Strain Name:
C57BL/6J-MtgxR8060Btlr/Mmmh
Stock Number:
067496-MU
Citation ID:
RRID:MMRRC_067496-MU
Other Names:
R8060 (G1)
Major Collection:

Strain Information

Pln
Name: phospholamban
Synonyms: PLB
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 18821
VEGA: 10
HGNC: HGNC:9080
Homologene: 2002
Sptbn1
Name: spectrin beta, non-erythrocytic 1
Synonyms: 9930031C03Rik, brain spectrin, elf1, spectrin G, beta fodrin, Spnb2, non-erythrocytic, Spnb-2, elf3
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 20742
Homologene: 2354
H2-DMa
Name: histocompatibility 2, class II, locus DMa
Synonyms: H2-Ma, H2-M alpha, H-2Ma
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 14998
HGNC: HGNC:4934
Homologene: 4464
Chrnb3
Name: cholinergic receptor, nicotinic, beta polypeptide 3
Synonyms: Acrb3, 5730417K16Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 108043
HGNC: HGNC:1963
Homologene: 36035
Dock1
Name: dedicator of cytokinesis 1
Synonyms: D630004B07Rik, Dock180, b2b3190Clo, 9130006G06Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 330662
HGNC: HGNC:2987
Homologene: 55575
Arhgef10
Name: Rho guanine nucleotide exchange factor 10
Synonyms: 6430549H08Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234094
Homologene: 22827
Mast4
Name: microtubule associated serine/threonine kinase family member 4
Synonyms: 4930420O11Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 328329
Homologene: 42094
Hnrnpll
Name: heterogeneous nuclear ribonucleoprotein L-like
Synonyms: Hnrpll, 2810036L13Rik, 2510028H02Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 72692
Homologene: 26701
Hnrnpul1
Name: heterogeneous nuclear ribonucleoprotein U-like 1
Synonyms: E130317O14Rik, Hnrnpul, E1BAP5, Hnrpul1, E1B-AP5
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 232989
Homologene: 31419
Nup107
Name: nucleoporin 107
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 103468
VEGA: 10
Homologene: 5555
Tshr
Name: thyroid stimulating hormone receptor
Synonyms: hyt, hypothroid, pet
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 22095
Homologene: 315
Cit
Name: citron
Synonyms: citron-N, citron kinase, CRIK-SK, Cit-k, C030025P15Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 12704
HGNC: HGNC:1985
Homologene: 21404
Trpm4
Name: transient receptor potential cation channel, subfamily M, member 4
Synonyms: TRPM4B, 1110030C19Rik, LTRPC4
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 68667
Homologene: 23033
Rbl2
Name: RB transcriptional corepressor like 2
Synonyms: Rb2, p130, retinoblastoma-like 2
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 19651
HGNC: HGNC:9894
Homologene: 4098
Copg1
Name: coatomer protein complex, subunit gamma 1
Synonyms: D6Wsu16e, Copg, D6Ertd71e
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 54161
HGNC: HGNC:2236
Homologene: 56745
Pomt2
Name: protein-O-mannosyltransferase 2
Synonyms: A830009D15Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 217734
VEGA: 12
Homologene: 5297
Moxd1
Name: monooxygenase, DBH-like 1
Synonyms: 3230402N08Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 59012
Homologene: 22904
Trpv5
Name: transient receptor potential cation channel, subfamily V, member 5
Synonyms: CaT2, ECaC1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 194352
HGNC: HGNC:3145
Homologene: 10520
Smco2
Name: single-pass membrane protein with coiled-coil domains 2
Synonyms: 1700023A16Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 69371
Homologene: 106211
Tnfrsf11b
Name: tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin)
Synonyms: OPG, Opg, osteoclastogenesis inhibitory factor, OCIF, TR1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 18383
VEGA: 15
Homologene: 1912
Rnpep
Name: arginyl aminopeptidase (aminopeptidase B)
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 215615
Homologene: 10628
Armc3
Name: armadillo repeat containing 3
Synonyms: 4921513G22Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 70882
Homologene: 31589
Myh1
Name: myosin, heavy polypeptide 1, skeletal muscle, adult
Synonyms: Myhs-f, Myhsf2, myosin heavy chain 2X, Myhs-f2, IId, IId/x, A530084A17Rik, MYHC-IIX, MyHC-IId/x
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 17879
HGNC: HGNC:7567
Homologene: 133718
Or4c10
Name: olfactory receptor family 4 subfamily C member 10
Synonyms: Olfr1258, GA_x6K02T2Q125-51361752-51362687, MOR232-3
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258980
Homologene: 82299
Spata16
Name: spermatogenesis associated 16
Synonyms: Nyd-sp12, spermatogenesis-related protein, 4930503K02Rik, 4921511F01Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 70862
Homologene: 49974
Fam171a2
Name: family with sequence similarity 171, member A2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217219
Homologene: 19144
Trim34a
Name: tripartite motif-containing 34A
Synonyms: Trim34, Trim34-1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 94094
Homologene: 128238
Trim42
Name: tripartite motif-containing 42
Synonyms: 4930486B16Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 78911
Homologene: 12712
Or5w20
Name: olfactory receptor family 5 subfamily W member 20
Synonyms: Olfr1153, MOR177-7, GA_x6K02T2Q125-49395950-49396882
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258633
Homologene: 27230
Spata20
Name: spermatogenesis associated 20
Synonyms: Tisp78
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217116
Homologene: 11264
Has2
Name: hyaluronan synthase 2
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 15117
HGNC: HGNC:4819
Homologene: 3892
Asb10
Name: ankyrin repeat and SOCS box-containing 10
Synonyms: Asb-10
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 117590
Homologene: 135975
Arhgef40
Name: Rho guanine nucleotide exchange factor 40
Synonyms: E130112L23Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 268739
Homologene: 19560
Ano5
Name: anoctamin 5
Synonyms: Tmem16e, Gdd1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233246
Homologene: 100071
Slc2a4
Name: solute carrier family 2 (facilitated glucose transporter), member 4
Synonyms: Glut-4, twgy, Glut4
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 20528
Homologene: 74381
Dsc2
Name: desmocollin 2
Synonyms: Dsc2a, Dsc2b
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 13506
HGNC: HGNC:3036
Homologene: 8397
Larp1b
Name: La ribonucleoprotein 1B
Synonyms: 1700108L22Rik, 4933421B21Rik, Larp2
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 214048
Homologene: 103869
Or4p7
Name: olfactory receptor family 4 subfamily P member 7
Synonyms: Olfr1178, GA_x6K02T2Q125-49870417-49871388, MOR225-6P
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258203
Homologene: 73979
Minpp1
Name: multiple inositol polyphosphate histidine phosphatase 1
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 17330
VEGA: 19
HGNC: HGNC:7102
Homologene: 37980
Cts3
Name: cathepsin 3
Synonyms: 1600000I23Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 117066
VEGA: 13
Ccdc112
Name: coiled-coil domain containing 112
Synonyms: 8430438M01Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 240261
VEGA: 18
Homologene: 17617
Snx20
Name: sorting nexin 20
Synonyms: 9130017C17Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 71607
Homologene: 12399
Catsperb
Name: cation channel sperm associated auxiliary subunit beta
Synonyms: 4932415G16Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 271036
VEGA: 12
Homologene: 81904
Or6c205
Name: olfactory receptor family 6 subfamily C member 205
Synonyms: GA_x6K02T2PULF-10936819-10937757, MOR111-6, Olfr1518, MOR111-7, MOR111-7, Olfr775
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 258538
Homologene: 115559
Or5p55
Name: olfactory receptor family 5 subfamily P member 55
Synonyms: MOR204-3, GA_x6K02T2PBJ9-10296787-10297719, Olfr476
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258926
Hoxd11
Name: homeobox D11
Synonyms: E230017H14Rik, Hox-5.4, Hox-4.6, Hox-5.5
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 15431
HGNC: HGNC:5134
Homologene: 7368
Slc23a4
Name: solute carrier family 23 member 4
Synonyms: LOC243753, 2010107G12Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 243753
Homologene: 134124
Vmn2r-ps117
Name: vomeronasal 2, receptor, pseudogene 117
Synonyms: EG665303
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 665303
Aamdc
Name: adipogenesis associated Mth938 domain containing
Synonyms: 1810020D17Rik, 1810037D19Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 66273
Homologene: 11658
Or1e27-ps1
Name: olfactory receptor family 1 subfamily E member 27, pseudogene 1
Synonyms: MOR135-17, GA_x6K02T2P1NL-3823071-3824002, Olfr387-ps1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 258210
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 135,266,920 bp
  • G to T, chromosome 2 at 19,288,909 bp
  • G to A, chromosome 2 at 74,682,376 bp
  • A to T, chromosome 2 at 87,896,973 bp
  • A to G, chromosome 2 at 88,391,504 bp
  • A to T, chromosome 2 at 89,930,349 bp
  • T to C, chromosome 3 at 26,840,720 bp
  • T to C, chromosome 3 at 40,985,402 bp
  • T to A, chromosome 5 at 24,533,835 bp
  • G to A, chromosome 5 at 115,908,727 bp
  • T to C, chromosome 6 at 34,948,401 bp
  • T to A, chromosome 6 at 41,674,531 bp
  • T to C, chromosome 6 at 87,909,721 bp
  • C to A, chromosome 6 at 146,866,785 bp
  • G to T, chromosome 7 at 25,748,343 bp
  • T to C, chromosome 7 at 45,305,451 bp
  • T to A, chromosome 7 at 51,587,783 bp
  • A to T, chromosome 7 at 97,575,648 bp
  • G to T, chromosome 7 at 104,260,976 bp
  • A to G, chromosome 7 at 107,967,405 bp
  • T to A, chromosome 7 at 134,990,629 bp
  • T to A, chromosome 7 at 135,168,403 bp
  • A to T, chromosome 8 at 14,954,446 bp
  • T to A, chromosome 8 at 27,394,560 bp
  • G to T, chromosome 8 at 88,627,645 bp
  • T to A, chromosome 8 at 91,096,869 bp
  • T to G, chromosome 9 at 97,363,479 bp
  • A to G, chromosome 10 at 24,301,612 bp
  • A to T, chromosome 10 at 53,343,897 bp
  • T to C, chromosome 10 at 117,763,769 bp
  • A to C, chromosome 10 at 129,251,046 bp
  • A to T, chromosome 11 at 30,101,616 bp
  • A to C, chromosome 11 at 67,215,251 bp
  • A to T, chromosome 11 at 69,945,010 bp
  • T to C, chromosome 11 at 73,664,939 bp
  • A to T, chromosome 11 at 94,482,239 bp
  • T to C, chromosome 11 at 102,438,610 bp
  • G to A, chromosome 12 at 87,129,006 bp
  • A to C, chromosome 12 at 91,538,360 bp
  • A to T, chromosome 12 at 101,602,766 bp
  • T to A, chromosome 13 at 61,566,766 bp
  • T to C, chromosome 13 at 102,737,676 bp
  • A to G, chromosome 14 at 51,984,995 bp
  • G to A, chromosome 15 at 54,254,109 bp
  • T to A, chromosome 15 at 56,669,945 bp
  • A to T, chromosome 17 at 18,837,862 bp
  • A to G, chromosome 17 at 34,137,285 bp
  • A to G, chromosome 17 at 80,034,105 bp
  • C to T, chromosome 18 at 20,032,274 bp
  • T to C, chromosome 18 at 46,293,462 bp
  • T to A, chromosome 19 at 32,493,903 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8060 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
067496-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.