Strain Name:
C57BL/6J-MtgxR7996Btlr/Mmmh
Stock Number:
046036-MU
Citation ID:
RRID:MMRRC_046036-MU
Other Names:
R7996 (G1)
Major Collection:

Strain Information

Ccne2
Name: cyclin E2
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 12448
HGNC: HGNC:1590
Homologene: 7660
Ssu72
Name: Ssu72 RNA polymerase II CTD phosphatase homolog (yeast)
Synonyms: 1500011L16Rik, 2610101M12Rik, 1190002E22Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 68991
Homologene: 6754
Paics
Name: phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoribosylaminoimidazole, succinocarboxamide synthetase
Synonyms: ADE2H1, 2610511I09Rik, AIRC, PAIS
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 67054
HGNC: HGNC:8587
Homologene: 4710
Rabggtb
Name: Rab geranylgeranyl transferase, b subunit
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 19352
HGNC: HGNC:9796
Homologene: 3371
Katnb1
Name: katanin p80 (WD40-containing) subunit B 1
Synonyms: 2410003J24Rik, KAT
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 74187
HGNC: HGNC:6217
Homologene: 4302
Snx16
Name: sorting nexin 16
Synonyms: 4930522N22Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 74718
Homologene: 11169
Emsy
Name: EMSY, BRCA2-interacting transcriptional repressor
Synonyms: 2210018M11Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233545
Homologene: 32465
Zgrf1
Name: zinc finger, GRF-type containing 1
Synonyms: 4930422G04Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 71643
Homologene: 34708
Tead1
Name: TEA domain family member 1
Synonyms: Tcf13, mTEF-1, TEF-1, Gtrgeo5, B230114H05Rik, TEAD-1, 2610024B07Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 21676
Homologene: 2418
Abcg5
Name: ATP binding cassette subfamily G member 5
Synonyms: cmp, trac, Sterolin-1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 27409
Homologene: 31909
Smoc2
Name: SPARC related modular calcium binding 2
Synonyms: Smoc2l, 1700056C05Rik, 5430426J21Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 64074
VEGA: 17
Homologene: 11150
Smtnl2
Name: smoothelin-like 2
Synonyms: D130058I21Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 276829
Homologene: 82367
Slc25a40
Name: solute carrier family 25, member 40
Synonyms: B230315F11Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 319653
Homologene: 6040
Amotl1
Name: angiomotin-like 1
Synonyms: 2310067L22Rik, 4932416D09Rik, JEAP, 2310010G08Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 75723
Homologene: 43977
Derl1
Name: Der1-like domain family, member 1
Synonyms: Derlin-1, 1110021N07Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 67819
VEGA: 15
Homologene: 11483
Hr
Name: lysine demethylase and nuclear receptor corepressor
Synonyms: N, rh, bldy, rh-bmh, ba
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 15460
HGNC: HGNC:5172
Homologene: 3774
Rhot1
Name: ras homolog family member T1
Synonyms: Arht1, Miro1, 2210403N23Rik, FLJ11040, C430039G08Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 59040
Homologene: 56803
Stk40
Name: serine/threonine kinase 40
Synonyms: 2310004N11Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 74178
Homologene: 12542
Memo1
Name: mediator of cell motility 1
Synonyms: 0610016J10Rik, D930048L02Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 76890
VEGA: 17
Homologene: 6272
Cfap70
Name: cilia and flagella associated protein 70
Synonyms: 5330402L21Rik, Ttc18
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 76670
Homologene: 17048
Dnah5
Name: dynein, axonemal, heavy chain 5
Synonyms: Dnahc5, Mdnah5, b2b1134Clo, b2b1154Clo, b2b1537Clo, b2b1565Clo, b2b3491Clo
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 110082
HGNC: HGNC:2950
Homologene: 1048
Syne2
Name: spectrin repeat containing, nuclear envelope 2
Synonyms: nesprin-2, D12Ertd777e, diminished cone electroretinogram, Cpfl8, Nesp2g, dice, syne-2, 6820443O06Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 319565
Homologene: 56700
Naip5
Name: NLR family, apoptosis inhibitory protein 5
Synonyms: Naip-rs3, Lgn1, Birc1e
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 17951
HGNC: HGNC:7634
Homologene: 113589
Sult3a2
Name: sulfotransferase family 3A, member 2
Synonyms: Gm4794
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 215895
VEGA: 10
Homologene: 111031
Garre1
Name: granule associated Rac and RHOG effector 1
Synonyms: 4931406P16Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233103
Homologene: 8795
Tubgcp6
Name: tubulin, gamma complex component 6
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 328580
Homologene: 32477
Garin3
Name: golgi associated RAB2 interactor 3
Synonyms: OTTMUSG00000005491, Fam71b
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 432552
Homologene: 51067
Trim14
Name: tripartite motif-containing 14
Synonyms: 5830400N10Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 74735
Homologene: 13241
Eif3m
Name: eukaryotic translation initiation factor 3, subunit M
Synonyms: Ga17, Pcid1, Tango7
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 98221
Homologene: 4639
Arid5a
Name: AT-rich interaction domain 5A
Synonyms: D430024K22Rik, Mrf1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 214855
Homologene: 34940
Elapor2
Name: endosome-lysosome associated apoptosis and autophagy regulator family member 2
Synonyms: 9330182L06Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231014
Homologene: 27396
Pnpla8
Name: patatin-like phospholipase domain containing 8
Synonyms: iPLA2 gamma, 1200006O19Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 67452
Homologene: 12136
Chrnd
Name: cholinergic receptor, nicotinic, delta polypeptide
Synonyms: Acrd, Achr-4
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 11447
HGNC: HGNC:1965
Homologene: 37340
Zpr1
Name: ZPR1 zinc finger
Synonyms: Zfp259, ZPR1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 22687
Homologene: 2900
Tmco4
Name: transmembrane and coiled-coil domains 4
Synonyms: 4632413C14Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 77056
Homologene: 57112
Vwa5a
Name: von Willebrand factor A domain containing 5A
Synonyms: Loh11cr2a, BCSC-1, 5830475I06Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 67776
HGNC: HGNC:6658
Homologene: 18222
Tgs1
Name: trimethylguanosine synthase 1
Synonyms: Pimt, D4Ertd800e, Ncoa6ip
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 116940
Homologene: 32608
Efcab12
Name: EF-hand calcium binding domain 12
Synonyms: BC060267
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 212516
Homologene: 18905
Gpr137b
Name: G protein-coupled receptor 137B
Synonyms: C80741, 2310041G17Rik, Tm7sf1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 83924
VEGA: 13
Homologene: 2454
Spata31e5
Name: spermatogenesis associated 31 subfamily E member 5
Synonyms: Gm597, LOC210962
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 210962
Cobll1
Name: Cobl-like 1
Synonyms: Coblr1, D430044D16Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 319876
Homologene: 8933
Sdr39u1
Name: short chain dehydrogenase/reductase family 39U, member 1
Synonyms: 2310014G06Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 654795
VEGA: 14
Homologene: 69295
Or4c58
Name: olfactory receptor family 4 subfamily C member 58
Synonyms: GA_x6K02T2Q125-51285881-51284976, IC3, MOR232-5, Olfr48
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 18347
Homologene: 85936
Vmn2r50
Name: vomeronasal 2, receptor 50
Synonyms: EG434117
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 434117
Homologene: 113703
Rps27
Name: ribosomal protein S27
Synonyms: 3200001M24Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 57294
Homologene: 136393
Sesn1
Name: sestrin 1
Synonyms: PA26, SEST1, 1110002G11Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 140742
Homologene: 8697
Mmel1
Name: membrane metallo-endopeptidase-like 1
Synonyms: Nep2, Nl1, SEP, NEPLP gamma, NEPLP beta, NEPLP alpha, Mell1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 27390
Homologene: 22778
Tbx2
Name: T-box 2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 21385
Homologene: 38123
Or7c70
Name: olfactory receptor family 7 subfamily C member 70
Synonyms: MOR142-2_p, GA_x6K02T2QGN0-2962025-2962987, Olfr1356, MOR142-1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 258305
Homologene: 71958
Pate13
Name: prostate and testis expressed 13
Synonyms: 9230113P08Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 77908
Gm3336
Name: predicted gene 3336
Synonyms: 2410018E23Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 100502950
Homologene: 136417
Pcdhgc4
Name: protocadherin gamma subfamily C, 4
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93707
HGNC: HGNC:8717
Homologene: 110932
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to T, chromosome 1 at 28,778,406 bp
  • G to T, chromosome 1 at 36,317,445 bp
  • A to G, chromosome 1 at 87,191,106 bp
  • T to A, chromosome 2 at 65,150,985 bp
  • T to C, chromosome 2 at 89,844,415 bp
  • T to C, chromosome 2 at 105,001,349 bp
  • G to T, chromosome 3 at 10,435,449 bp
  • A to G, chromosome 3 at 90,213,002 bp
  • C to T, chromosome 3 at 127,595,924 bp
  • T to C, chromosome 3 at 153,911,968 bp
  • T to C, chromosome 4 at 3,605,842 bp
  • C to A, chromosome 4 at 11,201,347 bp
  • A to T, chromosome 4 at 46,533,086 bp
  • C to A, chromosome 4 at 126,136,874 bp
  • T to C, chromosome 4 at 139,020,861 bp
  • C to G, chromosome 4 at 154,892,455 bp
  • A to C, chromosome 4 at 155,731,993 bp
  • A to G, chromosome 5 at 8,443,653 bp
  • A to C, chromosome 5 at 9,462,881 bp
  • A to G, chromosome 5 at 76,959,429 bp
  • T to C, chromosome 6 at 115,823,417 bp
  • A to T, chromosome 7 at 10,047,868 bp
  • G to T, chromosome 7 at 34,263,599 bp
  • T to A, chromosome 7 at 98,593,681 bp
  • T to C, chromosome 7 at 112,842,104 bp
  • A to T, chromosome 8 at 70,720,497 bp
  • A to T, chromosome 8 at 95,098,015 bp
  • T to C, chromosome 9 at 14,593,705 bp
  • G to A, chromosome 9 at 35,909,354 bp
  • T to A, chromosome 9 at 38,727,828 bp
  • A to G, chromosome 9 at 46,273,565 bp
  • T to C, chromosome 10 at 33,768,258 bp
  • T to A, chromosome 10 at 41,894,933 bp
  • A to T, chromosome 10 at 78,847,321 bp
  • T to C, chromosome 11 at 46,405,062 bp
  • T to A, chromosome 11 at 72,400,374 bp
  • G to A, chromosome 11 at 80,257,537 bp
  • A to G, chromosome 11 at 85,834,790 bp
  • T to A, chromosome 12 at 44,282,983 bp
  • T to C, chromosome 12 at 76,004,667 bp
  • T to C, chromosome 13 at 13,359,406 bp
  • A to G, chromosome 13 at 100,221,656 bp
  • A to G, chromosome 14 at 20,409,126 bp
  • C to A, chromosome 14 at 55,897,887 bp
  • G to A, chromosome 14 at 70,563,603 bp
  • T to A, chromosome 15 at 28,409,177 bp
  • T to G, chromosome 15 at 57,878,574 bp
  • T to A, chromosome 15 at 89,109,028 bp
  • C to T, chromosome 17 at 14,375,468 bp
  • A to T, chromosome 17 at 74,258,496 bp
  • A to T, chromosome 17 at 84,670,062 bp
  • C to T, chromosome 18 at 37,817,406 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7996 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
046036-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.