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Strain Name:
C57BL/6J-MtgxR7937Btlr/Mmmh
Stock Number:
045983-MU
Citation ID:
RRID:MMRRC_045983-MU
Other Names:
R7937 (G1)
Major Collection:

Strain Information

Camkk2
Name: calcium/calmodulin-dependent protein kinase kinase 2, beta
Synonyms: 6330570N16Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 207565
HGNC: HGNC:1470
Homologene: 32756
Spns1
Name: SPNS lysolipid transporter 1, lysophospholipid
Synonyms: 2210013K02Rik, spinster homolog
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 73658
Homologene: 41530
Bri3bp
Name: Bri3 binding protein
Synonyms: 2410150I18Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 76809
Homologene: 50955
Rictor
Name: RPTOR independent companion of MTOR, complex 2
Synonyms: 6030405M08Rik, D530039E11Rik, 4921505C17Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 78757
VEGA: 15
Homologene: 34317
Fgd4
Name: FYVE, RhoGEF and PH domain containing 4
Synonyms: Frabin-gamma, Frabin-beta, Frabin-alpha, Frabin, 9330209B17Rik, ZFYVE6
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 224014
Homologene: 26727
Dnajc11
Name: DnaJ heat shock protein family (Hsp40) member C11
Synonyms: E030019A03Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230935
Homologene: 14558
Snx4
Name: sorting nexin 4
Synonyms: 1810036H14Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 69150
VEGA: 16
Homologene: 36143
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 17,159,953 bp
  • A to G, chromosome 1 at 45,819,639 bp
  • G to T, chromosome 1 at 84,116,024 bp
  • T to C, chromosome 1 at 95,653,595 bp
  • A to G, chromosome 1 at 144,140,862 bp
  • G to A, chromosome 1 at 171,279,972 bp
  • A to G, chromosome 2 at 18,206,084 bp
  • GTTGATCCATACA to G, chromosome 2 at 69,323,873 bp
  • T to C, chromosome 2 at 111,944,530 bp
  • A to G, chromosome 3 at 79,609,816 bp
  • C to T, chromosome 3 at 89,070,317 bp
  • A to G, chromosome 4 at 15,958,080 bp
  • A to C, chromosome 4 at 76,095,535 bp
  • A to G, chromosome 4 at 107,627,526 bp
  • G to T, chromosome 4 at 133,582,997 bp
  • A to G, chromosome 4 at 137,550,932 bp
  • A to G, chromosome 4 at 151,950,452 bp
  • C to T, chromosome 5 at 6,771,866 bp
  • A to T, chromosome 5 at 86,309,490 bp
  • G to T, chromosome 5 at 108,419,773 bp
  • G to T, chromosome 5 at 122,764,034 bp
  • A to T, chromosome 5 at 125,454,331 bp
  • A to G, chromosome 6 at 121,861,169 bp
  • A to G, chromosome 6 at 129,331,011 bp
  • T to C, chromosome 7 at 6,393,786 bp
  • T to C, chromosome 7 at 26,464,146 bp
  • A to G, chromosome 7 at 126,374,054 bp
  • A to G, chromosome 7 at 128,010,319 bp
  • A to G, chromosome 7 at 130,219,093 bp
  • G to A, chromosome 9 at 9,748,445 bp
  • T to A, chromosome 9 at 38,269,048 bp
  • G to T, chromosome 9 at 44,264,789 bp
  • T to A, chromosome 9 at 69,410,785 bp
  • T to A, chromosome 9 at 88,569,270 bp
  • G to A, chromosome 9 at 99,536,219 bp
  • T to A, chromosome 10 at 5,833,078 bp
  • C to A, chromosome 10 at 53,633,706 bp
  • A to G, chromosome 10 at 106,863,372 bp
  • A to G, chromosome 11 at 67,855,789 bp
  • A to T, chromosome 11 at 69,517,685 bp
  • T to C, chromosome 12 at 16,716,669 bp
  • T to A, chromosome 12 at 81,377,905 bp
  • A to G, chromosome 13 at 23,812,665 bp
  • A to G, chromosome 13 at 43,077,729 bp
  • A to G, chromosome 14 at 52,227,506 bp
  • C to T, chromosome 15 at 6,772,154 bp
  • A to G, chromosome 15 at 18,964,249 bp
  • A to G, chromosome 15 at 26,409,237 bp
  • A to T, chromosome 15 at 89,782,617 bp
  • C to A, chromosome 15 at 95,972,589 bp
  • A to G, chromosome 16 at 16,469,773 bp
  • T to C, chromosome 16 at 33,291,829 bp
  • C to T, chromosome 16 at 49,155,646 bp
  • C to T, chromosome 17 at 3,197,207 bp
  • A to T, chromosome 17 at 43,037,925 bp
  • T to C, chromosome 19 at 8,623,889 bp
  • C to G, chromosome 19 at 38,795,003 bp
  • T to A, chromosome 19 at 39,993,758 bp
  • T to C, chromosome 19 at 40,777,292 bp
  • T to C, chromosome 19 at 46,134,729 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7937 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045983-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.