T, chromosome 10 at 58,478,455 bp
  • A to T, chromosome 10 at 62,134,492 bp
  • T to C, chromosome 10 at 68,128,941 bp
  • T to C, chromosome 10 at 82,287,622 bp
  • C to T, chromosome 10 at 128,886,341 bp
  • A to G, chromosome 11 at 4,668,389 bp
  • T to A, chromosome 11 at 71,788,734 bp
  • T to C, chromosome 11 at 86,213,062 bp
  • A to T, chromosome 11 at 98,768,431 bp
  • T to C, chromosome 12 at 102,369,476 bp
  • T to A, chromosome 13 at 21,142,923 bp
  • T to C, chromosome 13 at 23,163,193 bp
  • T to A, chromosome 13 at 73,788,604 bp
  • A to G, chromosome 14 at 79,427,366 bp
  • A to T, chromosome 14 at 121,625,984 bp
  • A to G, chromosome 15 at 8,209,962 bp
  • A to T, chromosome 16 at 31,139,641 bp
  • G to A, chromosome 16 at 46,009,702 bp
  • A to T, chromosome 17 at 15,553,542 bp
  • A to T, chromosome 17 at 55,792,016 bp
  • A to G, chromosome 17 at 56,312,884 bp
  • A to G, chromosome 18 at 35,647,860 bp
  • A to C, chromosome 19 at 20,715,979 bp
  • G to C, chromosome 19 at 59,937,223 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7875 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045927-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.