Strain Name:
C57BL/6J-MtgxR8112Btlr/Mmmh
Stock Number:
067541-MU
Citation ID:
RRID:MMRRC_067541-MU
Other Names:
R8112 (G1)
Major Collection:

Strain Information

Ippk
Name: inositol 1,3,4,5,6-pentakisphosphate 2-kinase
Synonyms: 1810043M15Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 75678
VEGA: 13
Homologene: 41495
Gfap
Name: glial fibrillary acidic protein
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 14580
HGNC: HGNC:4235
Homologene: 1554
Cbx5
Name: chromobox 5
Synonyms: HP1a, 2610029O15Rik, heterochromatin protein 1 alpha, Hp1alpha, HP1, Hp1a
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 12419
HGNC: HGNC:1555
Homologene: 7257
Ehmt1
Name: euchromatic histone methyltransferase 1
Synonyms: KMT1D, 9230102N17Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 77683
Homologene: 11698
Scn8a
Name: sodium channel, voltage-gated, type VIII, alpha
Synonyms: med, nmf335, mnd-2, nmf58, ataxia 3, nmf2, motor end-plate disease, NaCh6, mnd2, C630029C19Rik, seal, NMF335, Nav1.6, nur14
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 20273
Homologene: 7927
Depdc5
Name: DEP domain containing 5
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 277854
Homologene: 34718
Wap
Name: whey acidic protein
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 22373
Homologene: 137242
Sspn
Name: sarcospan
Synonyms: Krag
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 16651
Homologene: 3727
Ing3
Name: inhibitor of growth family, member 3
Synonyms: 1300013A07Rik, P47ING3
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 71777
Homologene: 6804
Malt1
Name: MALT1 paracaspase
Synonyms: paracaspase, Pcasp1, D430033E09Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 240354
HGNC: HGNC:6819
Homologene: 4938
Pgm3
Name: phosphoglucomutase 3
Synonyms: 2810473H05Rik, GlcNAc-P mutase, Pgm-3
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 109785
HGNC: HGNC:8907
Homologene: 9205
Tasor2
Name: transcription activation suppressor family member 2
Synonyms: Fam208b, BC016423
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 105203
VEGA: 13
Homologene: 26435
Cecr2
Name: CECR2, histone acetyl-lysine reader
Synonyms: 2610101O16Rik, cat eye syndrome chromosome region, candidate 2, 2810409N01Rik, Gtl4
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 330409
HGNC: HGNC:1840
Homologene: 64662
Themis
Name: thymocyte selection associated
Synonyms: Tsepa, E430004N04Rik, Gasp
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 210757
Homologene: 72287
Mindy1
Name: MINDY lysine 48 deubiquitinase 1
Synonyms: cI-40, Fam63a, NF-E2 inducible protein, 1810005H09Rik, 4930504E06Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 75007
Homologene: 32409
Ptprs
Name: protein tyrosine phosphatase receptor type S
Synonyms: PTP-NU3, RPTPsigma, Ptpt9, PTPsigma
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 19280
HGNC: HGNC:9681
Homologene: 20626
Smarcb1
Name: SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1
Synonyms: Baf47, integrase interactor 1, SNF5/INI1, Snf5, Ini1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 20587
Homologene: 2310
Eme2
Name: essential meiotic structure-specific endonuclease subunit 2
Synonyms: 2810013J18Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 193838
Homologene: 19180
Slmap
Name: sarcolemma associated protein
Synonyms: Miranda, D330001L02Rik, Slap
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 83997
Homologene: 31428
Trim37
Name: tripartite motif-containing 37
Synonyms: MUL, 1110032A10Rik, 2810004E07Rik, TEF3
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 68729
HGNC: HGNC:7523
Homologene: 9084
Emc1
Name: ER membrane protein complex subunit 1
Synonyms: C230096C10Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230866
Homologene: 9002
Trpa1
Name: transient receptor potential cation channel, subfamily A, member 1
Synonyms: ANKTM1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 277328
HGNC: HGNC:497
Homologene: 7189
Chmp3
Name: charged multivesicular body protein 3
Synonyms: 9130011K15Rik, 25.1, CGI-49, 4921505F14Rik, Vps24, D6Ertd286e
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 66700
Homologene: 6368
Abca13
Name: ATP-binding cassette, sub-family A member 13
Synonyms: A930002G16Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 268379
Homologene: 27991
Ttn
Name: titin
Synonyms: connectin, shru, D330041I19Rik, 2310057K23Rik, mdm, D830007G01Rik, 2310074I15Rik, 1100001C23Rik, 2310036G12Rik, L56
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 22138
Homologene: 130650
Lrp1
Name: low density lipoprotein receptor-related protein 1
Synonyms: CD91, b2b1554Clo, A2mr
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 16971
HGNC: HGNC:6692
Homologene: 1744
Aifm3
Name: apoptosis-inducing factor, mitochondrion-associated 3
Synonyms: 2810401C16Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 72168
Homologene: 13773
Alx3
Name: aristaless-like homeobox 3
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 11694
HGNC: HGNC:449
Homologene: 4737
Gen1
Name: GEN1, Holliday junction 5' flap endonuclease
Synonyms: 5830483C08Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 209334
VEGA: 12
Homologene: 35313
Wdfy4
Name: WD repeat and FYVE domain containing 4
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 545030
Homologene: 83473
Gm11639
Name: predicted gene 11639
Synonyms: Gm11639, Efcab15
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 105242472
Mrgprb1
Name: MAS-related GPR, member B1
Synonyms: MrgB1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233231
Homologene: 24986
Ptchd4
Name: patched domain containing 4
Synonyms: 3110082D06Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 627626
VEGA: 17
Homologene: 78322
Krt4
Name: keratin 4
Synonyms: Krt2-4, Krt-2.4, K4
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 16682
VEGA: 15
HGNC: HGNC:6441
Homologene: 20523
Muc5b
Name: mucin 5, subtype B, tracheobronchial
Synonyms: 2300002I04Rik, MUC5, MUC9
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 74180
HGNC: HGNC:7516
Homologene: 136756
Elfn2
Name: leucine rich repeat and fibronectin type III, extracellular 2
Synonyms: Lrrc62
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 207393
VEGA: 15
Homologene: 18835
Arfgef3
Name: ARFGEF family member 3
Synonyms: B930094H20Rik, BIG3, D10Bwg1379e
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 215821
VEGA: 10
Homologene: 41366
Mtus2
Name: microtubule associated tumor suppressor candidate 2
Synonyms: 5730592G18Rik, A730013O20Rik, C130038G02Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 77521
Homologene: 78141
Cyp2g1
Name: cytochrome P450, family 2, subfamily g, polypeptide 1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 13108
HGNC: HGNC:2633
Homologene: 75020
Prl8a9
Name: prolactin family8, subfamily a, member 9
Synonyms: 1600019F10Rik, PLP-Cbeta, Prlpc2
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 67310
Homologene: 11344
Grid2
Name: glutamate receptor, ionotropic, delta 2
Synonyms: tpr, B230104L07Rik, GluRdelta2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 14804
HGNC: HGNC:4576
Homologene: 74399
Atxn1
Name: ataxin 1
Synonyms: Atx1, Sca1, 2900016G23Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 20238
VEGA: 13
Homologene: 281
Psapl1
Name: prosaposin-like 1
Synonyms: 2310020A21Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 76943
Homologene: 105928
Ogfod3
Name: 2-oxoglutarate and iron-dependent oxygenase domain containing 3
Synonyms: 1110031I02Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 66179
Homologene: 11640
H2-M2
Name: histocompatibility 2, M region locus 2
Synonyms: H-2M2, Thy19.4
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 14990
Homologene: 133732
Zfp85
Name: zinc finger protein 85
Synonyms: KRAB19, Zfp71, Zfp85-rs1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 22746
Homologene: 133709
Lrrc8e
Name: leucine rich repeat containing 8 family, member E
Synonyms: 1810049O03Rik, C87354
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 72267
Homologene: 11817
Thoc2l
Name: THO complex subunit 2-like
Synonyms: BC005561, Gm3179
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 100042165
Noxa1
Name: NADPH oxidase activator 1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241275
Homologene: 18156
Rasgef1c
Name: RasGEF domain family, member 1C
Synonyms: 9130006A14Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 74563
Homologene: 17918
Slc7a11
Name: solute carrier family 7 (cationic amino acid transporter, y+ system), member 11
Synonyms: 9930009M05Rik, System xc, xc, xCT, sut
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 26570
Homologene: 22684
B3galt1
Name: UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1
Synonyms: 6330417G03Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 26877
HGNC: HGNC:916
Homologene: 41362
Or7g35
Name: olfactory receptor family 7 subfamily G member 35
Synonyms: Olfr855, MOR148-1, GA_x6K02T2PVTD-13330461-13331399
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258517
HGNC: HGNC:8466
Homologene: 74176
Or9i16
Name: olfactory receptor family 9 subfamily I member 16
Synonyms: MOR212-2, GA_x6K02T2RE5P-4223635-4222688, Olfr1504
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 258627
Homologene: 45020
Scd4
Name: stearoyl-coenzyme A desaturase 4
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 329065
Homologene: 77322
Plpbp
Name: pyridoxal phosphate binding protein
Synonyms: 2200002F22Rik, Prosc
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 114863
HGNC: HGNC:9457
Homologene: 5211
Art5
Name: ADP-ribosyltransferase 5
Synonyms: Yac-2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 11875
Homologene: 7231
Slc22a7
Name: solute carrier family 22 (organic anion transporter), member 7
Synonyms: NLT, OAT2
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 108114
VEGA: 17
Homologene: 21328
Terb1
Name: telomere repeat binding bouquet formation protein 1
Synonyms: Ccdc79, 4930532D21Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 320022
Homologene: 18330
Klhl3
Name: kelch-like 3
Synonyms: EG627648, 7530408C15Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 100503085
HGNC: HGNC:6354
Homologene: 79542
Or4f59
Name: olfactory receptor family 4 subfamily F member 59
Synonyms: MOR245-20, GA_x6K02T2Q125-73090482-73089529, Olfr1312
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258359
Homologene: 128122
Rinl
Name: Ras and Rab interactor-like
Synonyms: 9930116N10Rik, 5830482F20Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 320435
Homologene: 18556
Cdca7l
Name: cell division cycle associated 7 like
Synonyms: JPO2
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 217946
Homologene: 10285
Hps4
Name: HPS4, biogenesis of lysosomal organelles complex 3 subunit 2
Synonyms: C130020P05Rik, BLOC-3, Hermansky-Pudlak syndrome 4, 2010205O06Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 192232
Homologene: 11123
Scgb2b20
Name: secretoglobin, family 2B, member 20
Synonyms: Abpbg20, C2c, Abpd
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 494519
Homologene: 83171
Trac
Name: T cell receptor alpha constant
Synonyms: Gm16914, Tcra-C
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 100101484
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 14,904,266 bp
  • G to T, chromosome 2 at 24,863,384 bp
  • C to T, chromosome 2 at 25,092,541 bp
  • A to G, chromosome 2 at 68,118,358 bp
  • T to C, chromosome 2 at 76,750,185 bp
  • T to A, chromosome 2 at 112,042,637 bp
  • T to C, chromosome 3 at 50,417,991 bp
  • T to C, chromosome 3 at 95,294,811 bp
  • G to T, chromosome 3 at 107,604,984 bp
  • C to T, chromosome 4 at 139,367,187 bp
  • G to A, chromosome 5 at 32,968,706 bp
  • A to G, chromosome 5 at 36,205,575 bp
  • T to C, chromosome 5 at 104,521,635 bp
  • T to G, chromosome 5 at 112,370,111 bp
  • G to T, chromosome 5 at 148,076,903 bp
  • A to G, chromosome 6 at 21,952,182 bp
  • T to C, chromosome 6 at 63,908,907 bp
  • T to A, chromosome 6 at 71,561,028 bp
  • T to C, chromosome 6 at 120,762,214 bp
  • T to C, chromosome 6 at 145,955,635 bp
  • T to A, chromosome 7 at 26,819,461 bp
  • A to G, chromosome 7 at 28,790,589 bp
  • T to G, chromosome 7 at 33,364,544 bp
  • A to G, chromosome 7 at 48,447,934 bp
  • A to T, chromosome 7 at 102,098,011 bp
  • A to G, chromosome 7 at 141,862,028 bp
  • T to C, chromosome 8 at 4,235,575 bp
  • A to G, chromosome 8 at 27,046,041 bp
  • T to C, chromosome 8 at 104,468,767 bp
  • T to A, chromosome 9 at 19,584,724 bp
  • C to A, chromosome 9 at 86,564,775 bp
  • A to G, chromosome 10 at 18,652,631 bp
  • A to G, chromosome 10 at 28,797,506 bp
  • A to T, chromosome 10 at 75,910,152 bp
  • A to T, chromosome 10 at 127,605,846 bp
  • G to T, chromosome 11 at 6,636,724 bp
  • T to C, chromosome 11 at 9,314,624 bp
  • A to G, chromosome 11 at 49,967,401 bp
  • T to C, chromosome 11 at 87,218,267 bp
  • T to A, chromosome 11 at 102,897,102 bp
  • T to C, chromosome 11 at 104,950,200 bp
  • G to A, chromosome 11 at 121,204,550 bp
  • T to A, chromosome 12 at 11,254,373 bp
  • T to C, chromosome 12 at 117,877,044 bp
  • A to T, chromosome 13 at 3,569,516 bp
  • T to C, chromosome 13 at 27,559,372 bp
  • A to G, chromosome 13 at 45,567,957 bp
  • C to T, chromosome 13 at 49,446,342 bp
  • C to T, chromosome 13 at 58,013,863 bp
  • T to C, chromosome 13 at 67,748,774 bp
  • A to G, chromosome 14 at 26,422,548 bp
  • G to A, chromosome 14 at 33,104,115 bp
  • T to C, chromosome 14 at 54,223,100 bp
  • A to G, chromosome 15 at 78,673,435 bp
  • C to T, chromosome 15 at 101,029,837 bp
  • T to A, chromosome 15 at 101,920,289 bp
  • A to G, chromosome 15 at 103,199,744 bp
  • T to C, chromosome 16 at 17,502,940 bp
  • A to T, chromosome 17 at 24,894,835 bp
  • A to G, chromosome 17 at 37,483,492 bp
  • A to C, chromosome 17 at 42,503,175 bp
  • A to G, chromosome 17 at 46,436,830 bp
  • A to T, chromosome 17 at 56,434,532 bp
  • T to C, chromosome 18 at 65,449,609 bp
  • A to G, chromosome 19 at 13,887,389 bp
  • T to C, chromosome 19 at 44,337,506 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8112 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
067541-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.