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A loxPsite and a FRT site flanked neomycine resistance cassette were inserted intointron 2 and a second loxP site into intron 5. The neo cassette was removedthrough subsequent flp-mediated recombination. Exons 3-5 were deleted throughsubsequent cre-mediated recombination.
Rajkumar AP, Qvist P, Lazarus R, Lescai F, Ju J, Nyegaard M, Mors O, BørglumAD, Li Q, Christensen JH. Experimental validation of methods for differentialgene expression analysis and sample pooling in RNA-seq. BMC Genomics. 2015 Jul25;16:548. doi: 10.1186/s12864-015-1767-y. (Medline PMID: 26208977)
Qvist P, Rajkumar AP, Redrobe JP, Nyegaard M, Christensen JH, Mors O, Wegener G, Didriksen M, Børglum AD. Mice heterozygous for an inactivated allele of theschizophrenia associated Brd1 gene display selective cognitive deficits withtranslational relevance to schizophrenia. Neurobiol Learn Mem. 2017May;141:44-52. doi: 10.1016/j.nlm.2017.03.009. Epub 2017 Mar 21. (Medline PMID: 28341151)
Qvist P, Christensen JH, Vardya I, Rajkumar AP, Mørk A, Paternoster V,Füchtbauer EM, Pallesen J, Fryland T, Dyrvig M, Hauberg ME, Lundsberg B, FejginK, Nyegaard M, Jensen K, Nyengaard JR, Mors O, Didriksen M, Børglum AD. TheSchizophrenia-Associated BRD1 Gene Regulates Behavior, Neurotransmission, andExpression of Schizophrenia Risk Enriched Gene Sets in Mice. Biol Psychiatry.2017 Jul 1;82(1):62-76. doi: 10.1016/j.biopsych.2016.08.037. Epub 2016 Sep 15.(Medline PMID: 27837920)
Qvist P, Eskildsen SF, Hansen B, Baragji M, Ringgaard S, Roovers J,Paternoster V, Molgaard S, Corydon TJ, Stødkilde-Jørgensen H, Glerup S, Mors O,Wegener G, Nyengaard JR, Børglum AD, Christensen JH. Brain volumetric alterationsaccompanied with loss of striatal medium-sized spiny neurons and corticalparvalbumin expressing interneurons in Brd1(+/-) mice. Sci Rep. 2018 Nov7;8(1):16486. doi: 10.1038/s41598-018-34729-5. (Medline PMID: 30405140)
Paternoster V, Svanborg M, Edhager AV, Rajkumar AP, Eickhardt EA, Pallesen J, Grove J, Qvist P, Fryland T, Wegener G, Nyengaard JR, Mors O, Palmfeldt J,Børglum AD, Christensen JH. Brain proteome changes in female Brd1(+/-) miceunmask dendritic spine pathology and show enrichment for schizophrenia risk.Neurobiol Dis. 2019 Apr;124:479-488. doi: 10.1016/j.nbd.2018.12.011. Epub 2018Dec 24. (Medline PMID: 30590179)
Colony Surveillance Program and Current Health Reports
Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.
Cryopreserved material may be available upon request, please inquire to mmrrc@ucdavis.edu for more information.
Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.
Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.
Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.
1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.
2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.
3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.
4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.