Strain Name:
C57BL/6J-MtgxR7984Btlr/Mmmh
Stock Number:
046025-MU
Citation ID:
RRID:MMRRC_046025-MU
Other Names:
R7984 (G1)
Major Collection:

Strain Information

Cdon
Name: cell adhesion molecule-related/down-regulated by oncogenes
Synonyms: CDO, CAM-related/down-regulated by oncogenes
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 57810
Homologene: 22996
Dlc1
Name: deleted in liver cancer 1
Synonyms: p122-RhoGAP, STARD12, Arhgap7, A730069N07Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 50768
HGNC: HGNC:2897
Homologene: 4442
Lrp5
Name: low density lipoprotein receptor-related protein 5
Synonyms: LR3, LRP7
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 16973
Homologene: 1746
Itga5
Name: integrin alpha 5 (fibronectin receptor alpha)
Synonyms: Fnra, Cd49e
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 16402
VEGA: 15
HGNC: HGNC:6141
Homologene: 20508
Paip1
Name: polyadenylate binding protein-interacting protein 1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 218693
Homologene: 4709
Pibf1
Name: progesterone immunomodulatory binding factor 1
Synonyms: 1700017E21Rik, 4933438D16Rik, 4933439E17Rik, 4930513H15Rik, D14Ertd581e
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 52023
VEGA: 14
Homologene: 4628
Apbb2
Name: amyloid beta precursor protein binding family B member 2
Synonyms: TR2L, Rirl1, 2310007D03Rik, Zfra, FE65L1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 11787
HGNC: HGNC:582
Homologene: 32079
Sulf1
Name: sulfatase 1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 240725
Homologene: 49408
Xpo6
Name: exportin 6
Synonyms: Ranbp20, C230091E20Rik, 2610005L19Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 74204
Homologene: 12544
Nek1
Name: NIMA (never in mitosis gene a)-related expressed kinase 1
Synonyms: kat, kidney, anemia and testis, D8Ertd790e
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 18004
HGNC: HGNC:7744
Homologene: 14376
Kdm3b
Name: KDM3B lysine (K)-specific demethylase 3B
Synonyms: 5830462I21Rik, JHDM2B, Jmjd1b
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 277250
VEGA: 18
HGNC: HGNC:1337
Homologene: 41145
Dnah7a
Name: dynein, axonemal, heavy chain 7A
Synonyms: LOC381341, Dnahc7, Dnahc7a
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 627872
Homologene: 41287
Slit2
Name: slit guidance ligand 2
Synonyms: Slil3, Drad-1, E130320P19Rik, E030015M03Rik, b2b1200.1Clo
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 20563
Homologene: 3516
Dock7
Name: dedicator of cytokinesis 7
Synonyms: 3110056M06Rik, LOC242555, m
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 67299
Homologene: 23566
Vps13b
Name: vacuolar protein sorting 13B
Synonyms: 1810042B05Rik, Coh1, C330002D13Rik, 2310042E16Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 666173
VEGA: 15
HGNC: HGNC:2183
Homologene: 49516
Wdr25
Name: WD repeat domain 25
Synonyms: B930090D16Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 212198
VEGA: 12
Homologene: 56993
Grik4
Name: glutamate receptor, ionotropic, kainate 4
Synonyms: KA1, 6330551K01Rik, GluRgamma1, KA-1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 110637
HGNC: HGNC:4582
Homologene: 81829
Gle1
Name: GLE1 RNA export mediator
Synonyms: 4933405K21Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 74412
HGNC: HGNC:4315
Homologene: 20379
Emc1
Name: ER membrane protein complex subunit 1
Synonyms: C230096C10Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230866
Homologene: 9002
Mctp2
Name: multiple C2 domains, transmembrane 2
Synonyms: LOC244049
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 244049
Homologene: 69254
Siglecf
Name: sialic acid binding Ig-like lectin F
Synonyms: mSiglec-F, Siglec5
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233186
Homologene: 50482
Tmem130
Name: transmembrane protein 130
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 243339
Homologene: 17680
Dnah1
Name: dynein, axonemal, heavy chain 1
Synonyms: MDHC7, E030034C22Rik, B230373P09Rik, Dnahc1, G1-415-19, ferf1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 110084
VEGA: 14
HGNC: HGNC:2940
Homologene: 67131
Ank1
Name: ankyrin 1, erythroid
Synonyms: Ank-1, pale
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 11733
HGNC: HGNC:492
Homologene: 55427
Ldlrad4
Name: low density lipoprotein receptor class A domain containing 4
Synonyms: D330030L18Rik, A430108L08Rik, 8230401C20Rik, D18Ertd653e
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 52662
VEGA: 18
HGNC: HGNC:1224
Homologene: 3202
Ttn
Name: titin
Synonyms: connectin, L56, mdm, 1100001C23Rik, D830007G01Rik, 2310036G12Rik, 2310074I15Rik, 2310057K23Rik, D330041I19Rik, shru
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 22138
Homologene: 130650
Unc13b
Name: unc-13 homolog B
Synonyms: Unc13h2, Munc13-2
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 22249
Homologene: 31376
Or9s23
Name: olfactory receptor family 9 subfamily S member 23
Synonyms: GA_x6K02T2R7CC-81180849-81179878, MOR208-1, Olfr1413
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 259039
Homologene: 128165
Slc7a1
Name: solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
Synonyms: Rev-1, Rec-1, Atrc-1, Atrc1, 4831426K01Rik, mCAT-1, Cat1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 11987
Homologene: 20658
Obscn
Name: obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF
Synonyms: LOC380698, OTTMUSG00000005786
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 380698
Homologene: 70869
Rnf112
Name: ring finger protein 112
Synonyms: bfp, Zfp179, neurolastin
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 22671
Homologene: 5176
Trmt1l
Name: tRNA methyltransferase 1 like
Synonyms: Trm1-like, 1190005F20Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 98685
Homologene: 12801
Or9m1b
Name: olfactory receptor family 9 subfamily M member 1B
Synonyms: GA_x6K02T2Q125-49498697-49497765, MOR173-1, Olfr1160
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258643
Homologene: 74192
Vmn2r18
Name: vomeronasal 2, receptor 18
Synonyms: EG632671
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 632671
Or52e4
Name: olfactory receptor family 52 subfamily E member 4
Synonyms: GA_x6K02T2PBJ9-7685262-7686200, MOR32-11, Olfr677
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258355
Homologene: 81596
Heg1
Name: heart development protein with EGF-like domains 1
Synonyms: LOC268884, 5530401I02Rik, 9530025L16Rik, 4632417D23Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 77446
Homologene: 35276
Slc24a1
Name: solute carrier family 24 (sodium/potassium/calcium exchanger), member 1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 214111
VEGA: 9
Homologene: 3472
Kcng1
Name: potassium voltage-gated channel, subfamily G, member 1
Synonyms: OTTMUSG00000016048
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241794
HGNC: HGNC:6248
Homologene: 20515
Lrrk1
Name: leucine-rich repeat kinase 1
Synonyms: D130026O16Rik, C230002E15Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233328
Homologene: 23464
Pcnx2
Name: pecanex homolog 2
Synonyms: E330039K12Rik, Pcnxl2
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 270109
HGNC: HGNC:8736
Homologene: 8987
Man2a2
Name: mannosidase 2, alpha 2
Synonyms: alpha mannosidase IIx, MX, 4931438M07Rik, 1700052O22Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 140481
HGNC: HGNC:6825
Homologene: 55954
Prickle2
Name: prickle planar cell polarity protein 2
Synonyms: 6720451F06Rik, 6230400G14Rik, mpk2, Pk2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 243548
Homologene: 17889
Aldh1a7
Name: aldehyde dehydrogenase family 1, subfamily A7
Synonyms: Aldh-pb, Ahd2-like
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 26358
HGNC: HGNC:402
Homologene: 137245
Cpne7
Name: copine VII
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 102278
HGNC: HGNC:2320
Homologene: 65128
Meioc
Name: meiosis specific with coiled-coil domain
Synonyms: LOC380729, LOC268491, Gm1564
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 268491
Homologene: 19559
Vmn1r233
Name: vomeronasal 1 receptor 233
Synonyms: V1rf5
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 171236
Homologene: 128343
Ikbke
Name: inhibitor of kappaB kinase epsilon
Synonyms: IKK-i, IKKepsilon
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 56489
Homologene: 23168
Or6c69
Name: olfactory receptor family 6 subfamily C member 69
Synonyms: GA_x6K02T2PULF-11590830-11589892, MOR113-1, Olfr816
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 258667
Homologene: 133584
Hcn1
Name: hyperpolarization activated cyclic nucleotide gated potassium channel 1
Synonyms: HAC2, Bcng1, C630013B14Rik, hyperpolarization-activated, cyclic nucleotide-gated K+ 1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 15165
HGNC: HGNC:4845
Homologene: 32093
Pira2
Name: paired-Ig-like receptor A2
Synonyms: 6M23
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 18725
Homologene: 134028
Angel1
Name: angel homolog 1
Synonyms: 1110030H02Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 68737
Homologene: 32251
P2ry12
Name: purinergic receptor P2Y, G-protein coupled 12
Synonyms: P2Y12, 4921504D23Rik, 2900079B22Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 70839
Homologene: 11260
Fpr-rs7
Name: formyl peptide receptor, related sequence 7
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 321021
HGNC: HGNC:3827
Mrps24
Name: mitochondrial ribosomal protein S24
Synonyms: Rpms24, 3110030K20Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 64660
Homologene: 57043
Akr1e1
Name: aldo-keto reductase family 1, member E1
Synonyms: 1810061I10Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 56043
Homologene: 74313
Slco5a1
Name: solute carrier organic anion transporter family, member 5A1
Synonyms: A630033C23Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 240726
Homologene: 57135
Or8b36
Name: olfactory receptor family 8 subfamily B member 36
Synonyms: GA_x6K02T2PVTD-31705144-31706073, MOR162-6, Olfr883
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258414
Homologene: 86689
Vmn2r33
Name: vomeronasal 2, receptor 33
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 624512
Homologene: 113703
Or2a57
Name: olfactory receptor family 2 subfamily A member 57
Synonyms: IB12, MOR261-9, GA_x6K02T2P3E9-4322325-4321360, Olfr47
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 18346
Homologene: 133700
Card9
Name: caspase recruitment domain family, member 9
Synonyms: LOC332579
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 332579
Homologene: 14150
Nt5dc2
Name: 5'-nucleotidase domain containing 2
Synonyms: 2510015F01Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 70021
VEGA: 14
Homologene: 11290
Prl2c1
Name: Prolactin family 2, subfamily c, member 1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 666317
Homologene: 40763
Pcdhga3
Name: protocadherin gamma subfamily A, 3
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93711
HGNC: HGNC:8701
Homologene: 75100
Fer1l5
Name: fer-1 like family member 5
Synonyms: 4930533C12Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 100534273
Homologene: 85232
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 12,859,273 bp
  • T to A, chromosome 1 at 12,881,384 bp
  • T to A, chromosome 1 at 36,408,621 bp
  • A to T, chromosome 1 at 53,504,218 bp
  • A to G, chromosome 1 at 92,573,422 bp
  • T to A, chromosome 1 at 131,275,786 bp
  • A to C, chromosome 1 at 151,435,738 bp
  • T to G, chromosome 2 at 26,356,772 bp
  • T to A, chromosome 2 at 29,938,576 bp
  • A to T, chromosome 2 at 76,723,750 bp
  • T to A, chromosome 2 at 88,006,625 bp
  • C to A, chromosome 2 at 168,262,486 bp
  • T to A, chromosome 3 at 59,217,601 bp
  • A to T, chromosome 4 at 43,173,973 bp
  • A to T, chromosome 4 at 98,989,066 bp
  • T to A, chromosome 4 at 139,375,449 bp
  • A to G, chromosome 5 at 48,176,123 bp
  • T to C, chromosome 5 at 66,307,692 bp
  • C to T, chromosome 5 at 144,755,427 bp
  • A to G, chromosome 5 at 148,342,110 bp
  • G to A, chromosome 5 at 151,562,061 bp
  • T to G, chromosome 6 at 43,235,796 bp
  • T to C, chromosome 6 at 92,410,874 bp
  • A to T, chromosome 7 at 3,841,697 bp
  • A to T, chromosome 7 at 7,563,863 bp
  • A to C, chromosome 7 at 43,355,231 bp
  • T to C, chromosome 7 at 66,300,729 bp
  • T to C, chromosome 7 at 72,103,189 bp
  • T to G, chromosome 7 at 80,353,308 bp
  • T to C, chromosome 7 at 105,056,432 bp
  • A to G, chromosome 7 at 126,120,444 bp
  • G to A, chromosome 8 at 23,088,966 bp
  • T to A, chromosome 8 at 36,938,318 bp
  • G to T, chromosome 8 at 61,121,053 bp
  • T to G, chromosome 8 at 123,119,722 bp
  • T to G, chromosome 8 at 125,759,126 bp
  • C to T, chromosome 9 at 35,503,302 bp
  • A to G, chromosome 9 at 38,025,859 bp
  • G to A, chromosome 9 at 42,671,261 bp
  • A to T, chromosome 9 at 64,949,529 bp
  • A to G, chromosome 10 at 129,912,072 bp
  • A to T, chromosome 11 at 5,707,495 bp
  • G to T, chromosome 11 at 59,106,325 bp
  • A to G, chromosome 11 at 61,449,480 bp
  • T to A, chromosome 11 at 102,674,606 bp
  • T to C, chromosome 12 at 86,720,294 bp
  • A to T, chromosome 12 at 109,011,057 bp
  • G to T, chromosome 13 at 4,595,680 bp
  • G to A, chromosome 13 at 27,855,327 bp
  • C to T, chromosome 13 at 117,976,073 bp
  • C to T, chromosome 13 at 119,430,162 bp
  • A to G, chromosome 14 at 31,138,818 bp
  • A to T, chromosome 14 at 31,267,815 bp
  • T to C, chromosome 14 at 99,221,627 bp
  • G to A, chromosome 15 at 35,879,913 bp
  • G to A, chromosome 15 at 103,355,952 bp
  • A to C, chromosome 16 at 33,763,575 bp
  • T to C, chromosome 17 at 20,113,409 bp
  • C to T, chromosome 17 at 20,994,155 bp
  • G to T, chromosome 18 at 34,823,699 bp
  • C to A, chromosome 18 at 37,676,496 bp
  • G to T, chromosome 18 at 68,235,669 bp
  • A to G, chromosome 19 at 3,612,342 bp
  • T to C, chromosome 19 at 20,709,400 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7984 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
046025-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.