Strain Name:
B6.C3-Vangl2Lp-m1Jus/Mmucd
Stock Number:
000057-UCD
Citation ID:
RRID:MMRRC_000057-UCD
Other Names:
Looptail-m1Jus, Skam14Jus , B6.C3-Vangl2Lp-m1Jus/Mmcd

Strain Information

Vangl2Lp-m1Jus
Name: VANGL planar cell polarity 2; loop tail, mutation 1, Monica J Justice
Synonyms: Lpm1J
Type: Allele
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
Vangl2
Name: VANGL planar cell polarity 2
Synonyms: Lootl, loop-tail, skam17Jus, strabismus, Lpp1, Ltap, ska17, C530001F03Rik
Type: Gene
Species: Mouse
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 93840
Homologene: 62161
Genetic Alterations
A transversion point mutation that alters a T to an A at position 765. This mutation is predicted to change aspartate 255 to glutamate in the encoded protein.
Genotype Determination
Phenotype
Neural tube defects in homozygous lethal and looped tails in heterozygotes.
Mammalian Phenotype Terms
Allelic Composition: Vangl2Lp-m1Jus/Vangl2Lp-m1Jus (Genetic Background: involves: 101/Rl * C3H/Rl * C57BL/6J )

Allelic Composition: Vangl2Lp-m1Jus/Vangl2+ (Genetic Background: involves: 101/Rl * C3H/Rl * C57BL/6J )

Allelic Composition: Vangl2Lp/Vangl2Lp-m1Jus (Genetic Background: involves: 101/Rl * C3H/Rl * C57BL/6J * LPT/LeJ )

MeSH Terms
  • Amino Acid Sequence
  • Animals
  • Cloning, Molecular
  • DNA, Complementary/genetics
  • Drosophila/genetics
  • Drosophila Proteins
  • In Situ Hybridization
  • Membrane Proteins/genetics
  • Mice
  • Mice, Inbred Strains/genetics
  • Molecular Sequence Data
  • Mutation
  • Nerve Tissue Proteins/genetics
  • Neural Tube Defects/genetics
  • Sequence Homology, Amino Acid
  • Tissue Distribution
  • Alkylating Agents/toxicity
  • Alleles
  • Chromosome Mapping
  • Crosses, Genetic
  • Ethylnitrosourea/toxicity
  • Female
  • Genetic Complementation Test
  • Genotype
  • Male
  • Mice, Inbred C3H
  • Mice, Inbred C57BL
  • Mice, Mutant Strains
  • Neural Tube Defects/chemically induced
  • Neural Tube Defects/embryology
  • Phenotype
  • Pregnancy
Strain Development
The mutation was isolated on a C3H/R1 chromosome. Mutant stocks were bred to C57BL/6J. Resulting affected heterozygotes were sib mated with normal littermates.
Suggested Control Mice
  • Wildtype littermates
  • C57BL/6J
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@ucdavis.edu. Older strains may not have this information.
  • Neurobiology
  • Developmental Biology
  • Birth Defects
Donor
Dr. Monica Justice, Baylor College of Medicine
Primary Reference
  • Kibar Z, Vogan KJ, Groulx N, Justice MJ, Underhill DA, Gros P. Ltap, a mammalian homolog of Drosophila Strabismus/Van Gogh, is altered in the mouse neural tube mutant Loop-tail. Nat Genet. 2001 Jul;28(3):251-5. (Medline PMID: 11431695)
  • Kibar Z, Underhill DA, Canonne-Hergaux F, Gauthier S, Justice MJ, Gros P. Identification of a new chemically induced allele (Lpm1Jus) at the loop-tail locus: morphology, histology, and genetic mapping. Genomics. 2001 Mar 15;72(3):331-7. (Medline PMID: 11401449)

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@ucdavis.edu.
Coat Color
Black
MMRRC Breeding System
Backcross
Breeding Scheme(s)
  • Heterozygous Female x C57BL/6 Male
  • C57BL/6 Female x Heterozygous Male
Generation
Unknown
Overall Breeding Performance
Poor
Average litter size
7
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@ucdavis.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
000057-UCD-EMBRYO Cryo-preserved embryos $1,038.00 / Non-Profit Aliquot Approximate quantity2 : 20-40 embryos / aliquot
000057-UCD-SPERM Cryo-preserved spermatozoa $546.25 / Non-Profit Aliquot Approximate quantity3
000057-UCD-RESUS Litter recovered from cryo-archive $4,044.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.