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Strain Name:
C57BL/6J-MtgxR8035Btlr/Mmmh
Stock Number:
067472-MU
Citation ID:
RRID:MMRRC_067472-MU
Other Names:
R8035 (G1)
Major Collection:

Strain Information

Cdkn1a
Name: cyclin dependent kinase inhibitor 1A
Synonyms: P21, Waf1, mda6, CAP20, SDI1, CIP1, p21Cip1, p21WAF, Cdkn1, CDKI, p21WAF1/CIP1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 12575
HGNC: HGNC:1784
Homologene: 333
Rgs9
Name: regulator of G-protein signaling 9
Synonyms: Rgs9-2, RGS9-1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 19739
Homologene: 2845
Lims1
Name: LIM and senescent cell antigen-like domains 1
Synonyms: 2310016J22Rik, 4921524A02Rik, Lims1l, PINCH1, C430041B13Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 110829
HGNC: HGNC:6616
Homologene: 68428
Acot7
Name: acyl-CoA thioesterase 7
Synonyms: 2410041A17Rik, Bach, AU014716
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 70025
Homologene: 15780
Lgals9
Name: lectin, galactose binding, soluble 9
Synonyms: LGALS35, galectin-9, gal-9, Lgals5
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 16859
Homologene: 134662
Mtor
Name: mechanistic target of rapamycin kinase
Synonyms: FKBP-rapamycin-associated protein FRAP, 2610315D21Rik, RAPT1, RAFT1, flat, Frap1, mechanistic target of rapamycin (serine/threonine kinase)
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 56717
HGNC: HGNC:3942
Homologene: 3637
Tut7
Name: terminal uridylyl transferase 7
Synonyms: 6030448M23Rik, Zcchc6, Tent3b
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 214290
VEGA: 13
Homologene: 51941
Trip13
Name: thyroid hormone receptor interactor 13
Synonyms: 2410002G23Rik, D13Ertd328e
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 69716
Homologene: 3125
Ankle2
Name: ankyrin repeat and LEM domain containing 2
Synonyms: 1110001J12Rik, D5Ertd585e
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 71782
Homologene: 35424
Slx4ip
Name: SLX4 interacting protein
Synonyms: 2410004I22Rik, 2210009G21Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 74243
Homologene: 49913
Mtrex
Name: Mtr4 exosome RNA helicase
Synonyms: 2610528A15Rik, Skiv2l2
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 72198
VEGA: 13
Homologene: 6257
Bnip3
Name: BCL2/adenovirus E1B interacting protein 3
Synonyms: Nip3
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 12176
HGNC: HGNC:1084
Homologene: 2990
Hspb8
Name: heat shock protein 8
Synonyms: HSP20-like, HSP22, D5Ucla4, E2IG1, H11, Cryac, H11K
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 80888
Homologene: 8654
Ccdc6
Name: coiled-coil domain containing 6
Synonyms: 2810012H18Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 76551
Homologene: 34786
Ctr9
Name: CTR9 homolog, Paf1/RNA polymerase II complex component
Synonyms: Tsp, Tsbp, Sh2bp1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 22083
Homologene: 40668
Kdm3b
Name: KDM3B lysine (K)-specific demethylase 3B
Synonyms: 5830462I21Rik, JHDM2B, Jmjd1b
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 277250
VEGA: 18
HGNC: HGNC:1337
Homologene: 41145
Myt1
Name: myelin transcription factor 1
Synonyms: NZF-2b, NZF-2a, Nzf2, Nztf2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 17932
HGNC: HGNC:7622
Homologene: 3332
Tjp1
Name: tight junction protein 1
Synonyms: ZO-1, ZO1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 21872
Homologene: 2445
Hnrnpc
Name: heterogeneous nuclear ribonucleoprotein C
Synonyms: hnRNP C2, hnRNP C1, hnRNPC2, hnRNPC1, D14Wsu171e, Hnrpc2, Hnrpc1, Hnrpc
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 15381
VEGA: 14
HGNC: HGNC:5035
Homologene: 74524
Cdh9
Name: cadherin 9
Synonyms: T1-cadherin
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 12565
HGNC: HGNC:1768
Homologene: 9450
Pbrm1
Name: polybromo 1
Synonyms: BAF180, 2610016F04Rik, 2310032M22Rik, Pb1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 66923
Homologene: 10044
Zfp979
Name: zinc finger protein 979
Synonyms: 2610305D13Rik, Ssm1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 112422
Homologene: 133076
Rap1gds1
Name: RAP1, GTP-GDP dissociation stimulator 1
Synonyms: GDS1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229877
HGNC: HGNC:9859
Homologene: 41422
Zfp940
Name: zinc finger protein 940
Synonyms: BC027344
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233057
Homologene: 138421
Asap3
Name: ArfGAP with SH3 domain, ankyrin repeat and PH domain 3
Synonyms: UPLC1, 9430088F20Rik, Ddefl1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230837
Homologene: 41190
Gipc2
Name: GIPC PDZ domain containing family, member 2
Synonyms: 2200002N01Rik, Semcap2
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 54120
Homologene: 22994
Srcap
Name: Snf2-related CREBBP activator protein
Synonyms: F630004O05Rik, B930091H02Rik, D030022P06Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 100043597
Homologene: 38213
Hspa12b
Name: heat shock protein 12B
Synonyms: 2700081N06Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 72630
Homologene: 41749
Wdr72
Name: WD repeat domain 72
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 546144
Homologene: 52326
Arrdc2
Name: arrestin domain containing 2
Synonyms: 4632416I05Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 70807
Homologene: 79540
Trpm6
Name: transient receptor potential cation channel, subfamily M, member 6
Synonyms: CHAK2
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 225997
VEGA: 19
Homologene: 9767
Vmn1r37
Name: vomeronasal 1 receptor 37
Synonyms: V1rc10
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 171183
Homologene: 110800
Lrp1b
Name: low density lipoprotein-related protein 1B
Synonyms: 9630004P12Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 94217
HGNC: HGNC:6693
Homologene: 56810
Ccdc168
Name: coiled-coil domain containing 168
Synonyms: Gm8251
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 102636082
VEGA: 1
Homologene: 141149
Cyp2b19
Name: cytochrome P450, family 2, subfamily b, polypeptide 19
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 13090
HGNC: HGNC:2615
Homologene: 104114
A2ml1
Name: alpha-2-macroglobulin like 1
Synonyms: Ovos2, BC048546
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232400
Homologene: 45969
Ccr3
Name: C-C motif chemokine receptor 3
Synonyms: MIP-1 alphaRL2, CC-CKR3, CKR3, Cmkbr3
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 12771
VEGA: 9
HGNC: HGNC:1604
Homologene: 20436
Sppl2c
Name: signal peptide peptidase 2C
Synonyms: 4933407P14Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 237958
Homologene: 18491
Itih1
Name: inter-alpha trypsin inhibitor, heavy chain 1
Synonyms: inter-alpha (globulin) inhibitor, H1 polypeptide, Intin1, Itih-1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 16424
HGNC: HGNC:6166
Homologene: 1667
Or5b118
Name: olfactory receptor family 5 subfamily B member 118
Synonyms: GA_x6K02T2RE5P-3803583-3804527, MOR202-26P, MOR202-42, Olfr1474
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 258123
Homologene: 79417
Or6k4
Name: olfactory receptor family 6 subfamily K member 4
Synonyms: GA_x6K02T2P20D-21025190-21024243, MOR105-2, Olfr424
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 258716
Homologene: 103798
Slc26a7
Name: solute carrier family 26, member 7
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 208890
Homologene: 13770
Fdps
Name: farnesyl diphosphate synthetase
Synonyms: Fdpsl1, 6030492I17Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 110196
HGNC: HGNC:3631
Homologene: 1519
Klk6
Name: kallikrein related-peptidase 6
Synonyms: Bssp, protease M, neurosin, Prss9, Klk29, Prss18
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 19144
HGNC: HGNC:6367
Homologene: 68279
Igkv4-69
Name: immunoglobulin kappa variable 4-69
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 628541
Or56a3b
Name: olfactory receptor family 56 subfamily A member 3B
Synonyms: GA_x6K02T2PBJ9-7750163-7751110, MOR40-14, Olfr681
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 404318
Homologene: 81538
Fam161b
Name: family with sequence similarity 161, member B
Synonyms: 9830169C18Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 217705
Homologene: 17581
Mettl17
Name: methyltransferase like 17
Synonyms: 2310032K15Rik, D14Ertd209e, Mett11d1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 52535
Homologene: 11226
Semg1
Name: semenogelin 1
Synonyms: semenoclotin, SVS II, Svs2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 53878
Homologene: 49325
Zfp583
Name: zinc finger protein 583
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 213011
Homologene: 65048
Or8b38
Name: olfactory receptor family 8 subfamily B member 38
Synonyms: GA_x6K02T2PVTD-31740639-31741568, MOR162-12, Olfr885
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 257885
Homologene: 79400
Matn4
Name: matrilin 4
Synonyms: matrilin-4
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 17183
HGNC: HGNC:6910
Homologene: 2844
Mars2
Name: methionine-tRNA synthetase 2 (mitochondrial)
Synonyms: C730026E21Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 212679
Homologene: 6009
Gm21411
Name: predicted gene, 21411
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 115489953
VEGA: 4
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 44,061,551 bp
  • C to T, chromosome 1 at 55,238,297 bp
  • A to T, chromosome 1 at 174,136,924 bp
  • T to C, chromosome 1 at 174,719,871 bp
  • T to A, chromosome 2 at 40,860,655 bp
  • T to A, chromosome 2 at 131,140,939 bp
  • T to G, chromosome 2 at 137,044,025 bp
  • A to G, chromosome 2 at 164,237,133 bp
  • T to C, chromosome 2 at 164,397,040 bp
  • T to C, chromosome 2 at 181,795,739 bp
  • G to T, chromosome 3 at 89,095,476 bp
  • A to T, chromosome 3 at 139,015,550 bp
  • T to C, chromosome 3 at 152,094,229 bp
  • A to C, chromosome 4 at 14,621,338 bp
  • T to C, chromosome 4 at 136,241,203 bp
  • A to C, chromosome 4 at 146,897,710 bp
  • A to C, chromosome 4 at 147,613,306 bp
  • T to A, chromosome 4 at 148,546,399 bp
  • A to G, chromosome 4 at 152,253,154 bp
  • C to T, chromosome 5 at 110,254,452 bp
  • T to C, chromosome 5 at 116,415,426 bp
  • T to A, chromosome 6 at 66,731,393 bp
  • T to C, chromosome 6 at 69,283,937 bp
  • T to C, chromosome 6 at 86,447,355 bp
  • A to G, chromosome 6 at 128,553,280 bp
  • T to C, chromosome 7 at 6,316,772 bp
  • G to A, chromosome 7 at 26,771,250 bp
  • A to C, chromosome 7 at 29,845,523 bp
  • A to G, chromosome 7 at 43,828,662 bp
  • G to T, chromosome 7 at 65,342,702 bp
  • T to A, chromosome 7 at 105,121,550 bp
  • C to T, chromosome 7 at 111,034,457 bp
  • T to C, chromosome 7 at 127,542,612 bp
  • G to A, chromosome 7 at 138,891,937 bp
  • T to C, chromosome 8 at 70,839,382 bp
  • C to T, chromosome 9 at 38,061,665 bp
  • T to G, chromosome 9 at 74,179,501 bp
  • T to C, chromosome 9 at 124,028,975 bp
  • T to A, chromosome 10 at 58,410,441 bp
  • A to G, chromosome 10 at 70,097,501 bp
  • A to T, chromosome 11 at 78,963,476 bp
  • T to A, chromosome 11 at 104,187,366 bp
  • A to G, chromosome 11 at 109,273,324 bp
  • A to T, chromosome 12 at 84,348,656 bp
  • A to T, chromosome 13 at 59,789,190 bp
  • G to C, chromosome 13 at 73,913,254 bp
  • T to C, chromosome 13 at 112,898,802 bp
  • A to C, chromosome 14 at 30,942,525 bp
  • A to G, chromosome 14 at 31,084,152 bp
  • C to T, chromosome 14 at 51,891,490 bp
  • C to T, chromosome 14 at 52,084,262 bp
  • G to T, chromosome 15 at 16,831,066 bp
  • T to C, chromosome 17 at 29,099,376 bp
  • T to C, chromosome 18 at 34,808,728 bp
  • T to A, chromosome 18 at 60,916,370 bp
  • T to C, chromosome 19 at 13,471,899 bp
  • A to G, chromosome 19 at 18,792,862 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8035 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
067472-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.