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Strain Name:
C57BL/6J-MtgxR8083Btlr/Mmmh
Stock Number:
067516-MU
Citation ID:
RRID:MMRRC_067516-MU
Other Names:
R8083 (G1)
Major Collection:

Strain Information

Setd5
Name: SET domain containing 5
Synonyms: 2900045N06Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 72895
Homologene: 12485
Hbegf
Name: heparin-binding EGF-like growth factor
Synonyms: HB-EGF, Hegfl, Dtr
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 15200
VEGA: 18
HGNC: HGNC:3059
Homologene: 1466
Eri3
Name: exoribonuclease 3
Synonyms: PINT1, Prnpip1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 140546
Homologene: 15403
Rangap1
Name: RAN GTPase activating protein 1
Synonyms: Fug1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 19387
VEGA: 15
HGNC: HGNC:9854
Homologene: 55700
Ttc17
Name: tetratricopeptide repeat domain 17
Synonyms: D2Bwg1005e, 9130020K17Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 74569
Homologene: 10100
Rprd1b
Name: regulation of nuclear pre-mRNA domain containing 1B
Synonyms: 2810446G03Rik, 2610304G08Rik, Crept
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 70470
Homologene: 41426
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to A, chromosome 1 at 78,692,127 bp
  • T to C, chromosome 1 at 84,038,249 bp
  • T to C, chromosome 1 at 132,596,582 bp
  • G to A, chromosome 1 at 136,095,791 bp
  • A to T, chromosome 1 at 172,505,199 bp
  • T to A, chromosome 2 at 67,508,699 bp
  • C to A, chromosome 2 at 94,374,564 bp
  • A to G, chromosome 2 at 152,441,067 bp
  • T to G, chromosome 2 at 154,010,492 bp
  • T to C, chromosome 2 at 158,050,132 bp
  • C to T, chromosome 3 at 95,684,401 bp
  • T to C, chromosome 4 at 12,146,409 bp
  • C to T, chromosome 4 at 109,086,375 bp
  • T to A, chromosome 4 at 117,593,162 bp
  • A to C, chromosome 5 at 135,984,522 bp
  • T to G, chromosome 5 at 146,268,290 bp
  • G to T, chromosome 6 at 113,115,010 bp
  • G to A, chromosome 6 at 122,578,929 bp
  • A to C, chromosome 6 at 148,842,848 bp
  • T to C, chromosome 7 at 5,035,906 bp
  • A to G, chromosome 7 at 7,291,428 bp
  • C to A, chromosome 7 at 26,686,403 bp
  • T to A, chromosome 8 at 13,007,875 bp
  • A to T, chromosome 8 at 24,872,736 bp
  • T to C, chromosome 10 at 121,378,103 bp
  • A to T, chromosome 12 at 84,940,362 bp
  • G to T, chromosome 13 at 34,956,890 bp
  • GCAACAACA to GCAACAACAACA, chromosome 13 at 117,975,760 bp
  • C to T, chromosome 14 at 6,301,907 bp
  • A to T, chromosome 14 at 21,986,064 bp
  • A to G, chromosome 14 at 31,134,826 bp
  • A to T, chromosome 14 at 46,762,601 bp
  • A to C, chromosome 14 at 55,513,241 bp
  • A to T, chromosome 14 at 61,210,717 bp
  • A to G, chromosome 15 at 81,718,900 bp
  • T to A, chromosome 16 at 93,894,742 bp
  • G to A, chromosome 17 at 82,539,468 bp
  • A to T, chromosome 17 at 84,658,543 bp
  • T to C, chromosome 18 at 32,458,754 bp
  • A to T, chromosome 18 at 36,515,171 bp
  • A to G, chromosome 19 at 47,983,518 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8083 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
067516-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.