Strain Name:
C57BL/6J-MtgxR8018Btlr/Mmmh
Stock Number:
067458-MU
Citation ID:
RRID:MMRRC_067458-MU
Other Names:
R8018 (G1)
Major Collection:

Strain Information

Ctbp2
Name: C-terminal binding protein 2
Synonyms: D7Ertd45e, Ribeye, Gtrgeo6
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 13017
HGNC: HGNC:2495
Homologene: 75187
Pias2
Name: protein inhibitor of activated STAT 2
Synonyms: Dib, 6330408K17Rik, ARIP3, PIASxbeta, PIASxalpha, PIASxb, Miz1
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 17344
VEGA: 18
Homologene: 20979
Smad7
Name: SMAD family member 7
Synonyms: Madh7
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 17131
HGNC: HGNC:6773
Homologene: 4314
Secisbp2l
Name: SECIS binding protein 2-like
Synonyms: 3110001I20Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 70354
Homologene: 18923
Vps18
Name: VPS18 CORVET/HOPS core subunit
Synonyms: 9930024E13Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228545
Homologene: 13302
Grm7
Name: glutamate receptor, metabotropic 7
Synonyms: mGluR7, Gpr1g, E130018M02Rik, 6330570A01Rik, mGlu7a receptor
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 108073
HGNC: HGNC:4599
Homologene: 20233
Dnaaf4
Name: dynein axonemal assembly factor 4
Synonyms: EKN1, 1700010I24Rik, b2b811Clo, Dyx1c1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 67685
Homologene: 12173
Nbeal2
Name: neurobeachin-like 2
Synonyms: 1110014F23Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235627
Homologene: 86422
Fcrl2
Name: Fc receptor like 2
Synonyms: 2810439C17Rik, IFGP2, Fcrh2, moFcRH2sc, Msr2, Fcrls
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 80891
Homologene: 57117
Tia1
Name: cytotoxic granule-associated RNA binding protein 1
Synonyms: mTIA-1, 2310050N03Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 21841
Homologene: 20692
Tcea3
Name: transcription elongation factor A (SII), 3
Synonyms: S-II, SII-K1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 21401
Homologene: 20684
Nipal3
Name: NIPA-like domain containing 3
Synonyms: 9130020G22Rik, Npal3
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 74552
Homologene: 10722
Flcn
Name: folliculin
Synonyms: B430214A04Rik, BHD
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 216805
Homologene: 14583
Abca16
Name: ATP-binding cassette, sub-family A member 16
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233810
Homologene: 132942
Phf10
Name: PHD finger protein 10
Synonyms: 1810055P05Rik, Baf45a
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 72057
Homologene: 10112
Adar
Name: adenosine deaminase, RNA-specific
Synonyms: ADAR1, mZaADAR, Adar1p110, Adar1p150
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 56417
HGNC: HGNC:225
Homologene: 9281
Mthfd2l
Name: methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like
Synonyms: C630010D07Rik, 1110019K23Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 665563
Homologene: 28295
Ldlrad4
Name: low density lipoprotein receptor class A domain containing 4
Synonyms: D330030L18Rik, A430108L08Rik, 8230401C20Rik, D18Ertd653e
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 52662
VEGA: 18
HGNC: HGNC:1224
Homologene: 3202
Ptprd
Name: protein tyrosine phosphatase receptor type D
Synonyms: 3000002J10Rik, B230219D21Rik, 1110002J03Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 19266
HGNC: HGNC:9668
Ralgapa2
Name: Ral GTPase activating protein, alpha subunit 2 (catalytic)
Synonyms: A230067G21Rik, RGC2, AS250
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241694
Homologene: 28131
Adgrv1
Name: adhesion G protein-coupled receptor V1
Synonyms: VLGR1, Mass1, Mgr1, Gpr98
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 110789
Homologene: 19815
Ryr3
Name: ryanodine receptor 3
Synonyms: calcium release channel isoform 3
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 20192
Homologene: 68151
Anxa3
Name: annexin A3
Synonyms: Anx3
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 11745
HGNC: HGNC:541
Homologene: 68445
Vmn1r76
Name: vomeronasal 1 receptor 76
Synonyms: V1rg4
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 171239
Dynap
Name: dynactin associated protein
Synonyms: 2310002L13Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 75577
VEGA: 18
Homologene: 82463
St6gal1
Name: beta galactoside alpha 2,6 sialyltransferase 1
Synonyms: ST6Gal I, St6Gal-I, Siat1
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 20440
Homologene: 2281
Or2b4
Name: olfactory receptor family 2 subfamily B member 4
Synonyms: GA_x6K02T2PSCP-2264806-2265753, MOR256-3, A3, Olfr124, SR1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 259064
Homologene: 74266
Kcnh2
Name: potassium voltage-gated channel, subfamily H (eag-related), member 2
Synonyms: merg1a, ether a go-go related, M-erg, LQT, Lqt2, ERG1, merg1b
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 16511
HGNC: HGNC:6251
Homologene: 201
Elfn2
Name: leucine rich repeat and fibronectin type III, extracellular 2
Synonyms: Lrrc62
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 207393
VEGA: 15
Homologene: 18835
Ubxn8
Name: UBX domain protein 8
Synonyms: Rep8h, Rep-8, D0H8S2298E, Ubxd6
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 108159
Homologene: 4149
Gmip
Name: Gem-interacting protein
Synonyms: 5031419I10Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 78816
Homologene: 9570
Dao
Name: D-amino acid oxidase
Synonyms: DAO, Dao-1, Dao1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 13142
HGNC: HGNC:2671
Homologene: 37553
Oxa1l
Name: oxidase assembly 1-like
Synonyms: 1810020M02Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 69089
HGNC: HGNC:8526
Homologene: 31281
Ccdc158
Name: coiled-coil domain containing 158
Synonyms: 4932413O14Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 320696
Homologene: 18560
Niban1
Name: niban apoptosis regulator 1
Synonyms: Niban, Fam129a
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 63913
Homologene: 62170
Lancl2
Name: LanC (bacterial lantibiotic synthetase component C)-like 2
Synonyms: 1700003F10Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 71835
HGNC: HGNC:6509
Homologene: 23116
Ankmy1
Name: ankyrin repeat and MYND domain containing 1
Synonyms: 4930483I10Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 241158
Homologene: 9561
Tdrd9
Name: tudor domain containing 9
Synonyms: 4930441E05Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 74691
Homologene: 14311
Zfp444
Name: zinc finger protein 444
Synonyms: 2810031J10Rik, 6230401O10Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 72667
Homologene: 10139
Hs3st2
Name: heparan sulfate (glucosamine) 3-O-sulfotransferase 2
Synonyms: 6430516N12Rik, A830061E14Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 195646
HGNC: HGNC:5195
Homologene: 21220
Tubg1
Name: tubulin, gamma 1
Synonyms: 1500010O08Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 103733
Homologene: 833
AI429214
Name: expressed sequence AI429214
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 621080
Homologene: 82747
Cndp2
Name: CNDP dipeptidase 2
Synonyms: Pep-1, Dip-2, 0610010E05Rik, Cn2, Pep1
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 66054
VEGA: 18
Homologene: 10085
Prm3
Name: protamine 3
Synonyms: Pxg, PX, Pxg
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 19120
Homologene: 74292
Rapgefl1
Name: Rap guanine nucleotide exchange factor (GEF)-like 1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 268480
Homologene: 41126
4930563M21Rik
Name: RIKEN cDNA 4930563M21 gene
Synonyms: Rfpl3s
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 75258
VEGA: 9
Homologene: 138467
Rrp7a
Name: ribosomal RNA processing 7 homolog A
Synonyms: 1110014J01Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 74778
Homologene: 41060
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 92,886,281 bp
  • A to T, chromosome 1 at 151,717,255 bp
  • A to C, chromosome 2 at 112,678,432 bp
  • T to A, chromosome 2 at 119,294,011 bp
  • C to A, chromosome 2 at 125,745,909 bp
  • T to C, chromosome 2 at 146,340,391 bp
  • A to T, chromosome 3 at 87,259,626 bp
  • T to C, chromosome 3 at 89,747,575 bp
  • T to C, chromosome 4 at 76,085,520 bp
  • C to T, chromosome 4 at 135,447,348 bp
  • T to G, chromosome 4 at 136,257,918 bp
  • G to A, chromosome 5 at 24,320,016 bp
  • T to A, chromosome 5 at 90,959,813 bp
  • T to C, chromosome 5 at 92,623,401 bp
  • T to C, chromosome 5 at 94,613,980 bp
  • A to T, chromosome 5 at 96,820,429 bp
  • AGG to AG, chromosome 5 at 114,015,209 bp
  • A to G, chromosome 6 at 57,713,093 bp
  • C to T, chromosome 6 at 86,425,052 bp
  • A to G, chromosome 6 at 111,207,776 bp
  • A to G, chromosome 7 at 6,188,143 bp
  • A to G, chromosome 7 at 11,930,883 bp
  • A to G, chromosome 7 at 120,533,643 bp
  • A to G, chromosome 7 at 121,500,416 bp
  • T to C, chromosome 7 at 133,014,366 bp
  • A to G, chromosome 8 at 33,623,215 bp
  • A to T, chromosome 8 at 36,993,666 bp
  • A to G, chromosome 8 at 69,815,493 bp
  • G to A, chromosome 9 at 55,973,707 bp
  • T to A, chromosome 9 at 72,972,316 bp
  • G to T, chromosome 9 at 110,629,157 bp
  • T to C, chromosome 11 at 59,794,122 bp
  • T to G, chromosome 11 at 98,840,340 bp
  • G to T, chromosome 11 at 101,124,028 bp
  • T to C, chromosome 12 at 112,032,746 bp
  • C to T, chromosome 12 at 112,044,388 bp
  • A to T, chromosome 13 at 81,440,225 bp
  • A to G, chromosome 14 at 54,363,300 bp
  • A to G, chromosome 15 at 78,673,768 bp
  • C to T, chromosome 15 at 83,116,924 bp
  • CTCTTCTTCTTCTTC to CTCTTCTTCTTC, chromosome 16 at 10,790,701 bp
  • G to A, chromosome 16 at 23,357,835 bp
  • T to A, chromosome 17 at 14,954,116 bp
  • A to G, chromosome 17 at 37,805,147 bp
  • G to T, chromosome 18 at 68,235,669 bp
  • T to C, chromosome 18 at 70,242,022 bp
  • T to G, chromosome 18 at 75,369,284 bp
  • T to A, chromosome 18 at 77,128,958 bp
  • C to T, chromosome 18 at 84,668,602 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8018 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
067458-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.