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Strain Name:
C57BL/6J-MtgxR8080Btlr/Mmmh
Stock Number:
067513-MU
Citation ID:
RRID:MMRRC_067513-MU
Other Names:
R8080 (G1)
Major Collection:

Strain Information

Utp20
Name: UTP20 small subunit processome component
Synonyms: mDRIM, DRIM, 3830408P06Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 70683
VEGA: 10
Homologene: 38373
Usp7
Name: ubiquitin specific peptidase 7
Synonyms: 2210010O09Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 252870
Homologene: 2592
Zfp384
Name: zinc finger protein 384
Synonyms: C130073D16Rik, Ciz, Nmp4
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 269800
Homologene: 15849
Polr2a
Name: polymerase (RNA) II (DNA directed) polypeptide A
Synonyms: 220kDa, Rpo2-1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 20020
HGNC: HGNC:9187
Homologene: 721
Cdca2
Name: cell division cycle associated 2
Synonyms: 2610311M19Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 108912
Homologene: 18444
Ticrr
Name: TOPBP1-interacting checkpoint and replication regulator
Synonyms: 5730590G19Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 77011
Homologene: 67120
Nup205
Name: nucleoporin 205
Synonyms: 3830404O05Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 70699
Homologene: 45971
Fancc
Name: Fanconi anemia, complementation group C
Synonyms: Facc
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 14088
HGNC: HGNC:3584
Homologene: 109
Phip
Name: pleckstrin homology domain interacting protein
Synonyms: Wdr11, Ndrp, 2810004D21Rik, 4632404O06Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 83946
Homologene: 41209
Arb2a
Name: ARB2 cotranscriptional regulator A
Synonyms: pEN87, 53-E6, 2610318O14Rik, 9430037D06Rik, 1110033M05Rik, Fam172a
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 68675
VEGA: 13
Homologene: 12933
Syt9
Name: synaptotagmin IX
Synonyms: Sytv
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 60510
Homologene: 11062
Ctr9
Name: CTR9 homolog, Paf1/RNA polymerase II complex component
Synonyms: Tsp, Tsbp, Sh2bp1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 22083
Homologene: 40668
Cntn2
Name: contactin 2
Synonyms: Tax, TAG-1, axonin, D130012K04Rik, TAG1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 21367
HGNC: HGNC:2172
Homologene: 3720
Tlr4
Name: toll-like receptor 4
Synonyms: Lps, Rasl2-8, lipopolysaccharide response
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 21898
Homologene: 41317
Dmbt1
Name: deleted in malignant brain tumors 1
Synonyms: CRP-[b], CRP-[a], ebnerin, hensin, vomeroglandin, Crpd, MUCLIN, gp300
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 12945
HGNC: HGNC:2926
Homologene: 68990
Jcad
Name: junctional cadherin 5 associated
Synonyms: 9430020K01Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 240185
VEGA: 18
Homologene: 19370
Plpp1
Name: phospholipid phosphatase 1
Synonyms: mPAP, Lipid phosphate phosphatase 1, LPP1, LPP-1, Hpic53, Ppap2a
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 19012
VEGA: 13
HGNC: HGNC:9228
Homologene: 134049
Zfp600
Name: zinc finger protein 600
Synonyms: Gm13164
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 667666
Homologene: 133076
Tnc
Name: tenascin C
Synonyms: Hxb, TN-C, TN, C130033P17Rik, tenascin-C, cytotactin, hexabrachion
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 21923
HGNC: HGNC:5318
Homologene: 55636
Brca2
Name: breast cancer 2, early onset
Synonyms: RAB163, Fancd1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 12190
HGNC: HGNC:1101
Homologene: 41
Bcl2l11
Name: BCL2 like 11
Synonyms: Bod, Bim, 1500006F24Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 12125
HGNC: HGNC:994
Homologene: 7643
Bpnt1
Name: 3'(2'), 5'-bisphosphate nucleotidase 1
Synonyms: BPntase, bisphosphate 3'-nucleotidase 1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 23827
HGNC: HGNC:1096
Homologene: 4437
Stard3nl
Name: STARD3 N-terminal like
Synonyms: 0610035N01Rik, 6530409L22Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 76205
Homologene: 11501
Phlpp1
Name: PH domain and leucine rich repeat protein phosphatase 1
Synonyms: Plekhe1, Phlpp
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 98432
Homologene: 11015
Kalrn
Name: kalirin, RhoGEF kinase
Synonyms: LOC224126, Hapip, 2210407G14Rik, E530005C20Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 545156
HGNC: HGNC:4814
Homologene: 57160
Hydin
Name: HYDIN, axonemal central pair apparatus protein
Synonyms: hy-3, hy3, 1700034M11Rik, 4930545D19Rik, hyrh
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 244653
Homologene: 52118
Med12l
Name: mediator complex subunit 12-like
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 329650
Homologene: 43143
Pcdhb4
Name: protocadherin beta 4
Synonyms: Pcdhb5A, PcdhbD
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93875
HGNC: HGNC:8690
Homologene: 62176
Enpep
Name: glutamyl aminopeptidase
Synonyms: Bp-1/6C3, APA, Ly-51, Ly51, 6030431M22Rik, aminopeptidase-A
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 13809
HGNC: HGNC:3355
Homologene: 68216
Kdm5d
Name: lysine demethylase 5D
Synonyms: Smcy, Jarid1d, HY
Type: Gene
Species: Mouse
Chromosome: Y
NCBI: 20592
Homologene: 55838
Slc35e1
Name: solute carrier family 35, member E1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 270066
Homologene: 49075
Helz2
Name: helicase with zinc finger 2, transcriptional coactivator
Synonyms: BC006779
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 229003
Homologene: 14118
Hrc
Name: histidine rich calcium binding protein
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 15464
HGNC: HGNC:5178
Homologene: 137234
Mrgprb1
Name: MAS-related GPR, member B1
Synonyms: MrgB1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233231
Homologene: 24986
Myh1
Name: myosin, heavy polypeptide 1, skeletal muscle, adult
Synonyms: MyHC-IId/x, Myhs-f, Myhs-f2, Myhsf2, A530084A17Rik, MYHC-IIX, myosin heavy chain 2X, IId, IId/x
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 17879
HGNC: HGNC:7567
Homologene: 133718
Vmn2r111
Name: vomeronasal 2, receptor 111
Synonyms: EG210876
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 210876
Homologene: 86604
Egflam
Name: EGF-like, fibronectin type III and laminin G domains
Synonyms: nectican, pikachurin
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 268780
Homologene: 65044
Jmjd4
Name: jumonji domain containing 4
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 194952
Homologene: 11306
Or13a20
Name: olfactory receptor family 13 subfamily A member 20
Synonyms: IE12, MOR253-5, GA_x6K02T2PBJ9-42798103-42799038, Olfr53
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258962
Homologene: 133678
Slc9a3
Name: solute carrier family 9 (sodium/hydrogen exchanger), member 3
Synonyms: NHE3, 9030624O13Rik, NHE-3
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 105243
VEGA: 13
Homologene: 55804
Gmip
Name: Gem-interacting protein
Synonyms: 5031419I10Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 78816
Homologene: 9570
Rbm42
Name: RNA binding motif protein 42
Synonyms: 1700003D06Rik, 3100004P22Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 68035
Homologene: 32579
Cntnap5b
Name: contactin associated protein-like 5B
Synonyms: Caspr5-2, C230078M14Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 241175
Homologene: 104295
Garem2
Name: GRB2 associated regulator of MAPK1 subtype 2
Synonyms: LOC242915, Fam59b, Gareml
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 242915
Homologene: 19063
Zfp819
Name: zinc finger protein 819
Synonyms: 4930427I11Rik, 4933405K07Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 74400
Homologene: 128446
Vmn2r60
Name: vomeronasal 2, receptor 60
Synonyms: Casr-rs3, EG637898, Gprc2a-rs3
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 637898
Homologene: 129683
Or5v1b
Name: olfactory receptor family 5 subfamily V member 1B
Synonyms: MOR249-1P, GA_x6K02T2PSCP-1989071-1990024, Olfr111
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 545205
Homologene: 73968
Hoxc9
Name: homeobox C9
Synonyms: Hox-3.2
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 15427
HGNC: HGNC:5130
Homologene: 130558
Fam13a
Name: family with sequence similarity 13, member A
Synonyms: D430015B01Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 58909
Homologene: 135847
St3gal4
Name: ST3 beta-galactoside alpha-2,3-sialyltransferase 4
Synonyms: ST3Gal IV, Siat4c
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 20443
VEGA: 9
Homologene: 4572
Repin1
Name: replication initiator 1
Synonyms: Zfp464, AP4, E430037F08Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 58887
Homologene: 22810
Negr1
Name: neuronal growth regulator 1
Synonyms: Ntra, 5330422G01Rik, neurotractin
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 320840
Homologene: 41447
Or6c69b
Name: olfactory receptor family 6 subfamily C member 69B
Synonyms: GA_x6K02T2PULF-11470271-11469333, MOR113-4, Olfr810
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 258543
Homologene: 46347
Pigz
Name: phosphatidylinositol glycan anchor biosynthesis, class Z
Synonyms: F630022B06Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 239827
Homologene: 130742
Or4a81
Name: olfactory receptor family 4 subfamily A member 81
Synonyms: GA_x6K02T2Q125-51230155-51229211, MOR231-13, Olfr1254
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258468
Homologene: 103784
Aloxe3
Name: arachidonate lipoxygenase 3
Synonyms: e-LOX-3
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 23801
Homologene: 8013
Fbxo3
Name: F-box protein 3
Synonyms: Fba, 1700026K02Rik, 1200002G09Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 57443
Homologene: 8133
Or8c14-ps1
Name: olfactory receptor family 8 subfamily C member 14, pseudogene 1
Synonyms: GA_x6K02T2PVTD-31869885-31870831, MOR170-12, Olfr892-ps1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 257911
Gm17079
Name: predicted gene 17079
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 102640847
Homologene: 128452
Gm3696
Name: predicted gene 3696
Synonyms: Gm5794
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 100042149
Homologene: 115686
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 100,072,203 bp
  • A to G, chromosome 1 at 106,392,976 bp
  • T to C, chromosome 1 at 132,521,798 bp
  • A to G, chromosome 1 at 185,352,209 bp
  • T to C, chromosome 2 at 30,337,033 bp
  • T to A, chromosome 2 at 89,788,627 bp
  • A to G, chromosome 2 at 104,033,667 bp
  • T to C, chromosome 2 at 128,128,666 bp
  • T to A, chromosome 2 at 181,238,262 bp
  • A to G, chromosome 3 at 59,265,186 bp
  • A to G, chromosome 3 at 88,486,561 bp
  • A to T, chromosome 3 at 129,299,134 bp
  • C to A, chromosome 3 at 157,160,720 bp
  • A to C, chromosome 4 at 63,976,469 bp
  • T to A, chromosome 4 at 66,839,476 bp
  • T to A, chromosome 4 at 146,196,612 bp
  • A to G, chromosome 5 at 30,108,387 bp
  • T to C, chromosome 5 at 122,807,338 bp
  • A to T, chromosome 5 at 150,539,892 bp
  • T to C, chromosome 6 at 35,227,376 bp
  • G to T, chromosome 6 at 48,597,345 bp
  • A to G, chromosome 6 at 58,956,805 bp
  • T to C, chromosome 6 at 125,036,558 bp
  • G to T, chromosome 7 at 30,645,711 bp
  • A to G, chromosome 7 at 42,141,097 bp
  • A to G, chromosome 7 at 43,617,724 bp
  • A to G, chromosome 7 at 45,336,838 bp
  • T to C, chromosome 7 at 48,446,910 bp
  • A to T, chromosome 7 at 79,684,264 bp
  • T to A, chromosome 7 at 107,436,790 bp
  • G to A, chromosome 7 at 111,051,567 bp
  • A to G, chromosome 7 at 131,088,770 bp
  • T to C, chromosome 7 at 140,652,474 bp
  • C to T, chromosome 7 at 142,273,816 bp
  • A to T, chromosome 8 at 69,816,086 bp
  • G to A, chromosome 8 at 72,492,186 bp
  • A to G, chromosome 8 at 110,535,231 bp
  • T to C, chromosome 9 at 35,106,321 bp
  • T to C, chromosome 9 at 38,190,589 bp
  • A to G, chromosome 9 at 82,887,609 bp
  • A to G, chromosome 10 at 88,782,715 bp
  • T to C, chromosome 10 at 129,791,128 bp
  • A to G, chromosome 11 at 59,450,353 bp
  • T to A, chromosome 11 at 67,211,402 bp
  • A to G, chromosome 11 at 69,133,074 bp
  • A to T, chromosome 11 at 69,735,048 bp
  • T to C, chromosome 12 at 115,507,843 bp
  • G to T, chromosome 13 at 19,370,351 bp
  • G to T, chromosome 13 at 63,403,023 bp
  • A to C, chromosome 13 at 74,166,027 bp
  • T to A, chromosome 13 at 78,006,446 bp
  • A to G, chromosome 13 at 112,867,468 bp
  • A to T, chromosome 14 at 7,089,870 bp
  • T to C, chromosome 14 at 51,693,023 bp
  • G to A, chromosome 14 at 67,677,555 bp
  • T to A, chromosome 15 at 7,398,080 bp
  • C to T, chromosome 15 at 102,982,119 bp
  • C to A, chromosome 16 at 8,697,907 bp
  • T to C, chromosome 16 at 31,942,040 bp
  • C to T, chromosome 16 at 33,975,668 bp
  • T to C, chromosome 17 at 22,559,051 bp
  • G to A, chromosome 17 at 37,530,664 bp
  • A to G, chromosome 18 at 4,649,270 bp
  • A to G, chromosome 18 at 37,309,296 bp
  • T to C, chromosome Y at 910,742 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8080 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
067513-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.