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Zfp106 (formerly H3a) and H3b are minor histocompatibility genes that comprise the H3 locus. This strain, also known as "R19" is a minor histocompatibility congenic strain that carries the closely linked Zfp106H3a-b B2ma alleles derived from the LP strain on a C57BL/10Sn background. The companion MMRRC:50798 (also known as "R03") carries the LP-derived Zfp106H3a-b B2ma and H3bb alleles on a C57BL/10Sn background. Mice homozygous for the LP-derived alleles are viable and fertile.
Corneal allografts are one of the most common and successful tissue transplants in part because the cornea and anterior segment of the eye are immune-privileged sites and do not require major histocompatibility complex (MHC) matching. However, those grafts that are rejected express minor histocompatibility (H) alloantigens. Corneal and skin allografts between R03 and R19 result in rejection of R03 donor corneas (expressing the H3bb allele) by R19 recipients but not the reverse. R19 mice and R03 mice provide a tool to dissect the role of the minor H3 alloantigens in corneal and skin allografts.
Haskova Z, Sproule TJ, Roopenian DC, Ksander AB. An immunodominant minorhistocompatibility alloantigen that initiates corneal allograft rejection.Transplantation. 2003 Apr 27;75(8):1368-74. (Medline PMID: 12717232)
Roopenian DC, Davis AP, Christianson GJ, Mobraaten LE. The functional basis ofminor histocompatibility loci. J Immunol. 1993 Nov 1;151(9):4595-605. (Medline PMID: 8409421)
Michaelson J. Genetics of beta-2 microglobulin in the mouse. Immunogenetics.1983;17(3):219-60. Review. (Medline PMID: 6187676)
Cryo-recovered strains distributed by the MMRRC at JAX are shipped to the customer from the Pathogen & Opportunistic-Free Animal Room G200 - see https://www.jax.org/jax-mice-and-services/customer-support/customer-service/animal-health/health-status-reports.
Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.
Cryopreserved material may be available upon request, please inquire to csmmrrc@jax.org for more information.
Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.
Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.
1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.
2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.
3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.
4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.