Strain Name:
C57BL/6J-MtgxR7988Btlr/Mmmh
Stock Number:
046029-MU
Citation ID:
RRID:MMRRC_046029-MU
Other Names:
R7988 (G1)
Major Collection:

Strain Information

Itk
Name: IL2 inducible T cell kinase
Synonyms: Emt, Tsk, Tcsk
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 16428
HGNC: HGNC:6171
Homologene: 4051
Macf1
Name: microtubule-actin crosslinking factor 1
Synonyms: Acf7, Aclp7, trabeculin alpha
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 11426
Homologene: 136191
Eps8
Name: epidermal growth factor receptor pathway substrate 8
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 13860
HGNC: HGNC:3420
Homologene: 3272
Aopep
Name: aminopeptidase O
Synonyms: ApO, 2010111I01Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 72061
HGNC: HGNC:1361
Homologene: 66273
Usp38
Name: ubiquitin specific peptidase 38
Synonyms: 4631402N15Rik, 4833420O05Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 74841
Homologene: 12367
Eprs1
Name: glutamyl-prolyl-tRNA synthetase 1
Synonyms: 2410081F06Rik, Qprs, 3010002K18Rik, Eprs
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 107508
HGNC: HGNC:3418
Homologene: 5870
Birc6
Name: baculoviral IAP repeat-containing 6
Synonyms: apollon, Bruce, A430032G04Rik, D630005A10Rik, A430040A19Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 12211
Homologene: 7248
Osbpl8
Name: oxysterol binding protein-like 8
Synonyms: ORP-8, D330025H14Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 237542
VEGA: 10
Homologene: 68813
Ago1
Name: argonaute RISC catalytic subunit 1
Synonyms: argonaute 1, Eif2c1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 236511
HGNC: HGNC:3262
Homologene: 81826
Ccnt1
Name: cyclin T1
Synonyms: CycT1, 2810478G24Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 12455
HGNC: HGNC:1599
Homologene: 947
Zfp407
Name: zinc finger protein 407
Synonyms: LOC240469, LOC381139, 6430585N13Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 240476
Homologene: 86402
Tram1
Name: translocating chain-associating membrane protein 1
Synonyms: TRAMP, 1810049E02Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 72265
Homologene: 8621
Fbf1
Name: Fas binding factor 1
Synonyms: 1110033G01Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217335
Homologene: 16531
Setd1a
Name: SET domain containing 1A
Synonyms: KMT2F
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233904
Homologene: 52251
Cemip
Name: cell migration inducing protein, hyaluronan binding
Synonyms: 12H19.01.T7, 6330404C01Rik, 9930013L23Rik, Hybid
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 80982
Homologene: 10268
Aspn
Name: asporin
Synonyms: 4631401G09Rik, SLRR1C, PLAP-1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 66695
VEGA: 13
Homologene: 32357
Notch1
Name: notch 1
Synonyms: lin-12, Tan1, Mis6, 9930111A19Rik, Motch A, N1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 18128
HGNC: HGNC:7881
Homologene: 32049
Arhgef3
Name: Rho guanine nucleotide exchange factor 3
Synonyms: 1200004I24Rik, C76747, 9830169H03Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 71704
VEGA: 14
HGNC: HGNC:683
Homologene: 41329
Baz2b
Name: bromodomain adjacent to zinc finger domain, 2B
Synonyms: D2Ertd794e, 5830435C13Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 407823
HGNC: HGNC:963
Homologene: 8394
Ryr1
Name: ryanodine receptor 1, skeletal muscle
Synonyms: calcium release channel isoform 1, Ryr, skrr
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 20190
Homologene: 68069
Cubn
Name: cubilin
Synonyms: D2Wsu88e, intrinsic factor-cobalamin receptor
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 65969
HGNC: HGNC:2548
Homologene: 37434
Adgrf5
Name: adhesion G protein-coupled receptor F5
Synonyms: 8430401C09Rik, Gpr116
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 224792
VEGA: 17
Homologene: 9065
Ttn
Name: titin
Synonyms: connectin, L56, mdm, 1100001C23Rik, D830007G01Rik, 2310036G12Rik, 2310074I15Rik, 2310057K23Rik, D330041I19Rik, shru
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 22138
Homologene: 130650
Col27a1
Name: collagen, type XXVII, alpha 1
Synonyms: 5730512J02Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 373864
Homologene: 69400
Dnah14
Name: dynein, axonemal, heavy chain 14
Synonyms: LOC381311, A230079K17Rik, Gm980, Dnahc14
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 240960
HGNC: HGNC:2945
Homologene: 90078
Cma1
Name: chymase 1, mast cell
Synonyms: MMCP-5, Mcp-5, Mcpt5, Mcp5
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 17228
VEGA: 14
HGNC: HGNC:2097
Homologene: 55606
Sclt1
Name: sodium channel and clathrin linker 1
Synonyms: 4931421F20Rik, 2610207F23Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 67161
Homologene: 27031
Htra4
Name: HtrA serine peptidase 4
Synonyms: B430206E18Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 330723
Homologene: 17801
Otogl
Name: otogelin-like
Synonyms: Gm6924
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 628870
Homologene: 46008
Serpinb9c
Name: serine (or cysteine) peptidase inhibitor, clade B, member 9c
Synonyms: 3830421J05Rik, ovalbumin, Spi11, NK9
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 20707
HGNC: HGNC:8955
Gstm7
Name: glutathione S-transferase, mu 7
Synonyms: Cd203c, 0610005A07Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 68312
HGNC: HGNC:4634
Homologene: 41816
Ikzf4
Name: IKAROS family zinc finger 4
Synonyms: Eos, A630026H08Rik, Zfpn1a4
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 22781
Homologene: 69103
Spata31h1
Name: SPATA31 subfamily H member 1
Synonyms: 4932415D10Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 102635990
VEGA: 10
Homologene: 82476
Zcwpw1
Name: zinc finger, CW type with PWWP domain 1
Synonyms: LOC381678
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 381678
Homologene: 9944
Ppef2
Name: protein phosphatase, EF hand calcium-binding domain 2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 19023
HGNC: HGNC:9244
Homologene: 55959
Lmntd2
Name: lamin tail domain containing 2
Synonyms: 1600016N20Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 72000
Homologene: 104159
Phldb2
Name: pleckstrin homology like domain, family B, member 2
Synonyms: C820004H04Rik, LL5beta, LL5b
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 208177
Homologene: 17100
Sftpc
Name: surfactant associated protein C
Synonyms: SP-C, Sftp-2, Sftp2, pro-SpC, Bricd6, SPC
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 20389
VEGA: 14
Homologene: 2271
Cfap45
Name: cilia and flagella associated protein 45
Synonyms: 1700028D05Rik, Nesg1, Ccdc19
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 71870
Homologene: 71837
Colq
Name: collagen like tail subunit of asymmetric acetylcholinesterase
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 382864
HGNC: HGNC:2226
Scn11a
Name: sodium channel, voltage-gated, type XI, alpha
Synonyms: SNS2, NaN, NaT, NSS2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 24046
VEGA: 9
Homologene: 8041
Thnsl2
Name: threonine synthase-like 2 (bacterial)
Synonyms: TSH2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232078
Homologene: 5489
Klhdc10
Name: kelch domain containing 10
Synonyms: 2410127E18Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 76788
Homologene: 15267
Hook3
Name: hook microtubule tethering protein 3
Synonyms: E330005F07Rik, 5830454D03Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 320191
Homologene: 13022
Ky
Name: kyphoscoliosis peptidase
Synonyms: D9Mgc44e
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 16716
Homologene: 11506
Repin1
Name: replication initiator 1
Synonyms: AP4, E430037F08Rik, Zfp464
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 58887
Homologene: 22810
Btnl2
Name: butyrophilin-like 2
Synonyms: butyrophylin-like MHC class II associated, BTL-II, NG9, BTLN2
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 547431
HGNC: HGNC:1142
Homologene: 10482
Zfp446
Name: zinc finger protein 446
Synonyms: A630035I11Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 269870
Homologene: 9910
Insyn2a
Name: inhibitory synaptic factor 2A
Synonyms: B830028B13Rik, Fam196a
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 627214
Homologene: 85469
Adamtsl5
Name: ADAMTS-like 5
Synonyms: 2010109H09Rik, Thsd6
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 66548
Homologene: 19803
Lrrc36
Name: leucine rich repeat containing 36
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 270091
Homologene: 23090
Ccnl1
Name: cyclin L1
Synonyms: ania-6a, 2610030E23Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 56706
Homologene: 10541
Akr1cl
Name: aldo-keto reductase family 1, member C-like
Synonyms: 4921521F21Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 70861
Homologene: 133861
Cmtm1
Name: CKLF-like MARVEL transmembrane domain containing 1
Synonyms: CHLFH1a, CKLFH1, Cklfsf1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 100504164
Homologene: 134399
Fen1
Name: flap structure specific endonuclease 1
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 14156
HGNC: HGNC:3650
Homologene: 3034
Cfap54
Name: cilia and flagella associated protein 54
Synonyms: LOC380653, Gm872, 4930485B16Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 380654
Homologene: 133438
Ighv1-15
Name: immunoglobulin heavy variable 1-15
Synonyms: Gm16858
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 629865
HGNC: HGNC:5553
0610030E20Rik
Name: RIKEN cDNA 0610030E20 gene
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 68364
Homologene: 19243
Iqcf5
Name: IQ motif containing F5
Synonyms: 1700007L12Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 75470
Homologene: 20043
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 13,569,975 bp
  • T to C, chromosome 1 at 65,024,706 bp
  • A to G, chromosome 1 at 172,529,934 bp
  • A to G, chromosome 1 at 181,783,574 bp
  • A to G, chromosome 1 at 185,418,348 bp
  • T to C, chromosome 2 at 13,332,355 bp
  • C to T, chromosome 2 at 26,471,001 bp
  • T to C, chromosome 2 at 59,962,141 bp
  • A to T, chromosome 2 at 76,736,240 bp
  • G to A, chromosome 2 at 76,845,030 bp
  • C to A, chromosome 2 at 76,896,759 bp
  • T to A, chromosome 3 at 41,663,454 bp
  • T to A, chromosome 3 at 65,957,861 bp
  • A to T, chromosome 3 at 107,926,955 bp
  • A to G, chromosome 4 at 63,331,322 bp
  • A to T, chromosome 4 at 123,506,480 bp
  • A to G, chromosome 4 at 126,460,417 bp
  • A to T, chromosome 5 at 92,238,982 bp
  • T to G, chromosome 5 at 137,817,491 bp
  • T to C, chromosome 6 at 30,446,691 bp
  • G to T, chromosome 6 at 48,597,345 bp
  • T to C, chromosome 6 at 71,141,319 bp
  • C to T, chromosome 6 at 72,347,652 bp
  • C to T, chromosome 6 at 137,528,571 bp
  • T to A, chromosome 7 at 12,979,043 bp
  • G to A, chromosome 7 at 29,096,171 bp
  • C to A, chromosome 7 at 84,003,408 bp
  • T to A, chromosome 7 at 127,786,194 bp
  • T to G, chromosome 7 at 134,917,698 bp
  • T to C, chromosome 7 at 141,213,637 bp
  • A to C, chromosome 8 at 25,030,510 bp
  • A to T, chromosome 8 at 26,073,647 bp
  • T to A, chromosome 8 at 81,014,316 bp
  • T to C, chromosome 8 at 104,310,142 bp
  • C to A, chromosome 8 at 105,452,086 bp
  • T to C, chromosome 9 at 102,525,415 bp
  • T to A, chromosome 9 at 106,515,821 bp
  • T to A, chromosome 9 at 110,476,509 bp
  • T to C, chromosome 9 at 119,765,437 bp
  • C to T, chromosome 10 at 80,345,538 bp
  • T to C, chromosome 10 at 82,296,100 bp
  • T to A, chromosome 10 at 92,902,079 bp
  • C to T, chromosome 10 at 107,895,776 bp
  • T to G, chromosome 10 at 111,272,080 bp
  • T to A, chromosome 10 at 128,634,455 bp
  • A to G, chromosome 11 at 46,355,834 bp
  • T to C, chromosome 11 at 116,152,768 bp
  • T to C, chromosome 12 at 114,657,496 bp
  • T to A, chromosome 13 at 33,150,279 bp
  • T to C, chromosome 13 at 49,551,877 bp
  • A to G, chromosome 13 at 63,061,140 bp
  • A to T, chromosome 14 at 27,401,786 bp
  • T to A, chromosome 14 at 31,553,837 bp
  • T to C, chromosome 14 at 55,944,532 bp
  • T to C, chromosome 14 at 70,522,619 bp
  • T to C, chromosome 15 at 98,565,143 bp
  • T to G, chromosome 16 at 45,825,571 bp
  • A to T, chromosome 17 at 34,358,275 bp
  • A to T, chromosome 17 at 43,439,813 bp
  • G to A, chromosome 17 at 74,599,373 bp
  • G to A, chromosome 18 at 84,559,400 bp
  • C to T, chromosome 19 at 10,200,310 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7988 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
046029-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.