Strain Name:
C57BL/6J-MtgxR8042Btlr/Mmmh
Stock Number:
067479-MU
Citation ID:
RRID:MMRRC_067479-MU
Other Names:
R8042 (G1)
Major Collection:

Strain Information

Slc6a6
Name: solute carrier family 6 (neurotransmitter transporter, taurine), member 6
Synonyms: Taut
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 21366
Homologene: 2291
Cacna1h
Name: calcium channel, voltage-dependent, T type, alpha 1H subunit
Synonyms: T-type Cav3.2, alpha13.2, Cav3.2
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 58226
HGNC: HGNC:1395
Homologene: 56913
Tert
Name: telomerase reverse transcriptase
Synonyms: TR
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 21752
VEGA: 13
Homologene: 31141
Slc27a4
Name: solute carrier family 27 (fatty acid transporter), member 4
Synonyms: FATP4, fatty acid transport protein 4
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 26569
Homologene: 68437
Stam2
Name: signal transducing adaptor molecule (SH3 domain and ITAM motif) 2
Synonyms: 1200004O12Rik, 5730456G07Rik, Hbp
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 56324
Homologene: 68490
Pml
Name: promyelocytic leukemia
Synonyms: Trim19, 1200009E24Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 18854
HGNC: HGNC:9113
Homologene: 13245
Cep97
Name: centrosomal protein 97
Synonyms: 4932439K18Rik, 2810403B08Rik, Lrriq2, E130116N02Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 74201
Homologene: 11579
Mast4
Name: microtubule associated serine/threonine kinase family member 4
Synonyms: 4930420O11Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 328329
Homologene: 42094
Acly
Name: ATP citrate lyase
Synonyms: A730098H14Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 104112
HGNC: HGNC:115
Homologene: 854
Ctc1
Name: CTS telomere maintenance complex component 1
Synonyms: 1500010J02Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 68964
Homologene: 11830
Tnpo2
Name: transportin 2 (importin 3, karyopherin beta 2b)
Synonyms: TRN2, 1110034O24Rik, Kpnb2b
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 212999
Homologene: 8381
Sec24a
Name: SEC24 homolog A, COPII coat complex component
Synonyms: 9430090N21Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 77371
Homologene: 70131
Rsf1
Name: remodeling and spacing factor 1
Synonyms: Hbxap, p325, XAP8, C030033M12Rik, 4832420A03Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233532
Homologene: 41142
Dock4
Name: dedicator of cytokinesis 4
Synonyms: EST N28122, 6330411N01Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 238130
VEGA: 12
Homologene: 56680
Utp25
Name: UTP25 small subunit processome component
Synonyms: AA408296, Diexf, mDef
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 215193
Homologene: 6170
Adcy4
Name: adenylate cyclase 4
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 104110
VEGA: 14
HGNC: HGNC:235
Homologene: 23149
Pabpc1
Name: poly(A) binding protein, cytoplasmic 1
Synonyms: Pabpl1, Pabp1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 18458
Homologene: 37638
Cacna2d3
Name: calcium channel, voltage-dependent, alpha2/delta subunit 3
Synonyms: alpha 2 delta-3, alpha2delta3
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 12294
Homologene: 74929
Zfp738
Name: zinc finger protein 738
Synonyms: 6720487G11Rik, 3830402I07Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 408068
Homologene: 133713
Azi2
Name: 5-azacytidine induced gene 2
Synonyms: AZ2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 27215
Homologene: 8443
Arhgef3
Name: Rho guanine nucleotide exchange factor 3
Synonyms: C76747, 1200004I24Rik, 9830169H03Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 71704
VEGA: 14
HGNC: HGNC:683
Homologene: 41329
Nadk
Name: NAD kinase
Synonyms: 4432404C02Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 192185
Homologene: 49724
Crb1
Name: crumbs family member 1, photoreceptor morphogenesis associated
Synonyms: A930008G09Rik, 7530426H14Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 170788
HGNC: HGNC:2343
Homologene: 8092
Loxhd1
Name: lipoxygenase homology domains 1
Synonyms: 1700096C21Rik, sba
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 240411
Rnf213
Name: ring finger protein 213
Synonyms: D11Ertd759e
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 672511
Homologene: 45439
Dnah14
Name: dynein, axonemal, heavy chain 14
Synonyms: LOC381311, Gm980, A230079K17Rik, Dnahc14
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 240960
HGNC: HGNC:2945
Homologene: 90078
Ptpro
Name: protein tyrosine phosphatase receptor type O
Synonyms: D28, PTPROt, Ptpn15, PTP-oc, GLEPP1, PTP-U2, PTP-BK, PTP-phi
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 19277
HGNC: HGNC:9678
Homologene: 21564
Abca15
Name: ATP-binding cassette, sub-family A member 15
Synonyms: 4930500I12Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 320631
Homologene: 87255
Obscn
Name: obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF
Synonyms: OTTMUSG00000005786, LOC380698
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 380698
Homologene: 70869
Myh1
Name: myosin, heavy polypeptide 1, skeletal muscle, adult
Synonyms: IId, IId/x, Myhs-f2, A530084A17Rik, MyHC-IId/x, Myhs-f, Myhsf2, MYHC-IIX, myosin heavy chain 2X
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 17879
HGNC: HGNC:7567
Homologene: 133718
Pcsk6
Name: proprotein convertase subtilisin/kexin type 6
Synonyms: SPC4, PACE4, b2b2830Clo
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 18553
HGNC: HGNC:8569
Homologene: 20569
Ltbp2
Name: latent transforming growth factor beta binding protein 2
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 16997
HGNC: HGNC:6715
Homologene: 369
Tdrd7
Name: tudor domain containing 7
Synonyms: 5730495N10Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 100121
Homologene: 8618
Tmem147
Name: transmembrane protein 147
Synonyms: 5033425B17Rik, 2010004E11Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 69804
Homologene: 12330
Nt5dc1
Name: 5'-nucleotidase domain containing 1
Synonyms: 6030401B09Rik, Nt5c2l1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 319638
Homologene: 16281
Moxd2
Name: monooxygenase, DBH-like 2
Synonyms: Dbhl1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 194357
Homologene: 77226
Mgat4b
Name: mannoside acetylglucosaminyltransferase 4, isoenzyme B
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 103534
HGNC: HGNC:7048
Homologene: 8611
Cep85l
Name: centrosomal protein 85-like
Synonyms: Gm9766
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 100038725
VEGA: 10
Homologene: 52598
Lrrc9
Name: leucine rich repeat containing 9
Synonyms: 4930432K16Rik, 4921529O18Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 78257
Homologene: 12692
Mrc2
Name: mannose receptor, C type 2
Synonyms: uPARAP, novel lectin, Endo180
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 17534
Homologene: 4408
Vsig1
Name: V-set and immunoglobulin domain containing 1
Synonyms: 1700062D20Rik, 4930405J24Rik
Type: Gene
Species: Mouse
Chromosome: X
NCBI: 78789
Homologene: 12703
Gbp9
Name: guanylate-binding protein 9
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 236573
Homologene: 128731
Serpine1
Name: serine (or cysteine) peptidase inhibitor, clade E, member 1
Synonyms: PAI1, Planh1, PAI-1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 18787
HGNC: HGNC:8583
Homologene: 68070
Spns2
Name: SPNS lysolipid transporter 2, sphingosine-1-phosphate
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 216892
Homologene: 71040
Syt12
Name: synaptotagmin XII
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 171180
Homologene: 15895
Errfi1
Name: ERBB receptor feedback inhibitor 1
Synonyms: 1300002F13Rik, RALT, Mig-6
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 74155
Homologene: 10344
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 139,314,654 bp
  • T to C, chromosome 1 at 181,643,631 bp
  • A to G, chromosome 1 at 193,114,672 bp
  • T to A, chromosome 2 at 29,811,190 bp
  • A to G, chromosome 2 at 52,706,397 bp
  • T to A, chromosome 4 at 45,987,516 bp
  • T to C, chromosome 4 at 150,866,457 bp
  • G to T, chromosome 4 at 155,577,067 bp
  • T to A, chromosome 5 at 105,094,242 bp
  • A to T, chromosome 5 at 137,067,001 bp
  • T to C, chromosome 6 at 40,885,367 bp
  • A to C, chromosome 6 at 91,741,245 bp
  • A to G, chromosome 6 at 137,416,883 bp
  • T to A, chromosome 7 at 30,728,553 bp
  • T to G, chromosome 7 at 65,927,935 bp
  • G to GACGGCGGCA, chromosome 7 at 97,579,909 bp
  • A to G, chromosome 7 at 120,403,010 bp
  • C to T, chromosome 8 at 85,051,559 bp
  • C to A, chromosome 9 at 58,234,685 bp
  • C to A, chromosome 9 at 118,062,097 bp
  • T to C, chromosome 10 at 34,397,214 bp
  • A to G, chromosome 10 at 53,348,663 bp
  • T to A, chromosome 11 at 50,232,376 bp
  • T to C, chromosome 11 at 51,704,317 bp
  • T to C, chromosome 11 at 59,040,317 bp
  • A to T, chromosome 11 at 67,206,603 bp
  • T to A, chromosome 11 at 69,029,843 bp
  • A to T, chromosome 11 at 72,454,177 bp
  • A to G, chromosome 11 at 100,514,325 bp
  • T to C, chromosome 11 at 105,348,355 bp
  • A to G, chromosome 11 at 119,441,654 bp
  • T to C, chromosome 12 at 40,745,760 bp
  • A to T, chromosome 12 at 72,460,906 bp
  • T to C, chromosome 12 at 84,791,899 bp
  • A to G, chromosome 13 at 67,670,891 bp
  • T to A, chromosome 13 at 73,627,145 bp
  • T to C, chromosome 13 at 102,781,245 bp
  • T to A, chromosome 14 at 27,362,809 bp
  • A to T, chromosome 14 at 29,105,038 bp
  • A to G, chromosome 14 at 55,775,239 bp
  • A to G, chromosome 15 at 36,598,309 bp
  • C to A, chromosome 16 at 55,911,602 bp
  • G to T, chromosome 17 at 25,392,471 bp
  • C to T, chromosome 18 at 77,431,192 bp
  • C to A, chromosome 19 at 4,453,824 bp
  • C to T, chromosome X at 140,933,126 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8042 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
067479-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.