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Strain Name:
C57BL/6J-MtgxR7922Btlr/Mmmh
Stock Number:
045969-MU
Citation ID:
RRID:MMRRC_045969-MU
Other Names:
R7922 (G1)
Major Collection:

Strain Information

Ppp5c
Name: protein phosphatase 5, catalytic subunit
Synonyms: ANP receptor, PP5
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 19060
HGNC: HGNC:9322
Homologene: 4550
Utrn
Name: utrophin
Synonyms: G-utrophin, Dmdl, DRP
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 22288
VEGA: 10
Homologene: 21398
Frem2
Name: Fras1 related extracellular matrix protein 2
Synonyms: 8430406N05Rik, 6030440P17Rik, my, ne, b2b1562Clo
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 242022
Homologene: 18454
Adk
Name: adenosine kinase
Synonyms: AK, 5033405D03Rik, 2310026J05Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 11534
VEGA: 14
HGNC: HGNC:257
Homologene: 4891
Zfp553
Name: zinc finger protein 553
Synonyms: C330013F15Rik, 2600009K23Rik, ENSMUSG00000054461
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233887
Homologene: 27098
Pik3c2a
Name: phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha
Synonyms: PI3KC2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 18704
HGNC: HGNC:8971
Homologene: 20581
Fzd6
Name: frizzled class receptor 6
Synonyms: Fz6, rst
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 14368
VEGA: 15
HGNC: HGNC:4044
Homologene: 2617
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 74,741,257 bp
  • A to C, chromosome 1 at 93,301,553 bp
  • G to A, chromosome 1 at 107,272,014 bp
  • A to T, chromosome 1 at 156,524,992 bp
  • T to C, chromosome 1 at 185,249,920 bp
  • A to T, chromosome 2 at 11,674,366 bp
  • A to G, chromosome 2 at 30,176,811 bp
  • T to C, chromosome 3 at 53,653,304 bp
  • A to G, chromosome 3 at 94,391,188 bp
  • A to T, chromosome 3 at 108,044,671 bp
  • T to A, chromosome 4 at 41,190,812 bp
  • T to A, chromosome 4 at 88,780,340 bp
  • A to T, chromosome 5 at 30,588,531 bp
  • A to T, chromosome 5 at 71,007,972 bp
  • A to G, chromosome 5 at 72,604,882 bp
  • A to T, chromosome 5 at 113,774,282 bp
  • G to A, chromosome 5 at 113,774,349 bp
  • G to T, chromosome 5 at 115,614,468 bp
  • T to A, chromosome 5 at 131,440,373 bp
  • A to T, chromosome 5 at 135,231,679 bp
  • T to A, chromosome 6 at 30,390,875 bp
  • T to C, chromosome 6 at 52,224,309 bp
  • A to C, chromosome 6 at 85,447,968 bp
  • A to C, chromosome 6 at 90,403,980 bp
  • T to A, chromosome 6 at 148,926,146 bp
  • T to A, chromosome 7 at 16,425,722 bp
  • T to C, chromosome 7 at 17,027,800 bp
  • T to C, chromosome 7 at 20,167,711 bp
  • A to G, chromosome 7 at 21,133,662 bp
  • T to A, chromosome 7 at 25,615,743 bp
  • A to T, chromosome 7 at 29,097,224 bp
  • A to T, chromosome 7 at 101,404,414 bp
  • A to T, chromosome 7 at 105,668,514 bp
  • A to G, chromosome 7 at 107,571,149 bp
  • A to G, chromosome 7 at 116,391,282 bp
  • A to G, chromosome 7 at 127,236,596 bp
  • T to A, chromosome 7 at 141,993,220 bp
  • T to C, chromosome 8 at 83,661,228 bp
  • T to C, chromosome 9 at 18,584,825 bp
  • T to G, chromosome 9 at 44,842,860 bp
  • G to A, chromosome 9 at 114,513,085 bp
  • C to A, chromosome 9 at 119,074,652 bp
  • C to A, chromosome 10 at 12,667,527 bp
  • T to A, chromosome 10 at 60,382,706 bp
  • T to C, chromosome 10 at 90,999,753 bp
  • G to A, chromosome 11 at 8,849,013 bp
  • A to G, chromosome 11 at 8,909,857 bp
  • T to A, chromosome 11 at 34,707,327 bp
  • A to T, chromosome 11 at 68,533,875 bp
  • T to A, chromosome 11 at 68,808,893 bp
  • A to G, chromosome 11 at 80,265,803 bp
  • T to A, chromosome 11 at 86,244,627 bp
  • A to T, chromosome 11 at 86,271,005 bp
  • A to T, chromosome 11 at 95,471,328 bp
  • A to T, chromosome 11 at 95,832,793 bp
  • T to C, chromosome 11 at 98,327,628 bp
  • C to T, chromosome 11 at 115,820,782 bp
  • T to A, chromosome 12 at 51,790,195 bp
  • T to C, chromosome 12 at 64,967,738 bp
  • C to T, chromosome 12 at 71,164,406 bp
  • CA to C, chromosome 12 at 110,932,642 bp
  • G to A, chromosome 14 at 21,318,043 bp
  • A to G, chromosome 14 at 50,346,415 bp
  • G to A, chromosome 15 at 3,341,074 bp
  • A to T, chromosome 15 at 39,031,108 bp
  • C to T, chromosome 15 at 73,126,526 bp
  • A to G, chromosome 15 at 80,158,865 bp
  • C to A, chromosome 15 at 86,131,958 bp
  • C to T, chromosome 16 at 17,573,366 bp
  • GCAC to GC, chromosome 16 at 35,658,256 bp
  • A to G, chromosome 17 at 20,954,617 bp
  • A to T, chromosome 17 at 30,274,884 bp
  • A to T, chromosome 17 at 33,381,537 bp
  • G to C, chromosome 17 at 34,714,603 bp
  • G to T, chromosome 17 at 35,024,433 bp
  • A to T, chromosome 17 at 56,019,438 bp
  • G to A, chromosome 17 at 57,524,683 bp
  • T to A, chromosome 17 at 78,760,559 bp
  • A to T, chromosome 18 at 37,716,173 bp
  • T to C, chromosome 18 at 37,763,949 bp
  • A to G, chromosome 18 at 68,949,996 bp
  • T to A, chromosome 19 at 30,239,238 bp
  • A to T, chromosome 19 at 60,775,842 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
Gene Specific Genotyping:

To request gene-specific and other genotyping services for a strain, please contact the distribution MMRRC Center for more information.

Background Genetic Quality:

The MMRRC has developed a Genetic Quality Control pipeline using the MiniMUGA array to provide additional information to identify and validate genetic backgrounds of MMRRC strains. For more information on whether genetic background data is available, please contact MMRRC_GeneticQC@med.unc.edu. Note: that MiniMUGA genetic background data is not available on all strains, but can be ordered if desired.

Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7922 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045969-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.