Strain Name:
C57BL/6J-MtgxR7957Btlr/Mmmh
Stock Number:
046001-MU
Citation ID:
RRID:MMRRC_046001-MU
Other Names:
R7957 (G1)
Major Collection:

Strain Information

Park7
Name: Parkinson disease (autosomal recessive, early onset) 7
Synonyms: DJ-1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 57320
Homologene: 38295
Hpcal1
Name: hippocalcin-like 1
Synonyms: visinin like 3, VILIP3, neural visinin-like 3, Vnsl3, Nvp3
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 53602
VEGA: 12
HGNC: HGNC:5145
Homologene: 37586
Kansl2
Name: KAT8 regulatory NSL complex subunit 2
Synonyms: 2310037I24Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 69612
VEGA: 15
Homologene: 32367
Rapgef2
Name: Rap guanine nucleotide exchange factor (GEF) 2
Synonyms: nRapGEP, CNRasGEF, 5830453M24Rik, RA-GEF-1, Pdzgef1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 76089
Homologene: 35477
Chd9
Name: chromodomain helicase DNA binding protein 9
Synonyms: 1810014J18Rik, 9030205D12Rik, AD013, A330063D19Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 109151
Homologene: 11844
Rsf1
Name: remodeling and spacing factor 1
Synonyms: 4832420A03Rik, XAP8, Hbxap, C030033M12Rik, p325
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233532
Homologene: 41142
Myo9b
Name: myosin IXb
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 17925
HGNC: HGNC:7609
Homologene: 3058
Cebpa
Name: CCAAT/enhancer binding protein alpha
Synonyms: C/ebpalpha, Cebp, C/EBP alpha
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 12606
HGNC: HGNC:1833
Homologene: 3211
Ints13
Name: integrator complex subunit 13
Synonyms: Spata30, Asun, 4933424B01Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 71177
Homologene: 10043
Mmp14
Name: matrix metallopeptidase 14 (membrane-inserted)
Synonyms: MT1-MMP, sabe, Membrane type 1-MMP
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 17387
HGNC: HGNC:7160
Homologene: 21040
Ccn3
Name: cellular communication network factor 3
Synonyms: C130088N23Rik, Nov, CCN3
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 18133
HGNC: HGNC:7885
Homologene: 1884
Ilf2
Name: interleukin enhancer binding factor 2
Synonyms: Tex267, 6230405A16Rik, Tex261, TEG-267
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 67781
HGNC: HGNC:6037
Homologene: 26894
Fam193a
Name: family with sequence homology 193, member A
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231128
Homologene: 2746
Adamts12
Name: ADAM metallopeptidase with thrombospondin type 1 motif 12
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 239337
VEGA: 15
Homologene: 12808
Muc16
Name: mucin 16
Synonyms: 1110008I14Rik, LOC385009, Gm21044
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 73732
Homologene: 141193
Socs2
Name: suppressor of cytokine signaling 2
Synonyms: cytokine-inducible SH2 protein 2, SSI-2, JAB, STAT-induced STAT inhibitor 2, SOCS-2, D130043N08Rik, Cish2, CIS2
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 216233
Homologene: 2880
Alg8
Name: ALG8 alpha-1,3-glucosyltransferase
Synonyms: LOC381903
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 381903
Homologene: 6931
Cnot3
Name: CCR4-NOT transcription complex, subunit 3
Synonyms: A930039N10Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 232791
HGNC: HGNC:7879
Homologene: 133900
Zfp473
Name: zinc finger protein 473
Synonyms: D030014N22Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 243963
Homologene: 18698
Klhl6
Name: kelch-like 6
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 239743
Homologene: 15603
Ttn
Name: titin
Synonyms: connectin, 1100001C23Rik, D330041I19Rik, D830007G01Rik, 2310074I15Rik, 2310036G12Rik, mdm, 2310057K23Rik, shru, L56
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 22138
Homologene: 130650
Col5a3
Name: collagen, type V, alpha 3
Synonyms: Pro-alpha3(V)
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 53867
Homologene: 9253
Pik3r4
Name: phosphoinositide-3-kinase regulatory subunit 4
Synonyms: Vps15, p150
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 75669
HGNC: HGNC:8982
Homologene: 24678
Ugt2a3
Name: UDP glucuronosyltransferase 2 family, polypeptide A3
Synonyms: 2010321J07Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 72094
Homologene: 55988
Vmn2r88
Name: vomeronasal 2, receptor 88
Synonyms: V2r13, V2r3
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 669149
Homologene: 129606
Morc2b
Name: microrchidia 2B
Synonyms: 4932411A10Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 240069
Homologene: 18615
Abca8a
Name: ATP-binding cassette, sub-family A member 8a
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217258
HGNC: HGNC:38
Homologene: 131160
Vmn2r93
Name: vomeronasal 2, receptor 93
Synonyms: EG627132
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 627132
Homologene: 129750
Rhbdf1
Name: rhomboid 5 homolog 1
Synonyms: Dist1, Egfr-rs, Dist
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 13650
Homologene: 32085
Or12k5
Name: olfactory receptor family 12 subfamily K member 5
Synonyms: GA_x6K02T2NLDC-33697309-33696317, MOR159-4, Olfr358
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 227789
Homologene: 74157
Ttyh2
Name: tweety family member 2
Synonyms: 1110001A03Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 117160
Homologene: 41882
Zfp93
Name: zinc finger protein 93
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 22755
Homologene: 117959
Pappa2
Name: pappalysin 2
Synonyms: placenta-specific 3, Pappe, pregnancy-associated plasma preproprotein-A2, pregnancy-associated plasma protein-E, PAPP-A2, PLAC3
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 23850
Homologene: 10661
Fam83b
Name: family with sequence similarity 83, member B
Synonyms: C530008M07Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 208994
Homologene: 19478
Ntn4
Name: netrin 4
Synonyms: beta-netrin
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 57764
Homologene: 10934
Col17a1
Name: collagen, type XVII, alpha 1
Synonyms: Bpag2, Bpag, BP180, BPAg2
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 12821
HGNC: HGNC:2194
Homologene: 7276
Abhd2
Name: abhydrolase domain containing 2
Synonyms: 2210009N18Rik, LABH2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 54608
Homologene: 23121
Pank1
Name: pantothenate kinase 1
Synonyms: Pank1a, 5430426F23Rik, Pank1b, Pank1, 4632412I06Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 75735
VEGA: 19
HGNC: HGNC:8598
Homologene: 56979
Or8g17
Name: olfactory receptor family 8 subfamily G member 17
Synonyms: GA_x6K02T2PVTD-32715386-32714466, MOR171-10, Olfr146, M15
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258742
VEGA: 9
Slfn5
Name: schlafen 5
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 327978
Homologene: 18839
Scd4
Name: stearoyl-coenzyme A desaturase 4
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 329065
Homologene: 77322
Tlr12
Name: toll-like receptor 12
Synonyms: LOC384059, Tlr11
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 384059
Homologene: 135964
Gabrr2
Name: gamma-aminobutyric acid type A receptor subunit rho 2
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 14409
HGNC: HGNC:4091
Homologene: 20471
Thumpd2
Name: THUMP domain containing 2
Synonyms: 2810025A12Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 72167
VEGA: 17
Homologene: 11898
Nipa1
Name: non imprinted in Prader-Willi/Angelman syndrome 1 homolog (human)
Synonyms: A830014A18Rik, 1110027G09Rik, Spg6
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233280
Homologene: 42327
Or3a4
Name: olfactory receptor family 3 subfamily A member 4
Synonyms: MOR255-1, Olfr399, GA_x6K02T2P1NL-4211516-4210581
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 259006
Homologene: 27325
Gm15922
Name: predicted gene 15922
Type: Gene
Species: Mouse
Chromosome: 7
Crygs
Name: crystallin, gamma S
Synonyms: Opj
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 12970
VEGA: 16
HGNC: HGNC:2417
Homologene: 40695
Or4x13
Name: olfactory receptor family 4 subfamily X member 13
Synonyms: Olfr1274, Olfr1274-ps, MOR228-5, GA_x6K02T2Q125-51676372-51677301, MOR228-4
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258330
Homologene: 133650
Smim22
Name: small integral membrane protein 22
Synonyms: Gm5480
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 432995
Homologene: 133207
Or2t29
Name: olfactory receptor family 2 subfamily T member 29
Synonyms: GA_x6K02T2NKPP-882068-883006, Olfr329-ps, MOR275-6P, Olfr329
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 259148
Homologene: 133015
Gm3667
Name: predicted gene 3667
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 100042100
Homologene: 115686
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 158,761,561 bp
  • A to G, chromosome 2 at 37,004,960 bp
  • A to T, chromosome 2 at 76,764,855 bp
  • A to T, chromosome 2 at 90,401,051 bp
  • T to C, chromosome 3 at 79,214,969 bp
  • G to T, chromosome 3 at 90,487,470 bp
  • A to G, chromosome 4 at 33,081,410 bp
  • C to T, chromosome 4 at 128,616,690 bp
  • A to G, chromosome 4 at 150,903,884 bp
  • A to G, chromosome 5 at 34,462,086 bp
  • T to A, chromosome 5 at 87,327,191 bp
  • A to G, chromosome 6 at 146,550,766 bp
  • C to A, chromosome 7 at 3,658,222 bp
  • C to G, chromosome 7 at 3,737,320 bp
  • T to C, chromosome 7 at 24,275,574 bp
  • A to G, chromosome 7 at 35,120,442 bp
  • C to T, chromosome 7 at 44,732,492 bp
  • A to T, chromosome 7 at 55,979,799 bp
  • T to A, chromosome 7 at 79,325,446 bp
  • A to G, chromosome 7 at 97,390,924 bp
  • GGC to GGCCACGGCAGC, chromosome 7 at 97,579,906 bp
  • A to T, chromosome 8 at 71,354,761 bp
  • T to C, chromosome 8 at 91,051,698 bp
  • A to C, chromosome 9 at 18,643,471 bp
  • A to G, chromosome 9 at 20,774,051 bp
  • T to G, chromosome 9 at 39,019,053 bp
  • T to A, chromosome 9 at 76,491,985 bp
  • A to G, chromosome 9 at 105,687,209 bp
  • T to C, chromosome 10 at 93,644,473 bp
  • T to C, chromosome 10 at 95,414,950 bp
  • A to G, chromosome 11 at 32,210,523 bp
  • A to G, chromosome 11 at 58,542,798 bp
  • A to C, chromosome 11 at 74,054,156 bp
  • T to A, chromosome 11 at 82,956,787 bp
  • A to G, chromosome 11 at 110,091,613 bp
  • A to G, chromosome 11 at 114,708,864 bp
  • T to A, chromosome 12 at 17,791,170 bp
  • T to C, chromosome 14 at 6,872,332 bp
  • A to T, chromosome 14 at 51,413,132 bp
  • A to G, chromosome 14 at 54,436,250 bp
  • A to G, chromosome 15 at 11,317,212 bp
  • G to T, chromosome 15 at 54,746,338 bp
  • C to A, chromosome 15 at 98,524,618 bp
  • A to T, chromosome 16 at 5,008,225 bp
  • T to C, chromosome 16 at 19,949,451 bp
  • C to T, chromosome 16 at 22,805,332 bp
  • A to T, chromosome 17 at 18,325,692 bp
  • A to T, chromosome 17 at 33,135,773 bp
  • T to C, chromosome 17 at 81,026,728 bp
  • T to A, chromosome 19 at 34,813,696 bp
  • G to T, chromosome 19 at 44,341,248 bp
  • T to C, chromosome 19 at 47,661,117 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7957 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
046001-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.