Strain Name:
C57BL/6J-MtgxR7918Btlr/Mmmh
Stock Number:
045966-MU
Citation ID:
RRID:MMRRC_045966-MU
Other Names:
R7918 (G1)
Major Collection:

Strain Information

Cacna1g
Name: calcium channel, voltage-dependent, T type, alpha 1G subunit
Synonyms: Cav3.1d, a1G
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 12291
HGNC: HGNC:1394
Homologene: 22544
Exoc6b
Name: exocyst complex component 6B
Synonyms: G430127E12Rik, Sec15b, Sec15l2, 4930569O18Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 75914
Homologene: 44781
Dock1
Name: dedicator of cytokinesis 1
Synonyms: D630004B07Rik, Dock180, b2b3190Clo, 9130006G06Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 330662
HGNC: HGNC:2987
Homologene: 55575
Mast2
Name: microtubule associated serine/threonine kinase 2
Synonyms: Mtssk, MAST205
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 17776
Homologene: 7428
Zmym4
Name: zinc finger, MYM-type 4
Synonyms: 6330503C17Rik, Zfp262
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 67785
Homologene: 35470
Zc3h7b
Name: zinc finger CCCH type containing 7B
Synonyms: Scrg3
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 20286
VEGA: 15
Homologene: 9735
Trip12
Name: thyroid hormone receptor interactor 12
Synonyms: 6720416K24Rik, Gtl6, 1110036I07Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 14897
Homologene: 44226
Tbc1d8
Name: TBC1 domain family, member 8
Synonyms: AD3, BUB2-like protein 1, HBLP1, GRAM domain
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 54610
Homologene: 31421
Plcg1
Name: phospholipase C, gamma 1
Synonyms: Plc-gamma1, Plc-1, Plcg-1, Cded
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 18803
HGNC: HGNC:9065
Homologene: 1997
Epha8
Name: Eph receptor A8
Synonyms: EphA8, Eek, Hek3
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 13842
HGNC: HGNC:3391
Homologene: 22436
Nup107
Name: nucleoporin 107
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 103468
VEGA: 10
Homologene: 5555
Syne1
Name: spectrin repeat containing, nuclear envelope 1
Synonyms: A330049M09Rik, nesprin-1, C130039F11Rik, enaptin165, SYNE-1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 64009
VEGA: 10
Homologene: 52329
Clca4b
Name: chloride channel accessory 4B
Synonyms: AI747448
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 99709
HGNC: HGNC:2018
Homologene: 40808
Ints2
Name: integrator complex subunit 2
Synonyms: 2810417D08Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 70422
Homologene: 10801
Clstn1
Name: calsyntenin 1
Synonyms: Cst-1, calsyntenin-1, alcadein alpha, 1810034E21Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 65945
Homologene: 8814
Exoc1
Name: exocyst complex component 1
Synonyms: Sec3p, A730011E05Rik, Sec3l1, 2810407P21Rik, SEC3
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 69940
Homologene: 41241
Sucnr1
Name: succinate receptor 1
Synonyms: Gpr91
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 84112
HGNC: HGNC:4542
Homologene: 41865
Cep164
Name: centrosomal protein 164
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 214552
Homologene: 51110
Zbed5
Name: zinc finger BED-type containing 5
Synonyms: Zbed5, Chchd2l, 2410018M08Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 71970
Homologene: 84838
Or8b101
Name: olfactory receptor family 8 subfamily B member 101
Synonyms: Olfr888, GA_x6K02T2PVTD-31787920-31788864, MOR162-4
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258416
Homologene: 84577
Tmem132e
Name: transmembrane protein 132E
Synonyms: LOC270893
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 270893
Homologene: 41524
Syde2
Name: synapse defective 1, Rho GTPase, homolog 2 (C. elegans)
Synonyms: C430017H16Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 214804
Homologene: 19035
Vmn2r63
Name: vomeronasal 2, receptor 63
Synonyms: EG435975
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 435975
Homologene: 104832
Vmn1r231
Name: vomeronasal 1 receptor 231
Synonyms: V1re7
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 171230
Pde4dip
Name: phosphodiesterase 4D interacting protein (myomegalin)
Synonyms: D130016K21Rik, Usmg4, D3Bwg1078e, 4732458A06Rik, 9430063L05Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 83679
Homologene: 66961
Or1e1c
Name: olfactory receptor family 1 subfamily E member 1C
Synonyms: GA_x6K02T2P1NL-3535075-3536028, Olfr376, MOR135-12
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 258924
Homologene: 133579
Bank1
Name: B cell scaffold protein with ankyrin repeats 1
Synonyms: A530094C12Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 242248
Homologene: 9926
Adam26b
Name: a disintegrin and metallopeptidase domain 26B
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 382007
Homologene: 128363
Adam26a
Name: ADAM metallopeptidase domain 26A
Synonyms: Dtgn4, Adam26
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 13525
Homologene: 128363
Slc39a10
Name: solute carrier family 39 (zinc transporter), member 10
Synonyms: Zip10, 2900042E17Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 227059
Homologene: 34076
Tsnaxip1
Name: translin-associated factor X (Tsnax) interacting protein 1
Synonyms: 1700016K08Rik, TXI1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 72236
Homologene: 10194
Slc13a1
Name: solute carrier family 13 (sodium/sulfate symporters), member 1
Synonyms: NaSi-1, Nas1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 55961
Homologene: 31893
Adam21
Name: a disintegrin and metallopeptidase domain 21
Synonyms: ADAM31
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 56622
HGNC: HGNC:200
Homologene: 68365
Lrfn2
Name: leucine rich repeat and fibronectin type III domain containing 2
Synonyms: SALM1, 5730420O05Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 70530
Homologene: 19182
Catsperd
Name: cation channel sperm associated auxiliary subunit delta
Synonyms: 4921529N20Rik, Tmem146, 4933402B14Rik, Gm6095
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 106757
VEGA: 17
Homologene: 51896
Zfp874b
Name: zinc finger protein 874b
Synonyms: 9630025I21Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 408067
Homologene: 135597
Ankrd29
Name: ankyrin repeat domain 29
Synonyms: G630054C21Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 225187
Homologene: 17839
Kti12
Name: KTI12 homolog, chromatin associated
Synonyms: 1110001A12Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 100087
Homologene: 6347
Wdr5b
Name: WD repeat domain 5B
Synonyms: 2310009C03Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 69544
VEGA: 16
Homologene: 41307
Plxnb3
Name: plexin B3
Synonyms: Plxn6
Type: Gene
Species: Mouse
Chromosome: X
NCBI: 140571
HGNC: HGNC:9105
Homologene: 68468
Or8g37
Name: olfactory receptor family 8 subfamily G member 37
Synonyms: Olfr970, MOR171-16, GA_x6K02T2PVTD-33517322-33518257
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258604
VEGA: 9
Homologene: 121532
Plat
Name: plasminogen activator, tissue
Synonyms: tPA, D8Ertd2e, t-PA
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 18791
HGNC: HGNC:9051
Homologene: 717
A330070K13Rik
Name: RIKEN cDNA A330070K13 gene
Synonyms: LOC381673
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 381673
Gcsam
Name: germinal center associated, signaling and motility
Synonyms: M17, Gcet2
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 14525
Homologene: 49157
Lad1
Name: ladinin
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 16763
HGNC: HGNC:6472
Homologene: 4059
Ighv9-2
Name: immunoglobulin heavy variable V9-2
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 629818
Rnf223
Name: ring finger 223
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 100045778
Homologene: 27073
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to C, chromosome 1 at 39,402,728 bp
  • T to A, chromosome 1 at 46,835,752 bp
  • A to C, chromosome 1 at 84,745,063 bp
  • A to G, chromosome 1 at 135,829,716 bp
  • T to G, chromosome 2 at 160,753,665 bp
  • T to A, chromosome 3 at 60,086,369 bp
  • T to A, chromosome 3 at 97,715,223 bp
  • A to G, chromosome 3 at 136,093,362 bp
  • T to C, chromosome 3 at 144,913,272 bp
  • T to C, chromosome 3 at 146,002,415 bp
  • A to C, chromosome 4 at 108,848,246 bp
  • G to T, chromosome 4 at 108,848,247 bp
  • T to C, chromosome 4 at 116,435,535 bp
  • T to A, chromosome 4 at 126,911,004 bp
  • A to G, chromosome 4 at 136,934,566 bp
  • A to G, chromosome 4 at 149,644,051 bp
  • T to C, chromosome 4 at 156,132,783 bp
  • A to G, chromosome 5 at 76,543,993 bp
  • T to C, chromosome 5 at 129,901,663 bp
  • G to A, chromosome 5 at 130,384,428 bp
  • G to C, chromosome 6 at 24,118,066 bp
  • C to T, chromosome 6 at 85,069,350 bp
  • G to C, chromosome 7 at 42,903,531 bp
  • A to G, chromosome 7 at 135,145,418 bp
  • C to T, chromosome 8 at 22,773,639 bp
  • A to G, chromosome 8 at 43,521,101 bp
  • T to C, chromosome 8 at 43,569,529 bp
  • A to G, chromosome 8 at 105,844,535 bp
  • T to A, chromosome 9 at 38,108,807 bp
  • C to A, chromosome 9 at 39,820,110 bp
  • A to G, chromosome 9 at 45,779,688 bp
  • T to C, chromosome 10 at 5,359,078 bp
  • A to G, chromosome 10 at 117,782,000 bp
  • T to C, chromosome 11 at 73,375,097 bp
  • A to G, chromosome 11 at 82,445,290 bp
  • G to A, chromosome 11 at 86,222,217 bp
  • A to G, chromosome 11 at 94,444,030 bp
  • A to G, chromosome 12 at 81,560,604 bp
  • T to C, chromosome 12 at 114,109,291 bp
  • A to T, chromosome 13 at 67,474,160 bp
  • T to C, chromosome 15 at 81,768,988 bp
  • A to G, chromosome 16 at 36,041,822 bp
  • T to C, chromosome 16 at 45,620,139 bp
  • A to T, chromosome 17 at 20,889,974 bp
  • T to C, chromosome 17 at 49,071,184 bp
  • T to C, chromosome 17 at 56,631,564 bp
  • A to C, chromosome 18 at 12,295,922 bp
  • C to T, chromosome X at 73,767,645 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7918 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045966-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.