Strain Name:
C57BL/6J-MtgxR7992Btlr/Mmmh
Stock Number:
046033-MU
Citation ID:
RRID:MMRRC_046033-MU
Other Names:
R7992 (G1)
Major Collection:

Strain Information

Slc12a6
Name: solute carrier family 12, member 6
Synonyms: KCC3, gaxp
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 107723
Homologene: 21069
Fn1
Name: fibronectin 1
Synonyms: Fn, Fn-1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 14268
HGNC: HGNC:3778
Homologene: 1533
Gdf6
Name: growth differentiation factor 6
Synonyms: BMP13
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242316
HGNC: HGNC:4221
Homologene: 40883
Macf1
Name: microtubule-actin crosslinking factor 1
Synonyms: trabeculin alpha, Aclp7, Acf7
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 11426
Homologene: 136191
Fancd2
Name: Fanconi anemia, complementation group D2
Synonyms: 2410150O07Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 211651
HGNC: HGNC:3585
Homologene: 13212
Dock6
Name: dedicator of cytokinesis 6
Synonyms: 2410095B20Rik, 4931431C02Rik, C330023D02Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 319899
VEGA: 9
Homologene: 83291
Trpm7
Name: transient receptor potential cation channel, subfamily M, member 7
Synonyms: CHAK1, 2310022G15Rik, 5033407O22Rik, TRP-PLIK, LTRPC7, CHAK, Ltpr7, 4833414K03Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 58800
Homologene: 9774
Erp44
Name: endoplasmic reticulum protein 44
Synonyms: Txndc4, 1110001E24Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 76299
Homologene: 12638
Ints1
Name: integrator complex subunit 1
Synonyms: 1110015K06Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 68510
Homologene: 53111
Scaper
Name: S phase cyclin A-associated protein in the ER
Synonyms: Zfp291, D530014O03Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 244891
VEGA: 9
Homologene: 32488
Bptf
Name: bromodomain PHD finger transcription factor
Synonyms: 9430093H17Rik, Falz
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 207165
HGNC: HGNC:3581
Homologene: 114397
Plekha5
Name: pleckstrin homology domain containing, family A member 5
Synonyms: PEPP2, 2810431N21Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 109135
Homologene: 10377
Fkbp15
Name: FK506 binding protein 15
Synonyms: C430014M02Rik, FKBP133
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 338355
Homologene: 28743
Tmprss6
Name: transmembrane serine protease 6
Synonyms: matriptase-2, 1300008A22Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 71753
VEGA: 15
Homologene: 12408
Kif26a
Name: kinesin family member 26A
Synonyms: N-11 kinesin
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 668303
Homologene: 18970
Trmt6
Name: tRNA methyltransferase 6
Synonyms: 3300001M20Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 66926
Homologene: 6816
Themis
Name: thymocyte selection associated
Synonyms: Tsepa, E430004N04Rik, Gasp
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 210757
Homologene: 72287
Adamts12
Name: ADAM metallopeptidase with thrombospondin type 1 motif 12
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 239337
VEGA: 15
Homologene: 12808
Muc16
Name: mucin 16
Synonyms: 1110008I14Rik, LOC385009, Gm21044
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 73732
Homologene: 141193
Htt
Name: huntingtin
Synonyms: C430023I11Rik, Hdh, htt, huntingtin, HD, IT15
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 15194
HGNC: HGNC:4851
Homologene: 1593
Tes
Name: testin LIM domain protein
Synonyms: testin, Tes1, Tes2, testin2, D6Ertd352e
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 21753
Homologene: 41051
Npat
Name: nuclear protein in the AT region
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 244879
HGNC: HGNC:7896
Homologene: 1888
Mta2
Name: metastasis-associated gene family, member 2
Synonyms: Mta1l1, mmta2
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 23942
HGNC: HGNC:7411
Homologene: 3480
Shq1
Name: SHQ1 homolog (S. cerevisiae)
Synonyms: Grim-1, 2810403P18Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 72171
Homologene: 31683
Htr5a
Name: 5-hydroxytryptamine (serotonin) receptor 5A
Synonyms: Htr5
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 15563
HGNC: HGNC:5300
Homologene: 22461
Nlrp4a
Name: NLR family, pyrin domain containing 4A
Synonyms: Nalp4a, Nalp-eta, E330028A19Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 243880
Homologene: 79696
Il12rb1
Name: interleukin 12 receptor, beta 1
Synonyms: IL-12R[b], CD212
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 16161
HGNC: HGNC:5971
Homologene: 4042
Trpm6
Name: transient receptor potential cation channel, subfamily M, member 6
Synonyms: CHAK2
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 225997
VEGA: 19
Homologene: 9767
Il12rb2
Name: interleukin 12 receptor, beta 2
Synonyms: Ifnm, A930027I18Rik, IL-12RB2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 16162
HGNC: HGNC:5972
Homologene: 1197
Pdzph1
Name: PDZ and pleckstrin homology domains 1
Synonyms: 2610034M16Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 69239
Homologene: 130756
Pus7
Name: pseudouridylate synthase 7
Synonyms: C330017I15Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 78697
Homologene: 6998
Nckap5
Name: NCK-associated protein 5
Synonyms: LOC380609, E030049G20Rik, D130011D22Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 210356
Homologene: 35542
Iba57
Name: IBA57 homolog, iron-sulfur cluster assembly
Synonyms: A230051G13Rik, 4930543L23Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 216792
Homologene: 13844
Xab2
Name: XPA binding protein 2
Synonyms: 0610041O14Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 67439
Homologene: 5738
Ddx60
Name: DExD/H box helicase 60
Synonyms: DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234311
Homologene: 23031
Krt13
Name: keratin 13
Synonyms: Krt1-13, Krt-1.13, K13
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 16663
HGNC: HGNC:6415
Homologene: 40740
Stat2
Name: signal transducer and activator of transcription 2
Synonyms: 1600010G07Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 20847
VEGA: 10
Homologene: 3952
Klhdc7a
Name: kelch domain containing 7A
Synonyms: B230308G19Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242721
Homologene: 17567
Ankfn1
Name: ankyrin-repeat and fibronectin type III domain containing 1
Synonyms: nmf9, LOC382543, 4932411E22Rik, mWAKE
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 382543
Homologene: 34996
Gm5773
Name: predicted pseudogene 5773
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 436563
Usp45
Name: ubiquitin specific petidase 45
Synonyms: Gcap7, 4930550B20Rik, 3110003C05Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 77593
Homologene: 17674
Fcgr1
Name: Fc receptor, IgG, high affinity I
Synonyms: FcgammaRI, CD64
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 14129
Homologene: 475
Ano3
Name: anoctamin 3
Synonyms: B230324K02Rik, Tmem16c
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228432
Homologene: 57147
Ifi35
Name: interferon-induced protein 35
Synonyms: IFP35, 2010008K16Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 70110
HGNC: HGNC:5399
Homologene: 4040
Slc5a9
Name: solute carrier family 5 (sodium/glucose cotransporter), member 9
Synonyms: SGLT4
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230612
Homologene: 17081
Ptger4
Name: prostaglandin E receptor 4 (subtype EP4)
Synonyms: EP4, Ptgerep4
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 19219
HGNC: HGNC:9596
Homologene: 20261
Zfp938
Name: zinc finger protein 938
Synonyms: B230315N10Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 237411
Homologene: 135924
Ces1b
Name: carboxylesterase 1B
Synonyms: Gm5158
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 382044
HGNC: HGNC:1863
Homologene: 117484
Piwil4
Name: piwi-like RNA-mediated gene silencing 4
Synonyms: Miwi2, MIWI2, 9230101H05Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 330890
Homologene: 45122
Klhl40
Name: kelch-like 40
Synonyms: 2310024D23Rik, Kbtbd5
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 72330
VEGA: 9
Homologene: 17571
Senp5
Name: SUMO/sentrin specific peptidase 5
Synonyms: A730063F07Rik, 6230429P13Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 320213
Homologene: 17647
Ipp
Name: IAP promoted placental gene
Synonyms: D4Jhu8, Mipp
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 16351
HGNC: HGNC:6108
Homologene: 4309
Fam47e
Name: family with sequence similarity 47, member E
Synonyms: LOC384198, Gm1381
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 384198
Homologene: 129958
Hesx1
Name: homeobox gene expressed in ES cells
Synonyms: Rpx, HES-1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 15209
HGNC: HGNC:4877
Homologene: 20831
Arhgef37
Name: Rho guanine nucleotide exchange factor 37
Synonyms: 4933429F08Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 328967
VEGA: 18
Homologene: 28467
Lpcat2
Name: lysophosphatidylcholine acyltransferase 2
Synonyms: Aytl1, Aytl1a, lysoPAFAT/LPCAT2, LPCAT2
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 270084
Homologene: 41201
Rtkn2
Name: rhotekin 2
Synonyms: RTKN2, Plekhk1, Mbf, B130039D23Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 170799
Homologene: 17065
Cmc2
Name: C-X9-C motif containing 2
Synonyms: 2310061C15Rik, 1110046L09Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 66531
Homologene: 41350
Or4c15b
Name: olfactory receptor family 4 subfamily C member 15B
Synonyms: MOR233-22, Olfr1229, GA_x6K02T2Q125-50727797-50726862, MOR233-19
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 257921
Homologene: 79376
Or4f56
Name: olfactory receptor family 4 subfamily F member 56
Synonyms: MOR245-8, GA_x6K02T2Q125-72930843-72929905, Olfr1305
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258396
Homologene: 74056
Oog1
Name: oogenesin 1
Synonyms: Oog, c-1
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 193322
VEGA: 12
Homologene: 103830
Scand1
Name: SCAN domain-containing 1
Synonyms: Leap1, Ppargc2, 2310003H23Rik, PGC-2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 19018
VEGA: 2
Homologene: 10642
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 71,599,666 bp
  • A to T, chromosome 1 at 126,026,810 bp
  • A to G, chromosome 2 at 89,282,738 bp
  • T to C, chromosome 2 at 110,775,022 bp
  • C to T, chromosome 2 at 111,872,935 bp
  • T to A, chromosome 2 at 112,335,911 bp
  • T to C, chromosome 2 at 126,825,534 bp
  • G to A, chromosome 2 at 132,811,039 bp
  • G to A, chromosome 2 at 156,312,312 bp
  • T to A, chromosome 3 at 93,773,066 bp
  • A to G, chromosome 3 at 96,284,581 bp
  • A to G, chromosome 4 at 9,844,652 bp
  • G to A, chromosome 4 at 21,824,543 bp
  • A to G, chromosome 4 at 48,218,136 bp
  • T to C, chromosome 4 at 62,312,301 bp
  • T to A, chromosome 4 at 111,890,532 bp
  • T to G, chromosome 4 at 116,524,256 bp
  • A to G, chromosome 4 at 123,395,960 bp
  • A to G, chromosome 4 at 139,965,734 bp
  • A to G, chromosome 5 at 23,746,467 bp
  • T to C, chromosome 5 at 27,850,997 bp
  • T to C, chromosome 5 at 34,829,881 bp
  • T to C, chromosome 5 at 92,574,682 bp
  • C to G, chromosome 5 at 139,756,527 bp
  • G to T, chromosome 6 at 17,096,243 bp
  • A to T, chromosome 6 at 67,351,327 bp
  • A to G, chromosome 6 at 100,637,011 bp
  • T to C, chromosome 6 at 113,565,204 bp
  • C to A, chromosome 6 at 140,526,541 bp
  • A to T, chromosome 7 at 26,450,645 bp
  • A to T, chromosome 8 at 3,618,622 bp
  • A to G, chromosome 8 at 61,954,535 bp
  • G to T, chromosome 8 at 70,812,589 bp
  • T to C, chromosome 8 at 92,855,558 bp
  • A to G, chromosome 8 at 93,060,359 bp
  • A to T, chromosome 8 at 116,889,707 bp
  • T to A, chromosome 9 at 14,703,149 bp
  • G to T, chromosome 9 at 18,656,429 bp
  • C to T, chromosome 9 at 21,832,839 bp
  • T to C, chromosome 9 at 53,562,867 bp
  • T to C, chromosome 9 at 55,858,154 bp
  • C to A, chromosome 9 at 121,778,682 bp
  • A to T, chromosome 10 at 28,761,346 bp
  • C to T, chromosome 10 at 68,040,093 bp
  • T to A, chromosome 10 at 82,225,943 bp
  • T to A, chromosome 10 at 128,284,962 bp
  • T to A, chromosome 11 at 59,161,462 bp
  • A to C, chromosome 11 at 89,523,033 bp
  • T to C, chromosome 11 at 100,117,652 bp
  • C to T, chromosome 11 at 101,457,481 bp
  • C to T, chromosome 11 at 107,110,883 bp
  • G to A, chromosome 12 at 87,608,482 bp
  • A to G, chromosome 12 at 112,176,047 bp
  • T to C, chromosome 14 at 27,001,422 bp
  • T to C, chromosome 15 at 5,234,900 bp
  • A to G, chromosome 15 at 11,310,818 bp
  • C to T, chromosome 15 at 78,442,464 bp
  • T to A, chromosome 16 at 31,977,696 bp
  • T to A, chromosome 17 at 58,879,110 bp
  • T to A, chromosome 18 at 61,505,756 bp
  • T to C, chromosome 19 at 8,947,787 bp
  • T to C, chromosome 19 at 18,815,350 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7992 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
046033-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.