Loading Mouse GIF
Loading...

Strain Name:
C57BL/6J-MtgxR8078Btlr/Mmmh
Stock Number:
067512-MU
Citation ID:
RRID:MMRRC_067512-MU
Other Names:
R8078 (G1)
Major Collection:

Strain Information

Sncg
Name: synuclein, gamma
Synonyms: persyn, C79089
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 20618
Homologene: 2322
Ncam2
Name: neural cell adhesion molecule 2
Synonyms: RNCAM, R4B12 antigen, Ncam-2, Ocam
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 17968
HGNC: HGNC:7657
Homologene: 3336
Mtor
Name: mechanistic target of rapamycin kinase
Synonyms: FKBP-rapamycin-associated protein FRAP, 2610315D21Rik, RAPT1, RAFT1, flat, Frap1, mechanistic target of rapamycin (serine/threonine kinase)
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 56717
HGNC: HGNC:3942
Homologene: 3637
Cep290
Name: centrosomal protein 290
Synonyms: Nphp6, b2b1454Clo, b2b1752Clo, Kiaa
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 216274
VEGA: 10
Homologene: 77213
Ddx55
Name: DEAD box helicase 55
Synonyms: 2810021H22Rik, DEAD (Asp-Glu-Ala-Asp) box polypeptide 55
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 67848
Homologene: 12196
Coro1c
Name: coronin, actin binding protein 1C
Synonyms: coronin 3, CRN2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 23790
HGNC: HGNC:2254
Homologene: 56537
Tfap2c
Name: transcription factor AP-2, gamma
Synonyms: Ap-2.2, Stra2, AP2gamma, Tcfap2c
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 21420
Homologene: 2423
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 65,161,066 bp
  • A to G, chromosome 1 at 81,241,057 bp
  • A to T, chromosome 1 at 105,817,684 bp
  • A to G, chromosome 1 at 173,341,059 bp
  • C to A, chromosome 2 at 26,604,101 bp
  • T to A, chromosome 2 at 84,982,260 bp
  • T to A, chromosome 2 at 111,983,270 bp
  • T to A, chromosome 2 at 154,552,570 bp
  • T to C, chromosome 2 at 170,418,612 bp
  • T to A, chromosome 2 at 172,551,472 bp
  • C to A, chromosome 3 at 58,416,032 bp
  • T to G, chromosome 3 at 93,200,275 bp
  • G to A, chromosome 4 at 107,209,491 bp
  • T to A, chromosome 4 at 107,567,902 bp
  • T to A, chromosome 4 at 128,711,062 bp
  • A to T, chromosome 4 at 136,254,514 bp
  • T to C, chromosome 4 at 137,508,022 bp
  • T to G, chromosome 4 at 148,468,287 bp
  • A to T, chromosome 4 at 148,613,778 bp
  • C to T, chromosome 4 at 152,028,346 bp
  • C to A, chromosome 4 at 152,360,991 bp
  • T to A, chromosome 5 at 63,939,721 bp
  • T to C, chromosome 5 at 89,179,707 bp
  • G to C, chromosome 5 at 90,467,355 bp
  • G to T, chromosome 5 at 113,882,103 bp
  • G to A, chromosome 5 at 124,566,388 bp
  • T to C, chromosome 6 at 25,750,108 bp
  • G to T, chromosome 6 at 48,597,345 bp
  • A to T, chromosome 6 at 67,423,593 bp
  • T to A, chromosome 6 at 72,358,323 bp
  • T to A, chromosome 6 at 118,517,893 bp
  • A to G, chromosome 6 at 129,409,033 bp
  • C to A, chromosome 6 at 136,697,921 bp
  • G to A, chromosome 7 at 12,481,015 bp
  • T to A, chromosome 7 at 55,052,762 bp
  • T to C, chromosome 7 at 110,899,735 bp
  • T to A, chromosome 8 at 10,562,078 bp
  • A to G, chromosome 9 at 7,858,741 bp
  • A to G, chromosome 9 at 53,705,955 bp
  • T to C, chromosome 9 at 56,890,259 bp
  • T to C, chromosome 10 at 100,572,887 bp
  • C to A, chromosome 10 at 130,429,495 bp
  • G to A, chromosome 11 at 9,301,279 bp
  • G to T, chromosome 11 at 35,797,901 bp
  • G to A, chromosome 11 at 102,668,400 bp
  • A to G, chromosome 12 at 81,975,280 bp
  • A to G, chromosome 13 at 59,715,449 bp
  • A to T, chromosome 13 at 116,924,983 bp
  • C to A, chromosome 14 at 34,374,770 bp
  • T to A, chromosome 14 at 121,276,300 bp
  • G to T, chromosome 16 at 81,443,248 bp
  • T to A, chromosome 17 at 19,590,245 bp
  • T to C, chromosome 17 at 21,723,455 bp
  • T to C, chromosome 17 at 22,559,051 bp
  • A to T, chromosome 17 at 67,791,294 bp
  • C to T, chromosome 19 at 7,579,161 bp
  • T to C, chromosome 19 at 33,822,957 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8078 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
067512-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.