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Strain Name:
C57BL/6J-MtgxR7996Btlr/Mmmh
Stock Number:
046036-MU
Citation ID:
RRID:MMRRC_046036-MU
Other Names:
R7996 (G1)
Major Collection:

Strain Information

Ssu72
Name: Ssu72 RNA polymerase II CTD phosphatase homolog (yeast)
Synonyms: 2610101M12Rik, 1190002E22Rik, 1500011L16Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 68991
Homologene: 6754
Paics
Name: phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoribosylaminoimidazole, succinocarboxamide synthetase
Synonyms: ADE2H1, PAIS, AIRC, 2610511I09Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 67054
HGNC: HGNC:8587
Homologene: 4710
Rabggtb
Name: Rab geranylgeranyl transferase, b subunit
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 19352
HGNC: HGNC:9796
Homologene: 3371
Katnb1
Name: katanin p80 (WD40-containing) subunit B 1
Synonyms: KAT, 2410003J24Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 74187
HGNC: HGNC:6217
Homologene: 4302
Snx16
Name: sorting nexin 16
Synonyms: 4930522N22Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 74718
Homologene: 11169
Emsy
Name: EMSY, BRCA2-interacting transcriptional repressor
Synonyms: 2210018M11Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233545
Homologene: 32465
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to T, chromosome 1 at 28,778,406 bp
  • G to T, chromosome 1 at 36,317,445 bp
  • A to G, chromosome 1 at 87,191,106 bp
  • T to A, chromosome 2 at 65,150,985 bp
  • T to C, chromosome 2 at 89,844,415 bp
  • T to C, chromosome 2 at 105,001,349 bp
  • G to T, chromosome 3 at 10,435,449 bp
  • A to G, chromosome 3 at 90,213,002 bp
  • C to T, chromosome 3 at 127,595,924 bp
  • T to C, chromosome 3 at 153,911,968 bp
  • T to C, chromosome 4 at 3,605,842 bp
  • C to A, chromosome 4 at 11,201,347 bp
  • A to T, chromosome 4 at 46,533,086 bp
  • C to A, chromosome 4 at 126,136,874 bp
  • T to C, chromosome 4 at 139,020,861 bp
  • C to G, chromosome 4 at 154,892,455 bp
  • A to C, chromosome 4 at 155,731,993 bp
  • A to G, chromosome 5 at 8,443,653 bp
  • A to C, chromosome 5 at 9,462,881 bp
  • A to G, chromosome 5 at 76,959,429 bp
  • T to C, chromosome 6 at 115,823,417 bp
  • A to T, chromosome 7 at 10,047,868 bp
  • G to T, chromosome 7 at 34,263,599 bp
  • T to A, chromosome 7 at 98,593,681 bp
  • T to C, chromosome 7 at 112,842,104 bp
  • A to T, chromosome 8 at 70,720,497 bp
  • A to T, chromosome 8 at 95,098,015 bp
  • T to C, chromosome 9 at 14,593,705 bp
  • G to A, chromosome 9 at 35,909,354 bp
  • T to A, chromosome 9 at 38,727,828 bp
  • A to G, chromosome 9 at 46,273,565 bp
  • T to C, chromosome 10 at 33,768,258 bp
  • T to A, chromosome 10 at 41,894,933 bp
  • A to T, chromosome 10 at 78,847,321 bp
  • T to C, chromosome 11 at 46,405,062 bp
  • T to A, chromosome 11 at 72,400,374 bp
  • G to A, chromosome 11 at 80,257,537 bp
  • A to G, chromosome 11 at 85,834,790 bp
  • T to A, chromosome 12 at 44,282,983 bp
  • T to C, chromosome 12 at 76,004,667 bp
  • T to C, chromosome 13 at 13,359,406 bp
  • A to G, chromosome 13 at 100,221,656 bp
  • A to G, chromosome 14 at 20,409,126 bp
  • C to A, chromosome 14 at 55,897,887 bp
  • G to A, chromosome 14 at 70,563,603 bp
  • T to A, chromosome 15 at 28,409,177 bp
  • T to G, chromosome 15 at 57,878,574 bp
  • T to A, chromosome 15 at 89,109,028 bp
  • C to T, chromosome 17 at 14,375,468 bp
  • A to T, chromosome 17 at 74,258,496 bp
  • A to T, chromosome 17 at 84,670,062 bp
  • C to T, chromosome 18 at 37,817,406 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
Gene Specific Genotyping:

To request gene-specific and other genotyping services for a strain, please contact the distribution MMRRC Center for more information.

Background Genetic Quality:

The MMRRC has developed a Genetic Quality Control pipeline using the MiniMUGA array to provide additional information to identify and validate genetic backgrounds of MMRRC strains. For more information on whether genetic background data is available, please contact MMRRC_GeneticQC@med.unc.edu. Note: that MiniMUGA genetic background data is not available on all strains, but can be ordered if desired.

Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7996 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
046036-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.