Strain Name:
C57BL/6J-MtgxR8047Btlr/Mmmh
Stock Number:
067484-MU
Citation ID:
RRID:MMRRC_067484-MU
Other Names:
R8047 (G1)
Major Collection:

Strain Information

Abce1
Name: ATP-binding cassette, sub-family E member 1
Synonyms: RNS4l (Eye), Oabp, Rnaseli
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 24015
HGNC: HGNC:69
Homologene: 2205
Zbtb7c
Name: zinc finger and BTB domain containing 7C
Synonyms: Kr-pok, B230208J24Rik, Zbtb36
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 207259
VEGA: 18
Homologene: 17070
Eef1e1
Name: eukaryotic translation elongation factor 1 epsilon 1
Synonyms: 1110003A02Rik, AIMP3
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 66143
VEGA: 13
HGNC: HGNC:3212
Homologene: 3161
Ppat
Name: phosphoribosyl pyrophosphate amidotransferase
Synonyms: 5730454C12Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231327
HGNC: HGNC:9238
Homologene: 68272
Msra
Name: methionine sulfoxide reductase A
Synonyms: 6530413P12Rik, 2310045J23Rik, MSR-A
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 110265
HGNC: HGNC:7377
Homologene: 5812
Grhl2
Name: grainyhead like transcription factor 2
Synonyms: clft3, BOM, Tcfcp2l3, 0610015A08Rik, grainyheadlike
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 252973
HGNC: HGNC:2799
Homologene: 32616
Plk4
Name: polo like kinase 4
Synonyms: Stk18, Sak
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 20873
Homologene: 7962
Kif1b
Name: kinesin family member 1B
Synonyms: N-3 kinesin, KIF1Bp130, KIF1Bp204, A530096N05Rik, Kif1b beta, Kif1b alpha, D4Mil1e
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 16561
Homologene: 99835
Patz1
Name: POZ (BTB) and AT hook containing zinc finger 1
Synonyms: 8430401L15Rik, POZ-AT hook-zinc finger protein, Zfp278, MAZR
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 56218
Homologene: 8636
Mccc2
Name: methylcrotonoyl-Coenzyme A carboxylase 2 (beta)
Synonyms: 4930552N12Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 78038
VEGA: 13
HGNC: HGNC:6937
Homologene: 11145
Tiam1
Name: T cell lymphoma invasion and metastasis 1
Synonyms: D16Ium10, D16Ium10e
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 21844
Homologene: 2443
Ncapd2
Name: non-SMC condensin I complex, subunit D2
Synonyms: CNAP1, 2810406C15Rik, 2810465G24Rik, CAP-D2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 68298
Homologene: 6497
Coch
Name: cochlin
Synonyms: D12H14S564E, Coch-5B2
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 12810
VEGA: 12
HGNC: HGNC:2180
Homologene: 20868
Npc1
Name: NPC intracellular cholesterol transporter 1
Synonyms: lcsd, nmf164, C85354, A430089E03Rik, D18Ertd723e, D18Ertd139e
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 18145
HGNC: HGNC:7897
Homologene: 228
Gpihbp1
Name: GPI-anchored HDL-binding protein 1
Synonyms: 1110002J19Rik, GPI-HBP1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 68453
Homologene: 136164
Reck
Name: reversion-inducing-cysteine-rich protein with kazal motifs
Synonyms: St15
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 53614
Homologene: 9622
Ston2
Name: stonin 2
Synonyms: 4933401N24Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 108800
Homologene: 84338
Cep152
Name: centrosomal protein 152
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 99100
Homologene: 37159
Dpy19l4
Name: dpy-19 like 4
Synonyms: Narg3, LOC381510
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 381510
Homologene: 18773
Mecom
Name: MDS1 and EVI1 complex locus
Synonyms: Jbo, Mds1, Evi-1, Evi1, ZNFPR1B1, Prdm3, MDS1-EVI1, D630039M04Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 14013
HGNC: HGNC:3498
Homologene: 21086
Gipc3
Name: GIPC PDZ domain containing family, member 3
Synonyms: Ahl5, Gipc3, Rgs19ip3
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 209047
Homologene: 77068
Gsap
Name: gamma-secretase activating protein
Synonyms: Pion, A530088I07Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 212167
Homologene: 45504
Unc13c
Name: unc-13 homolog C
Synonyms: Unc13h3, D9Ertd414e, 1500037O19Rik, Munc13-3
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 208898
Homologene: 45443
Dock3
Name: dedicator of cyto-kinesis 3
Synonyms: Moca, PBP
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 208869
HGNC: HGNC:2989
Homologene: 21030
Madd
Name: MAP-kinase activating death domain
Synonyms: Rab3 GEP, 9630059K23Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228355
HGNC: HGNC:6766
Homologene: 14249
Dnaaf9
Name: dynein axonemal assembly factor 9
Synonyms: 4930402H24Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228602
Homologene: 12623
Eln
Name: elastin
Synonyms: tropoelastin, E030024M20Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 13717
HGNC: HGNC:3327
Clstn3
Name: calsyntenin 3
Synonyms: alcadein-beta, Clstn3b, CSTN3, Cst-3
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232370
Homologene: 22836
Spag16
Name: sperm associated antigen 16
Synonyms: 4930585K05Rik, Wdr29, Pf20, 4930524F24Rik, 4921511D23Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 66722
Homologene: 11572
Rd3
Name: retinal degeneration 3
Synonyms: rd-3, rd3, 3322402L07Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 74023
Homologene: 11373
Vmn2r89
Name: vomeronasal 2, receptor 89
Synonyms: V2r11, V2r10
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 22301
Engase
Name: endo-beta-N-acetylglucosaminidase
Synonyms: D230014K01Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217364
Homologene: 13666
Rmc1
Name: regulator of MON1-CCZ1
Synonyms: 3110002H16Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 76482
Homologene: 8341
Psg26
Name: pregnancy-specific beta-1-glycoprotein 26
Synonyms: cea14, EG574429
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 574429
Homologene: 110989
Myo18b
Name: myosin XVIIIb
Synonyms: 4932408L24Rik, 4933411E19Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 74376
Homologene: 53435
Krt8
Name: keratin 8
Synonyms: cytokeratin-8, K8, Card2, Krt2-8, Krt-2.8, cytokeratin8, cytokeratin 8, EndoA
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 16691
VEGA: 15
HGNC: HGNC:6446
Homologene: 55643
Rab3il1
Name: RAB3A interacting protein (rabin3)-like 1
Synonyms: Rab3ail1, 1200014K04Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 74760
HGNC: HGNC:9780
Homologene: 40880
D6Ertd527e
Name: DNA segment, Chr 6, ERATO Doi 527, expressed
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 52372
Radil
Name: Ras association and DIL domains
Synonyms: D930005D10Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231858
Homologene: 77648
Prss23
Name: serine protease 23
Synonyms: 2310046G15Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 76453
Homologene: 5191
Selenov
Name: selenoprotein V
Synonyms: BC089491
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 280621
Homologene: 35357
Zfp764
Name: zinc finger protein 764
Synonyms: 8030466O12Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233893
Homologene: 62158
Fbxo40
Name: F-box protein 40
Synonyms: 9830003A13Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 207215
Homologene: 9459
Lrrc69
Name: leucine rich repeat containing 69
Synonyms: 1700034K16Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 73314
Homologene: 78018
Cdh22
Name: cadherin 22
Synonyms: PB-cadherin
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 104010
Homologene: 23148
Krtap4-21
Name: keratin associated protein 4-21
Synonyms: Gm11569
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 670472
Homologene: 124486
Or5m11b
Name: olfactory receptor family 5 subfamily M member 11B
Synonyms: MOR198-1P, Olfr1029, GA_x6K02T2Q125-47454152-47455126
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258154
Homologene: 73972
Pbx2
Name: pre B cell leukemia homeobox 2
Synonyms: G17
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 18515
HGNC: HGNC:8633
Homologene: 48115
Tlnrd1
Name: talin rod domain containing 1
Synonyms: Mesdc1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 80889
Homologene: 11209
Ighv6-5
Name: immunoglobulin heavy variable V6-5
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 639510
HGNC: HGNC:5623
Lta
Name: lymphotoxin A
Synonyms: hlb382, lymphotoxin alpha, Ltx, LT-[a], LT-alpha, LT[a], Tnfb, lymphotoxin, TNF beta, LT, TNF-beta, Tnfsf1b, LTalpha
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 16992
HGNC: HGNC:6709
Homologene: 497
Gm43302
Name: predicted gene 43302
Type: Gene
Species: Mouse
Chromosome: 5
Cd200l2
Name: CD200 molecule like 2
Synonyms: Gm17783, iSEC2
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 100047671
VEGA: 16
Homologene: 86707
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 69,842,996 bp
  • A to T, chromosome 1 at 191,977,659 bp
  • T to C, chromosome 2 at 85,975,927 bp
  • A to G, chromosome 2 at 91,179,201 bp
  • A to T, chromosome 2 at 125,564,327 bp
  • A to T, chromosome 2 at 130,775,099 bp
  • G to A, chromosome 2 at 165,170,767 bp
  • T to A, chromosome 3 at 30,238,255 bp
  • T to C, chromosome 3 at 40,805,752 bp
  • A to G, chromosome 4 at 11,317,139 bp
  • A to T, chromosome 4 at 14,773,726 bp
  • T to C, chromosome 4 at 43,927,221 bp
  • C to A, chromosome 4 at 149,214,922 bp
  • A to T, chromosome 5 at 21,257,868 bp
  • G to T, chromosome 5 at 76,925,710 bp
  • T to C, chromosome 5 at 105,274,757 bp
  • G to T, chromosome 5 at 112,723,815 bp
  • CTCCAGCTCCGAT to C, chromosome 5 at 134,729,149 bp
  • A to G, chromosome 5 at 142,494,940 bp
  • G to T, chromosome 6 at 87,111,472 bp
  • T to A, chromosome 6 at 124,432,013 bp
  • C to T, chromosome 6 at 125,189,799 bp
  • G to T, chromosome 7 at 18,478,549 bp
  • A to C, chromosome 7 at 28,290,683 bp
  • A to T, chromosome 7 at 83,882,861 bp
  • T to A, chromosome 7 at 89,509,928 bp
  • T to C, chromosome 7 at 127,406,240 bp
  • G to A, chromosome 8 at 79,701,188 bp
  • T to A, chromosome 9 at 73,812,354 bp
  • T to C, chromosome 9 at 106,993,009 bp
  • T to A, chromosome 10 at 81,341,298 bp
  • C to T, chromosome 11 at 3,306,283 bp
  • T to C, chromosome 11 at 99,798,790 bp
  • T to C, chromosome 11 at 118,486,456 bp
  • G to A, chromosome 12 at 51,603,713 bp
  • C to T, chromosome 12 at 91,641,843 bp
  • T to C, chromosome 12 at 114,416,571 bp
  • T to C, chromosome 13 at 38,646,246 bp
  • C to T, chromosome 13 at 99,954,673 bp
  • T to A, chromosome 14 at 51,455,092 bp
  • C to T, chromosome 14 at 64,285,163 bp
  • T to A, chromosome 15 at 37,336,221 bp
  • A to G, chromosome 15 at 75,597,778 bp
  • A to T, chromosome 15 at 102,003,971 bp
  • T to A, chromosome 16 at 36,969,869 bp
  • T to C, chromosome 16 at 45,520,466 bp
  • A to G, chromosome 16 at 89,897,784 bp
  • T to C, chromosome 17 at 34,595,288 bp
  • T to C, chromosome 17 at 35,204,035 bp
  • C to T, chromosome 18 at 12,180,529 bp
  • A to G, chromosome 18 at 12,213,317 bp
  • A to C, chromosome 18 at 76,137,150 bp
  • G to T, chromosome 19 at 10,033,802 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8047 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
067484-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.