Loading Mouse GIF
Loading...

Strain Name:
C57BL/6J-MtgxR8088Btlr/Mmmh
Stock Number:
067521-MU
Citation ID:
RRID:MMRRC_067521-MU
Other Names:
R8088 (G1)
Major Collection:

Strain Information

S1pr1
Name: sphingosine-1-phosphate receptor 1
Synonyms: S1P1, S1P, Edg1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 13609
HGNC: HGNC:3165
Homologene: 1071
Dspp
Name: dentin sialophosphoprotein
Synonyms: Dmp3, Dpp, Dsp
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 666279
HGNC: HGNC:3054
Sgsm1
Name: small G protein signaling modulator 1
Synonyms: 2410098H20Rik, D5Bwg1524e, Rutbc2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 52850
Homologene: 64485
Ssr2
Name: signal sequence receptor, beta
Synonyms: TRAPbeta
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 66256
Homologene: 2369
Dhx9
Name: DExH-box helicase 9
Synonyms: leukophysin, nuclear DNA helicase II, RNA helicase, Ddx9, NDH II, NDHII, RHA
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 13211
HGNC: HGNC:2750
Homologene: 1039
Gstcd
Name: glutathione S-transferase, C-terminal domain containing
Synonyms: 4933434L15Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 67553
Homologene: 11693
Xrcc5
Name: X-ray repair complementing defective repair in Chinese hamster cells 5
Synonyms: Ku80, Ku86
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 22596
VEGA: 1
Homologene: 40681
Atp2c1
Name: ATPase, Ca++-sequestering
Synonyms: SPCA, ATP2C1A, PMR1, 1700121J11Rik, D930003G21Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235574
Homologene: 56672
Heatr5a
Name: HEAT repeat containing 5A
Synonyms: D930036F22Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 320487
VEGA: 12
Homologene: 19635
Jam3
Name: junction adhesion molecule 3
Synonyms: JAM-3, 1110002N23Rik, Jcam3, JAM-C
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 83964
Homologene: 11338
Il3
Name: interleukin 3
Synonyms: Il-3, PSF, MCGF, HCGF, BPA, Csfmu
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 16187
HGNC: HGNC:6011
Homologene: 49243
Mff
Name: mitochondrial fission factor
Synonyms: 5230400G24Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 75734
Homologene: 87000
Trf
Name: transferrin
Synonyms: Tfn, HP
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 22041
Homologene: 68153
Myh14
Name: myosin, heavy polypeptide 14
Synonyms: NMHC II-C, 2400004E04Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 71960
Homologene: 23480
Neurl1a
Name: neuralized E3 ubiquitin protein ligase 1A
Synonyms: Nlz, 2410129E16Rik, Neu1, Rnf67, Neur1, Neurl
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 18011
VEGA: 19
HGNC: HGNC:7761
Homologene: 32503
Rbm18
Name: RNA binding motif protein 18
Synonyms: 2010004P11Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 67889
Homologene: 12204
Lzts1
Name: leucine zipper, putative tumor suppressor 1
Synonyms: F37, FEZ1, PSD-Zip70
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 211134
Homologene: 10873
Muc16
Name: mucin 16
Synonyms: LOC385009, 1110008I14Rik, Gm21044
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 73732
Homologene: 141193
Pold3
Name: polymerase (DNA-directed), delta 3, accessory subunit
Synonyms: P68, P66, 2410142G14Rik, C85233, GC12
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 67967
Homologene: 38202
Slx9
Name: SLX9 ribosome biogenesis factor
Synonyms: 1810008A18Rik, Fam207a
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 108707
VEGA: 10
Homologene: 14384
Sec31a
Name: SEC31 homolog A, COPII coat complex component
Synonyms: 1810024J13Rik, Sec31l1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 69162
Homologene: 42056
Scfd2
Name: Sec1 family domain containing 2
Synonyms: STXBP1L1, E430013M20Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 212986
Homologene: 77411
Ehbp1
Name: EH domain binding protein 1
Synonyms: Flj21950, KIAA0903-like
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 216565
Homologene: 22880
Entpd3
Name: ectonucleoside triphosphate diphosphohydrolase 3
Synonyms: NTPDase-3, HB6, Cd39l3
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 215446
HGNC: HGNC:3365
Homologene: 68171
Dnah10
Name: dynein, axonemal, heavy chain 10
Synonyms: Dnahc10
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 56087
HGNC: HGNC:2941
Homologene: 25816
Spata31
Name: spermatogenesis associated 31
Synonyms: Spata31a, Fam75a, 4930458L03Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 78124
Homologene: 84621
Loxhd1
Name: lipoxygenase homology domains 1
Synonyms: 1700096C21Rik, sba
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 240411
Pcdhac1
Name: protocadherin alpha subfamily C, 1
Synonyms: CNRc1
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 353236
HGNC: HGNC:8676
Homologene: 49561
Cplane1
Name: ciliogenesis and planar polarity effector 1
Synonyms: b2b012Clo, Jbts17, Hug, 2410089E03Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 73692
Homologene: 11315
Gm11639
Name: predicted gene 11639
Synonyms: Gm11639, Efcab15
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 105242472
Pnldc1
Name: poly(A)-specific ribonuclease (PARN)-like domain containing 1
Synonyms: LOC240023
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 240023
VEGA: 17
Homologene: 15054
Mroh2b
Name: maestro heat-like repeat family member 2B
Synonyms: 4930455B06Rik, Heatr7b2
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 223825
VEGA: 15
Homologene: 128807
Gm19410
Name: predicted gene, 19410
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 100502846
Homologene: 132117
Nrp1
Name: neuropilin 1
Synonyms: Neuropilin-1, NP-1, NPN-1, Npn1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 18186
HGNC: HGNC:8004
Homologene: 2876
Umodl1
Name: uromodulin-like 1
Synonyms: D17Ertd488e
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 52020
VEGA: 17
Homologene: 45466
Kcnt1
Name: potassium channel, subfamily T, member 1
Synonyms: slo2, Slack, C030030G16Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 227632
Homologene: 11055
Ccdc134
Name: coiled-coil domain containing 134
Synonyms: 2310042L06Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 76457
VEGA: 15
Homologene: 77543
Sspo
Name: SCO-spondin
Synonyms: C79529, Scospondin
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 243369
Homologene: 45453
St18
Name: suppression of tumorigenicity 18
Synonyms: Nzf3, Myt3
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 240690
Homologene: 8792
Fam83c
Name: family with sequence similarity 83, member C
Synonyms: 5530400B04Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 71405
Homologene: 18669
Defb12
Name: defensin beta 12
Synonyms: 9230103N16Rik, mBD-12
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 77674
Homologene: 17531
Myo18b
Name: myosin XVIIIb
Synonyms: 4932408L24Rik, 4933411E19Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 74376
Homologene: 53435
Sprr2k
Name: small proline-rich protein 2K
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 20765
Slco6d1
Name: solute carrier organic anion transporter family, member 6d1
Synonyms: 4921511I05Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 70866
Homologene: 86643
Kif28
Name: kinesin family member 28
Synonyms: LOC383592, Gm1305
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 383592
Homologene: 130945
Scgb1a1
Name: secretoglobin, family 1A, member 1
Synonyms: CCSP, CC10, Blastokinin, UG, Utg, CC16, PCB-BP, club cell secretory protein
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 22287
Homologene: 2518
Repin1
Name: replication initiator 1
Synonyms: Zfp464, AP4, E430037F08Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 58887
Homologene: 22810
Dus2
Name: dihydrouridine synthase 2
Synonyms: 2310016K04Rik, Dus2l
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 66369
Homologene: 6838
Ccdc162
Name: coiled-coil domain containing 162
Synonyms: 5033413D22Rik, Gm29096, Gm6976
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 75973
Homologene: 136355
Slc5a11
Name: solute carrier family 5 (sodium/glucose cotransporter), member 11
Synonyms: 2010013B02Rik, Kst1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233836
Homologene: 14184
Ldlrad1
Name: low density lipoprotein receptor class A domain containing 1
Synonyms: OTTMUSG00000008594
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 546840
Homologene: 54473
Flot1
Name: flotillin 1
Synonyms: reggie-2
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 14251
HGNC: HGNC:3757
Homologene: 31337
Or2y3
Name: olfactory receptor family 2 subfamily Y member 3
Synonyms: MOR256-4, GA_x6K02T2PSCP-2531299-2530355, Olfr131
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 258867
Homologene: 105889
Dusp13b
Name: dual specificity phosphatase 13B
Synonyms: TMDP, LMW-DSP6, TS-DSP6, LOC382853, Dusp13
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 27389
Homologene: 121602
Thap11
Name: THAP domain containing 11
Synonyms: CTG-B45d, Ronin, 2810036E22Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 59016
Homologene: 10726
Or4f47
Name: olfactory receptor family 4 subfamily F member 47
Synonyms: GA_x6K02T2Q125-73188162-73189112, MOR245-4, Olfr1317
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258440
Homologene: 71983
Pm20d1
Name: peptidase M20 domain containing 1
Synonyms: 4732466D17Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 212933
Homologene: 65049
Mettl4
Name: methyltransferase 4, N6-adenosine
Synonyms: HsT661, 2410198H06Rik, A730091E08Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 76781
VEGA: 17
Homologene: 35305
Rdh14
Name: retinol dehydrogenase 14 (all-trans and 9-cis)
Synonyms: PAN2, 3110030G19Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 105014
VEGA: 12
Homologene: 75139
Pcdhga9
Name: protocadherin gamma subfamily A, 9
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93717
HGNC: HGNC:8707
Homologene: 56827
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to A, chromosome 1 at 6,828,005 bp
  • C to A, chromosome 1 at 72,312,436 bp
  • A to G, chromosome 1 at 82,751,649 bp
  • A to T, chromosome 1 at 98,466,706 bp
  • A to C, chromosome 1 at 131,801,763 bp
  • C to A, chromosome 1 at 153,462,697 bp
  • T to A, chromosome 1 at 179,700,354 bp
  • G to A, chromosome 2 at 25,894,314 bp
  • G to A, chromosome 2 at 31,426,903 bp
  • G to A, chromosome 2 at 35,292,647 bp
  • A to C, chromosome 2 at 36,127,184 bp
  • T to A, chromosome 2 at 112,142,257 bp
  • C to A, chromosome 2 at 155,831,639 bp
  • A to G, chromosome 2 at 181,322,345 bp
  • A to G, chromosome 3 at 55,051,071 bp
  • A to G, chromosome 3 at 88,579,883 bp
  • C to T, chromosome 3 at 92,433,489 bp
  • A to G, chromosome 3 at 115,712,034 bp
  • C to T, chromosome 3 at 133,082,107 bp
  • G to A, chromosome 4 at 107,209,491 bp
  • A to G, chromosome 5 at 74,531,363 bp
  • A to T, chromosome 5 at 100,378,862 bp
  • A to G, chromosome 5 at 104,177,256 bp
  • T to A, chromosome 5 at 112,879,510 bp
  • A to G, chromosome 5 at 113,255,268 bp
  • A to G, chromosome 5 at 124,754,266 bp
  • G to A, chromosome 6 at 48,457,613 bp
  • G to T, chromosome 6 at 48,597,345 bp
  • A to T, chromosome 7 at 44,665,496 bp
  • A to G, chromosome 7 at 100,112,301 bp
  • T to C, chromosome 7 at 123,265,728 bp
  • T to C, chromosome 8 at 19,112,821 bp
  • A to G, chromosome 8 at 35,806,841 bp
  • A to C, chromosome 8 at 69,135,822 bp
  • A to T, chromosome 8 at 105,855,895 bp
  • A to G, chromosome 8 at 106,030,441 bp
  • G to A, chromosome 8 at 128,468,516 bp
  • A to T, chromosome 9 at 18,519,300 bp
  • T to C, chromosome 9 at 27,098,860 bp
  • C to A, chromosome 9 at 103,211,931 bp
  • A to T, chromosome 9 at 105,452,569 bp
  • A to C, chromosome 9 at 120,554,173 bp
  • G to T, chromosome 10 at 41,623,414 bp
  • T to C, chromosome 10 at 77,514,395 bp
  • G to A, chromosome 11 at 22,089,572 bp
  • A to G, chromosome 11 at 54,265,549 bp
  • A to T, chromosome 11 at 104,998,246 bp
  • T to C, chromosome 12 at 10,394,551 bp
  • T to C, chromosome 12 at 51,947,996 bp
  • T to A, chromosome 13 at 64,920,865 bp
  • A to G, chromosome 14 at 21,741,237 bp
  • A to T, chromosome 15 at 4,900,503 bp
  • A to G, chromosome 15 at 8,186,318 bp
  • T to A, chromosome 15 at 82,131,789 bp
  • T to C, chromosome 17 at 12,897,302 bp
  • A to G, chromosome 17 at 30,973,796 bp
  • G to A, chromosome 17 at 35,829,978 bp
  • T to A, chromosome 17 at 38,082,561 bp
  • A to G, chromosome 17 at 94,735,367 bp
  • T to C, chromosome 18 at 37,091,754 bp
  • A to G, chromosome 18 at 37,736,954 bp
  • T to C, chromosome 18 at 77,342,013 bp
  • T to C, chromosome 19 at 7,434,998 bp
  • C to T, chromosome 19 at 9,085,235 bp
  • C to A, chromosome 19 at 47,257,434 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8088 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
067521-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.