Strain Name:
C57BL/6J-MtgxR8010Btlr/Mmmh
Stock Number:
046050-MU
Citation ID:
RRID:MMRRC_046050-MU
Other Names:
R8010 (G1)
Major Collection:

Strain Information

Kitl
Name: kit ligand
Synonyms: SF, blz, SLF, SCF, Gb, Kitlg, Steel factor, Sl, stem cell factor, Mgf, grizzle-belly, Steel
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 17311
HGNC: HGNC:6343
Homologene: 692
Dicer1
Name: dicer 1, ribonuclease type III
Synonyms: D12Ertd7e, Dicer1, 1110006F08Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 192119
VEGA: 12
Homologene: 13251
Krt5
Name: keratin 5
Synonyms: 3300001P10Rik, K5, Krt2-5, Tfip8
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 110308
HGNC: HGNC:6442
Homologene: 55461
Plcb4
Name: phospholipase C, beta 4
Synonyms: A930039J07Rik, C230058B11Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 18798
HGNC: HGNC:9059
Homologene: 8471
Hnrnpll
Name: heterogeneous nuclear ribonucleoprotein L-like
Synonyms: Hnrpll, 2810036L13Rik, 2510028H02Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 72692
Homologene: 26701
Abca1
Name: ATP-binding cassette, sub-family A member 1
Synonyms: ABC1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 11303
HGNC: HGNC:29
Homologene: 21130
Xdh
Name: xanthine dehydrogenase
Synonyms: Xox1, Xox-1, xanthine oxidase, Xor, XO
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 22436
VEGA: 17
Homologene: 324
Ecpas
Name: Ecm29 proteasome adaptor and scaffold
Synonyms: AI314180
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230249
Homologene: 6056
Cd55
Name: CD55 molecule, decay accelerating factor for complement
Synonyms: Cromer blood group, Daf-GPI, GPI-DAF, complement-glycosylphosphatidylinositol, Daf1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 13136
HGNC: HGNC:2665
Homologene: 479
Jcad
Name: junctional cadherin 5 associated
Synonyms: 9430020K01Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 240185
VEGA: 18
Homologene: 19370
Scn10a
Name: sodium channel, voltage-gated, type X, alpha
Synonyms: Nav1.8
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 20264
VEGA: 9
Homologene: 21300
Tdp2
Name: tyrosyl-DNA phosphodiesterase 2
Synonyms: D13Ertd656e, Ttrap
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 56196
Homologene: 9591
Tpd52l1
Name: tumor protein D52-like 1
Synonyms: D53
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 21987
VEGA: 10
Homologene: 2468
Arhgdib
Name: Rho, GDP dissociation inhibitor beta
Synonyms: D4, Ly-GDI, Gdid4
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 11857
HGNC: HGNC:679
Homologene: 20318
Mtmr4
Name: myotubularin related protein 4
Synonyms: ZFYVE11, ESTM44, FYVE-DSP2, FYVE zinc finger phosphatase
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 170749
HGNC: HGNC:7452
Homologene: 3440
Ddr1
Name: discoidin domain receptor family, member 1
Synonyms: CD167a, Cak
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 12305
HGNC: HGNC:2730
Homologene: 68212
Dnajc6
Name: DnaJ heat shock protein family (Hsp40) member C6
Synonyms: auxilin, 2810027M23Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 72685
Homologene: 8865
Cep164
Name: centrosomal protein 164
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 214552
Homologene: 51110
Cubn
Name: cubilin
Synonyms: intrinsic factor-cobalamin receptor, D2Wsu88e
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 65969
HGNC: HGNC:2548
Homologene: 37434
Sell
Name: selectin, lymphocyte
Synonyms: Ly-22, Lyam1, L-selectin, CD62L, LECAM-1, Ly-m22, Lnhr, Lyam-1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 20343
Homologene: 539
Ptpn13
Name: protein tyrosine phosphatase, non-receptor type 13
Synonyms: PTP-BL, PTPL1, Ptpri
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 19249
HGNC: HGNC:9646
Homologene: 7909
Mrm3
Name: mitochondrial rRNA methyltransferase 3
Synonyms: Rnmtl1, 4833420N02Rik, HC90
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 67390
Homologene: 10033
Syne2
Name: spectrin repeat containing, nuclear envelope 2
Synonyms: D12Ertd777e, Cpfl8, dice, 6820443O06Rik, nesprin-2, syne-2, Nesp2g, diminished cone electroretinogram
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 319565
Homologene: 56700
Tet3
Name: tet methylcytosine dioxygenase 3
Synonyms: B430006D22Rik, D230004J03Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 194388
Homologene: 35360
Chsy3
Name: chondroitin sulfate synthase 3
Synonyms: 4833446K15Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 78923
VEGA: 18
Homologene: 28624
Atp1a3
Name: ATPase, Na+/K+ transporting, alpha 3 polypeptide
Synonyms: Atpa-2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 232975
HGNC: HGNC:801
Homologene: 113729
Wdfy4
Name: WD repeat and FYVE domain containing 4
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 545030
Homologene: 83473
Gm7298
Name: predicted gene 7298
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 640530
HGNC: HGNC:9750
Mapk4
Name: mitogen-activated protein kinase 4
Synonyms: Erk3-related, p63Mapk, A330097D03Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 225724
HGNC: HGNC:6878
Homologene: 2058
A2ml1
Name: alpha-2-macroglobulin like 1
Synonyms: Ovos2, BC048546
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232400
Homologene: 45969
Rbbp8
Name: retinoblastoma binding protein 8, endonuclease
Synonyms: CtIP, 9930104E21Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 225182
VEGA: 18
HGNC: HGNC:9891
Homologene: 28546
Sp140l2
Name: Sp140 nuclear body protein like 2
Synonyms: C130026I21Rik, OTTMUSG00000029174
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 620078
Homologene: 131208
Rpap2
Name: RNA polymerase II associated protein 2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231571
Homologene: 11733
Frmpd1
Name: FERM and PDZ domain containing 1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 666060
Homologene: 8939
Aoc1
Name: amine oxidase, copper-containing 1
Synonyms: Abp1, 1600012D06Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 76507
HGNC: HGNC:80
Homologene: 68159
Pla2r1
Name: phospholipase A2 receptor 1
Synonyms: Pla2g1br, PLA2-I receptor, M-type receptor
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 18779
HGNC: HGNC:9042
Homologene: 32016
Atrnl1
Name: attractin like 1
Synonyms: Alp
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 226255
VEGA: 19
Homologene: 45809
Megf6
Name: multiple EGF-like-domains 6
Synonyms: Egfl3, 2600001P17Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230971
HGNC: HGNC:3232
Homologene: 45412
Psg20
Name: pregnancy-specific beta-1-glycoprotein 20
Synonyms: cea7, EG434540
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 434540
Homologene: 110989
Nek8
Name: NIMA (never in mitosis gene a)-related expressed kinase 8
Synonyms: 4632401F23Rik, b2b1449Clo
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 140859
Homologene: 84442
Cttnbp2
Name: cortactin binding protein 2
Synonyms: Cortbp2, 3010022N24Rik, 4732477G22Rik, ORF4, 9130022E09Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 30785
Homologene: 14125
Xirp1
Name: xin actin-binding repeat containing 1
Synonyms: Cmya1, mXin alpha, Xin
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 22437
VEGA: 9
Homologene: 7998
Ttll10
Name: tubulin tyrosine ligase-like family, member 10
Synonyms: Ttll5, 4930595O22Rik, 4833412E22Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 330010
Homologene: 51912
Or13g1
Name: olfactory receptor family 13 subfamily G member 1
Synonyms: GA_x6K02T2NHDJ-9801340-9802266, MOR251-4P, Olfr309
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258196
Homologene: 47595
Fbh1
Name: F-box DNA helicase 1
Synonyms: Fbx18, Fbxo18
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 50755
Homologene: 9272
Wars2
Name: tryptophanyl tRNA synthetase 2 (mitochondrial)
Synonyms: 9430020O07Rik, TrpRS
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 70560
Homologene: 5673
Rgs18
Name: regulator of G-protein signaling 18
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 64214
Homologene: 11281
Or5ac21
Name: olfactory receptor family 5 subfamily AC member 21
Synonyms: MOR182-5, Olfr203, GA_x54KRFPKG5P-55517445-55518365
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 258479
Homologene: 122781
Or7g30
Name: olfactory receptor family 7 subfamily G member 30
Synonyms: MOR151-1, Olfr849, GA_x6K02T2PVTD-13176842-13177780
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258520
HGNC: HGNC:8466
Homologene: 74179
Slc14a1
Name: solute carrier family 14 (urea transporter), member 1
Synonyms: UT-B, 3021401A05Rik, 2610507K20Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 108052
Homologene: 9285
Krtap5-5
Name: keratin associated protein 5-5
Synonyms: A030001H12Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 114666
Ccdc107
Name: coiled-coil domain containing 107
Synonyms: 1110032O22Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 622404
Homologene: 52163
Cdc42ep1
Name: CDC42 effector protein 1
Synonyms: 1810058K22Rik, CEP1, MSE55, Borg5
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 104445
VEGA: 15
Homologene: 5128
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to A, chromosome 1 at 85,246,950 bp
  • A to T, chromosome 1 at 130,459,616 bp
  • A to G, chromosome 1 at 144,756,000 bp
  • C to T, chromosome 1 at 164,065,512 bp
  • A to T, chromosome 2 at 11,767,632 bp
  • A to G, chromosome 2 at 13,336,086 bp
  • T to C, chromosome 2 at 60,514,960 bp
  • C to T, chromosome 2 at 135,907,560 bp
  • C to A, chromosome 3 at 99,216,830 bp
  • G to T, chromosome 4 at 43,495,768 bp
  • T to A, chromosome 4 at 45,284,272 bp
  • A to G, chromosome 4 at 53,127,600 bp
  • T to A, chromosome 4 at 58,832,681 bp
  • C to T, chromosome 4 at 101,618,414 bp
  • T to C, chromosome 4 at 154,270,507 bp
  • T to C, chromosome 4 at 156,047,161 bp
  • C to T, chromosome 5 at 103,559,937 bp
  • G to A, chromosome 5 at 107,603,605 bp
  • G to C, chromosome 6 at 18,426,093 bp
  • T to C, chromosome 6 at 48,905,648 bp
  • A to T, chromosome 6 at 83,403,246 bp
  • A to G, chromosome 6 at 121,735,583 bp
  • T to A, chromosome 6 at 128,580,340 bp
  • A to G, chromosome 6 at 136,926,722 bp
  • T to C, chromosome 7 at 18,681,067 bp
  • T to A, chromosome 7 at 24,980,645 bp
  • T to A, chromosome 7 at 86,307,052 bp
  • T to C, chromosome 7 at 142,229,911 bp
  • A to T, chromosome 9 at 19,441,692 bp
  • A to T, chromosome 9 at 45,823,671 bp
  • C to T, chromosome 9 at 119,661,167 bp
  • T to A, chromosome 9 at 120,017,824 bp
  • T to G, chromosome 10 at 31,358,013 bp
  • A to T, chromosome 10 at 100,051,903 bp
  • A to T, chromosome 11 at 76,250,347 bp
  • T to C, chromosome 11 at 78,176,596 bp
  • T to G, chromosome 11 at 87,598,864 bp
  • A to T, chromosome 12 at 75,930,738 bp
  • C to A, chromosome 12 at 104,692,132 bp
  • C to T, chromosome 13 at 24,836,027 bp
  • C to A, chromosome 14 at 32,971,627 bp
  • C to T, chromosome 14 at 47,705,773 bp
  • C to T, chromosome 15 at 78,847,799 bp
  • T to C, chromosome 15 at 101,712,356 bp
  • T to C, chromosome 16 at 59,303,504 bp
  • T to A, chromosome 17 at 35,691,492 bp
  • A to T, chromosome 17 at 73,909,317 bp
  • T to C, chromosome 17 at 80,061,956 bp
  • A to G, chromosome 18 at 4,674,581 bp
  • A to T, chromosome 18 at 11,722,233 bp
  • A to G, chromosome 18 at 59,410,154 bp
  • A to T, chromosome 18 at 73,930,576 bp
  • A to T, chromosome 18 at 78,116,489 bp
  • T to C, chromosome 19 at 57,682,446 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8010 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
046050-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.