Strain Name:
C57BL/6J-MtgxR8038Btlr/Mmmh
Stock Number:
067475-MU
Citation ID:
RRID:MMRRC_067475-MU
Other Names:
R8038 (G1)
Major Collection:

Strain Information

Rtn4rl1
Name: reticulon 4 receptor-like 1
Synonyms: Ngrh2, Ngrl2, Ngr3
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 237847
Homologene: 18611
Cacna1h
Name: calcium channel, voltage-dependent, T type, alpha 1H subunit
Synonyms: Cav3.2, alpha13.2, T-type Cav3.2
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 58226
HGNC: HGNC:1395
Homologene: 56913
Dnmt1
Name: DNA methyltransferase 1
Synonyms: MTase, Dnmt1o, MommeD2, Cxxc9
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 13433
VEGA: 9
HGNC: HGNC:2976
Homologene: 124071
Chuk
Name: conserved helix-loop-helix ubiquitous kinase
Synonyms: IKKalpha, IKK-1, IKK alpha, IKK 1, IKK-alpha, IkappaB kinase alpha, IKK[a], IKK1, Chuk1
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 12675
HGNC: HGNC:1974
Homologene: 979
Scarb2
Name: scavenger receptor class B, member 2
Synonyms: LIMP II, LIMP-2, Cd36l2, 9330185J12Rik, LGP85
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 12492
HGNC: HGNC:1665
Homologene: 48353
Uba2
Name: ubiquitin-like modifier activating enzyme 2
Synonyms: Uble1b, SAE2, Arx, anthracycline-associated resistance, UBA2, Sumo-1 activating enzyme subunit 2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 50995
Homologene: 4018
Llgl2
Name: LLGL2 scribble cell polarity complex component
Synonyms: 9130006H11Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217325
HGNC: HGNC:6629
Homologene: 3323
Depdc5
Name: DEP domain containing 5
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 277854
Homologene: 34718
Cops2
Name: COP9 signalosome subunit 2
Synonyms: Sgn2, Trip15, alien-like, Csn2, alien homologue
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 12848
Homologene: 3124
Kdm2b
Name: lysine (K)-specific demethylase 2B
Synonyms: Cxxc2, Fbxl10, Jhdm1b
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 30841
Homologene: 13069
Tab1
Name: TGF-beta activated kinase 1/MAP3K7 binding protein 1
Synonyms: Map3k7ip1, b2b449Clo, Tak1-binding protein 1, 2310012M03Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 66513
VEGA: 15
Homologene: 4461
Mettl3
Name: methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit
Synonyms: Spo8, 2310024F18Rik, M6A
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 56335
Homologene: 10501
Zfp64
Name: zinc finger protein 64
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 22722
Homologene: 7604
Wapl
Name: WAPL cohesin release factor
Synonyms: Wapal, A530089A20Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 218914
Homologene: 41002
Tg
Name: thyroglobulin
Synonyms: Tgn
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 21819
Homologene: 2430
Alkbh5
Name: alkB homolog 5, RNA demethylase
Synonyms: Abh5, Ofoxd
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 268420
Homologene: 9818
Tmem126b
Name: transmembrane protein 126B
Synonyms: 1110001A23Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 68472
Homologene: 10222
Hoxa5
Name: homeobox A5
Synonyms: Hox-1.3
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 15402
HGNC: HGNC:5106
Homologene: 40726
Acaca
Name: acetyl-Coenzyme A carboxylase alpha
Synonyms: A530025K05Rik, Acac, LOC327983, acetyl-CoA carboxylase, Acc1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 107476
HGNC: HGNC:84
Homologene: 31015
Ppfia1
Name: protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1
Synonyms: liprin, Liprin-alpha1, C030014K08Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233977
HGNC: HGNC:9245
Homologene: 20802
Recql5
Name: RecQ protein-like 5
Synonyms: Recql5b, Recq5b
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 170472
HGNC: HGNC:9950
Homologene: 31232
Ppib
Name: peptidylprolyl isomerase B
Synonyms: cyclophilin B, CyP-20b, Cphn2, Cphn-2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 19035
VEGA: 9
HGNC: HGNC:9255
Homologene: 726
Spint2
Name: serine protease inhibitor, Kunitz type 2
Synonyms: HAI-2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 20733
Homologene: 7955
Tecpr2
Name: tectonin beta-propeller repeat containing 2
Synonyms: 4930573I19Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 104859
VEGA: 12
Homologene: 8897
Itga2
Name: integrin alpha 2
Synonyms: DX5, VLA-2 receptor, alpha 2 subunit, CD49B
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 16398
VEGA: 13
HGNC: HGNC:6137
Homologene: 1662
Rap1gap2
Name: RAP1 GTPase activating protein 2
Synonyms: Garnl4, LOC380710
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 380711
Homologene: 56695
Foxn4
Name: forkhead box N4
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 116810
Homologene: 17526
Or8d6
Name: olfactory receptor family 8 subfamily D member 6
Synonyms: Olfr974, GA_x6K02T2PVTD-33640290-33641222, MOR171-1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 259111
VEGA: 9
Homologene: 133680
Col7a1
Name: collagen, type VII, alpha 1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 12836
HGNC: HGNC:2214
Homologene: 73
Naip2
Name: NLR family, apoptosis inhibitory protein 2
Synonyms: Birc1b, Naip2, Naip-rs6
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 17948
HGNC: HGNC:7634
Homologene: 136092
Slc13a5
Name: solute carrier family 13 (sodium-dependent citrate transporter), member 5
Synonyms: Indy, Nact, NaC2/NaCT, mINDY
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 237831
Homologene: 21941
Nat8f5
Name: N-acetyltransferase 8 (GCN5-related) family member 5
Synonyms: Cml5, 1810018F03Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 69049
Homologene: 87019
Accs
Name: 1-aminocyclopropane-1-carboxylate synthase (inactive)
Synonyms: 2610203E10Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 329470
Homologene: 75335
Sycp2
Name: synaptonemal complex protein 2
Synonyms: 4930518F03Rik, 3830402K23Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 320558
Homologene: 8604
Or10w1
Name: olfactory receptor family 10 subfamily W member 1
Synonyms: MOR266-6P, Olfr1490, GA_x6K02T2RE5P-3987000-3987950
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 258098
Homologene: 79418
Pld5
Name: phospholipase D family member 5
Synonyms: B230365F16Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 319455
Homologene: 16081
Ctcfl
Name: CCCTC-binding factor like
Synonyms: Boris, OTTMUSG00000016680
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 664799
Homologene: 46476
Spib
Name: Spi-B transcription factor (Spi-1/PU.1 related)
Synonyms: Spi-B
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 272382
Homologene: 79220
Lrrcc1
Name: leucine rich repeat and coiled-coil domain containing 1
Synonyms: 4932441F23Rik, 1200008A14Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 71710
Homologene: 12559
Rabggta
Name: Rab geranylgeranyl transferase, a subunit
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 56187
VEGA: 14
HGNC: HGNC:9795
Homologene: 32443
Or4c113
Name: olfactory receptor family 4 subfamily C member 113
Synonyms: Olfr1218, MOR233-12, GA_x6K02T2Q125-50536041-50535106
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258815
Homologene: 73986
Or7e166
Name: olfactory receptor family 7 subfamily E member 166
Synonyms: GA_x6K02T2PVTD-13452606-13453535, Olfr857, MOR146-8P
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 257963
Homologene: 134093
Fam90a1a
Name: family with sequence similarity 90, member A1A
Synonyms: C86695
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 97476
Homologene: 135718
Vwa2
Name: von Willebrand factor A domain containing 2
Synonyms: Amaco
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 240675
Homologene: 18238
Skint4
Name: selection and upkeep of intraepithelial T cells 4
Synonyms: 9530098N22Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 320640
Lrriq3
Name: leucine-rich repeats and IQ motif containing 3
Synonyms: 4930438B07Rik, Lrrc44, 4930511J15Rik, 4933403H06Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 74435
Homologene: 23668
Ighe
Name: Immunoglobulin heavy constant epsilon
Synonyms: LOC380792, Gm900
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 380792
HGNC: HGNC:5522
Zfp786
Name: zinc finger protein 786
Synonyms: A730012O14Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 330301
Homologene: 51849
Gm15922
Name: predicted gene 15922
Type: Gene
Species: Mouse
Chromosome: 7
Lsm10
Name: U7 snRNP-specific Sm-like protein LSM10
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 116748
Homologene: 13154
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 176,044,897 bp
  • A to T, chromosome 2 at 89,054,868 bp
  • A to T, chromosome 2 at 93,842,917 bp
  • A to T, chromosome 2 at 125,832,286 bp
  • A to G, chromosome 2 at 168,900,012 bp
  • A to T, chromosome 2 at 173,101,905 bp
  • A to T, chromosome 2 at 178,403,778 bp
  • T to A, chromosome 3 at 14,565,830 bp
  • A to T, chromosome 3 at 155,164,001 bp
  • T to G, chromosome 4 at 112,119,806 bp
  • T to C, chromosome 4 at 126,098,097 bp
  • T to C, chromosome 5 at 32,959,348 bp
  • A to T, chromosome 5 at 92,451,448 bp
  • T to C, chromosome 5 at 114,256,597 bp
  • T to C, chromosome 5 at 122,960,895 bp
  • C to T, chromosome 6 at 47,821,254 bp
  • A to G, chromosome 6 at 52,204,329 bp
  • T to A, chromosome 6 at 85,817,685 bp
  • C to G, chromosome 7 at 3,737,320 bp
  • A to G, chromosome 7 at 29,260,129 bp
  • A to T, chromosome 7 at 34,147,597 bp
  • A to G, chromosome 7 at 44,529,886 bp
  • C to T, chromosome 7 at 90,469,622 bp
  • C to A, chromosome 7 at 144,514,916 bp
  • A to T, chromosome 8 at 21,963,439 bp
  • G to T, chromosome 9 at 19,713,680 bp
  • A to C, chromosome 9 at 20,941,564 bp
  • T to A, chromosome 9 at 39,942,881 bp
  • T to C, chromosome 9 at 66,060,333 bp
  • A to G, chromosome 9 at 108,957,292 bp
  • T to C, chromosome 11 at 60,538,985 bp
  • T to C, chromosome 11 at 72,253,370 bp
  • T to C, chromosome 11 at 74,392,283 bp
  • G to C, chromosome 11 at 75,265,881 bp
  • T to A, chromosome 11 at 84,215,904 bp
  • T to G, chromosome 11 at 115,851,103 bp
  • A to G, chromosome 11 at 115,927,352 bp
  • T to C, chromosome 12 at 110,936,420 bp
  • A to T, chromosome 12 at 113,269,433 bp
  • A to G, chromosome 12 at 115,145,590 bp
  • T to C, chromosome 13 at 100,162,062 bp
  • A to T, chromosome 13 at 114,853,755 bp
  • A to G, chromosome 14 at 34,691,682 bp
  • A to G, chromosome 14 at 52,299,964 bp
  • A to T, chromosome 14 at 55,718,930 bp
  • A to G, chromosome 15 at 66,688,875 bp
  • A to G, chromosome 15 at 80,160,270 bp
  • C to T, chromosome 17 at 25,375,891 bp
  • G to A, chromosome 19 at 13,655,355 bp
  • A to G, chromosome 19 at 44,078,977 bp
  • A to G, chromosome 19 at 56,897,888 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8038 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
067475-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.