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Strain Name:
C57BL/6J-MtgxR8041Btlr/Mmmh
Stock Number:
067478-MU
Citation ID:
RRID:MMRRC_067478-MU
Other Names:
R8041 (G1)
Major Collection:

Strain Information

Slc1a3
Name: solute carrier family 1 (glial high affinity glutamate transporter), member 3
Synonyms: MGluT1, Eaat1, B430115D02Rik, GLAST, Gmt1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 20512
Homologene: 20882
Kcns2
Name: K+ voltage-gated channel, subfamily S, 2
Synonyms: Kv9.2, E130006J24Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 16539
VEGA: 15
HGNC: HGNC:6301
Homologene: 22465
Shc1
Name: src homology 2 domain-containing transforming protein C1
Synonyms: p66, ShcA, p66shc
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 20416
Homologene: 7934
Dlg1
Name: discs large MAGUK scaffold protein 1
Synonyms: B130052P05Rik, SAP97, Dlgh1
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 13383
HGNC: HGNC:2900
Homologene: 20869
Gtf2i
Name: general transcription factor II I
Synonyms: TFII-I, BAP-135, 6030441I21Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 14886
HGNC: HGNC:4659
Homologene: 7748
Aopep
Name: aminopeptidase O
Synonyms: ApO, 2010111I01Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 72061
HGNC: HGNC:1361
Homologene: 66273
Pml
Name: promyelocytic leukemia
Synonyms: Trim19, 1200009E24Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 18854
HGNC: HGNC:9113
Homologene: 13245
Ddx4
Name: DEAD box helicase 4
Synonyms: mvh / m'vasa, VASA, Mvh, DEAD (Asp-Glu-Ala-Asp) box polypeptide 4
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 13206
VEGA: 13
Homologene: 49227
Ago1
Name: argonaute RISC catalytic subunit 1
Synonyms: argonaute 1, Eif2c1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 236511
HGNC: HGNC:3262
Homologene: 81826
Sipa1l3
Name: signal-induced proliferation-associated 1 like 3
Synonyms: 2610511M17Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 74206
Homologene: 77938
Krit1
Name: KRIT1, ankyrin repeat containing
Synonyms: Krit1, 2010007K12Rik, Krit1B, Krit1A, A630036P20Rik, Ccm1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 79264
HGNC: HGNC:1573
Homologene: 12746
Jph3
Name: junctophilin 3
Synonyms: JP-3
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 57340
Homologene: 10762
Foxo1
Name: forkhead box O1
Synonyms: FKHR, Afxh, Fkhr1, Foxo1a
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 56458
HGNC: HGNC:3819
Homologene: 1527
Eapp
Name: E2F-associated phosphoprotein
Synonyms: EAPP, 1810011O16Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 66266
Homologene: 10206
Nadk
Name: NAD kinase
Synonyms: 4432404C02Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 192185
Homologene: 49724
Tex15
Name: testis expressed gene 15 meiosis and synapsis associated
Synonyms: 2210014E14Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 104271
Homologene: 12837
Hydin
Name: HYDIN, axonemal central pair apparatus protein
Synonyms: hy-3, hy3, 1700034M11Rik, 4930545D19Rik, hyrh
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 244653
Homologene: 52118
Dchs1
Name: dachsous cadherin related 1
Synonyms: C130033F22Rik, 3110041P15Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233651
Homologene: 2771
Afap1l1
Name: actin filament associated protein 1-like 1
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 106877
Homologene: 18728
Wdfy4
Name: WD repeat and FYVE domain containing 4
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 545030
Homologene: 83473
Gm11639
Name: predicted gene 11639
Synonyms: Gm11639, Efcab15
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 105242472
Vmn2r19
Name: vomeronasal 2, receptor 19
Synonyms: EG232358
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232358
Homologene: 84037
Or12d17
Name: olfactory receptor family 12 subfamily D member 17
Synonyms: MOR250-1, GA_x6K02T2PSCP-1914078-1915022, Olfr109
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 258832
Homologene: 12811
Fgd5
Name: FYVE, RhoGEF and PH domain containing 5
Synonyms: ZFYVE23, C330025N11Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232237
Homologene: 27798
Ifi207
Name: interferon activated gene 207
Synonyms: AI607873, Pyhin-A
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226691
HGNC: HGNC:5395
Homologene: 115929
Rpgrip1
Name: retinitis pigmentosa GTPase regulator interacting protein 1
Synonyms: A930002K18Rik, 4930505G06Rik, 4930401L23Rik, nmf247
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 77945
Homologene: 10679
Unc79
Name: unc-79 homolog
Synonyms: 9030205A07Rik, Mlca3
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 217843
Homologene: 41397
Col14a1
Name: collagen, type XIV, alpha 1
Synonyms: 5730412L22Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 12818
HGNC: HGNC:2191
Homologene: 18741
Ttll9
Name: tubulin tyrosine ligase-like family, member 9
Synonyms: 4930509O20Rik, 1700016F23Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 74711
Homologene: 41769
Pitpnm2
Name: phosphatidylinositol transfer protein, membrane-associated 2
Synonyms: RDGBA2, NIR3, Rdgb2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 19679
Homologene: 7915
Cacna1b
Name: calcium channel, voltage-dependent, N type, alpha 1B subunit
Synonyms: Cchn1a, alpha(1B), Cav2.2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 12287
HGNC: HGNC:1389
Homologene: 20184
Fyb2
Name: FYN binding protein 2
Synonyms: 1700024P16Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242594
Homologene: 52981
Krt20
Name: keratin 20
Synonyms: 9030623C06Rik, CK20, cytokeratin 20
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 66809
Homologene: 56837
Or51ai2
Name: olfactory receptor family 51 subfamily AI member 2
Synonyms: GA_x6K02T2PBJ9-6671256-6672209, MOR2-1, Olfr632
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 259123
Homologene: 64963
Cmah
Name: cytidine monophospho-N-acetylneuraminic acid hydroxylase
Synonyms: CMP-NeuAc hydroxylase
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 12763
HGNC: HGNC:2098
Homologene: 7269
Albfm1
Name: albumin superfamily member 1
Synonyms: ARG, Gm17754, 5830473C10Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 622307
Homologene: 129803
Nrap
Name: nebulin-related anchoring protein
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 18175
HGNC: HGNC:7988
Homologene: 4499
Or5p69
Name: olfactory receptor family 5 subfamily P member 69
Synonyms: GA_x6K02T2PBJ9-10697517-10698461, MOR204-10, Olfr494
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258732
Homologene: 133602
Mamdc4
Name: MAM domain containing 4
Synonyms: LOC381352
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 381352
Homologene: 17102
Ccdc40
Name: coiled-coil domain containing 40
Synonyms: B930008I02Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 207607
Homologene: 27890
Mmp13
Name: matrix metallopeptidase 13
Synonyms: interstitial collagenase, Collagenase-3, collagenase-1, Clg, Mmp1, MMP-13
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 17386
VEGA: 9
HGNC: HGNC:7159
Homologene: 20548
Igfn1
Name: immunoglobulin-like and fibronectin type III domain containing 1
Synonyms: 9830123M21Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226438
Homologene: 130054
Pcdhb19
Name: protocadherin beta 19
Synonyms: Pcdhb11, PcdhbS
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93890
Homologene: 128411
Unc5c
Name: unc-5 netrin receptor C
Synonyms: Unc5h3, B130051O18Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 22253
Homologene: 2765
Kcnt2
Name: potassium channel, subfamily T, member 2
Synonyms: E330038N15Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 240776
Homologene: 16121
Cntnap5a
Name: contactin associated protein-like 5A
Synonyms: Caspr5-1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 636808
Homologene: 43974
Cd48
Name: CD48 antigen
Synonyms: BLAST-1, Sgp-60, Bcm-1, BCM1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12506
HGNC: HGNC:1683
Homologene: 1347
Or4b12
Name: olfactory receptor family 4 subfamily B member 12
Synonyms: GA_x6K02T2Q125-51620802-51619885, MOR227-5, Olfr1271
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258789
HGNC: HGNC:8290
Hrh1
Name: histamine receptor H1
Synonyms: Bphs, Hir
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 15465
HGNC: HGNC:5182
Homologene: 668
Cnnm4
Name: cyclin M4
Synonyms: Acdp4, 5430430O18Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 94220
HGNC: HGNC:105
Homologene: 75662
Vsig1
Name: V-set and immunoglobulin domain containing 1
Synonyms: 1700062D20Rik, 4930405J24Rik
Type: Gene
Species: Mouse
Chromosome: X
NCBI: 78789
Homologene: 12703
Tas1r2
Name: taste receptor, type 1, member 2
Synonyms: TR2, T1r2, Gpr71
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 83770
Homologene: 75323
Zbtb49
Name: zinc finger and BTB domain containing 49
Synonyms: 4930518A03Rik, Zfp509
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 75079
Homologene: 34825
Slc6a17
Name: solute carrier family 6 (neurotransmitter transporter), member 17
Synonyms: D130012J15Rik, NTT4
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229706
Homologene: 27775
Aoc3
Name: amine oxidase, copper containing 3
Synonyms: SSAO, semicarbazide-sensitive amine oxidase, VAP1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 11754
HGNC: HGNC:550
Homologene: 2770
Reep4
Name: receptor accessory protein 4
Synonyms: 2700029E10Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 72549
VEGA: 14
Homologene: 11888
Dpysl5
Name: dihydropyrimidinase-like 5
Synonyms: Crmp5, CRMP-5, CRAM
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 65254
Homologene: 41347
Kbtbd7
Name: kelch repeat and BTB (POZ) domain containing 7
Synonyms: LOC211255, 1110008P08Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 211255
VEGA: 14
Homologene: 41849
Dok6
Name: docking protein 6
Synonyms: Dok-6
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 623279
Homologene: 45143
Comtd1
Name: catechol-O-methyltransferase domain containing 1
Synonyms: 1810030M08Rik, MT773
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 69156
Homologene: 41703
Ly6g5c
Name: lymphocyte antigen 6 family member G5C
Synonyms: NG33, G5c
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 114652
Homologene: 11896
Ccnjl
Name: cyclin J-like
Synonyms: LOC380694
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 380694
Homologene: 11588
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 36,472,093 bp
  • T to A, chromosome 1 at 116,259,479 bp
  • C to A, chromosome 1 at 135,968,059 bp
  • A to G, chromosome 1 at 140,609,660 bp
  • T to C, chromosome 1 at 171,699,390 bp
  • T to C, chromosome 1 at 173,727,702 bp
  • A to T, chromosome 2 at 24,657,299 bp
  • A to G, chromosome 2 at 25,564,695 bp
  • A to T, chromosome 2 at 90,266,144 bp
  • T to A, chromosome 2 at 113,364,594 bp
  • G to C, chromosome 2 at 153,003,036 bp
  • T to A, chromosome 3 at 52,345,623 bp
  • T to C, chromosome 3 at 89,422,953 bp
  • T to A, chromosome 3 at 107,474,428 bp
  • T to A, chromosome 3 at 141,465,784 bp
  • C to A, chromosome 4 at 105,000,484 bp
  • G to A, chromosome 4 at 126,441,936 bp
  • A to T, chromosome 4 at 139,659,979 bp
  • G to T, chromosome 4 at 155,577,067 bp
  • A to T, chromosome 5 at 3,807,309 bp
  • A to G, chromosome 5 at 30,796,314 bp
  • T to C, chromosome 5 at 38,200,854 bp
  • T to A, chromosome 5 at 90,593,005 bp
  • A to G, chromosome 5 at 124,121,456 bp
  • A to T, chromosome 5 at 134,293,745 bp
  • A to T, chromosome 6 at 92,061,856 bp
  • G to A, chromosome 6 at 114,479,917 bp
  • T to C, chromosome 6 at 123,335,791 bp
  • A to G, chromosome 7 at 29,364,220 bp
  • T to C, chromosome 7 at 103,937,581 bp
  • T to A, chromosome 7 at 105,755,188 bp
  • T to C, chromosome 7 at 108,367,534 bp
  • G to T, chromosome 8 at 33,575,846 bp
  • A to T, chromosome 8 at 110,574,994 bp
  • A to C, chromosome 8 at 121,789,462 bp
  • A to T, chromosome 9 at 7,280,865 bp
  • C to A, chromosome 9 at 58,234,685 bp
  • T to C, chromosome 11 at 43,579,711 bp
  • T to A, chromosome 11 at 99,437,837 bp
  • T to C, chromosome 11 at 101,332,306 bp
  • T to G, chromosome 11 at 104,919,479 bp
  • T to C, chromosome 11 at 119,231,681 bp
  • A to G, chromosome 12 at 54,692,865 bp
  • A to G, chromosome 12 at 103,088,467 bp
  • A to G, chromosome 13 at 24,468,618 bp
  • G to C, chromosome 13 at 63,033,107 bp
  • A to T, chromosome 13 at 112,626,394 bp
  • T to A, chromosome 14 at 21,847,917 bp
  • A to G, chromosome 14 at 33,154,008 bp
  • A to G, chromosome 14 at 52,119,245 bp
  • T to C, chromosome 14 at 70,548,187 bp
  • T to A, chromosome 14 at 79,428,704 bp
  • G to A, chromosome 15 at 8,636,199 bp
  • A to T, chromosome 15 at 34,839,145 bp
  • A to G, chromosome 15 at 55,455,230 bp
  • A to G, chromosome 16 at 31,838,067 bp
  • A to G, chromosome 17 at 35,111,832 bp
  • T to C, chromosome 17 at 37,466,649 bp
  • T to C, chromosome 18 at 37,497,314 bp
  • A to T, chromosome 18 at 61,758,683 bp
  • A to G, chromosome 18 at 89,560,089 bp
  • A to T, chromosome 19 at 56,364,336 bp
  • C to T, chromosome X at 140,933,126 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8041 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
067478-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.