Strain Name:
C57BL/6J-MtgxR8072Btlr/Mmmh
Stock Number:
067507-MU
Citation ID:
RRID:MMRRC_067507-MU
Other Names:
R8072 (G1)
Major Collection:

Strain Information

Col3a1
Name: collagen, type III, alpha 1
Synonyms: Col3a-1, Tsk2, Tsk-2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12825
HGNC: HGNC:2201
Homologene: 55433
Esco2
Name: establishment of sister chromatid cohesion N-acetyltransferase 2
Synonyms: 2410004I17Rik, D030072L07Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 71988
Homologene: 12432
Kcnj1
Name: potassium inwardly-rectifying channel, subfamily J, member 1
Synonyms: ROMK-2, Kir1.1, ROMK
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 56379
VEGA: 9
HGNC: HGNC:6255
Homologene: 56764
Smad2
Name: SMAD family member 2
Synonyms: Smad 2, Madr2, 7120426M23Rik, Madh2
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 17126
HGNC: HGNC:6768
Homologene: 21197
Atp9b
Name: ATPase, class II, type 9B
Synonyms: IIb
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 50771
VEGA: 18
Homologene: 21915
Arhgef17
Name: Rho guanine nucleotide exchange factor 17
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 207212
Homologene: 129601
Pwp2
Name: PWP2 periodic tryptophan protein homolog (yeast)
Synonyms: Pwp2h, Pwp2, 6530411D08Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 110816
VEGA: 10
HGNC: HGNC:9711
Homologene: 3702
Atad2
Name: ATPase family, AAA domain containing 2
Synonyms: 2610509G12Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 70472
VEGA: 15
Homologene: 6044
Taf4b
Name: TATA-box binding protein associated factor 4b
Synonyms: 105kDa, 4932409F03Rik, Taf2c2, 2610524B04Rik, TAFII105
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 72504
VEGA: 18
Homologene: 28266
Ythdc1
Name: YTH domain containing 1
Synonyms: A730098D12Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231386
Homologene: 15796
Sh2d3c
Name: SH2 domain containing 3C
Synonyms: SH2-containing Eph receptor-binding protein 1, Nsp3, Shep1, Chat, Cas/HEF1-associated signal transducer
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 27387
Homologene: 69145
Abca13
Name: ATP-binding cassette, sub-family A member 13
Synonyms: A930002G16Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 268379
Homologene: 27991
Hmcn1
Name: hemicentin 1
Synonyms: LOC240793, EG545370
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 545370
Homologene: 23741
Ptprd
Name: protein tyrosine phosphatase receptor type D
Synonyms: 3000002J10Rik, 1110002J03Rik, B230219D21Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 19266
HGNC: HGNC:9668
Mrgprb1
Name: MAS-related GPR, member B1
Synonyms: MrgB1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233231
Homologene: 24986
Prg4
Name: proteoglycan 4 (megakaryocyte stimulating factor, articular superficial zone protein)
Synonyms: SZP, MSF, DOL54, lubricin
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 96875
HGNC: HGNC:9364
Homologene: 137352
Mthfsd
Name: methenyltetrahydrofolate synthetase domain containing
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234814
Homologene: 11245
Mmp1a
Name: matrix metallopeptidase 1a (interstitial collagenase)
Synonyms: Mcol-A
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 83995
VEGA: 9
HGNC: HGNC:7155
Homologene: 20544
Acad9
Name: acyl-Coenzyme A dehydrogenase family, member 9
Synonyms: NPD002, 2600017P15Rik, C630012L17Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229211
Homologene: 8539
Ctns
Name: cystinosis, nephropathic
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 83429
HGNC: HGNC:2518
Homologene: 3625
Cyp2b23
Name: cytochrome P450, family 2, subfamily b, polypeptide 23
Synonyms: EG243881
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 243881
HGNC: HGNC:2615
Homologene: 117483
Igsf9b
Name: immunoglobulin superfamily, member 9B
Synonyms: AI414108, LOC235086
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235086
Homologene: 19472
Vmn2r90
Name: vomeronasal 2, receptor 90
Synonyms: EG626942
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 626942
Fggy
Name: FGGY carbohydrate kinase domain containing
Synonyms: 2310009E04Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 75578
Homologene: 49535
Dcbld2
Name: discoidin, CUB and LCCL domain containing 2
Synonyms: CLCP1, 1700055P21Rik, Esdn
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 73379
Homologene: 12499
Hspa4l
Name: heat shock protein 4 like
Synonyms: APG-1, Osp94, 94kDa
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 18415
Homologene: 22610
Fhod3
Name: formin homology 2 domain containing 3
Synonyms: A930009H06Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 225288
VEGA: 18
Homologene: 45323
Apol6
Name: apolipoprotein L 6
Synonyms: 2310076O14Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 71939
Homologene: 49940
Hook2
Name: hook microtubule tethering protein 2
Synonyms: A630054I03Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 170833
Homologene: 8332
Ace
Name: angiotensin I converting enzyme
Synonyms: CD143
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 11421
HGNC: HGNC:2707
Homologene: 37351
Slc34a3
Name: solute carrier family 34 (sodium phosphate), member 3
Synonyms: NPTIIc, Npt2c
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 142681
Homologene: 15444
Sp110
Name: Sp110 nuclear body protein
Synonyms: 5830484A20Rik, Ifi75, 5031415C07Rik, 52kDa, Ipr1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 109032
HGNC: HGNC:5401
Homologene: 82192
H2-M11
Name: histocompatibility 2, M region locus 11
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 224754
Homologene: 52241
Gm4846
Name: predicted gene 4846
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226601
Homologene: 136281
Atg3
Name: autophagy related 3
Synonyms: Apg3l, 2610016C12Rik, PC3-96, APG3
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 67841
Homologene: 6836
Col10a1
Name: collagen, type X, alpha 1
Synonyms: Col10a-1, Col10
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 12813
HGNC: HGNC:2185
Homologene: 55466
Lin28a
Name: lin-28 homolog A
Synonyms: Tex17, Lin-28, Lin28a, Lin28
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 83557
Homologene: 32592
Ubxn6
Name: UBX domain protein 6
Synonyms: 2210415J11Rik, Ubxd1, Ubxdc2, 1200008L11Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 66530
Homologene: 11538
Rhd
Name: Rh blood group, D antigen
Synonyms: Rhced, Rhl1, Rh
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 19746
Homologene: 7918
Tial1
Name: Tia1 cytotoxic granule-associated RNA binding protein-like 1
Synonyms: mTIAR, TIAR, 5330433G13Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 21843
Homologene: 87796
Loxl4
Name: lysyl oxidase-like 4
Synonyms: 4833426I20Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 67573
Homologene: 12977
Spata21
Name: spermatogenesis associated 21
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 329972
Homologene: 18639
Plpp7
Name: phospholipid phosphatase 7 (inactive)
Synonyms: NET39, D830019K17Rik, Ppapdc3
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 227721
Homologene: 41885
Pcdhac2
Name: protocadherin alpha subfamily C, 2
Synonyms: CNRc2
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 353237
HGNC: HGNC:8677
Homologene: 49562
Igkv4-68
Name: immunoglobulin kappa variable 4-68
Synonyms: LOC232058, LOC384515
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 384515
Mup11
Name: major urinary protein 11
Synonyms: Gm12549
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 100039028
Homologene: 74304
Lcn8
Name: lipocalin 8
Synonyms: EP17, mEP17, 9230106L18Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 78076
Homologene: 69532
Ankrd66
Name: ankyrin repeat domain 66
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 100043332
VEGA: 17
Homologene: 104917
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to A, chromosome 1 at 45,321,574 bp
  • GTACT to GTACTACT, chromosome 1 at 85,587,486 bp
  • T to C, chromosome 1 at 150,456,023 bp
  • T to A, chromosome 1 at 150,656,505 bp
  • T to C, chromosome 1 at 166,494,672 bp
  • A to C, chromosome 2 at 25,229,277 bp
  • T to G, chromosome 2 at 25,655,172 bp
  • G to T, chromosome 2 at 32,096,109 bp
  • C to T, chromosome 2 at 32,753,138 bp
  • G to A, chromosome 3 at 36,075,255 bp
  • A to T, chromosome 3 at 40,786,746 bp
  • A to T, chromosome 4 at 60,659,778 bp
  • A to G, chromosome 4 at 76,086,036 bp
  • A to G, chromosome 4 at 95,844,157 bp
  • A to G, chromosome 4 at 134,018,142 bp
  • A to G, chromosome 4 at 134,884,149 bp
  • C to T, chromosome 4 at 141,112,006 bp
  • T to A, chromosome 5 at 86,821,274 bp
  • C to T, chromosome 6 at 69,305,129 bp
  • A to T, chromosome 7 at 26,666,006 bp
  • C to A, chromosome 7 at 48,448,147 bp
  • T to A, chromosome 7 at 100,881,797 bp
  • T to C, chromosome 7 at 128,442,470 bp
  • G to A, chromosome 8 at 84,994,491 bp
  • A to C, chromosome 8 at 121,098,816 bp
  • TG to TGG, chromosome 9 at 7,465,083 bp
  • C to A, chromosome 9 at 27,317,364 bp
  • G to A, chromosome 9 at 32,397,297 bp
  • G to T, chromosome 10 at 34,390,667 bp
  • G to A, chromosome 10 at 78,172,096 bp
  • T to C, chromosome 11 at 9,294,574 bp
  • T to C, chromosome 11 at 73,191,746 bp
  • T to C, chromosome 11 at 105,972,959 bp
  • A to T, chromosome 14 at 65,832,681 bp
  • C to T, chromosome 15 at 58,099,978 bp
  • A to T, chromosome 15 at 77,051,103 bp
  • G to T, chromosome 16 at 45,187,685 bp
  • G to A, chromosome 16 at 58,463,097 bp
  • A to T, chromosome 17 at 17,726,880 bp
  • G to T, chromosome 17 at 36,548,134 bp
  • T to C, chromosome 17 at 43,543,635 bp
  • C to A, chromosome 17 at 56,073,195 bp
  • A to G, chromosome 18 at 14,821,528 bp
  • TGAGGAGGAGGAGGAGGA to TGAGGAGGAGGAGGA, chromosome 18 at 25,020,665 bp
  • G to A, chromosome 18 at 37,145,664 bp
  • T to C, chromosome 18 at 76,286,951 bp
  • A to C, chromosome 18 at 80,765,061 bp
  • T to C, chromosome 19 at 42,607,582 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8072 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
067507-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.