Strain Name:
C57BL/6J-MtgxR7886Btlr/Mmmh
Stock Number:
045938-MU
Citation ID:
RRID:MMRRC_045938-MU
Other Names:
R7886 (G1)
Major Collection:

Strain Information

B4galnt1
Name: beta-1,4-N-acetyl-galactosaminyl transferase 1
Synonyms: beta1,4GalNAC-T, GM2/GD2 synthase, GalNAcT, Gal-NAc-T, 4933429D13Rik, Ggm-2, Galgt1, GalNAc-T, Ggm2
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 14421
VEGA: 10
HGNC: HGNC:4117
Homologene: 1133
Kcnc1
Name: potassium voltage gated channel, Shaw-related subfamily, member 1
Synonyms: C230009H10Rik, KV4, NGK2, Shaw, Kv3.1, Kcr2-1, KShIIIB
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 16502
HGNC: HGNC:6233
Homologene: 68134
Dnajc7
Name: DnaJ heat shock protein family (Hsp40) member C7
Synonyms: 2010003F24Rik, 2010004G07Rik, Ttc2, mTpr2, mDj11
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 56354
Homologene: 68306
Wdr70
Name: WD repeat domain 70
Synonyms: 4833422F06Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 545085
VEGA: 15
Homologene: 9972
Numa1
Name: nuclear mitotic apparatus protein 1
Synonyms: NuMA, 6720401E04Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 101706
HGNC: HGNC:8059
Homologene: 38150
Usp25
Name: ubiquitin specific peptidase 25
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 30940
VEGA: 16
Homologene: 8374
Eftud2
Name: elongation factor Tu GTP binding domain containing 2
Synonyms: 116kDa, Snrp116, U5-116kD
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 20624
Homologene: 3133
Pik3c3
Name: phosphatidylinositol 3-kinase catalytic subunit type 3
Synonyms: 5330434F23Rik, Vps34
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 225326
HGNC: HGNC:8974
Homologene: 1986
Tbc1d23
Name: TBC1 domain family, member 23
Synonyms: D030022P07Rik, 4930451A13Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 67581
VEGA: 16
Homologene: 10126
Sltm
Name: SAFB-like, transcription modulator
Synonyms: 5730555F13Rik, 5730455C01Rik, 9130215G10Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 66660
VEGA: 9
Homologene: 11696
Nfs1
Name: nitrogen fixation gene 1 (S. cerevisiae)
Synonyms: m-Nfs1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 18041
Homologene: 5463
Pou4f1
Name: POU domain, class 4, transcription factor 1
Synonyms: Brn-3, E130119J07Rik, Brn3, Brn-3.0, Brn3a
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 18996
HGNC: HGNC:9218
Homologene: 21255
Frem1
Name: Fras1 related extracellular matrix protein 1
Synonyms: heb, eyem02Jus, eyes2, QBRICK, crf11
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 329872
Homologene: 27049
Dcc
Name: deleted in colorectal carcinoma
Synonyms: Igdcc1, C030036D22Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 13176
HGNC: HGNC:2701
Homologene: 21081
Ppfia1
Name: protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1
Synonyms: Liprin-alpha1, liprin, C030014K08Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233977
HGNC: HGNC:9245
Homologene: 20802
Macrod2
Name: mono-ADP ribosylhydrolase 2
Synonyms: 2610107G07Rik, 2900006F19Rik, 1110033L15Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 72899
Homologene: 85987
Zfp369
Name: zinc finger protein 369
Synonyms: B930030B22Rik, NRIF2, D230020H11Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 170936
Homologene: 129707
Muc16
Name: mucin 16
Synonyms: 1110008I14Rik, LOC385009, Gm21044
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 73732
Homologene: 141193
Atad2
Name: ATPase family, AAA domain containing 2
Synonyms: 2610509G12Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 70472
VEGA: 15
Homologene: 6044
Pom121
Name: nuclear pore membrane protein 121
Synonyms: 2610027A18Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 107939
Homologene: 70878
Pglyrp2
Name: peptidoglycan recognition protein 2
Synonyms: Pglyrpl, tagl-beta, C730002N09Rik, PGRP-L, tagL-alpha, tagL
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 57757
VEGA: 17
Homologene: 49671
Tnik
Name: TRAF2 and NCK interacting kinase
Synonyms: 4831440I19Rik, C530008O15Rik, 1500031A17Rik, C630040K21Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 665113
Homologene: 77943
Hmcn1
Name: hemicentin 1
Synonyms: LOC240793, EG545370
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 545370
Homologene: 23741
Nlgn1
Name: neuroligin 1
Synonyms: 6330415N05Rik, NL1, Nlg1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 192167
Homologene: 56690
Depdc1a
Name: DEP domain containing 1a
Synonyms: 5830484J08Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 76131
Homologene: 9834
Naip5
Name: NLR family, apoptosis inhibitory protein 5
Synonyms: Naip-rs3, Lgn1, Birc1e
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 17951
HGNC: HGNC:7634
Homologene: 113589
Rdh19
Name: retinol dehydrogenase 19
Synonyms: Rdhs, RDH-S
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 216453
Homologene: 129514
Pold2
Name: polymerase (DNA directed), delta 2, regulatory subunit
Synonyms: 50kDa, po1D2, p50
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 18972
HGNC: HGNC:9176
Homologene: 4538
Igsf10
Name: immunoglobulin superfamily, member 10
Synonyms: Adlican2, CMF608, 6530405F15Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 242050
Homologene: 18712
Sirpb1c
Name: signal-regulatory protein beta 1C
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 100038947
Homologene: 82993
Pygl
Name: liver glycogen phosphorylase
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 110095
HGNC: HGNC:9725
Homologene: 84371
Ccdc51
Name: coiled-coil domain containing 51
Synonyms: Mitok, 5730568A12Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 66658
Homologene: 11646
Mapkbp1
Name: mitogen-activated protein kinase binding protein 1
Synonyms: 2810483F24Rik, Jnkbp1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 26390
Homologene: 69109
Ano5
Name: anoctamin 5
Synonyms: Tmem16e, Gdd1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233246
Homologene: 100071
Gabrg3
Name: gamma-aminobutyric acid type A receptor, subunit gamma 3
Synonyms: B230362M20Rik, Gabrg-3
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 14407
HGNC: HGNC:4088
Homologene: 22444
Or4k2
Name: olfactory receptor family 4 subfamily K member 2
Synonyms: GA_x6K02T2PMLR-5881670-5880717, MOR247-1, Olfr730
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 258486
Homologene: 17269
Or10k2
Name: olfactory receptor family 10 subfamily K member 2
Synonyms: Olfr370, GA_x6K02T2NUPS-11609807-11610751, MOR267-16
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 258267
Homologene: 74037
Pde11a
Name: phosphodiesterase 11A
Synonyms: A630086N24Rik, 6330414F14Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241489
HGNC: HGNC:8773
Homologene: 56763
Get1
Name: guided entry of tail-anchored proteins factor 1
Synonyms: Wrb, C030018G21Rik, 5530402J05Rik, Chd5
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 71446
Homologene: 37945
Fam184a
Name: family with sequence similarity 184, member A
Synonyms: 4930589M24Rik, 3110012E06Rik, 4930438C08Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 75906
Homologene: 11600
Klhdc2
Name: kelch domain containing 2
Synonyms: D12Ertd522e, 2310022K15Rik, HCLP-1
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 69554
Homologene: 8631
C1s2
Name: complement component 1, s subcomponent 2
Synonyms: Gm5077
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 317677
HGNC: HGNC:1247
Homologene: 1314
Tpmt
Name: thiopurine methyltransferase
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 22017
Homologene: 313
Or7a39
Name: olfactory receptor family 7 subfamily A member 39
Synonyms: MOR139-6, GA_x6K02T2QGN0-2932609-2931677, Olfr1355
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 257734
Homologene: 136441
A730049H05Rik
Name: RIKEN cDNA A730049H05 gene
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 74516
Or7g29
Name: olfactory receptor family 7 subfamily G member 29
Synonyms: Olfr847, GA_x6K02T2PVTD-13113073-13112135, MOR149-2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258518
Homologene: 17281
Fdx2
Name: ferredoxin 2
Synonyms: B230118G17Rik, Fdx1l
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 68165
VEGA: 9
Homologene: 31955
Or2t48
Name: olfactory receptor family 2 subfamily T member 48
Synonyms: Olfr330, GA_x6K02T2NKPP-895420-896349, MOR275-1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 258879
Homologene: 133015
Vmn1r91
Name: vomeronasal 1 receptor 91
Synonyms: Gm8442
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 667067
Homologene: 104166
Zbed3
Name: zinc finger, BED type containing 3
Synonyms: 2610005H11Rik, 0610037K01Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 72114
VEGA: 13
Homologene: 12442
Mettl21a
Name: methyltransferase 21A, HSPA lysine
Synonyms: Fam119a, 2310038H17Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 67099
Homologene: 41658
Dchs2
Name: dachsous cadherin related 2
Synonyms: LOC229459
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 100534287
Scgb1b12
Name: secretoglobin, family 1B, member 12
Synonyms: Abpa12, Gm9140
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 668381
Homologene: 114479
Gm42669
Name: predicted gene 42669
Type: Gene
Species: Mouse
Chromosome: 5
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 64,615,184 bp
  • A to T, chromosome 1 at 150,657,470 bp
  • C to T, chromosome 2 at 76,291,203 bp
  • T to C, chromosome 2 at 120,012,647 bp
  • G to A, chromosome 2 at 141,724,645 bp
  • T to A, chromosome 2 at 156,142,061 bp
  • C to T, chromosome 3 at 15,832,202 bp
  • T to C, chromosome 3 at 25,435,907 bp
  • A to G, chromosome 3 at 28,666,139 bp
  • T to C, chromosome 3 at 59,328,327 bp
  • A to T, chromosome 3 at 83,305,085 bp
  • G to A, chromosome 3 at 159,516,069 bp
  • T to C, chromosome 4 at 83,016,406 bp
  • C to A, chromosome 4 at 88,683,269 bp
  • A to G, chromosome 5 at 107,508,706 bp
  • T to C, chromosome 5 at 135,381,994 bp
  • T to G, chromosome 6 at 92,834,456 bp
  • T to C, chromosome 6 at 124,628,330 bp
  • T to A, chromosome 7 at 20,101,565 bp
  • A to G, chromosome 7 at 32,334,497 bp
  • C to A, chromosome 7 at 46,427,621 bp
  • A to G, chromosome 7 at 51,570,393 bp
  • G to A, chromosome 7 at 56,724,481 bp
  • C to T, chromosome 7 at 102,013,865 bp
  • G to T, chromosome 7 at 144,519,283 bp
  • T to C, chromosome 8 at 83,541,947 bp
  • A to T, chromosome 9 at 18,585,982 bp
  • A to T, chromosome 9 at 19,375,906 bp
  • A to T, chromosome 9 at 21,073,327 bp
  • C to G, chromosome 9 at 70,586,673 bp
  • G to T, chromosome 9 at 109,091,587 bp
  • T to C, chromosome 10 at 53,675,160 bp
  • A to G, chromosome 10 at 78,879,823 bp
  • T to C, chromosome 10 at 127,167,054 bp
  • A to G, chromosome 10 at 127,850,300 bp
  • T to C, chromosome 11 at 5,872,714 bp
  • C to A, chromosome 11 at 58,529,054 bp
  • A to T, chromosome 11 at 100,601,803 bp
  • C to T, chromosome 11 at 102,840,108 bp
  • G to A, chromosome 12 at 69,304,632 bp
  • A to G, chromosome 12 at 70,206,356 bp
  • C to A, chromosome 13 at 47,040,162 bp
  • A to G, chromosome 13 at 65,292,054 bp
  • A to G, chromosome 13 at 95,336,125 bp
  • A to T, chromosome 13 at 100,246,181 bp
  • A to T, chromosome 14 at 50,186,564 bp
  • A to T, chromosome 14 at 104,466,792 bp
  • C to T, chromosome 15 at 8,079,249 bp
  • A to T, chromosome 15 at 58,126,136 bp
  • T to C, chromosome 16 at 57,189,383 bp
  • A to T, chromosome 16 at 77,113,771 bp
  • T to A, chromosome 16 at 96,145,568 bp
  • A to G, chromosome 17 at 32,418,761 bp
  • C to T, chromosome 18 at 30,319,588 bp
  • G to A, chromosome 18 at 71,954,868 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7886 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045938-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.