Strain Name:
C57BL/6J-MtgxR7905Btlr/Mmmh
Stock Number:
045957-MU
Citation ID:
RRID:MMRRC_045957-MU
Other Names:
R7905 (G1)
Major Collection:

Strain Information

Nedd4
Name: neural precursor cell expressed, developmentally down-regulated 4
Synonyms: Nedd4a, Nedd4-1, Nedd4, E430025J12Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 17999
HGNC: HGNC:7727
Homologene: 134533
Cd40
Name: CD40 antigen
Synonyms: Cd40, p50, Bp50, Tnfrsf5
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 21939
Homologene: 954
Adcy10
Name: adenylate cyclase 10
Synonyms: soluble adenylyl cyclase, 4930431D04Rik, sAC, Sacy
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 271639
Homologene: 10188
Tfdp2
Name: transcription factor Dp 2
Synonyms: A330080J22Rik, DP-3, DP3, 1110029I05Rik, DP3
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 211586
Homologene: 4578
Ufc1
Name: ubiquitin-fold modifier conjugating enzyme 1
Synonyms: 1110021H02Rik, ESTM29
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 66155
Homologene: 9500
Nf1
Name: neurofibromin 1
Synonyms: neurofibromin, Mhdadsk9, Dsk9, Nf-1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 18015
HGNC: HGNC:7765
Homologene: 226
Cep290
Name: centrosomal protein 290
Synonyms: Kiaa, b2b1752Clo, Nphp6, b2b1454Clo
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 216274
VEGA: 10
Homologene: 77213
Taf4
Name: TATA-box binding protein associated factor 4
Synonyms: TAFII130, Taf4a, Taf2c1, TAFII135
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228980
Homologene: 55723
Trit1
Name: tRNA isopentenyltransferase 1
Synonyms: MOD5, 2310075G14Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 66966
Homologene: 7010
Myo1b
Name: myosin IB
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 17912
HGNC: HGNC:7596
Homologene: 7856
Ets2
Name: E26 avian leukemia oncogene 2, 3' domain
Synonyms: Ets-2
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 23872
HGNC: HGNC:3489
Homologene: 3838
Taf2
Name: TATA-box binding protein associated factor 2
Synonyms: CIF150, 150kDa, TAFII150, TAF2B, 4732460C16Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 319944
VEGA: 15
Homologene: 31137
Slc49a4
Name: solute carrier family 49 member 4
Synonyms: Dirc2, RCC4
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 224132
Homologene: 13137
Dsg4
Name: desmoglein 4
Synonyms: lah, CDHF13
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 16769
Homologene: 65341
Degs1
Name: delta 4-desaturase, sphingolipid 1
Synonyms: Des1, Mdes
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 13244
Homologene: 55770
Osbpl10
Name: oxysterol binding protein-like 10
Synonyms: 4933433D06Rik, C820004B04Rik, OPR-10
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 74486
Homologene: 69240
Ttc13
Name: tetratricopeptide repeat domain 13
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234875
Homologene: 11569
Spink7
Name: serine peptidase inhibitor, Kazal type 7 (putative)
Synonyms: EG408198
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 408198
VEGA: 18
Homologene: 57174
Susd2
Name: sushi domain containing 2
Synonyms: 1200011D11Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 71733
VEGA: 10
Homologene: 10481
Cnbd1
Name: cyclic nucleotide binding domain containing 1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 435772
Homologene: 27843
Myh11
Name: myosin, heavy polypeptide 11, smooth muscle
Synonyms: SM2, smMHC, SM1
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 17880
VEGA: 16
HGNC: HGNC:7569
Homologene: 128512
Hfm1
Name: HFM1, ATP-dependent DNA helicase homolog
Synonyms: LOC381663, Sec63d1, A330009G12Rik, Mer3
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 330149
Homologene: 87103
Dll3
Name: delta like canonical Notch ligand 3
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 13389
HGNC: HGNC:2909
Homologene: 7291
Stard9
Name: StAR related lipid transfer domain containing 9
Synonyms: E230025N21Rik, Kif16a, 4831403C07Rik, N-3 kinesin
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 668880
Homologene: 130712
Aox1
Name: aldehyde oxidase 1
Synonyms: retinal oxidase, Aox-2, Aox2, Aox-1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 11761
HGNC: HGNC:553
Homologene: 68165
Nek9
Name: NIMA (never in mitosis gene a)-related expressed kinase 9
Synonyms: C130021H08Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 217718
Homologene: 13222
Golgb1
Name: golgin B1
Synonyms: 6330407A06Rik, Gm6840, C130074L01Rik, F730017E11Rik, Giantin
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 224139
HGNC: HGNC:4429
Homologene: 68401
Slc4a10
Name: solute carrier family 4, sodium bicarbonate cotransporter-like, member 10
Synonyms: NCBE
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 94229
Homologene: 23340
Spata31h1
Name: SPATA31 subfamily H member 1
Synonyms: 4932415D10Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 102635990
VEGA: 10
Homologene: 82476
Trim46
Name: tripartite motif-containing 46
Synonyms: TRIFIC
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 360213
Homologene: 11815
Plxnb1
Name: plexin B1
Synonyms: 2900002G15Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235611
HGNC: HGNC:9103
Homologene: 130508
Kcna5
Name: potassium voltage-gated channel, shaker-related subfamily, member 5
Synonyms: Kv1.5
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 16493
HGNC: HGNC:6224
Homologene: 1683
Ccdc28a
Name: coiled-coil domain containing 28A
Synonyms: 1700009P13Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 215814
Homologene: 56705
Gbp4
Name: guanylate binding protein 4
Synonyms: Mpa-2, Mag-2, Mpa2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 17472
Homologene: 128731
Zbbx
Name: zinc finger, B-box domain containing
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 213234
Homologene: 11661
Psg26
Name: pregnancy-specific beta-1-glycoprotein 26
Synonyms: EG574429, cea14
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 574429
Homologene: 110989
Tha1
Name: threonine aldolase 1
Synonyms: GLY1, 1300017K07Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 71776
Homologene: 57081
Bpifa5
Name: BPI fold containing family A, member 5
Synonyms: 2310074B19Rik, 2310021H06Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 67135
Homologene: 12087
Actl9
Name: actin-like 9
Synonyms: 1700029I08Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 69481
Homologene: 77642
Pcdhb6
Name: protocadherin beta 6
Synonyms: PcdhbF, Pcdhb5B
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93877
HGNC: HGNC:8690
Homologene: 62177
Zfp768
Name: zinc finger protein 768
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233890
Homologene: 11650
Mief1
Name: mitochondrial elongation factor 1
Synonyms: Smcr7l
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 239555
VEGA: 15
Homologene: 10374
Or6c203
Name: olfactory receptor family 6 subfamily C member 203
Synonyms: MOR114-3, Olfr772, GA_x6K02T2PULF-10860457-10859522
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 257666
Homologene: 123776
Trem6l
Name: triggering receptor expressed on myeloid cells-like 6
Synonyms: B430306N03Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 320148
Homologene: 138443
Ldhc
Name: lactate dehydrogenase C
Synonyms: Ldh3, Ldhc4, Ldh-3
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 16833
HGNC: HGNC:6544
Homologene: 22767
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 51,763,884 bp
  • G to A, chromosome 1 at 58,104,398 bp
  • T to A, chromosome 1 at 165,513,168 bp
  • T to A, chromosome 1 at 171,289,935 bp
  • A to C, chromosome 1 at 182,279,036 bp
  • A to G, chromosome 2 at 62,268,151 bp
  • T to C, chromosome 2 at 120,696,081 bp
  • T to C, chromosome 2 at 154,165,588 bp
  • T to C, chromosome 2 at 165,062,325 bp
  • G to A, chromosome 2 at 179,932,029 bp
  • T to C, chromosome 3 at 75,085,513 bp
  • T to C, chromosome 3 at 89,244,326 bp
  • T to C, chromosome 4 at 18,907,100 bp
  • A to G, chromosome 4 at 123,016,715 bp
  • A to G, chromosome 5 at 105,121,087 bp
  • A to T, chromosome 5 at 106,898,553 bp
  • T to C, chromosome 6 at 126,534,868 bp
  • T to A, chromosome 7 at 18,475,317 bp
  • T to G, chromosome 7 at 28,301,535 bp
  • A to G, chromosome 7 at 46,875,531 bp
  • T to C, chromosome 7 at 127,344,659 bp
  • A to T, chromosome 8 at 124,688,596 bp
  • A to T, chromosome 9 at 72,677,379 bp
  • T to C, chromosome 9 at 96,310,606 bp
  • G to A, chromosome 9 at 109,109,232 bp
  • T to C, chromosome 9 at 115,062,010 bp
  • A to T, chromosome 10 at 18,218,328 bp
  • A to T, chromosome 10 at 75,639,657 bp
  • A to G, chromosome 10 at 82,296,102 bp
  • A to G, chromosome 10 at 100,554,490 bp
  • A to T, chromosome 10 at 129,174,187 bp
  • G to A, chromosome 11 at 79,547,112 bp
  • A to C, chromosome 11 at 117,871,067 bp
  • A to C, chromosome 12 at 85,305,596 bp
  • A to T, chromosome 15 at 55,047,432 bp
  • C to G, chromosome 15 at 80,249,398 bp
  • A to T, chromosome 16 at 14,207,681 bp
  • G to A, chromosome 16 at 35,768,950 bp
  • C to T, chromosome 16 at 36,913,685 bp
  • T to A, chromosome 16 at 95,706,437 bp
  • T to C, chromosome 17 at 33,433,827 bp
  • T to A, chromosome 17 at 48,316,960 bp
  • A to T, chromosome 18 at 20,454,669 bp
  • T to C, chromosome 18 at 37,334,554 bp
  • G to T, chromosome 18 at 62,592,416 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7905 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045957-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.