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Strain Name:
C57BL/6J-MtgxR8090Btlr/Mmmh
Stock Number:
067523-MU
Citation ID:
RRID:MMRRC_067523-MU
Other Names:
R8090 (G1)
Major Collection:

Strain Information

Mpc1
Name: mitochondrial pyruvate carrier 1
Synonyms: 0610006G08Rik, 3830411I18Rik, Brp44l
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 55951
Homologene: 9384
Atn1
Name: atrophin 1
Synonyms: atrophin-1, Atr1, Drpla
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 13498
HGNC: HGNC:3033
Homologene: 1461
Grin3a
Name: glutamate receptor ionotropic, NMDA3A
Synonyms: NMDAR-L, NR3A, A830097C19Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242443
Homologene: 128613
Arpp21
Name: cyclic AMP-regulated phosphoprotein, 21
Synonyms: ARPP-21, Tarpp, D9Bwg1012e, 0710001E13Rik, R3hdm3
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 74100
Homologene: 32306
Gon4l
Name: gon-4 like
Synonyms: 1500041I23Rik, 2610100B20Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 76022
Homologene: 13002
Lrp2
Name: low density lipoprotein receptor-related protein 2
Synonyms: Megalin, Gp330, D230004K18Rik, b2b1625.2Clo
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 14725
HGNC: HGNC:6694
Homologene: 20952
Odf2l
Name: outer dense fiber of sperm tails 2-like
Synonyms: 4733401D09Rik, 9630045K08Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 52184
Homologene: 12011
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to A, chromosome 1 at 39,577,223 bp
  • A to T, chromosome 1 at 171,236,678 bp
  • G to A, chromosome 2 at 10,461,379 bp
  • G to T, chromosome 2 at 37,795,491 bp
  • G to T, chromosome 2 at 69,464,745 bp
  • A to T, chromosome 2 at 90,905,839 bp
  • T to C, chromosome 2 at 91,155,623 bp
  • T to G, chromosome 2 at 132,831,649 bp
  • T to C, chromosome 3 at 86,348,489 bp
  • C to T, chromosome 3 at 86,986,657 bp
  • A to G, chromosome 3 at 88,892,624 bp
  • A to G, chromosome 3 at 94,779,953 bp
  • G to T, chromosome 3 at 145,127,035 bp
  • A to T, chromosome 4 at 49,714,224 bp
  • A to T, chromosome 4 at 118,387,002 bp
  • A to T, chromosome 5 at 145,159,535 bp
  • T to A, chromosome 6 at 47,820,009 bp
  • G to T, chromosome 6 at 83,929,819 bp
  • G to T, chromosome 6 at 112,781,035 bp
  • G to A, chromosome 6 at 113,462,289 bp
  • G to A, chromosome 6 at 115,956,617 bp
  • G to A, chromosome 6 at 124,745,341 bp
  • A to G, chromosome 7 at 29,244,301 bp
  • T to A, chromosome 7 at 100,300,652 bp
  • A to T, chromosome 7 at 103,564,841 bp
  • G to A, chromosome 8 at 21,831,071 bp
  • T to A, chromosome 9 at 57,529,063 bp
  • T to A, chromosome 9 at 109,841,951 bp
  • A to G, chromosome 9 at 112,116,701 bp
  • A to G, chromosome 9 at 121,908,979 bp
  • T to C, chromosome 11 at 45,887,440 bp
  • A to G, chromosome 11 at 53,470,238 bp
  • T to A, chromosome 11 at 99,316,590 bp
  • T to C, chromosome 11 at 99,336,489 bp
  • T to C, chromosome 11 at 116,596,191 bp
  • C to A, chromosome 12 at 86,983,620 bp
  • T to C, chromosome 12 at 112,015,935 bp
  • C to A, chromosome 13 at 81,448,834 bp
  • G to A, chromosome 14 at 33,104,115 bp
  • C to T, chromosome 14 at 65,742,137 bp
  • T to C, chromosome 14 at 69,172,016 bp
  • A to G, chromosome 15 at 74,624,701 bp
  • A to G, chromosome 15 at 82,856,006 bp
  • T to A, chromosome 15 at 89,505,458 bp
  • A to G, chromosome 16 at 22,842,055 bp
  • A to C, chromosome 17 at 8,296,873 bp
  • C to T, chromosome 17 at 32,820,975 bp
  • G to C, chromosome 17 at 35,621,725 bp
  • A to G, chromosome 17 at 36,856,748 bp
  • G to A, chromosome 17 at 73,382,854 bp
  • C to T, chromosome 18 at 20,032,274 bp
  • A to G, chromosome 19 at 7,865,736 bp
  • T to C, chromosome 19 at 25,154,242 bp
  • C to T, chromosome 19 at 28,964,871 bp
  • T to A, chromosome 19 at 34,573,262 bp
  • C to T, chromosome Y at 1,264,897 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8090 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
067523-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.