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Strain Name:
C57BL/6J-MtgxR7980Btlr/Mmmh
Stock Number:
046021-MU
Citation ID:
RRID:MMRRC_046021-MU
Other Names:
R7980 (G1)
Major Collection:

Strain Information

Tyrp1
Name: tyrosinase-related protein 1
Synonyms: Tyrp, isa, TRP-1, TRP1, Oca3
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 22178
Homologene: 464
Cdc25a
Name: cell division cycle 25A
Synonyms: D9Ertd393e
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 12530
HGNC: HGNC:1725
Homologene: 1355
Sez6
Name: seizure related gene 6
Synonyms: sez-6, D11Bhm177e
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 20370
Homologene: 10948
Map2k6
Name: mitogen-activated protein kinase kinase 6
Synonyms: MAP kinase kinase 6, MKK6, SAPKK3, Prkmk6
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 26399
HGNC: HGNC:6846
Homologene: 55686
Arhgef12
Name: Rho guanine nucleotide exchange factor 12
Synonyms: LARG, 2310014B11Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 69632
VEGA: 9
Homologene: 9088
Itsn1
Name: intersectin 1 (SH3 domain protein 1A)
Synonyms: Ese1, EHSH1, Sh3p17, Eh domain, SH3 domain regulator of endocytosis 1, Intersectin-L
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 16443
HGNC: HGNC:6183
Homologene: 2277
Zranb3
Name: zinc finger, RAN-binding domain containing 3
Synonyms: 4933425L19Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226409
Homologene: 32770
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 55,078,626 bp
  • A to C, chromosome 1 at 74,565,305 bp
  • T to C, chromosome 1 at 96,836,925 bp
  • A to G, chromosome 1 at 127,479,511 bp
  • T to C, chromosome 1 at 128,102,934 bp
  • G to T, chromosome 1 at 178,003,044 bp
  • C to T, chromosome 1 at 192,846,881 bp
  • A to G, chromosome 2 at 14,604,515 bp
  • G to A, chromosome 2 at 52,051,058 bp
  • A to G, chromosome 2 at 85,904,598 bp
  • T to A, chromosome 2 at 91,190,884 bp
  • T to A, chromosome 2 at 122,347,320 bp
  • G to A, chromosome 2 at 132,878,176 bp
  • A to C, chromosome 2 at 150,472,803 bp
  • C to T, chromosome 3 at 87,697,990 bp
  • G to C, chromosome 3 at 89,446,341 bp
  • T to A, chromosome 3 at 92,429,099 bp
  • A to T, chromosome 3 at 95,231,855 bp
  • T to C, chromosome 3 at 106,202,744 bp
  • A to G, chromosome 3 at 108,217,692 bp
  • A to T, chromosome 3 at 116,792,181 bp
  • C to T, chromosome 4 at 80,840,627 bp
  • A to G, chromosome 4 at 88,868,078 bp
  • A to T, chromosome 4 at 120,711,297 bp
  • G to T, chromosome 4 at 139,418,406 bp
  • A to T, chromosome 4 at 149,269,921 bp
  • T to A, chromosome 5 at 31,260,644 bp
  • A to G, chromosome 5 at 108,680,620 bp
  • A to G, chromosome 5 at 120,851,475 bp
  • T to A, chromosome 5 at 143,931,091 bp
  • T to C, chromosome 6 at 38,014,809 bp
  • T to A, chromosome 6 at 40,572,220 bp
  • T to C, chromosome 6 at 57,258,414 bp
  • A to T, chromosome 6 at 66,553,321 bp
  • T to C, chromosome 6 at 71,138,668 bp
  • A to T, chromosome 6 at 100,787,209 bp
  • A to T, chromosome 7 at 30,435,567 bp
  • T to A, chromosome 7 at 103,173,035 bp
  • T to A, chromosome 7 at 103,383,763 bp
  • T to A, chromosome 7 at 103,470,297 bp
  • C to T, chromosome 7 at 104,304,128 bp
  • C to A, chromosome 7 at 130,824,367 bp
  • T to A, chromosome 7 at 131,234,777 bp
  • T to A, chromosome 8 at 3,536,562 bp
  • A to G, chromosome 8 at 22,926,416 bp
  • A to G, chromosome 8 at 41,354,030 bp
  • C to T, chromosome 8 at 111,011,445 bp
  • T to C, chromosome 9 at 39,751,121 bp
  • A to T, chromosome 9 at 42,971,299 bp
  • T to C, chromosome 9 at 109,156,571 bp
  • T to A, chromosome 9 at 109,879,881 bp
  • G to T, chromosome 10 at 27,363,613 bp
  • T to A, chromosome 10 at 58,278,752 bp
  • C to T, chromosome 10 at 79,975,725 bp
  • C to T, chromosome 10 at 81,387,892 bp
  • T to C, chromosome 10 at 92,982,060 bp
  • A to G, chromosome 11 at 8,854,375 bp
  • A to G, chromosome 11 at 29,833,205 bp
  • A to G, chromosome 11 at 32,237,357 bp
  • A to T, chromosome 11 at 53,280,577 bp
  • A to G, chromosome 11 at 77,953,842 bp
  • A to G, chromosome 11 at 101,188,893 bp
  • T to A, chromosome 11 at 110,499,384 bp
  • T to C, chromosome 11 at 115,243,754 bp
  • A to T, chromosome 12 at 3,496,630 bp
  • T to C, chromosome 12 at 8,713,904 bp
  • A to T, chromosome 12 at 17,321,612 bp
  • A to G, chromosome 12 at 59,108,865 bp
  • A to T, chromosome 13 at 21,960,206 bp
  • A to G, chromosome 13 at 25,020,238 bp
  • A to G, chromosome 13 at 54,999,506 bp
  • A to G, chromosome 14 at 25,719,761 bp
  • T to A, chromosome 14 at 50,034,795 bp
  • T to C, chromosome 14 at 64,078,689 bp
  • G to A, chromosome 15 at 11,263,337 bp
  • A to G, chromosome 15 at 51,965,026 bp
  • G to A, chromosome 15 at 89,102,029 bp
  • G to A, chromosome 16 at 32,617,149 bp
  • A to T, chromosome 16 at 62,928,153 bp
  • T to A, chromosome 16 at 91,905,294 bp
  • A to G, chromosome 16 at 93,884,527 bp
  • A to T, chromosome 17 at 38,067,521 bp
  • A to G, chromosome 17 at 40,602,301 bp
  • A to T, chromosome 18 at 20,531,360 bp
  • T to A, chromosome 18 at 31,648,129 bp
  • A to T, chromosome 18 at 37,748,592 bp
  • G to A, chromosome 19 at 4,867,922 bp
  • C to T, chromosome 19 at 8,101,473 bp
  • T to C, chromosome 19 at 8,742,438 bp
  • C to T, chromosome 19 at 10,252,042 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7980 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
046021-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.