Strain Name:
C57BL/6J-MtgxR7927Btlr/Mmmh
Stock Number:
045974-MU
Citation ID:
RRID:MMRRC_045974-MU
Other Names:
R7927 (G1)
Major Collection:

Strain Information

Cntnap2
Name: contactin associated protein-like 2
Synonyms: 5430425M22Rik, Caspr2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 66797
Homologene: 69159
Slc35a1
Name: solute carrier family 35 (CMP-sialic acid transporter), member 1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 24060
Homologene: 38181
Pkp4
Name: plakophilin 4
Synonyms: Armrp, 5031422I09Rik, 9430019K17Rik, p0071
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 227937
HGNC: HGNC:9026
Homologene: 2689
Gch1
Name: GTP cyclohydrolase 1
Synonyms: GTPCH, GTP-CH
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 14528
VEGA: 14
HGNC: HGNC:4193
Homologene: 132
Strn4
Name: striatin, calmodulin binding protein 4
Synonyms: ZIN, zinedin
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 97387
Homologene: 8378
Usp5
Name: ubiquitin specific peptidase 5 (isopeptidase T)
Synonyms: Ucht
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 22225
Homologene: 55758
Zmym4
Name: zinc finger, MYM-type 4
Synonyms: 6330503C17Rik, Zfp262
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 67785
Homologene: 35470
Agrn
Name: agrin
Synonyms: nmf380, NMF380, Agrin
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 11603
HGNC: HGNC:329
Homologene: 27907
Tdp1
Name: tyrosyl-DNA phosphodiesterase 1
Synonyms: SCAN1, Gm40556, 2810481F14Rik, 4921509N21Rik, E430034L06Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 104884
Homologene: 5424
Ndufa5
Name: NADH:ubiquinone oxidoreductase subunit A5
Synonyms: 2900002J19Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 68202
HGNC: HGNC:7688
Homologene: 3664
Rsf1
Name: remodeling and spacing factor 1
Synonyms: Hbxap, p325, XAP8, C030033M12Rik, 4832420A03Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233532
Homologene: 41142
Fnta
Name: farnesyltransferase, CAAX box, alpha
Synonyms: FTA
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 14272
HGNC: HGNC:3782
Homologene: 1534
Scaf8
Name: SR-related CTD-associated factor 8
Synonyms: A930036P18Rik, A630086M08Rik, Rbm16
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 106583
VEGA: 17
Homologene: 8928
Lrp6
Name: low density lipoprotein receptor-related protein 6
Synonyms: skam26Jus, ska26, skax26, Cd
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 16974
HGNC: HGNC:6698
Homologene: 1747
Rnf34
Name: ring finger protein 34
Synonyms: phafin 1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 80751
Homologene: 11839
Cftr
Name: cystic fibrosis transmembrane conductance regulator
Synonyms: Abcc7
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 12638
HGNC: HGNC:1884
Homologene: 55465
Slf2
Name: SMC5-SMC6 complex localization factor 2
Synonyms: Fam178a, 6030443O07Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 226151
VEGA: 19
Homologene: 23077
Lig4
Name: ligase IV, DNA, ATP-dependent
Synonyms: DNA ligase IV, tiny, 5830471N16Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 319583
HGNC: HGNC:6601
Homologene: 1736
Phf24
Name: PHD finger protein 24
Synonyms: N28178, GINIP
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230085
Homologene: 18208
Dpy19l2
Name: dpy-19 like 2
Synonyms: 4932443J21Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 320752
VEGA: 9
Homologene: 77569
Hsd17b14
Name: hydroxysteroid (17-beta) dehydrogenase 14
Synonyms: 0610039E24Rik, Dhrs10, retSDR3
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 66065
Homologene: 133800
Myo19
Name: myosin XIX
Synonyms: 1110055A02Rik, Myohd1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 66196
Homologene: 49819
Zfp574
Name: zinc finger protein 574
Synonyms: A630056B21Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 232976
Homologene: 11238
Scn4a
Name: sodium channel, voltage-gated, type IV, alpha
Synonyms: Nav1.4, SkM1, mH2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 110880
Homologene: 283
Hydin
Name: HYDIN, axonemal central pair apparatus protein
Synonyms: 4930545D19Rik, hyrh, hy-3, hy3, 1700034M11Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 244653
Homologene: 52118
Fbn1
Name: fibrillin 1
Synonyms: Fib-1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 14118
HGNC: HGNC:3603
Homologene: 30958
Hmcn1
Name: hemicentin 1
Synonyms: LOC240793, EG545370
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 545370
Homologene: 23741
Muc4
Name: mucin 4
Synonyms: 4933405I11Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 140474
HGNC: HGNC:7514
Homologene: 124469
Dnah3
Name: dynein, axonemal, heavy chain 3
Synonyms: Dnahc3
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 381917
HGNC: HGNC:2949
Homologene: 19674
Hrc
Name: histidine rich calcium binding protein
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 15464
HGNC: HGNC:5178
Homologene: 137234
B4galt3
Name: UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 3
Synonyms: ESTM26, beta4GalT-III, R74981, 9530061M23Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 57370
HGNC: HGNC:926
Homologene: 48241
Pramel25
Name: PRAME like 25
Synonyms: MGC:91194, Gm13023
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 194227
Homologene: 103830
BC034090
Name: cDNA sequence BC034090
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 207792
Homologene: 19490
Or10a2
Name: olfactory receptor family 10 subfamily A member 2
Synonyms: Olfr714, MOR263-2, GA_x6K02T2PBJ9-9453401-9454354, P4
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 259035
Homologene: 72055
Grm5
Name: glutamate receptor, metabotropic 5
Synonyms: Glu5R, mGluR5, Gprc1e, 6430542K11Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 108071
HGNC: HGNC:4597
Homologene: 37354
Arhgef4
Name: Rho guanine nucleotide exchange factor 4
Synonyms: 9330140K16Rik, C230030N03Rik, Asef
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226970
HGNC: HGNC:684
Homologene: 49414
Tecrl
Name: trans-2,3-enoyl-CoA reductase-like
Synonyms: Srd5a2l2, D330017N19Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 243078
Homologene: 27549
Trim50
Name: tripartite motif-containing 50
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 215061
Homologene: 14548
Sh3rf2
Name: SH3 domain containing ring finger 2
Synonyms: 9130023G24Rik, RNF158
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 269016
Homologene: 17618
Adprhl1
Name: ADP-ribosylhydrolase like 1
Synonyms: D330008N11Rik, Arh2
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234072
Homologene: 16311
Cstpp1
Name: centriolar satellite-associated tubulin polyglutamylase complex regulator 1
Synonyms: 1110051M20Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228356
Homologene: 11471
Grik2
Name: glutamate receptor, ionotropic, kainate 2 (beta 2)
Synonyms: Glurbeta2, Glur-6, C130030K03Rik, Glur6
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 14806
HGNC: HGNC:4580
Homologene: 40717
Fbln5
Name: fibulin 5
Synonyms: EVEC
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 23876
VEGA: 12
HGNC: HGNC:3602
Homologene: 38170
Vmn2r45
Name: vomeronasal 2, receptor 45
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 100042810
Homologene: 113703
Ssx2ip
Name: SSX family member 2 interacting protein
Synonyms: Adip
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 99167
Homologene: 8522
4921539E11Rik
Name: RIKEN cDNA 4921539E11 gene
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 70941
Homologene: 52843
Serpina1e
Name: serine (or cysteine) peptidase inhibitor, clade A, member 1E
Synonyms: Spi1-5, PI5
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 20704
HGNC: HGNC:8941
Homologene: 20103
Kti12
Name: KTI12 homolog, chromatin associated
Synonyms: 1110001A12Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 100087
Homologene: 6347
Rftn1
Name: raftlin lipid raft linker 1
Synonyms: 2310015N21Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 76438
Homologene: 18745
Amz2
Name: archaelysin family metallopeptidase 2
Synonyms: ESTM12
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 13929
Spsb2
Name: splA/ryanodine receptor domain and SOCS box containing 2
Synonyms: SSB2, Grcc9
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 14794
Homologene: 8404
Rbm12b2
Name: RNA binding motif protein 12 B2
Synonyms: C430048L16Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 77604
Homologene: 28658
Tcp10b
Name: t-complex protein 10b
Synonyms: Tcp-10bt, D17Leh66ba, Tcp-10b, D17Leh66B, T66B-a
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 21462
Homologene: 83254
Spmip8
Name: sperm microtubule inner protein 8
Synonyms: 1700055M20Rik, Tepp
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 73407
Homologene: 28311
Banf2
Name: BANF family member 2
Synonyms: 4930517K23Rik, LOC228710, barrier to autointegration factor 2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 403171
Homologene: 18671
G530012D18Rik
Name: RIKEN cDNA G530012D1 gene
Type: Gene
Species: Mouse
Chromosome: 1
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to T, chromosome 1 at 34,807,253 bp
  • C to G, chromosome 1 at 85,577,214 bp
  • T to A, chromosome 1 at 150,609,775 bp
  • A to T, chromosome 1 at 155,241,625 bp
  • T to A, chromosome 1 at 171,271,772 bp
  • A to T, chromosome 2 at 59,311,754 bp
  • T to A, chromosome 2 at 91,421,905 bp
  • T to C, chromosome 2 at 125,383,736 bp
  • T to A, chromosome 2 at 144,073,798 bp
  • T to G, chromosome 3 at 146,432,610 bp
  • C to T, chromosome 4 at 12,095,417 bp
  • A to G, chromosome 4 at 34,669,021 bp
  • A to C, chromosome 4 at 42,934,774 bp
  • A to G, chromosome 4 at 103,266,342 bp
  • A to C, chromosome 4 at 108,848,246 bp
  • G to T, chromosome 4 at 108,848,247 bp
  • A to G, chromosome 4 at 126,905,377 bp
  • T to A, chromosome 4 at 143,792,966 bp
  • C to T, chromosome 4 at 156,172,809 bp
  • T to C, chromosome 5 at 83,354,819 bp
  • T to A, chromosome 5 at 122,850,225 bp
  • T to C, chromosome 5 at 135,353,611 bp
  • A to G, chromosome 6 at 18,267,971 bp
  • A to G, chromosome 6 at 24,527,292 bp
  • G to T, chromosome 6 at 47,095,687 bp
  • T to C, chromosome 6 at 124,809,373 bp
  • G to T, chromosome 6 at 124,824,229 bp
  • G to T, chromosome 6 at 134,520,550 bp
  • C to A, chromosome 7 at 8,483,514 bp
  • T to A, chromosome 7 at 16,826,631 bp
  • T to A, chromosome 7 at 25,080,147 bp
  • T to A, chromosome 7 at 45,336,053 bp
  • T to C, chromosome 7 at 45,565,971 bp
  • T to A, chromosome 7 at 88,036,174 bp
  • GGCGGCGGC to GGCGGCGGCAGCGGCGGC, chromosome 7 at 97,579,924 bp
  • T to C, chromosome 7 at 107,074,289 bp
  • A to G, chromosome 7 at 119,951,271 bp
  • A to T, chromosome 8 at 9,973,629 bp
  • C to T, chromosome 8 at 13,248,682 bp
  • G to A, chromosome 8 at 26,004,426 bp
  • T to A, chromosome 8 at 95,313,158 bp
  • T to C, chromosome 8 at 110,580,844 bp
  • A to G, chromosome 9 at 24,695,901 bp
  • A to T, chromosome 10 at 49,240,794 bp
  • A to G, chromosome 11 at 84,900,220 bp
  • T to A, chromosome 11 at 106,342,383 bp
  • A to G, chromosome 11 at 109,429,058 bp
  • G to T, chromosome 12 at 99,912,296 bp
  • T to C, chromosome 12 at 101,818,388 bp
  • A to G, chromosome 12 at 103,951,191 bp
  • G to A, chromosome 14 at 47,155,923 bp
  • A to G, chromosome 16 at 32,771,637 bp
  • T to A, chromosome 17 at 3,159,220 bp
  • A to G, chromosome 17 at 13,069,692 bp
  • G to T, chromosome 17 at 50,047,380 bp
  • A to G, chromosome 18 at 42,111,422 bp
  • A to G, chromosome 19 at 44,935,301 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7927 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045974-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.