Strain Name:
C57BL/6J-MtgxR8003Btlr/Mmmh
Stock Number:
046043-MU
Citation ID:
RRID:MMRRC_046043-MU
Other Names:
R8003 (G1)
Major Collection:

Strain Information

Lars1
Name: leucyl-tRNA synthetase 1
Synonyms: 3110009L02Rik, Lars, 2310045K21Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 107045
VEGA: 18
HGNC: HGNC:6512
Homologene: 7083
Arfgef2
Name: ADP ribosylation factor guanine nucleotide exchange factor 2
Synonyms: BIG2, E230011G24Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 99371
Homologene: 111880
Tnpo3
Name: transportin 3
Synonyms: C430013M08Rik, D6Ertd313e, 5730544L10Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 320938
Homologene: 40848
Ephx2
Name: epoxide hydrolase 2, cytoplasmic
Synonyms: sEP, sEH, Eph2
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 13850
VEGA: 14
HGNC: HGNC:3402
Homologene: 37558
Mthfd1l
Name: methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like
Synonyms: Fthfsdc1, 2410004L15Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 270685
Homologene: 56706
Ybx3
Name: Y box protein 3
Synonyms: oxyR, dbpA, MSY3, Yb2, Dpba, Csda, MSY4
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 56449
HGNC: HGNC:2428
Homologene: 2708
Dhx38
Name: DEAH-box helicase 38
Synonyms: Ddx38, Prp16, 5730550P09Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 64340
Homologene: 8512
Sulf1
Name: sulfatase 1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 240725
Homologene: 49408
Herc2
Name: HECT and RLD domain containing E3 ubiquitin protein ligase 2
Synonyms: D15F32S1h, D7H15F37S1, jdf2, rjs, D7H15F32S1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 15204
HGNC: HGNC:4868
Homologene: 3430
Brca1
Name: breast cancer 1, early onset
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 12189
HGNC: HGNC:1100
Homologene: 5276
Slc45a4
Name: solute carrier family 45, member 4
Synonyms: 9330175B01Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 106068
Homologene: 69908
Cct4
Name: chaperonin containing TCP1 subunit 4
Synonyms: 2610204B21Rik, A45, TCP-1 delta, Cctd, T complex protein 1, delta
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 12464
HGNC: HGNC:1617
Homologene: 4695
Dclk2
Name: doublecortin-like kinase 2
Synonyms: Dcamkl2, 6330415M09Rik, Click-II
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 70762
Homologene: 69431
Lrpprc
Name: leucine-rich PPR-motif containing
Synonyms: Lrp130, 3110001K13Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 72416
Homologene: 32695
Adcy4
Name: adenylate cyclase 4
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 104110
VEGA: 14
HGNC: HGNC:235
Homologene: 23149
Hectd4
Name: HECT domain E3 ubiquitin protein ligase 4
Synonyms: Gm15800
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 269700
Homologene: 28297
Wnt8b
Name: wingless-type MMTV integration site family, member 8B
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 22423
VEGA: 19
Homologene: 2550
Pkd2l2
Name: polycystic kidney disease 2-like 2
Synonyms: TRPP5, Polycystin - L2
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 53871
VEGA: 18
HGNC: HGNC:9012
Homologene: 22812
Trim9
Name: tripartite motif-containing 9
Synonyms: C030048G07Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 94090
VEGA: 12
Homologene: 9045
Myh8
Name: myosin, heavy polypeptide 8, skeletal muscle, perinatal
Synonyms: Myhs-p, 4832426G23Rik, Myhsp, MyHC-pn
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 17885
HGNC: HGNC:7578
Homologene: 68256
Col6a3
Name: collagen, type VI, alpha 3
Synonyms: Col6a-3
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12835
HGNC: HGNC:2213
Homologene: 37917
Slc24a2
Name: solute carrier family 24 (sodium/potassium/calcium exchanger), member 2
Synonyms: 6330417K15Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 76376
Homologene: 10669
Cass4
Name: Cas scaffolding protein family member 4
Synonyms: F730031O20Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 320664
Homologene: 75128
Eif2ak2
Name: eukaryotic translation initiation factor 2-alpha kinase 2
Synonyms: 4732414G15Rik, 2310047A08Rik, Pkr, IFN-induced and double-stranded RNA-activated kinase, IFN- type I-induced and dsRNA-activated kinase, dsRNA-activated kinase, Tik, eIF-2 alpha, eIF-2 alpha, Prkr
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 19106
HGNC: HGNC:9437
Homologene: 48134
Wdr41
Name: WD repeat domain 41
Synonyms: MSTP048, B830029I03Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 218460
Homologene: 23087
Kmt2b
Name: lysine (K)-specific methyltransferase 2B
Synonyms: 2610014H22Rik, Wbp7, Mll2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 75410
Homologene: 22838
Gtf3c5
Name: general transcription factor IIIC, polypeptide 5
Synonyms: TFIIIC63, 2700084A09Rik, TFiiiC2-63, TFIIICepsilon
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 70239
HGNC: HGNC:4668
Homologene: 40806
Slc7a4
Name: solute carrier family 7 (cationic amino acid transporter, y+ system), member 4
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 224022
Homologene: 20883
Vmn2r80
Name: vomeronasal 2, receptor 80
Synonyms: EG624765
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 624765
Homologene: 83483
Fbxw10
Name: F-box and WD-40 domain protein 10
Synonyms: Fbw10, SM25H2, SM2SH2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 213980
Homologene: 32757
Zmynd15
Name: zinc finger, MYND-type containing 15
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 574428
Homologene: 12995
Mybpc2
Name: myosin binding protein C, fast-type
Synonyms: Fast-type C-protein
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233199
HGNC: HGNC:7550
Homologene: 3331
Csmd2
Name: CUB and Sushi multiple domains 2
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 329942
Homologene: 89034
Map3k6
Name: mitogen-activated protein kinase kinase kinase 6
Synonyms: MAPKKK6, Ask2, MEKK6
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 53608
HGNC: HGNC:6858
Homologene: 3435
Plch2
Name: phospholipase C, eta 2
Synonyms: Plcl4, PLCeta2, A930027K05Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 269615
Homologene: 85172
Ccdc178
Name: coiled coil domain containing 178
Synonyms: 4921528I01Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 70950
VEGA: 18
Homologene: 12373
Col5a1
Name: collagen, type V, alpha 1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 12831
HGNC: HGNC:2209
Homologene: 55434
Npc1l1
Name: NPC1 like intracellular cholesterol transporter 1
Synonyms: 9130221N23Rik, Niemann-Pick disease, type C1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 237636
HGNC: HGNC:7898
Homologene: 56585
Galnt13
Name: polypeptide N-acetylgalactosaminyltransferase 13
Synonyms: pp-GalNAc-T13
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 271786
Homologene: 62167
Ptpre
Name: protein tyrosine phosphatase receptor type E
Synonyms: PTPe, RPTPepsilon, PTPepsilon
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 19267
HGNC: HGNC:9669
Homologene: 31387
Or5d37
Name: olfactory receptor family 5 subfamily D member 37
Synonyms: Olfr1164, MOR174-11, GA_x6K02T2Q125-49585842-49584862
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258634
Homologene: 74077
Rgs6
Name: regulator of G-protein signaling 6
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 50779
Homologene: 68385
Sbds
Name: SBDS ribosome maturation factor
Synonyms: Shwachman-Bodian-Diamond syndrome homolog (human), 4733401P19Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 66711
Homologene: 6438
Psg22
Name: pregnancy-specific beta-1-glycoprotein 22
Synonyms: cea9
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 243862
HGNC: HGNC:1816
Homologene: 110989
C2cd2
Name: C2 calcium-dependent domain containing 2
Synonyms: 5830404H04Rik, ORF25
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 207781
VEGA: 16
HGNC: HGNC:1266
Homologene: 18368
Mylip
Name: myosin regulatory light chain interacting protein
Synonyms: Mir, Idol, 9430057C20Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 218203
VEGA: 13
Homologene: 8309
Mtmr6
Name: myotubularin related protein 6
Synonyms: Gm38641, 4022440C11Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 219135
VEGA: 14
HGNC: HGNC:7453
Homologene: 55842
Slc1a7
Name: solute carrier family 1 (glutamate transporter), member 7
Synonyms: EAAT5, A930031E15Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242607
Homologene: 21327
Syt1
Name: synaptotagmin I
Synonyms: G630098F17Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 20979
Homologene: 4122
Or12e13
Name: olfactory receptor family 12 subfamily E member 13
Synonyms: GA_x6K02T2Q125-49334566-49335510, MOR264-7, Olfr1148
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258220
Homologene: 79465
Cish
Name: cytokine inducible SH2-containing protein
Synonyms: CIS1, Cis, F23, cytokine-inducible SH2 protein
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 12700
HGNC: HGNC:1984
Homologene: 7667
Gm5591
Name: predicted gene 5591
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 434171
Homologene: 80005
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to A, chromosome 1 at 12,838,601 bp
  • G to T, chromosome 1 at 90,775,733 bp
  • G to A, chromosome 2 at 27,958,328 bp
  • A to G, chromosome 2 at 28,569,361 bp
  • G to T, chromosome 2 at 55,060,485 bp
  • A to G, chromosome 2 at 87,833,737 bp
  • A to T, chromosome 2 at 88,093,245 bp
  • A to G, chromosome 2 at 166,853,288 bp
  • T to C, chromosome 2 at 172,427,959 bp
  • T to C, chromosome 3 at 86,793,301 bp
  • A to T, chromosome 4 at 87,176,315 bp
  • T to C, chromosome 4 at 101,835,933 bp
  • G to A, chromosome 4 at 108,012,276 bp
  • T to A, chromosome 4 at 128,539,187 bp
  • A to G, chromosome 4 at 133,248,882 bp
  • C to T, chromosome 4 at 155,054,523 bp
  • G to A, chromosome 5 at 121,339,518 bp
  • C to A, chromosome 5 at 130,250,885 bp
  • C to A, chromosome 6 at 29,551,901 bp
  • A to T, chromosome 6 at 131,368,437 bp
  • A to C, chromosome 7 at 18,724,425 bp
  • G to T, chromosome 7 at 30,569,377 bp
  • G to T, chromosome 7 at 38,519,759 bp
  • A to T, chromosome 7 at 44,509,064 bp
  • A to G, chromosome 7 at 56,168,904 bp
  • C to A, chromosome 7 at 135,669,036 bp
  • A to T, chromosome 8 at 109,556,140 bp
  • T to C, chromosome 9 at 107,297,028 bp
  • T to G, chromosome 10 at 3,984,147 bp
  • T to C, chromosome 10 at 79,148,877 bp
  • T to C, chromosome 10 at 108,636,573 bp
  • T to C, chromosome 11 at 6,215,129 bp
  • T to C, chromosome 11 at 22,996,040 bp
  • T to G, chromosome 11 at 62,857,761 bp
  • T to A, chromosome 11 at 67,299,760 bp
  • T to A, chromosome 11 at 70,460,941 bp
  • C to T, chromosome 11 at 101,524,477 bp
  • T to C, chromosome 12 at 70,346,834 bp
  • T to C, chromosome 12 at 82,985,370 bp
  • T to A, chromosome 13 at 45,404,471 bp
  • C to A, chromosome 13 at 95,013,146 bp
  • A to G, chromosome 14 at 55,781,635 bp
  • G to A, chromosome 14 at 60,282,095 bp
  • A to G, chromosome 14 at 66,124,333 bp
  • G to T, chromosome 15 at 73,585,313 bp
  • A to C, chromosome 16 at 17,574,451 bp
  • A to G, chromosome 16 at 97,886,086 bp
  • C to A, chromosome 17 at 78,876,223 bp
  • A to C, chromosome 17 at 84,752,317 bp
  • A to T, chromosome 18 at 21,844,887 bp
  • G to A, chromosome 18 at 34,428,179 bp
  • A to T, chromosome 18 at 42,221,619 bp
  • T to A, chromosome 19 at 44,511,957 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8003 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
046043-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.