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Strain Name:
C57BL/6J-MtgxR8049Btlr/Mmmh
Stock Number:
067486-MU
Citation ID:
RRID:MMRRC_067486-MU
Other Names:
R8049 (G1)
Major Collection:

Strain Information

Th
Name: tyrosine hydroxylase
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 21823
Homologene: 307
Ptprk
Name: protein tyrosine phosphatase receptor type K
Synonyms: PTPk, RPTPkappa
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 19272
VEGA: 10
HGNC: HGNC:9674
Homologene: 55693
Gpr55
Name: G protein-coupled receptor 55
Synonyms: LOC227326, CTFL
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 227326
HGNC: HGNC:4511
Homologene: 36184
Rgs12
Name: regulator of G-protein signaling 12
Synonyms: 4632412M04Rik, 1200016K18Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 71729
HGNC: HGNC:9994
Homologene: 2195
Ndnf
Name: neuron-derived neurotrophic factor
Synonyms: epidermacan, A930038C07Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 68169
Homologene: 11593
Lsm12
Name: LSM12 homolog
Synonyms: 1110032E16Rik, 2600001B17Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 268490
Homologene: 6114
Ddx55
Name: DEAD box helicase 55
Synonyms: 2810021H22Rik, DEAD (Asp-Glu-Ala-Asp) box polypeptide 55
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 67848
Homologene: 12196
Ubxn4
Name: UBX domain protein 4
Synonyms: 1300013G12Rik, Ubxd2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 67812
Homologene: 40962
Dnaja2
Name: DnaJ heat shock protein family (Hsp40) member A2
Synonyms: mDj3, DNJ3, PRO3015, HIRIP4, 2010206B19Rik, 1500017M13Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 56445
Homologene: 21193
Gtf2b
Name: general transcription factor IIB
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229906
HGNC: HGNC:4648
Homologene: 1158
Iqgap3
Name: IQ motif containing GTPase activating protein 3
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 404710
Homologene: 26400
Plppr1
Name: phospholipid phosphatase related 1
Synonyms: PRG-3, E130309F12Rik, Lppr1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 272031
Homologene: 9815
Lpin1
Name: lipin 1
Synonyms: Lipin1
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 14245
VEGA: 12
Homologene: 9266
Setd6
Name: SET domain containing 6
Synonyms: 0610039J04Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 66083
Homologene: 38743
Mtfr2
Name: mitochondrial fission regulator 2
Synonyms: 4933412C16Rik, 2610016C23Rik, Fam54a
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 71804
VEGA: 10
Homologene: 69441
Wrnip1
Name: Werner helicase interacting protein 1
Synonyms: WHIP, 4833444L21Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 78903
Homologene: 10592
Noc3l
Name: NOC3 like DNA replication regulator
Synonyms: Fad24
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 57753
VEGA: 19
Homologene: 39642
Dpy19l4
Name: dpy-19 like 4
Synonyms: LOC381510, Narg3
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 381510
Homologene: 18773
Treml2
Name: triggering receptor expressed on myeloid cells-like 2
Synonyms: LOC328833
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 328833
VEGA: 17
Homologene: 81906
Armh4
Name: armadillo-like helical domain containing 4
Synonyms: 3632451O06Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 67419
Homologene: 12127
Dcn
Name: decorin
Synonyms: DC, SLRR1B
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 13179
VEGA: 10
HGNC: HGNC:2705
Homologene: 22430
Abca13
Name: ATP-binding cassette, sub-family A member 13
Synonyms: A930002G16Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 268379
Homologene: 27991
Fat2
Name: FAT atypical cadherin 2
Synonyms: LOC245827, mKIAA0811, Fath2, EMI2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 245827
HGNC: HGNC:3596
Homologene: 1110
Col7a1
Name: collagen, type VII, alpha 1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 12836
HGNC: HGNC:2214
Homologene: 73
C3ar1
Name: complement component 3a receptor 1
Synonyms: anaphylatoxin C3a receptor, C3aR
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 12267
HGNC: HGNC:1319
Homologene: 2992
Esyt1
Name: extended synaptotagmin-like protein 1
Synonyms: vp115, Mbc2, Fam62a
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 23943
VEGA: 10
Homologene: 40794
Efna5
Name: ephrin A5
Synonyms: AL-1, RAGS, Ephrin-A5, Epl7, EFL-5, LERK-7
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 13640
HGNC: HGNC:3225
Homologene: 1482
Cfap69
Name: cilia and flagella associated protein 69
Synonyms: A330021E22Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 207686
Homologene: 11718
Fbxw14
Name: F-box and WD-40 domain protein 14
Synonyms: Fbx12, E330009N23Rik, Fbxo12
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 50757
Homologene: 110776
Pcnx1
Name: pecanex 1
Synonyms: 3526401J03Rik, 2900024E21Rik, Pcnx
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 54604
VEGA: 12
Homologene: 40997
Rnf122
Name: ring finger protein 122
Synonyms: 1110063C11Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 68867
Homologene: 11717
Eml6
Name: echinoderm microtubule associated protein like 6
Synonyms: 2900083P10Rik, C230094A16Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 237711
Homologene: 104282
Gmcl1
Name: germ cell-less, spermatogenesis associated 1
Synonyms: mglc-1, 2810049L19Rik, Gcl, Btbd13
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 23885
Homologene: 8021
Rars2
Name: arginyl-tRNA synthetase 2, mitochondrial
Synonyms: PRO1992, 1500002I10Rik, Rarsl
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 109093
Homologene: 5707
Adgrg6
Name: adhesion G protein-coupled receptor G6
Synonyms: LOC215798, 1190004A11Rik, DREG, Gpr126
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 215798
Homologene: 10724
Gpr137b
Name: G protein-coupled receptor 137B
Synonyms: C80741, 2310041G17Rik, Tm7sf1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 83924
VEGA: 13
Homologene: 2454
Or52h2
Name: olfactory receptor family 52 subfamily H member 2
Synonyms: GA_x6K02T2PBJ9-6924585-6923647, MOR31-7, Olfr649
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 259057
Homologene: 74119
Scn11a
Name: sodium channel, voltage-gated, type XI, alpha
Synonyms: SNS2, NaN, NaT, NSS2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 24046
VEGA: 9
Homologene: 8041
5730455P16Rik
Name: RIKEN cDNA 5730455P16 gene
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 70591
Homologene: 11177
Kplce
Name: KPRP N-terminal and LCE C-terminal like protein
Synonyms: 2310050C09Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 66533
Homologene: 104374
Fam184a
Name: family with sequence similarity 184, member A
Synonyms: 3110012E06Rik, 4930438C08Rik, 4930589M24Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 75906
Homologene: 11600
Pde6b
Name: phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide
Synonyms: rd, r, Pdeb, rd10, rd1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 18587
HGNC: HGNC:8786
Homologene: 237
Trappc13
Name: trafficking protein particle complex 13
Synonyms: 2610524F24Rik, 2410002O22Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 66975
Homologene: 11792
Cdc14a
Name: CDC14 cell division cycle 14A
Synonyms: CDC14A2, CDC14a1, Cdc14, A830059A17Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229776
HGNC: HGNC:1718
Homologene: 75343
Or9r7
Name: olfactory receptor family 9 subfamily R member 7
Synonyms: GA_x6K02T2PULF-11797746-11796799, MOR210-3, Olfr824
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 258669
Homologene: 45026
Pphln1-ps1
Name: periphilin 1, pseudogene 1
Synonyms: 3110001I22Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 66598
Crb2
Name: crumbs family member 2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241324
Homologene: 45474
Dctn5
Name: dynactin 5
Synonyms: p25 dynactin subunit, 4930427E12Rik, b2b315Clo
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 59288
Homologene: 10998
Tex19.1
Name: testis expressed gene 19.1
Synonyms: 2410081M02Rik, Tex19, Tex19.1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 73679
Homologene: 75271
Fam78a
Name: family with sequence similarity 78, member A
Synonyms: A130092J06Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241303
Homologene: 14115
Or5c1
Name: olfactory receptor family 5 subfamily C member 1
Synonyms: GA_x6K02T2NLDC-34015743-34016726, MOR178-1, Olfr368
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258371
HGNC: HGNC:8331
Homologene: 71970
Rasl10a
Name: RAS-like, family 10, member A
Synonyms: 2210403B10Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 75668
Homologene: 4732
Krtap13-20
Name: keratin associated protein 13-20
Synonyms: 2310034C09Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 117172
Homologene: 114409
Ifit3
Name: interferon-induced protein with tetratricopeptide repeats 3
Synonyms: Ifi49
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 15959
HGNC: HGNC:5411
Homologene: 1189
Or1e27-ps1
Name: olfactory receptor family 1 subfamily E member 27, pseudogene 1
Synonyms: GA_x6K02T2P1NL-3823071-3824002, MOR135-17, Olfr387-ps1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 258210
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 85,941,697 bp
  • T to C, chromosome 1 at 128,256,196 bp
  • C to A, chromosome 2 at 32,083,023 bp
  • A to T, chromosome 2 at 37,332,334 bp
  • G to A, chromosome 2 at 37,793,240 bp
  • A to G, chromosome 2 at 176,809,078 bp
  • T to A, chromosome 2 at 177,508,518 bp
  • T to A, chromosome 3 at 88,104,302 bp
  • A to T, chromosome 3 at 92,868,895 bp
  • T to C, chromosome 3 at 116,293,928 bp
  • T to G, chromosome 3 at 142,778,214 bp
  • T to C, chromosome 4 at 11,303,982 bp
  • T to A, chromosome 4 at 34,650,217 bp
  • A to T, chromosome 4 at 49,300,942 bp
  • A to T, chromosome 5 at 5,619,085 bp
  • T to A, chromosome 5 at 35,026,030 bp
  • C to T, chromosome 5 at 108,425,252 bp
  • T to C, chromosome 5 at 124,556,758 bp
  • T to C, chromosome 6 at 65,703,430 bp
  • G to T, chromosome 6 at 86,721,426 bp
  • T to A, chromosome 6 at 122,850,100 bp
  • C to A, chromosome 7 at 104,189,810 bp
  • G to A, chromosome 7 at 122,133,243 bp
  • G to A, chromosome 7 at 142,894,123 bp
  • T to A, chromosome 8 at 31,128,580 bp
  • T to A, chromosome 8 at 85,539,247 bp
  • C to A, chromosome 8 at 95,716,688 bp
  • A to T, chromosome 8 at 129,220,074 bp
  • C to T, chromosome 9 at 108,975,563 bp
  • A to T, chromosome 9 at 109,276,143 bp
  • T to A, chromosome 9 at 119,755,083 bp
  • A to T, chromosome 10 at 14,428,199 bp
  • T to C, chromosome 10 at 20,352,857 bp
  • C to G, chromosome 10 at 28,383,569 bp
  • C to A, chromosome 10 at 53,633,706 bp
  • C to A, chromosome 10 at 97,513,617 bp
  • C to G, chromosome 10 at 128,512,086 bp
  • A to T, chromosome 10 at 130,126,600 bp
  • A to T, chromosome 11 at 5,059,823 bp
  • T to A, chromosome 11 at 9,291,867 bp
  • A to G, chromosome 11 at 29,893,201 bp
  • A to G, chromosome 11 at 55,312,066 bp
  • G to T, chromosome 11 at 73,665,162 bp
  • A to G, chromosome 11 at 80,377,972 bp
  • T to C, chromosome 11 at 102,165,409 bp
  • A to G, chromosome 11 at 121,147,322 bp
  • T to C, chromosome 12 at 16,563,684 bp
  • C to T, chromosome 12 at 81,918,819 bp
  • T to C, chromosome 13 at 13,359,406 bp
  • A to G, chromosome 13 at 32,821,977 bp
  • T to C, chromosome 13 at 104,144,544 bp
  • G to T, chromosome 14 at 49,773,536 bp
  • C to T, chromosome 16 at 13,677,759 bp
  • A to T, chromosome 16 at 88,759,104 bp
  • A to T, chromosome 17 at 48,302,734 bp
  • G to T, chromosome 17 at 62,650,982 bp
  • A to T, chromosome 19 at 34,588,080 bp
  • A to T, chromosome 19 at 38,812,429 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8049 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
067486-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.