Strain Name:
C57BL/6J-MtgxR8090Btlr/Mmmh
Stock Number:
067523-MU
Citation ID:
RRID:MMRRC_067523-MU
Other Names:
R8090 (G1)
Major Collection:

Strain Information

Mpc1
Name: mitochondrial pyruvate carrier 1
Synonyms: Brp44l, 3830411I18Rik, 0610006G08Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 55951
Homologene: 9384
Atn1
Name: atrophin 1
Synonyms: Drpla, Atr1, atrophin-1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 13498
HGNC: HGNC:3033
Homologene: 1461
Grin3a
Name: glutamate receptor ionotropic, NMDA3A
Synonyms: NR3A, A830097C19Rik, NMDAR-L
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242443
Homologene: 128613
Arpp21
Name: cyclic AMP-regulated phosphoprotein, 21
Synonyms: Tarpp, ARPP-21, 0710001E13Rik, R3hdm3, D9Bwg1012e
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 74100
Homologene: 32306
Gon4l
Name: gon-4 like
Synonyms: 2610100B20Rik, 1500041I23Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 76022
Homologene: 13002
Lrp2
Name: low density lipoprotein receptor-related protein 2
Synonyms: b2b1625.2Clo, Gp330, Megalin, D230004K18Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 14725
HGNC: HGNC:6694
Homologene: 20952
Odf2l
Name: outer dense fiber of sperm tails 2-like
Synonyms: 9630045K08Rik, 4733401D09Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 52184
Homologene: 12011
Plxnd1
Name: plexin D1
Synonyms: b2b1863Clo, 6230425C21Rik, b2b553Clo
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 67784
HGNC: HGNC:9107
Homologene: 22866
Zfp638
Name: zinc finger protein 638
Synonyms: Zfml, Np220
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 18139
Homologene: 7447
Sfmbt2
Name: Scm-like with four mbt domains 2
Synonyms: D2Wsu23e, D330030P06Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 353282
Homologene: 82485
Lrba
Name: LPS-responsive beige-like anchor
Synonyms: D3Ertd775e, Lba
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 80877
HGNC: HGNC:1742
Homologene: 36205
Krt25
Name: keratin 25
Synonyms: 4631426H08Rik, mIRSa1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 70810
Homologene: 77127
Clint1
Name: clathrin interactor 1
Synonyms: Epn4, C530049I24Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 216705
Homologene: 133740
Tcf20
Name: transcription factor 20
Synonyms: 2810438H08Rik, SPBP, stromelysin 1 PDGF responsive element binding protein
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 21411
VEGA: 15
Homologene: 4131
Zfp799
Name: zinc finger protein 799
Synonyms: 6030490I01Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 240064
Homologene: 107106
Il17re
Name: interleukin 17 receptor E
Synonyms: Il25r
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 57890
Homologene: 17109
Cox5a
Name: cytochrome c oxidase subunit 5A
Synonyms: CcOX
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 12858
VEGA: 9
HGNC: HGNC:2267
Homologene: 37905
Ddx3y
Name: DEAD box helicase 3, Y-linked
Synonyms: D1Pas1-rs1, Dby, 8030469F12Rik, DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, Y-linked
Type: Gene
Species: Mouse
Chromosome: Y
NCBI: 26900
HGNC: HGNC:2699
Homologene: 55839
Szt2
Name: SZT2 subunit of KICSTOR complex
Synonyms: seaizure threshold 2
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230676
Homologene: 49413
Dock8
Name: dedicator of cytokinesis 8
Synonyms: 1200017A24Rik, A130095G14Rik, 5830472H07Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 76088
VEGA: 19
Homologene: 52414
Tbccd1
Name: TBCC domain containing 1
Synonyms: 5730478M09Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 70573
VEGA: 16
Homologene: 32392
Yif1b
Name: Yip1 interacting factor homolog B (S. cerevisiae)
Synonyms: 9430029K10Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 77254
Homologene: 60114
Srgap3
Name: SLIT-ROBO Rho GTPase activating protein 3
Synonyms: D130026O08Rik, Arhgap14
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 259302
Homologene: 56686
Mroh4
Name: maestro heat-like repeat family member 4
Synonyms: 1700016M24Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 69439
Homologene: 72545
Wdfy4
Name: WD repeat and FYVE domain containing 4
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 545030
Homologene: 83473
Adgrv1
Name: adhesion G protein-coupled receptor V1
Synonyms: Mgr1, Gpr98, Mass1, VLGR1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 110789
Homologene: 19815
Ifit2
Name: interferon-induced protein with tetratricopeptide repeats 2
Synonyms: Ifi54
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 15958
HGNC: HGNC:5409
Homologene: 1187
Madd
Name: MAP-kinase activating death domain
Synonyms: 9630059K23Rik, Rab3 GEP
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228355
HGNC: HGNC:6766
Homologene: 14249
Plpp6
Name: phospholipid phosphatase 6
Synonyms: 4932443D16Rik, Ppapdc2
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 74411
Homologene: 45228
Scara5
Name: scavenger receptor class A, member 5
Synonyms: 4932433F15Rik, 4933425F03Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 71145
Homologene: 12556
Trim26
Name: tripartite motif-containing 26
Synonyms: Zfp173
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 22670
Homologene: 31159
Cgn
Name: cingulin
Synonyms: 6330408J11Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 70737
Homologene: 41394
Or51ac3
Name: olfactory receptor family 51 subfamily AC member 3
Synonyms: GA_x6K02T2PBJ9-6289676-6288723, Olfr616, MOR19-1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 259103
Homologene: 64957
Capn13
Name: calpain 13
Synonyms: LOC381122
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 381122
VEGA: 17
Homologene: 27026
Krt26
Name: keratin 26
Synonyms: 4732407F15Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 320864
Homologene: 37118
Slc22a27
Name: solute carrier family 22, member 27
Synonyms: mOAT6 related protein, AB056442
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 171405
Homologene: 77136
Dsc2
Name: desmocollin 2
Synonyms: Dsc2a, Dsc2b
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 13506
HGNC: HGNC:3036
Homologene: 8397
Shank3
Name: SH3 and multiple ankyrin repeat domains 3
Synonyms: ProSAP2
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 58234
Homologene: 75163
Mcm8
Name: minichromosome maintenance 8 homologous recombination repair factor
Synonyms: 5730432L01Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 66634
Homologene: 12001
Muc21
Name: mucin 21
Synonyms: Gm9573, epiglycanin
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 672682
Ackr2
Name: atypical chemokine receptor 2
Synonyms: chemokine decoy receptor D6, Ccbp2, D6
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 59289
VEGA: 9
HGNC: HGNC:1565
Homologene: 992
Tdrd9
Name: tudor domain containing 9
Synonyms: 4930441E05Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 74691
Homologene: 14311
Kbtbd4
Name: kelch repeat and BTB (POZ) domain containing 4
Synonyms: 2510026C23Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 67136
Homologene: 32320
Nkx2-6
Name: NK2 homeobox 6
Synonyms: Tix, Nkx-2.6, Nkx2.6, tinman
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 18092
Homologene: 22604
Cd1d2
Name: CD1d2 antigen
Synonyms: Cd1b, CD1.2
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 12480
HGNC: HGNC:1637
Zdhhc22
Name: zinc finger, DHHC-type containing 22
Synonyms: LOC238331
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 238331
VEGA: 12
Homologene: 45486
P4ha3
Name: procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha polypeptide III
Synonyms: D930031A02Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 320452
Homologene: 27943
Aanat
Name: arylalkylamine N-acetyltransferase
Synonyms: Nat4, Nat-2, SNAT
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 11298
HGNC: HGNC:19
Homologene: 31013
Ndufs2
Name: NADH:ubiquinone oxidoreductase core subunit S2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226646
HGNC: HGNC:7708
Homologene: 56659
Zfp786
Name: zinc finger protein 786
Synonyms: A730012O14Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 330301
Homologene: 51849
Rnf149
Name: ring finger protein 149
Synonyms: 1600023E10Rik, Greul4
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 67702
Homologene: 18337
Crb2
Name: crumbs family member 2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241324
Homologene: 45474
Nme6
Name: NME/NM23 nucleoside diphosphate kinase 6
Synonyms: non-metastatic cells 6, protein expressed in (nucleoside-diphosphate kinase), nm23-M6
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 54369
Homologene: 4231
Gm9837
Name: predicted gene 9837
Type: Gene
Species: Mouse
Chromosome: 11
Ptcd1
Name: pentatricopeptide repeat domain 1
Synonyms: 1110069M14Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 71799
Homologene: 33161
Defb50
Name: defensin beta 50
Synonyms: Pbd1, Defb37
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 387334
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to A, chromosome 1 at 39,577,223 bp
  • A to T, chromosome 1 at 171,236,678 bp
  • G to A, chromosome 2 at 10,461,379 bp
  • G to T, chromosome 2 at 37,795,491 bp
  • G to T, chromosome 2 at 69,464,745 bp
  • A to T, chromosome 2 at 90,905,839 bp
  • T to C, chromosome 2 at 91,155,623 bp
  • T to G, chromosome 2 at 132,831,649 bp
  • T to C, chromosome 3 at 86,348,489 bp
  • C to T, chromosome 3 at 86,986,657 bp
  • A to G, chromosome 3 at 88,892,624 bp
  • A to G, chromosome 3 at 94,779,953 bp
  • G to T, chromosome 3 at 145,127,035 bp
  • A to T, chromosome 4 at 49,714,224 bp
  • A to T, chromosome 4 at 118,387,002 bp
  • A to T, chromosome 5 at 145,159,535 bp
  • T to A, chromosome 6 at 47,820,009 bp
  • G to T, chromosome 6 at 83,929,819 bp
  • G to T, chromosome 6 at 112,781,035 bp
  • G to A, chromosome 6 at 113,462,289 bp
  • G to A, chromosome 6 at 115,956,617 bp
  • G to A, chromosome 6 at 124,745,341 bp
  • A to G, chromosome 7 at 29,244,301 bp
  • T to A, chromosome 7 at 100,300,652 bp
  • A to T, chromosome 7 at 103,564,841 bp
  • G to A, chromosome 8 at 21,831,071 bp
  • T to A, chromosome 9 at 57,529,063 bp
  • T to A, chromosome 9 at 109,841,951 bp
  • A to G, chromosome 9 at 112,116,701 bp
  • A to G, chromosome 9 at 121,908,979 bp
  • T to C, chromosome 11 at 45,887,440 bp
  • A to G, chromosome 11 at 53,470,238 bp
  • T to A, chromosome 11 at 99,316,590 bp
  • T to C, chromosome 11 at 99,336,489 bp
  • T to C, chromosome 11 at 116,596,191 bp
  • C to A, chromosome 12 at 86,983,620 bp
  • T to C, chromosome 12 at 112,015,935 bp
  • C to A, chromosome 13 at 81,448,834 bp
  • G to A, chromosome 14 at 33,104,115 bp
  • C to T, chromosome 14 at 65,742,137 bp
  • T to C, chromosome 14 at 69,172,016 bp
  • A to G, chromosome 15 at 74,624,701 bp
  • A to G, chromosome 15 at 82,856,006 bp
  • T to A, chromosome 15 at 89,505,458 bp
  • A to G, chromosome 16 at 22,842,055 bp
  • A to C, chromosome 17 at 8,296,873 bp
  • C to T, chromosome 17 at 32,820,975 bp
  • G to C, chromosome 17 at 35,621,725 bp
  • A to G, chromosome 17 at 36,856,748 bp
  • G to A, chromosome 17 at 73,382,854 bp
  • C to T, chromosome 18 at 20,032,274 bp
  • A to G, chromosome 19 at 7,865,736 bp
  • T to C, chromosome 19 at 25,154,242 bp
  • C to T, chromosome 19 at 28,964,871 bp
  • T to A, chromosome 19 at 34,573,262 bp
  • C to T, chromosome Y at 1,264,897 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8090 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
067523-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.