Strain Name:
C57BL/6J-MtgxR7998Btlr/Mmmh
Stock Number:
046038-MU
Citation ID:
RRID:MMRRC_046038-MU
Other Names:
R7998 (G1)
Major Collection:

Strain Information

Shprh
Name: SNF2 histone linker PHD RING helicase
Synonyms: 2610103K11Rik, D230017O13Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 268281
Homologene: 6489
Dicer1
Name: dicer 1, ribonuclease type III
Synonyms: 1110006F08Rik, Dicer1, D12Ertd7e
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 192119
VEGA: 12
Homologene: 13251
Wrn
Name: Werner syndrome RecQ like helicase
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 22427
Homologene: 6659
Vcan
Name: versican
Synonyms: PG-M, hdf, heart defect, 5430420N07Rik, DPEAAE, Cspg2
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 13003
HGNC: HGNC:2464
Homologene: 3228
Kcnc1
Name: potassium voltage gated channel, Shaw-related subfamily, member 1
Synonyms: KShIIIB, Kcr2-1, Kv3.1, Shaw, C230009H10Rik, KV4, NGK2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 16502
HGNC: HGNC:6233
Homologene: 68134
Nrxn2
Name: neurexin II
Synonyms: 6430591O13Rik, neurexin II alpha, neurexin II beta
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 18190
HGNC: HGNC:8009
Homologene: 86984
Mix23
Name: mitochondrial matrix import factor 23
Synonyms: A930007B11Rik, Ccdc58
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 381045
VEGA: 16
Homologene: 18028
Nup188
Name: nucleoporin 188
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 227699
Homologene: 45683
Itsn1
Name: intersectin 1 (SH3 domain protein 1A)
Synonyms: Ese1, Sh3p17, Intersectin-L, Eh domain, SH3 domain regulator of endocytosis 1, EHSH1
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 16443
HGNC: HGNC:6183
Homologene: 2277
Alox12b
Name: arachidonate 12-lipoxygenase, 12R type
Synonyms: Aloxe2, e-LOX2, 12R-LOX
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 11686
HGNC: HGNC:430
Homologene: 884
Usp32
Name: ubiquitin specific peptidase 32
Synonyms: 6430526O11Rik, 2900074J03Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 237898
Homologene: 13066
Map4
Name: microtubule-associated protein 4
Synonyms: MAP 4, Mtap4
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 17758
HGNC: HGNC:6862
Homologene: 1780
Cog3
Name: component of oligomeric golgi complex 3
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 338337
VEGA: 14
Homologene: 5854
Leo1
Name: Leo1, Paf1/RNA polymerase II complex component
Synonyms: LOC235497
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235497
VEGA: 9
Homologene: 133895
Mier1
Name: MEIR1 treanscription regulator
Synonyms: 5830411K19Rik, 4933425I22Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 71148
Homologene: 136176
Itpr1
Name: inositol 1,4,5-trisphosphate receptor 1
Synonyms: Ip3r, IP3R1, Pcp1, opt, wblo, Itpr-1, Pcp-1, P400, InsP3R type I
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 16438
HGNC: HGNC:6180
Homologene: 1673
Nup107
Name: nucleoporin 107
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 103468
VEGA: 10
Homologene: 5555
Arid1b
Name: AT-rich interaction domain 1B
Synonyms: 9330189K18Rik, B230217J03Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 239985
Homologene: 32344
Ppp2r1a
Name: protein phosphatase 2, regulatory subunit A, alpha
Synonyms: 6330556D22Rik, PP2A, protein phosphatase PP2A, PR65
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 51792
HGNC: HGNC:9302
Homologene: 68559
Zmat3
Name: zinc finger matrin type 3
Synonyms: Wig1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 22401
Homologene: 32545
Cux2
Name: cut-like homeobox 2
Synonyms: Cutl2, ENSMUSG00000072641, Cux2, Cux-2, 1700051K22Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 13048
Homologene: 22426
Cpne6
Name: copine VI
Synonyms: neuronal copine
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 12891
HGNC: HGNC:2319
Homologene: 81815
Muc16
Name: mucin 16
Synonyms: 1110008I14Rik, LOC385009, Gm21044
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 73732
Homologene: 141193
Wdr36
Name: WD repeat domain 36
Synonyms: 5730444A13Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 225348
VEGA: 18
Homologene: 6536
Acsl3
Name: acyl-CoA synthetase long-chain family member 3
Synonyms: 2610510B12Rik, Facl3, C85929
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 74205
HGNC: HGNC:3570
Homologene: 3278
Ptov1
Name: prostate tumor over expressed gene 1
Synonyms: 1110030G05Rik, Gcap3
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 84113
HGNC: HGNC:9632
Homologene: 9687
G2e3
Name: G2/M-phase specific E3 ubiquitin ligase
Synonyms: 6030408C04Rik, D930034K21Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 217558
Homologene: 32362
Pla2g7
Name: phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
Synonyms: PAF acetylhydrolase, PAF-AH
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 27226
HGNC: HGNC:9040
Homologene: 3725
Astl
Name: astacin like metalloendopeptidase
Synonyms: C87576, Sas1b, Ovastacin
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 215095
Homologene: 128191
Mov10l1
Name: Mov10 like RISC complex RNA helicase 1
Synonyms: Csm, CHAMP
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 83456
HGNC: HGNC:7201
Homologene: 56835
Cib1
Name: calcium and integrin binding 1
Synonyms: Kip
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 23991
Homologene: 4654
Med28
Name: mediator complex subunit 28
Synonyms: Eg1, 1500003D12Rik, magicin
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 66999
Homologene: 11873
Ttn
Name: titin
Synonyms: connectin, L56, mdm, 1100001C23Rik, D830007G01Rik, 2310036G12Rik, 2310074I15Rik, 2310057K23Rik, D330041I19Rik, shru
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 22138
Homologene: 130650
Mroh7
Name: maestro heat-like repeat family member 7
Synonyms: LOC381538, Gm1027, Heatr8
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 381538
Homologene: 19633
Syne2
Name: spectrin repeat containing, nuclear envelope 2
Synonyms: nesprin-2, syne-2, D12Ertd777e, 6820443O06Rik, Nesp2g, Cpfl8, diminished cone electroretinogram, dice
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 319565
Homologene: 56700
Csn1s1
Name: casein alpha s1
Synonyms: Csna
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 12990
HGNC: HGNC:2445
Sdk2
Name: sidekick cell adhesion molecule 2
Synonyms: 5330435L01Rik, 4632412F08Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 237979
Homologene: 10406
Gm10800
Name: predicted gene 10800
Type: Gene
Species: Mouse
Chromosome: 2
Mast3
Name: microtubule associated serine/threonine kinase 3
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 546071
Homologene: 66191
Fbxw16
Name: F-box and WD-40 domain protein 16
Synonyms: 7420402K12Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 320083
Homologene: 110776
Vmn2r88
Name: vomeronasal 2, receptor 88
Synonyms: V2r13, V2r3
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 669149
Homologene: 129606
Ttll9
Name: tubulin tyrosine ligase-like family, member 9
Synonyms: 4930509O20Rik, 1700016F23Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 74711
Homologene: 41769
Or5ac23
Name: olfactory receptor family 5 subfamily AC member 23
Synonyms: MOR182-11P, GA_x54KRFPKG5P-55543875-55542958, Olfr205
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 257881
Homologene: 79469
Chl1
Name: cell adhesion molecule L1-like
Synonyms: LICAM2, CALL, A530023M13Rik, close homolog of L1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 12661
HGNC: HGNC:1939
Homologene: 21314
Or13f5
Name: olfactory receptor family 13 subfamily F member 5
Synonyms: GA_x6K02T2N78B-7168533-7167574, MOR262-2, Olfr275
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 258857
Homologene: 17418
Ttc41
Name: tetratricopeptide repeat domain 41
Synonyms: Gnn, BC030307
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 103220
VEGA: 10
Homologene: 52968
Slc28a2b
Name: solute carrier family 28 member 2b
Synonyms: Gm14085
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 381417
Gstm7
Name: glutathione S-transferase, mu 7
Synonyms: 0610005A07Rik, Cd203c
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 68312
HGNC: HGNC:4634
Homologene: 41816
Tmprss15
Name: transmembrane protease, serine 15
Synonyms: enteropeptidase, enterokinase, A130097D21Rik, Prss7
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 19146
HGNC: HGNC:9490
Homologene: 2075
Themis2
Name: thymocyte selection associated family member 2
Synonyms: ICB-1, BC013712
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230787
Homologene: 21009
Prex1
Name: phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1
Synonyms: P-REX1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 277360
Homologene: 10821
Gpr137b
Name: G protein-coupled receptor 137B
Synonyms: Tm7sf1, 2310041G17Rik, C80741
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 83924
VEGA: 13
Homologene: 2454
Dsc2
Name: desmocollin 2
Synonyms: Dsc2b, Dsc2a
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 13506
HGNC: HGNC:3036
Homologene: 8397
Npffr2
Name: neuropeptide FF receptor 2
Synonyms: NPFF2, Gpr74
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 104443
HGNC: HGNC:4525
Homologene: 56982
Ciao2b
Name: cytosolic iron-sulfur assembly component 2B
Synonyms: Fam96b, 1110019N10Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 68523
Homologene: 6115
4930474N05Rik
Name: RIKEN cDNA 4930474N05 gene
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 218921
Homologene: 138428
Itga7
Name: integrin alpha 7
Synonyms: alpha7, [a]7
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 16404
VEGA: 10
HGNC: HGNC:6143
Homologene: 37592
Hspa8
Name: heat shock protein 8
Synonyms: 2410008N15Rik, Hsc73, Hsc71, Hsp73, Hsc70
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 15481
HGNC: HGNC:5241
Homologene: 68524
Nemp1
Name: nuclear envelope integral membrane protein 1
Synonyms: Tmem194
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 210035
Homologene: 18346
Btbd7
Name: BTB domain containing 7
Synonyms: FUP1, E130118E17Rik, 5730507E09Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 238386
VEGA: 12
Homologene: 34300
Gpr18
Name: G protein-coupled receptor 18
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 110168
VEGA: 14
HGNC: HGNC:4472
Homologene: 18814
Reg3a
Name: regenerating islet-derived 3 alpha
Synonyms: RegIII (alpha)
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 19694
HGNC: HGNC:8601
Homologene: 136247
Gm10837
Name: predicted gene 10837
Type: Gene
Species: Mouse
Chromosome: 14
Larp6
Name: La ribonucleoprotein 6, translational regulator
Synonyms: Achn, 5430431G03Rik, acheron
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 67557
Homologene: 32408
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to T, chromosome 1 at 78,694,271 bp
  • T to C, chromosome 2 at 30,330,971 bp
  • C to A, chromosome 2 at 76,903,309 bp
  • A to AC, chromosome 2 at 98,667,033 bp
  • T to C, chromosome 2 at 122,494,358 bp
  • T to C, chromosome 2 at 127,350,499 bp
  • T to C, chromosome 2 at 152,991,626 bp
  • A to G, chromosome 2 at 166,587,045 bp
  • T to C, chromosome 3 at 32,341,666 bp
  • T to A, chromosome 3 at 107,930,341 bp
  • A to T, chromosome 4 at 52,825,970 bp
  • T to C, chromosome 4 at 103,162,615 bp
  • T to C, chromosome 4 at 106,711,281 bp
  • A to G, chromosome 4 at 132,792,564 bp
  • T to A, chromosome 5 at 45,525,199 bp
  • A to G, chromosome 5 at 87,674,228 bp
  • T to C, chromosome 5 at 89,583,290 bp
  • T to C, chromosome 5 at 121,868,585 bp
  • T to C, chromosome 6 at 78,381,149 bp
  • T to C, chromosome 6 at 103,729,289 bp
  • T to C, chromosome 6 at 108,417,948 bp
  • A to G, chromosome 7 at 44,864,929 bp
  • A to G, chromosome 7 at 46,397,799 bp
  • A to T, chromosome 7 at 80,228,414 bp
  • T to C, chromosome 8 at 33,292,643 bp
  • A to G, chromosome 8 at 70,783,570 bp
  • T to A, chromosome 8 at 104,641,036 bp
  • G to T, chromosome 9 at 18,639,892 bp
  • A to G, chromosome 9 at 40,804,514 bp
  • A to G, chromosome 9 at 60,724,355 bp
  • G to T, chromosome 9 at 75,445,276 bp
  • A to G, chromosome 9 at 109,436,698 bp
  • G to A, chromosome 9 at 110,079,861 bp
  • T to A, chromosome 10 at 11,185,341 bp
  • C to A, chromosome 10 at 86,736,847 bp
  • A to G, chromosome 10 at 117,757,994 bp
  • C to A, chromosome 10 at 127,693,489 bp
  • T to C, chromosome 10 at 128,934,151 bp
  • T to C, chromosome 11 at 69,168,837 bp
  • G to T, chromosome 11 at 84,994,426 bp
  • T to A, chromosome 11 at 113,859,938 bp
  • A to T, chromosome 12 at 51,353,841 bp
  • T to C, chromosome 12 at 76,087,858 bp
  • A to C, chromosome 12 at 102,795,240 bp
  • A to T, chromosome 12 at 104,704,069 bp
  • T to C, chromosome 13 at 13,359,406 bp
  • T to A, chromosome 13 at 89,704,327 bp
  • C to T, chromosome 14 at 36,096,692 bp
  • T to C, chromosome 14 at 51,414,108 bp
  • A to C, chromosome 14 at 55,516,294 bp
  • G to T, chromosome 14 at 75,747,093 bp
  • T to C, chromosome 14 at 121,911,981 bp
  • G to T, chromosome 14 at 122,490,641 bp
  • T to A, chromosome 15 at 89,053,439 bp
  • T to A, chromosome 16 at 36,085,033 bp
  • T to A, chromosome 16 at 59,329,270 bp
  • C to A, chromosome 16 at 79,001,843 bp
  • G to T, chromosome 16 at 91,850,936 bp
  • A to G, chromosome 17 at 5,327,684 bp
  • T to C, chromosome 17 at 20,961,639 bp
  • A to T, chromosome 17 at 43,611,318 bp
  • T to A, chromosome 18 at 20,034,663 bp
  • T to G, chromosome 18 at 32,852,519 bp
  • T to C, chromosome 19 at 6,509,875 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7998 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
046038-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.