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Strain Detail Sheet

Published:
Revised: 03/02/2024

Strain Name:
C57BL/6J-MtgxR8108Btlr/Mmmh
Stock Number:
067537-MU
Citation ID:
RRID:MMRRC_067537-MU
Other Names:
R8108 (G1)
Major Collection:
Beutler Mutagenetix

Strain Information

Gene Details

Grm1
Name: glutamate receptor, metabotropic 1
Synonyms: mGluR1, Grm1, Gprc1a, nmf373, rcw, 4930455H15Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 14816
HGNC: HGNC:4593
Homologene: 649

Additional Resources
IMPC
Google
Entrez
PubMed
IMSR
Gene Ontology
BioGPS
Gene Cloud
IGTC
Mouse Phenome DB
Mouse Mine
KOMP Phenotyping
Monarch
GeneCards
ClinGen
Rubcn
Name: RUN domain and cysteine-rich domain containing, Beclin 1-interacting protein
Synonyms: 1700021K19Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 100502698
Homologene: 15687

Additional Resources
IMPC
Google
Entrez
PubMed
IMSR
Gene Ontology
BioGPS
Gene Cloud
IGTC
Mouse Phenome DB
Mouse Mine
KOMP Phenotyping
Monarch
GeneCards
ClinGen
Ep400
Name: E1A binding protein p400
Synonyms: p400, mDomino, 1700020J09Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 75560
Homologene: 38779

Additional Resources
IMPC
Google
Entrez
PubMed
IMSR
Gene Ontology
BioGPS
Gene Cloud
IGTC
Mouse Phenome DB
Mouse Mine
KOMP Phenotyping
Monarch
GeneCards
ClinGen
Uri1
Name: URI1, prefoldin-like chaperone
Synonyms: NNX3, Rmp, C80913
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 19777
Homologene: 2813

Additional Resources
IMPC
Google
Entrez
PubMed
IMSR
Gene Ontology
BioGPS
Gene Cloud
IGTC
Mouse Phenome DB
Mouse Mine
KOMP Phenotyping
Monarch
GeneCards
ClinGen
Pdzd2
Name: PDZ domain containing 2
Synonyms: 4930537L06Rik, LOC223364, A930022H17Rik, Pdzk3, Gm21706
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 68070
Homologene: 23393

Additional Resources
IMPC
Google
Entrez
PubMed
IMSR
Gene Ontology
BioGPS
Gene Cloud
IGTC
Mouse Phenome DB
Mouse Mine
KOMP Phenotyping
Monarch
GeneCards
ClinGen
Dusp16
Name: dual specificity phosphatase 16
Synonyms: MKP-7, MKP7, 3830417M17Rik, D6Ertd213e
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 70686
Homologene: 15604

Additional Resources
IMPC
Google
Entrez
PubMed
IMSR
Gene Ontology
BioGPS
Gene Cloud
IGTC
Mouse Phenome DB
Mouse Mine
KOMP Phenotyping
Monarch
GeneCards
ClinGen
Kifap3
Name: kinesin-associated protein 3
Synonyms: KAP3
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 16579
Homologene: 7799

Additional Resources
IMPC
Google
Entrez
PubMed
IMSR
Gene Ontology
BioGPS
Gene Cloud
IGTC
Mouse Phenome DB
Mouse Mine
KOMP Phenotyping
Monarch
GeneCards
ClinGen
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 63,150,012 bp
  • T to A, chromosome 1 at 163,797,362 bp
  • A to G, chromosome 1 at 180,696,702 bp
  • A to G, chromosome 1 at 185,464,154 bp
  • A to G, chromosome 2 at 30,396,246 bp
  • C to A, chromosome 2 at 31,184,869 bp
  • T to C, chromosome 2 at 85,608,749 bp
  • T to C, chromosome 2 at 111,479,234 bp
  • T to C, chromosome 3 at 37,431,782 bp
  • T to A, chromosome 3 at 53,472,088 bp
  • G to A, chromosome 3 at 55,819,315 bp
  • T to A, chromosome 3 at 64,103,050 bp
  • T to A, chromosome 3 at 136,932,225 bp
  • A to T, chromosome 3 at 154,720,115 bp
  • A to T, chromosome 4 at 98,375,023 bp
  • A to T, chromosome 4 at 144,670,669 bp
  • T to A, chromosome 4 at 145,899,305 bp
  • A to T, chromosome 4 at 154,667,036 bp
  • T to G, chromosome 5 at 32,945,049 bp
  • A to G, chromosome 5 at 65,148,587 bp
  • T to C, chromosome 5 at 110,378,379 bp
  • A to T, chromosome 5 at 110,687,883 bp
  • T to A, chromosome 6 at 78,376,079 bp
  • A to G, chromosome 6 at 129,584,222 bp
  • A to G, chromosome 6 at 134,739,873 bp
  • T to C, chromosome 7 at 37,981,673 bp
  • T to C, chromosome 7 at 96,854,728 bp
  • A to T, chromosome 7 at 143,638,373 bp
  • T to A, chromosome 8 at 71,348,342 bp
  • C to T, chromosome 8 at 90,933,224 bp
  • T to C, chromosome 8 at 95,093,945 bp
  • T to C, chromosome 8 at 120,229,810 bp
  • T to C, chromosome 8 at 128,980,153 bp
  • T to A, chromosome 9 at 20,212,451 bp
  • T to C, chromosome 9 at 26,920,661 bp
  • A to G, chromosome 9 at 38,539,410 bp
  • T to C, chromosome 9 at 44,711,161 bp
  • G to T, chromosome 9 at 53,571,129 bp
  • C to A, chromosome 10 at 10,720,132 bp
  • A to T, chromosome 10 at 105,823,179 bp
  • T to C, chromosome 10 at 118,859,829 bp
  • T to C, chromosome 11 at 4,066,198 bp
  • T to A, chromosome 11 at 59,061,634 bp
  • T to A, chromosome 11 at 73,433,854 bp
  • T to A, chromosome 11 at 100,266,957 bp
  • G to A, chromosome 11 at 103,503,057 bp
  • T to C, chromosome 11 at 119,507,411 bp
  • G to T, chromosome 12 at 72,454,059 bp
  • C to T, chromosome 12 at 81,918,819 bp
  • T to A, chromosome 12 at 84,017,361 bp
  • T to C, chromosome 13 at 13,359,406 bp
  • C to T, chromosome 13 at 19,650,960 bp
  • G to T, chromosome 13 at 67,443,234 bp
  • A to T, chromosome 13 at 116,867,073 bp
  • C to T, chromosome 14 at 25,698,326 bp
  • A to G, chromosome 14 at 57,826,102 bp
  • T to A, chromosome 14 at 87,486,266 bp
  • G to A, chromosome 15 at 12,373,506 bp
  • A to T, chromosome 16 at 32,856,950 bp
  • T to C, chromosome 16 at 46,464,121 bp
  • T to C, chromosome 16 at 58,872,236 bp
  • G to C, chromosome 16 at 96,643,879 bp
  • G to T, chromosome 17 at 24,700,916 bp
  • A to G, chromosome 17 at 25,795,030 bp
  • T to C, chromosome 17 at 32,978,003 bp
  • T to C, chromosome 17 at 50,742,086 bp
  • T to A, chromosome 17 at 88,742,050 bp
  • T to G, chromosome 18 at 12,984,331 bp
  • T to A, chromosome 18 at 76,940,525 bp
  • A to G, chromosome 19 at 6,082,200 bp
  • C to T, chromosome 19 at 16,640,787 bp
  • A to G, chromosome 19 at 18,811,790 bp
  • C to G, chromosome 19 at 38,402,829 bp
  • T to A, chromosome 19 at 38,402,831 bp

Strain Description

Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
Gene Specific Genotyping:

To request gene-specific and other genotyping services for a strain, please contact the distribution MMRRC Center for more information.

Background Genetic Quality:

The MMRRC has developed a Genetic Quality Control pipeline using the MiniMUGA array to provide additional information to identify and validate genetic backgrounds of MMRRC strains. For more information on whether genetic background data is available, please contact MMRRC_GeneticQC@med.unc.edu. Note: that MiniMUGA genetic background data is not available on all strains, but can be ordered if desired.

Suggested Control Mice
Littermates of all relevant genotypes.

Strain Origin

Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8108 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Health Status Report

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.

Appearance

Coat Color
Black

Breeding

MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain

Reproductive Statistics

Average litter size
Undetermined
Recommended wean age
3 weeks

Order Information

Availability Level

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Conditions of Distribution

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Fees

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*		 Units Notes
067537-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.