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Availability & Fees Order this Strain
IL17RA-/-RC-/- mice
Double-knockout mice where exons 5-9 were deleted in the Il17ra gene and exons 1-5 in the Il17rc gene.
Double-knockout mice were generated by applying CRISPR genome-editing technology to fertilized eggs of Il17rc-/- mice (B6N.129S5-Il17rctm1Lex/Mmucd, MMRRC:32386). Founder mice were backcrossed twice with C57BL/6J to dilute possible off-target alterations. Homozygous mice were generated by intra-strain mating of heterozygous offspring and maintained by homozygote mating.
C57BL/6, Il17ra-/- mice (MRRC:67347), Ilr17rc−/− (MMRRC:32386)
Hirose S, Jaggi U, Wang S, Tormanen K, Nagaoka Y, Katsumata M, Ghiasi H. Role of TH17 Responses in Increasing Herpetic Keratitis in the Eyes of Mice Infected with HSV-1. Invest Ophthalmol Vis Sci. 2020 Jun 3;61(6):20. doi: 10.1167/iovs.61.6.20. (Medline PMID: 32516406)
This strain of mice is kept in an SPF environment. Since the IL17 pathway is important in immune response, these mice might have unknown deficiencies in immune response and susceptibility to various pathogens.
Colony Surveillance Program and Current Health Reports
Backcross and random intra-strain mating
N2 (C57BL/6J)
7-9
Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.
Cryopreserved material may be available upon request, please inquire to mmrrc@ucdavis.edu for more information.
Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.
A Commercial License Agreement from the Donor is required for for-profit entities to use this strain.
Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.
1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.
2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.
3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.
4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.