Strain Name:
C57BL/6J-MtgxR7986Btlr/Mmmh
Stock Number:
046027-MU
Citation ID:
RRID:MMRRC_046027-MU
Other Names:
R7986 (G1)
Major Collection:

Strain Information

Setd5
Name: SET domain containing 5
Synonyms: 2900045N06Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 72895
Homologene: 12485
Npy2r
Name: neuropeptide Y receptor Y2
Synonyms: NPY-Y2 receptor
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 18167
HGNC: HGNC:7957
Homologene: 701
Btbd17
Name: BTB domain containing 17
Synonyms: Tango10a, 1500005I02Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 72014
Homologene: 46324
Akap10
Name: A kinase anchor protein 10
Synonyms: D-AKAP2, 1500031L16Rik, B130049N18Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 56697
HGNC: HGNC:368
Homologene: 32452
Zfp423
Name: zinc finger protein 423
Synonyms: Ebfaz, Roaz, Zfp104, ataxia1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 94187
Homologene: 9010
Secisbp2
Name: SECIS binding protein 2
Synonyms: 2210413N07Rik, 2810012K13Rik, SBP2
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 75420
Homologene: 11415
Ybx3
Name: Y box protein 3
Synonyms: oxyR, Dpba, MSY3, MSY4, dbpA, Yb2, Csda
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 56449
HGNC: HGNC:2428
Homologene: 2708
Arhgap21
Name: Rho GTPase activating protein 21
Synonyms: 5530401C11Rik, ARHGAP10
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 71435
Homologene: 10822
Virma
Name: vir like m6A methyltransferase associated
Synonyms: 1110037F02Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 66185
Homologene: 41043
Sorbs1
Name: sorbin and SH3 domain containing 1
Synonyms: Sh3d5, Ponsin, c-Cbl-associated protein, CAP, 9530001P15Rik, 2310065E01Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 20411
VEGA: 19
Homologene: 83252
Trps1
Name: transcriptional repressor GATA binding 1
Synonyms: D15Ertd586e, trichorhinophalangeal syndrome I (human)
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 83925
Homologene: 8556
Ccdc141
Name: coiled-coil domain containing 141
Synonyms: ENSMUSG00000075261, 2610301F02Rik, CAMDI
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 545428
Homologene: 52149
Raph1
Name: Ras association (RalGDS/AF-6) and pleckstrin homology domains 1
Synonyms: 9430025M21Rik, C730009O10Rik, Lpd, lamellipodin
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 77300
Homologene: 71030
Tmem178
Name: transmembrane protein 178
Synonyms: 2810417M05Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 68027
VEGA: 17
Homologene: 12226
Grin1
Name: glutamate receptor, ionotropic, NMDA1 (zeta 1)
Synonyms: M100174, Nmdar, Rgsc174, NR1, NMDAR1, GluRzeta1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 14810
HGNC: HGNC:4584
Homologene: 7187
Nr4a3
Name: nuclear receptor subfamily 4, group A, member 3
Synonyms: Nor1, MINOR, NOR-1, TEC
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 18124
HGNC: HGNC:7982
Homologene: 5074
Cacna1a
Name: calcium channel, voltage-dependent, P/Q type, alpha 1A subunit
Synonyms: Cacnl1a4, nmf352, smrl, alpha1A, SCA6, Ccha1a
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 12286
HGNC: HGNC:1388
Homologene: 56383
Ldlrad4
Name: low density lipoprotein receptor class A domain containing 4
Synonyms: 8230401C20Rik, D330030L18Rik, D18Ertd653e, A430108L08Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 52662
VEGA: 18
HGNC: HGNC:1224
Homologene: 3202
Lmod2
Name: leiomodin 2 (cardiac)
Synonyms: C-Lmod
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 93677
HGNC: HGNC:6648
Homologene: 28302
Fstl5
Name: follistatin-like 5
Synonyms: 9130207J01Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 213262
Homologene: 10584
Nek10
Name: NIMA (never in mitosis gene a)- related kinase 10
Synonyms: LOC238944
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 674895
Homologene: 130947
Col12a1
Name: collagen, type XII, alpha 1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 12816
HGNC: HGNC:2188
Homologene: 3217
Loxhd1
Name: lipoxygenase homology domains 1
Synonyms: 1700096C21Rik, sba
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 240411
Slc46a2
Name: solute carrier family 46, member 2
Synonyms: Ly110, Tscot, 5430429N04Rik, TSO-1C12
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 30936
Homologene: 23273
Ptpdc1
Name: protein tyrosine phosphatase domain containing 1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 218232
VEGA: 13
Homologene: 17576
Wdfy4
Name: WD repeat and FYVE domain containing 4
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 545030
Homologene: 83473
D430041D05Rik
Name: RIKEN cDNA D430041D05 gene
Synonyms: G2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241589
Homologene: 115928
Cd109
Name: CD109 antigen
Synonyms: Gov platelet alloantigens, 9930012E15Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235505
Homologene: 25183
Bpifb4
Name: BPI fold containing family B, member 4
Synonyms: Gm1006, LOC381399
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 381399
Homologene: 66971
Rtl1
Name: retrotransposon Gaglike 1
Synonyms: Mart1, Mor1, Mar
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 353326
VEGA: 12
Homologene: 120261
Adamts1
Name: ADAM metallopeptidase with thrombospondin type 1 motif 1
Synonyms: METH-1, ADAM-TS1, METH1, ADAMTS-1
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 11504
HGNC: HGNC:217
Homologene: 21381
Nemp2
Name: nuclear envelope integral membrane protein 2
Synonyms: 5330401P04Rik, Tmem194b
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 227094
Homologene: 67089
Col6a2
Name: collagen, type VI, alpha 2
Synonyms: Col6a-2
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 12834
HGNC: HGNC:2212
Homologene: 1392
Prss1l
Name: serine protease 1 (trypsin 1) like
Synonyms: Gm5771
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 436523
Homologene: 88408
Dffb
Name: DNA fragmentation factor, beta subunit
Synonyms: DFF40, CPAN, CAD, caspase-activated DNase, 40kDa, 5730477D02Rik, Didff
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 13368
HGNC: HGNC:2773
Homologene: 3241
Pramel26
Name: PRAME like 26
Synonyms: Gm13084
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 381569
Homologene: 77858
Llgl1
Name: LLGL1 scribble cell polarity complex component
Synonyms: Lgl1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 16897
HGNC: HGNC:6628
Homologene: 31220
Vmn1r230
Name: vomeronasal 1 receptor 230
Synonyms: V1re8
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 171231
Homologene: 136306
Or5an1b
Name: olfactory receptor family 5 subfamily AN member 1B
Synonyms: MOR214-6, Olfr1437, GA_x6K02T2RE5P-2658227-2657289
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 258117
Homologene: 83129
Or10ag52
Name: olfactory receptor family 10 subfamily AG member 52
Synonyms: MOR264-25, GA_x6K02T2Q125-48697747-48698727, Olfr1113
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 404327
Homologene: 27114
Masp2
Name: MBL associated serine protease 2
Synonyms: MASP-2, MAp19
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 17175
HGNC: HGNC:6902
Homologene: 4819
Nr1h4
Name: nuclear receptor subfamily 1, group H, member 4
Synonyms: FXR, Fxr, RIP14, Rxrip14, HRR1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 20186
HGNC: HGNC:7967
Homologene: 3760
Sirt6
Name: sirtuin 6
Synonyms: 2810449N18Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 50721
Homologene: 6924
Gpt2
Name: glutamic pyruvate transaminase (alanine aminotransferase) 2
Synonyms: ALT2, 4631422C05Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 108682
Homologene: 68832
Csf1r
Name: colony stimulating factor 1 receptor
Synonyms: Fim2, CD115, Fms, Fim-2, M-CSFR, CSF-1R, Csfmr
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 12978
HGNC: HGNC:2433
Homologene: 3817
Krt28
Name: keratin 28
Synonyms: 4733401L19Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 70843
Homologene: 124711
Cby3
Name: chibby family member 3
Synonyms: 1700121K02Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 76653
Homologene: 67734
Cavin1
Name: caveolae associated 1
Synonyms: 2310075E07Rik, Cavin, cavin-1, Ptrf
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 19285
HGNC: HGNC:9688
Homologene: 7499
Hoxa1
Name: homeobox A1
Synonyms: early retinoic acid, ERA1, Hox-1.6
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 15394
HGNC: HGNC:5099
Homologene: 4032
Gm29106
Name: predicted gene 29106
Type: Gene
Species: Mouse
Chromosome: 1
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to T, chromosome 1 at 52,630,822 bp
  • T to C, chromosome 1 at 60,496,286 bp
  • A to T, chromosome 1 at 118,200,270 bp
  • A to C, chromosome 2 at 20,863,156 bp
  • G to T, chromosome 2 at 25,295,829 bp
  • A to G, chromosome 2 at 77,015,117 bp
  • A to G, chromosome 2 at 87,213,578 bp
  • A to G, chromosome 2 at 104,256,751 bp
  • A to G, chromosome 2 at 153,957,730 bp
  • T to A, chromosome 3 at 76,429,790 bp
  • T to A, chromosome 3 at 82,541,496 bp
  • T to A, chromosome 4 at 11,540,023 bp
  • T to C, chromosome 4 at 48,055,954 bp
  • G to T, chromosome 4 at 59,911,858 bp
  • A to T, chromosome 4 at 143,812,020 bp
  • A to G, chromosome 4 at 148,602,826 bp
  • G to A, chromosome 4 at 153,970,047 bp
  • A to G, chromosome 6 at 24,603,449 bp
  • T to C, chromosome 6 at 41,396,124 bp
  • T to C, chromosome 6 at 52,158,038 bp
  • T to C, chromosome 6 at 113,128,457 bp
  • T to A, chromosome 6 at 131,379,399 bp
  • C to G, chromosome 8 at 84,638,779 bp
  • T to A, chromosome 8 at 85,509,210 bp
  • T to C, chromosome 8 at 87,780,350 bp
  • A to G, chromosome 9 at 78,688,766 bp
  • C to T, chromosome 9 at 79,604,392 bp
  • A to G, chromosome 10 at 76,615,138 bp
  • A to G, chromosome 10 at 81,622,510 bp
  • A to T, chromosome 10 at 89,454,772 bp
  • A to G, chromosome 11 at 50,359,279 bp
  • G to T, chromosome 11 at 60,711,395 bp
  • C to T, chromosome 11 at 61,930,064 bp
  • T to C, chromosome 11 at 99,366,825 bp
  • A to G, chromosome 11 at 100,970,276 bp
  • A to G, chromosome 11 at 114,792,515 bp
  • A to G, chromosome 12 at 109,592,058 bp
  • G to A, chromosome 13 at 48,592,570 bp
  • T to C, chromosome 13 at 51,665,359 bp
  • A to C, chromosome 14 at 15,001,020 bp
  • G to A, chromosome 14 at 33,104,115 bp
  • T to G, chromosome 15 at 50,661,736 bp
  • A to G, chromosome 15 at 50,889,623 bp
  • G to T, chromosome 16 at 85,799,547 bp
  • T to C, chromosome 17 at 20,846,857 bp
  • A to G, chromosome 17 at 81,000,844 bp
  • A to G, chromosome 18 at 61,114,832 bp
  • G to T, chromosome 18 at 68,235,669 bp
  • A to T, chromosome 18 at 77,375,194 bp
  • C to T, chromosome 19 at 12,322,738 bp
  • T to A, chromosome 19 at 40,365,005 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7986 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
046027-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.