Strain Name:
C57BL/6J-MtgxR8083Btlr/Mmmh
Stock Number:
067516-MU
Citation ID:
RRID:MMRRC_067516-MU
Other Names:
R8083 (G1)
Major Collection:

Strain Information

Setd5
Name: SET domain containing 5
Synonyms: 2900045N06Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 72895
Homologene: 12485
Hbegf
Name: heparin-binding EGF-like growth factor
Synonyms: Hegfl, Dtr, HB-EGF
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 15200
VEGA: 18
HGNC: HGNC:3059
Homologene: 1466
Eri3
Name: exoribonuclease 3
Synonyms: PINT1, Prnpip1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 140546
Homologene: 15403
Cdk8
Name: cyclin dependent kinase 8
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 264064
HGNC: HGNC:1779
Homologene: 55565
Rangap1
Name: RAN GTPase activating protein 1
Synonyms: Fug1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 19387
VEGA: 15
HGNC: HGNC:9854
Homologene: 55700
Ttc17
Name: tetratricopeptide repeat domain 17
Synonyms: D2Bwg1005e, 9130020K17Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 74569
Homologene: 10100
Rprd1b
Name: regulation of nuclear pre-mRNA domain containing 1B
Synonyms: 2810446G03Rik, 2610304G08Rik, Crept
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 70470
Homologene: 41426
Pid1
Name: phosphotyrosine interaction domain containing 1
Synonyms: 5033414K04Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 98496
Homologene: 9924
Abcg5
Name: ATP binding cassette subfamily G member 5
Synonyms: cmp, trac, Sterolin-1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 27409
Homologene: 31909
Arel1
Name: apoptosis resistant E3 ubiquitin protein ligase 1
Synonyms: 1110018G07Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 68497
Homologene: 8885
Zp3
Name: zona pellucida glycoprotein 3
Synonyms: Zp-3
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 22788
Homologene: 5178
Apobec1
Name: apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 11810
HGNC: HGNC:604
Homologene: 1243
Osbpl9
Name: oxysterol binding protein-like 9
Synonyms: 2600011I06Rik, ORP-9
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 100273
Homologene: 69380
Mcf2l
Name: mcf.2 transforming sequence-like
Synonyms: C130040G20Rik, Dbs
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 17207
Homologene: 11804
Cpne6
Name: copine VI
Synonyms: neuronal copine
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 12891
HGNC: HGNC:2319
Homologene: 81815
Adam32
Name: a disintegrin and metallopeptidase domain 32
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 353188
Homologene: 17021
Acsl3
Name: acyl-CoA synthetase long-chain family member 3
Synonyms: C85929, Facl3, 2610510B12Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 74205
HGNC: HGNC:3570
Homologene: 3278
Caprin2
Name: caprin family member 2
Synonyms: RNG140, C1qdc1, Eeg1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232560
Homologene: 11393
Eci3
Name: enoyl-Coenzyme A delta isomerase 3
Synonyms: 1810022C23Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 69123
Homologene: 74357
Xirp2
Name: xin actin-binding repeat containing 2
Synonyms: mXin beta, myomaxin, 2310003D02Rik, Cmya3, 2310008C07Rik, A530024P18Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241431
Homologene: 19388
Cfap58
Name: cilia and flagella associated protein 58
Synonyms: Ccdc147, LOC381229
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 381229
VEGA: 19
Homologene: 77312
Cacna1s
Name: calcium channel, voltage-dependent, L type, alpha 1S subunit
Synonyms: Cchl1a3, Cav1.1, muscle dysgenesis, DHPR alpha1s, mdg, sj, fmd
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12292
HGNC: HGNC:1397
Homologene: 37257
Cdkn3
Name: cyclin dependent kinase inhibitor 3
Synonyms: 2410006H10Rik, KAP
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 72391
VEGA: 14
HGNC: HGNC:1791
Homologene: 3805
Gns
Name: glucosamine (N-acetyl)-6-sulfatase
Synonyms: G6S, 2610016K11Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 75612
VEGA: 10
HGNC: HGNC:4422
Homologene: 1568
Sacs
Name: sacsin
Synonyms: E130115J16Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 50720
Chaf1b
Name: chromatin assembly factor 1, subunit B
Synonyms: CAF-1 subunit B, CAF-IP60, 2600017H24Rik, CAF1, MPHOSPH7, CAF1P60, CAF-I 60 kDa subunit, CAF1A
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 110749
HGNC: HGNC:1911
Homologene: 48346
Adamtsl4
Name: ADAMTS-like 4
Synonyms: Tsrc1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229595
Homologene: 23141
Cyp2b23
Name: cytochrome P450, family 2, subfamily b, polypeptide 23
Synonyms: EG243881
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 243881
HGNC: HGNC:2615
Homologene: 117483
Clcn4
Name: chloride channel, voltage-sensitive 4
Synonyms: Clcn4-2, Clc4-2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 12727
HGNC: HGNC:2022
Homologene: 68207
Nfasc
Name: neurofascin
Synonyms: D430023G06Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 269116
Homologene: 24945
Zfp503
Name: zinc finger protein 503
Synonyms: Zpo2, ZNF503, Nolz1, B830002A16Rik, Nolz-1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 218820
Homologene: 41888
Hcn1
Name: hyperpolarization activated cyclic nucleotide gated potassium channel 1
Synonyms: C630013B14Rik, hyperpolarization-activated, cyclic nucleotide-gated K+ 1, HAC2, Bcng1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 15165
HGNC: HGNC:4845
Homologene: 32093
Rbm12b1
Name: RNA binding motif protein 12 B1
Synonyms: Rbm12b, 3000004N20Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 72397
Homologene: 28658
Tagln2
Name: transgelin 2
Synonyms: 2700094C18Rik, Sm22B
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 21346
Homologene: 20789
6820408C15Rik
Name: RIKEN cDNA 6820408C15 gene
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228778
Homologene: 51916
Zfp784
Name: zinc finger protein 784
Synonyms: C730049F21Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 654801
Homologene: 52408
Bpifa2
Name: BPI fold containing family A, member 2
Synonyms: Psp, Bpifa2e
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 19194
Homologene: 69034
Nt5dc2
Name: 5'-nucleotidase domain containing 2
Synonyms: 2510015F01Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 70021
VEGA: 14
Homologene: 11290
Gm6594
Name: predicted pseudogene 6594
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 625514
VEGA: 17
Gm21103
Name: predicted gene, 21103
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 118567363
Tex51
Name: testis expressed 51
Synonyms: Gm35060
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 102638514
Homologene: 132337
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to A, chromosome 1 at 78,692,127 bp
  • T to C, chromosome 1 at 84,038,249 bp
  • T to C, chromosome 1 at 132,596,582 bp
  • G to A, chromosome 1 at 136,095,791 bp
  • A to T, chromosome 1 at 172,505,199 bp
  • T to A, chromosome 2 at 67,508,699 bp
  • C to A, chromosome 2 at 94,374,564 bp
  • A to G, chromosome 2 at 152,441,067 bp
  • T to G, chromosome 2 at 154,010,492 bp
  • T to C, chromosome 2 at 158,050,132 bp
  • C to T, chromosome 3 at 95,684,401 bp
  • T to C, chromosome 4 at 12,146,409 bp
  • C to T, chromosome 4 at 109,086,375 bp
  • T to A, chromosome 4 at 117,593,162 bp
  • A to C, chromosome 5 at 135,984,522 bp
  • T to G, chromosome 5 at 146,268,290 bp
  • G to T, chromosome 6 at 113,115,010 bp
  • G to A, chromosome 6 at 122,578,929 bp
  • A to C, chromosome 6 at 148,842,848 bp
  • T to C, chromosome 7 at 5,035,906 bp
  • A to G, chromosome 7 at 7,291,428 bp
  • C to A, chromosome 7 at 26,686,403 bp
  • T to A, chromosome 8 at 13,007,875 bp
  • A to T, chromosome 8 at 24,872,736 bp
  • T to C, chromosome 10 at 121,378,103 bp
  • A to T, chromosome 12 at 84,940,362 bp
  • G to T, chromosome 13 at 34,956,890 bp
  • GCAACAACA to GCAACAACAACA, chromosome 13 at 117,975,760 bp
  • C to T, chromosome 14 at 6,301,907 bp
  • A to T, chromosome 14 at 21,986,064 bp
  • A to G, chromosome 14 at 31,134,826 bp
  • A to T, chromosome 14 at 46,762,601 bp
  • A to C, chromosome 14 at 55,513,241 bp
  • A to T, chromosome 14 at 61,210,717 bp
  • A to G, chromosome 15 at 81,718,900 bp
  • T to A, chromosome 16 at 93,894,742 bp
  • G to A, chromosome 17 at 82,539,468 bp
  • A to T, chromosome 17 at 84,658,543 bp
  • T to C, chromosome 18 at 32,458,754 bp
  • A to T, chromosome 18 at 36,515,171 bp
  • A to G, chromosome 19 at 47,983,518 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8083 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
067516-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.